Current Neuropharmacology最新文献

{"title":"Exogenous Melatonin as a Sleep-promoting Agent beyond its Chronobiotic Properties: A Scoping Review of its Effects on Key Sleep-wake Neurotransmitters.","authors":"Letizia Biso, Nicola Luigi Bragazzi, Marco Bonaso, Erik Bersanetti, Sergio Garbarino, Marco Scarselli","doi":"10.2174/011570159X379708250702084616","DOIUrl":"https://doi.org/10.2174/011570159X379708250702084616","url":null,"abstract":"<p><strong>Introduction: </strong>Exogenous melatonin (exo-MLT) is a sleep-promoting agent that modulates key sleep-wake neurotransmitters.</p><p><strong>Methods: </strong>This scoping review analyzed 623 studies retrieved from PubMed/MEDLINE and ISI/ Web of Science, applying PRISMA methodology to ensure rigorous inclusion criteria. After screening, 58 original research papers were analyzed for exo-MLT's effects on gamma-aminobutyric acid (GABA), serotonin, dopamine, glutamine, norepinephrine, epinephrine, orexin, acetylcholine, adenosine, glycine, galanin, and histamine.</p><p><strong>Results: </strong>We identified 20 studies on the GABAergic system, showing that exo-MLT enhances GABA activity through different mechanisms, promoting non-REM sleep and reducing stress-related hyperarousal. On serotonin, 16 studies revealed limited and variable effects depending on the dose and physiological conditions. Total 13 dopamine studies suggested that exo-MLT does not alter physiological dopamine turnover, restoring dopaminergic balance in pathological states. On the glutamatergic system, seven studies showed a compensatory role of exo-MLT on glutamate excitotoxicity. Six studies on norepinephrine highlighted exo-MLT's ability to regulate sympathetic activity. The orexinergic system was the focus of five studies, indicating exo-MLT's inhibitory action on orexinergic neurons, enhancing sleep quality and consolidation. Five studies investigated exo-MLT on the cholinergic system, revealing an enhancing effect on acetylcholine activity in physiological and pathophysiological conditions. Lastly, four studies exploring adenosine and glycine were inconclusive of the exo-MLT effect, while we could not find any data on histamine and galanin.</p><p><strong>Discussion: </strong>This review underscores exo-MLT's mechanisms beyond circadian regulation, offering therapeutic promise in sleep disorders associated with other neuropsychiatric conditions.</p><p><strong>Conclusion: </strong>Exo-MLT's interactions provide insights into its safety and non-addictive characteristics, supporting its integration into personalized sleep medicine.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resilience and Recalibration of Bibliometric Indicators in Neurosciences and Neuropharmacology Journals After COVID-19: A Longitudinal Rate of Change Analysis Using Mixed-Effects Models.","authors":"Camilo Rios-Castañeda, Heriberto Aguirre-Meneses, Marco-Antonio Nuñez-Gaona, Ernesto Roldan-Valadez","doi":"10.2174/011570159X384613250702110845","DOIUrl":"https://doi.org/10.2174/011570159X384613250702110845","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The COVID-19 pandemic triggered unprecedented changes in the scholarly publishing landscape, particularly in biomedical fields such as Neurosciences and Neuropharmacology. Several journals experienced steep, short-term increases in citation metrics during 2020-2022. However, it remains uncertain whether these surges reflected a sustainable impact or temporary inflation. This study aimed to analyze post-pandemic bibliometric behavior by evaluating the Rate of Change (RoC) in key journal-level indicators from 2013 to 2023.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective longitudinal study was conducted on 233 neuroscience journals indexed in the Journal Citation Reports. Six indicators were analyzed: Journal Impact Factor (JIF), Eigenfactor Score, Immediacy Index, Article Influence Score, Cited Half-Life, and Total Citations. RoC was calculated for each metric on an annual basis. Mixed-effects models with random intercepts and slopes were constructed to evaluate longitudinal trajectories and identify changes associated with three defined periods: prepandemic (2013-2019), pandemic (2020-2022), and post-pandemic (2023). Subgroup analyses assessed journal quartiles and categories to explore variations in impact resilience.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The pandemic period (2020-2022) showed significant increases in RoC for JIF (mean β = +4.85, p = 0.004), Immediacy Index (β = +6.22, p = 0.002), and Total Citations (β = +5.88, p &lt; 0.001). These changes were more prominent in top-quartile journals and those classified under Neuropharmacology. In contrast, alternative metrics such as the Eigenfactor Score and Article Influence Score remained relatively stable across the same period. In 2023, most indicators exhibited a normalization trend, with JIF and Immediacy Index showing marked deceleration in RoC, suggesting a post-pandemic recalibration. Journals with sustained positive trajectories were primarily concentrated in high-impact clusters, with Current Neuropharmacology ranking among the top performers by RoC slope.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;The findings demonstrate that the surge in citations during the pandemic was primarily transitory and varied across bibliometric indicators. Traditional metrics like JIF and Immediacy Index were more sensitive to systemic shocks, while influence-based indicators (Eigenfactor and Article Influence Score) showed higher temporal resilience. The application of RoC allowed for a nuanced interpretation of metric trajectories and minimized misinterpretation of short-term spikes. Limitations include reliance on publicly available data and potential lag effects in citation behavior not fully captured within the 10-year window.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study reveals that pandemic-era citation inflation in Neuroscience journals was largely temporary and metric-dependent. RoC-based modeling offers a reproducible and adaptable approach for assessing the sustainability ","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of the Microbiota-Gut-Brain Axis in Perinatal Depression: Novel Insights for Treatment.","authors":"Jiajing Chao, Zhangmin Tan, Zhe Li, Chengfang Xu","doi":"10.2174/011570159X380460250710061340","DOIUrl":"https://doi.org/10.2174/011570159X380460250710061340","url":null,"abstract":"<p><p>Perinatal depression, a prevalent mood disorder complicating pregnancy and childbirth, poses significant threats to maternal health and neonatal development. While psychotherapy and antidepressants constitute current standard treatments, their clinical application faces substantial limitations during pregnancy and lactation, including safety concerns, treatment resistance, and poor adherence rates. These therapeutic constraints have spurred growing interest in novel gut-brain axis (GBA)-targeted interventions. Emerging evidence suggests that the gut microbiota communicates with the brain through a complex network of neural, immune, and endocrine pathways, playing a critical role in regulating mood, behavior, and cognitive functions. Interventions such as probiotics and fecal microbiota transplantation (FMT) are increasingly explored for their potential to restore microbial balance and alleviate depressive symptoms. This review aims to systematically examine the role of the GBA in the context of perinatal depression, offering novel insights to inform clinical treatment strategies. Furthermore, it evaluates the promise and limitations of microbiota-targeted interventions while discussing future directions for personalized microbiome therapeutics.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intercellular Communication Pathways in Cerebral Ischemia: Mechanisms, Molecular Insights, and Therapeutic Implications.","authors":"Guoqian Cui, Wenbo Guo, Muzi Li, Shengshuang Chen, Xin Shao, Jie Liao, Xiaohui Fan","doi":"10.2174/011570159X388985250711064325","DOIUrl":"https://doi.org/10.2174/011570159X388985250711064325","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral ischemia (CI) is a severe neurological disorder characterized by high incidence and disability rates. Its pathogenesis is complex, involving multiple interrelated biological processes. Among these, intercellular communication has emerged as a key mechanism regulating the damage and recovery phases of CI. It controls information exchange between cells, thereby playing a crucial role in cellular responses to ischemic injury. Understanding how intercellular communication promotes the pathophysiology of CI may provide valuable insights into new therapeutic targets.</p><p><strong>Methods: </strong>To elucidate the role of intercellular communication in CI, recent literature was analyzed, with a focus on how intercellular communication influences cellular behaviors and metabolism. This review integrates data from molecular biology, cellular signaling studies, and cerebral ischemia models.</p><p><strong>Results: </strong>Studies indicate that intercellular communication significantly influences the progression and outcomes of CI. Intercellular communication not only participates in regulating the inflammatory response following injury but also plays a dual role in neuroprotection and regeneration.</p><p><strong>Discussion: </strong>The dual role of intercellular communication-exacerbating damage through inflammatory cascades and promoting recovery through neuroprotective mechanisms-highlights its complex contribution to the pathology of CI. Cellular crosstalk between neurons, glial cells, endothelial cells, and immune cells coordinates the dynamic response to ischemic injury. Understanding these dynamics offers promising opportunities for targeted interventions.</p><p><strong>Conclusion: </strong>Intercellular communication plays a central role in the mechanisms of injury and repair in cerebral ischemia. By influencing inflammation, neuroprotection, and regeneration, it serves as both a mediator of injury and a potential therapeutic target. Further research is needed to fully elucidate these mechanisms and translate them into effective clinical strategies for treating CI.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Hotspots and Frontiers of Ischemic Stroke and Traditional Chinese Medicine: A Knowledge Mapping and Text Mining Analysis.","authors":"Jian Xie, Teng Li, Yuan Zhang","doi":"10.2174/011570159X378811250702095624","DOIUrl":"https://doi.org/10.2174/011570159X378811250702095624","url":null,"abstract":"<p><strong>Background and objective: </strong>Ischemic stroke is a complex neurological disease with poor prognosis, resulting in significant economic burdens for patients, their families, and society at large. Traditional Chinese Medicine (TCM) offers unique advantages and has been utilized for thousands of years in the prevention and treatment of ischemic stroke. However, there is currently a lack of bibliometric analysis and knowledge mapping regarding TCM treatments for this condition. To identify the key areas and future directions of TCM treatment for Ischemic Stroke.</p><p><strong>Methods: </strong>We extracted articles on TCM treatments for ischemic stroke from the Web of Science Core Collection (WoSCC) database, spanning from January 1, 1990, to March 20, 2025, and conducted a bibliometric analysis. Data processing was performed using CiteSpace, VOSviewer, and Origin2024b.</p><p><strong>Results: </strong>We collected 506 published papers, with China accounting for the majority of these publications (97.0 %, 418 articles). The Journal of Ethnopharmacology and Frontiers in Pharmacology were the two most frequently published journals. The leading institutions contributing to this research included the Chinese Academy of Medical Sciences, Beijing University of Chinese Medicine, and Peking Union Medical College (now known as Capital Medical University). The primary research hotspots in TCM treatment for ischemic stroke focused on protective effects, brain injury, and neural regeneration. Notably, network pharmacology, molecular docking, and metabolomics were identified as the commonly used research methods. Among them, network pharmacology was the most frequently used research method. Additionally, we summarized the TCM remedies that have been extensively researched and cited in the context of ischemic stroke, including catalpol, angong niuhuang wan, buyang huanwu decoction, jeo-dang-tang, yiqifumai powder injection, and gualou guizhi decoction.</p><p><strong>Conclusion: </strong>The work highlights the key topics and recent research frontiers, providing valuable resources for scholars interested in the role of TCM in treating ischemic stroke.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proton-Sensitive Receptors/Channels: Therapeutic Target for Ischemic Stroke, Focusing on Their Roles and Mechanisms.","authors":"Yao Cheng, Yu-Jie Zhai, Shao-Shuai Wang, Yan-Ying Fan","doi":"10.2174/011570159X381737250710050221","DOIUrl":"https://doi.org/10.2174/011570159X381737250710050221","url":null,"abstract":"<p><p>Ischemic stroke is a common cerebrovascular disease. However, its pathophysiological mechanisms and therapeutic targets remain unclear. In physiological states, the brain maintains an acid-base balance through various mechanisms that are crucial for normal brain function. However, during cerebral ischemia, the disruption of this balance leads to acidosis of the ischemic brain tissue, primarily due to the interruption of energy supply and alterations in ion homeostasis. Studies have indicated that proton-sensitive receptors/channels, such as acid-sensing ion channels, protonsensitive G-protein-coupled receptors, and proton-activated chloride channels, exhibit distinct mechanisms in response to decreased pH. These targets are intricately linked to the pathophysiological processes, such as neuroprotection, neurorestoration, and neuroinflammation, underlying ischemic stroke. Recent studies have uncovered novel patterns of recognition, activation, subcellular distribution, and emerging functions of these proton-sensing receptors/channels, offering deeper insights into their roles and mechanisms in ischemic brain injury. This review summarizes the current insights regarding different contributions of these proton-sensing receptors/channels following ischemic stroke, and highlights the significance of targeting them for advancing novel therapeutic strategies for stroke intervention.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Microbiota and Bipolar Disorder: Advances in Translational Applications.","authors":"Liujiao Yan, Shaoxia Zhang, Xiaobing Lu, Zezhi Li","doi":"10.2174/011570159X379789250626044050","DOIUrl":"https://doi.org/10.2174/011570159X379789250626044050","url":null,"abstract":"<p><p>Bipolar disorder is a severe, recurrent affective disorder that imposes significant pain and burden on both the patients themselves and the social economy. Recent studies have indicated the involvement of intestinal flora in emotional regulation, as well as its close association with the occurrence and progression of diseases such as bipolar disorder. Therefore, conducting comprehensive research on the impact of intestinal microflora and the \"gut-brain axis\" on bipolar disorder becomes imperative, offering novel insights into its etiology, diagnosis, and treatment options. Consequently, this article provides an overview of the role and potential mechanisms underlying intestinal microbiota in bipolar disorder.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membrane Protein Modulators in Neuroinflammation.","authors":"Ligang Chen, Zheng Zou, Chao Dang, Geyu Wang, Tingzhun Zhu, Guobiao Liang","doi":"10.2174/011570159X375716250701111204","DOIUrl":"https://doi.org/10.2174/011570159X375716250701111204","url":null,"abstract":"<p><p>Neuroinflammation has emerged as a critical pathological process that significantly contributes to the development and progression of a wide range of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Recent advances in neuroscience have underscored the pivotal role of neuroinflammation not only in exacerbating these diseases but also in accelerating neuronal degeneration. The growing prevalence of these conditions worldwide, coupled with the limited efficacy of current therapeutic approaches, highlights the urgent need for new therapeutic strategies. Given the central role of neuroinflammation in disease progression, targeting the neuroinflammatory process offers a compelling opportunity for effective intervention. Membrane proteins are key regulators in cellular signal transduction and intercellular communication, and their dysregulation may trigger and sustain neuroinflammatory responses. Consequently, modulators of membrane proteins have emerged as promising candidates for managing neuroinflammation. Current research indicates that natural products and small-molecule compounds can modulate membrane protein activity, effectively mitigating excessive inflammatory responses and exhibiting potent anti-neuroinflammatory effects. This review systematically examines the classification and functional roles of membrane proteins in neuroinflammation, with a particular focus on the therapeutic potential of channel proteins, transporter proteins, and receptor proteins across various neurological conditions. The identification and development of membrane protein modulators present an innovative and urgent avenue for advancing anti-neuroinflammatory therapies, offering potential breakthroughs in treating these prevalent and debilitating diseases.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dealing with Early-Onset Schizophrenia and the Role of Lurasidone: An Expert Opinion.","authors":"Sergio De Filippis, Gabriele Masi, Gianluca Serafini, Stefano Vicari, Antonio Vita, Benedetto Vitiello","doi":"10.2174/011570159X385722250701114931","DOIUrl":"https://doi.org/10.2174/011570159X385722250701114931","url":null,"abstract":"<p><p>Compared to schizophrenia in adults, Early Onset Schizophrenia (EOS) features diagnostic, clinical, and therapeutic peculiarities that are the subject of ongoing discussion among psychiatrists and neuropsychiatrists. This article presents the outcomes of a meeting and a series of virtual roundtable discussions among specialists who validated practical recommendations for the diagnosis and management of EOS in light of recent literature. The identification of risk factors and prodromal symptoms, as well as the differentiation of EOS from other psychiatric conditions, is crucial for early detection. Timely identification enables the implementation of appropriate psycho-behavioural and pharmacological interventions and supports close monitoring of the developmental trajectories associated with EOS. The collaboration between the different professionals who deal with EOS patients and a therapeutic approach that allows a normal cognitive, sexual, and psychophysical development makes it possible to ensure the therapeutic alliance necessary for the optimal management of the disease over time. In a scenario that is complicated by negative prognostic factors, such as the late recognition of the disease, comorbid and latent psychiatric conditions, the increasingly widespread use of substances among adolescents, and a poor therapeutic adherence often due to antipsychotics side effects, a growing body of literature emphasizes the advantages of lurasidone in the treatment of EOS. Compared to other pharmacological agents commonly used in schizophrenia, lurasidone has been shown to intervene comprehensively and effectively against the positive and negative symptoms of EOS, with manageable side effects and the preservation of a good QoL.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venlafaxine and Delirium: Understanding the Association.","authors":"Francisco Epelde","doi":"10.2174/011570159X378277250702051515","DOIUrl":"https://doi.org/10.2174/011570159X378277250702051515","url":null,"abstract":"<p><p>Delirium represents a significant clinical, economic, and societal challenge, frequently arising in hospitalized patients due to multiple factors, including pharmacological triggers. Recognizing and preventing delirium is crucial to improving patient outcomes and reducing healthcare costs. This review focuses on the association between venlafaxine, a commonly used antidepressant, and delirium. We explore potential mechanisms, clinical presentations, and risk factors linked to venlafaxine-induced delirium, emphasizing the need for heightened awareness among clinicians. The findings underscore the importance of vigilance during drug initiation, dosage adjustment, or withdrawal to mitigate the risk of this neuropsychiatric condition.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}