Current Neuropharmacology最新文献

{"title":"The Role and Mechanism of Estrogen in Perimenopausal Depression.","authors":"Yaqi Liu, Xiying Fu, Boyun Guan, Ranji Cui, Wei Yang","doi":"10.2174/011570159X371863250327073835","DOIUrl":"https://doi.org/10.2174/011570159X371863250327073835","url":null,"abstract":"<p><p>Depression is a severe psychiatric disorder characterized by high prevalence rates, elevated suicide risks, and significant relapse rates. Women, particularly during the perimenopausal period, are more vulnerable to developing depression. Fluctuations in estrogen levels during perimenopause can heighten a woman's sensitivity to psychosocial stress. Clinical trials have demonstrated the short-term antidepressant efficacy of estradiol in perimenopausal women. However, the precise mechanisms through which estrogen influences mood disorders during perimenopause remain unclear. This review summarizes the risk factors associated with perimenopausal depression (PMD), examines current research on estrogen therapy, and explores the potential mechanisms and related pathological processes involved in estrogen's role in treating depression. Understanding how estrogen mitigates depressive symptoms in perimenopausal women may help reduce the morbidity and mortality associated with PMD while also alleviating its socioeconomic burden.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Understanding of Psychomotor Agitation: From Causes to Hospital Care.","authors":"Antonio Del Casale, Jan Francesco Arena, Christian Napoli, Fabiano Grassi, Serena Mancino, Cristina Di Legge, Barbara Adriani, Giovanna Parmigiani, Alessandro Vento, Giorgio Veneziani, Carlo Lai, Stefano Ferracuti","doi":"10.2174/011570159X340145250109080932","DOIUrl":"https://doi.org/10.2174/011570159X340145250109080932","url":null,"abstract":"<p><p>Psychomotor agitation is a syndrome characterized by abnormal psychic and motor activation, with a concrete possibility of escalation to aggression or violence. It represents a frequent reason for attending emergency departments and can stem from various organic conditions and mental disorders. In emergency settings, prompt identification of the possible underlying cause and optimal management are crucial to ensure the safety of both patients and healthcare providers. However, current management strategies are based on evidence focused on too specific clinical contexts or aspects of patient care. This narrative review aims to consolidate available evidence on clinical-diagnostic evaluation, severity assessment, patient-specific interventions, and hospital management. Patients should always be approached using de-escalation techniques while providing a rapid and systematic assessment of the key differential elements between organic and psychiatric causes. Pharmacological interventions are recommended as secondary measures to ensure safety and should be directed at facilitating the therapeutic relationship. Physical restraints and seclusion should be used only as a last resort, for the shortest duration, and under strict medical supervision. There is a pressing need for the systematic organization of evidence into effective guidelines to optimize the clinical approach to psychomotor agitation, improving both patient outcomes and safety in emergency settings.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota-gut-brain axis: Novel Potential Pathways for Developing Antiepileptogenic Drugs.","authors":"Huifeng Li, Huanling Lai, Yue Xing, Shangnan Zou, Xiaofeng Yang","doi":"10.2174/1570159X23666250414094040","DOIUrl":"https://doi.org/10.2174/1570159X23666250414094040","url":null,"abstract":"<p><p>The treatment of epilepsy remains imperfect due to a lack of understanding of its pathogenesis. Although antiseizure medications can control most seizures, up to 30% of patients experience uncontrolled seizures, leading to refractory epilepsy. Therefore, elucidating the pathogenesis of epilepsy and exploring new avenues to design antiepileptic drugs may improve epilepsy treatment. Recent studies have identified an imbalance of the gut microbiota (GM) in both patients with epilepsy and various animal models of epilepsy. In response to this phenomenon, an increasing number of studies have focused on controlling seizures by regulating GM homeostasis, utilizing methods such as dietary restrictions, fecal microbiota transplantation, and the use of prebiotics. Surprisingly, these interventions have shown promising antiepileptic effects, suggesting that GM, through the regulatory role of the microbiota-gut-brain axis (gut-brain axis), may emerge as a novel strategy for treating epilepsy. This review aims to discuss the research progress on the relationship between GM and epilepsy, incorporating the latest clinical studies and animal experiments. We will specifically concentrate on the potential key role of the gut-brain axis in epileptogenesis, epilepsy development, and outcomes of epilepsy. Through a detailed analysis of the underlying mechanisms of the gut-brain axis, we aim to provide a more comprehensive perspective on understanding the pathophysiology of epilepsy and lay the groundwork for the development of new antiepileptic drugs in the future.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic and Photothermal Therapies using Nanotechnology Approach in Alzheimer's Disease.","authors":"Büşra Öztürk, Huriye Demir, Mine Silindir Günay, Yagmur Akdag, Selma Sahin, Tugba Gulsun","doi":"10.2174/011570159X370790250317045223","DOIUrl":"https://doi.org/10.2174/011570159X370790250317045223","url":null,"abstract":"<p><p>Alzheimer's disease is a neurodegenerative disease that impairs cognitive function. The incidence of Alzheimer's disease increases with the increase in the elderly population. Although the clear pathogenesis of Alzheimer's disease is not yet known, the formation of amyloid plaques and tau fibrils, diminished acetylcholine levels, and increased inflammation can be observed in patients. Alzheimer's disease, whose pathogenesis is not fully demonstrated, cannot be treated radically. Since it has been observed that only pharmacological treatment alone isn't sufficient, alternative approaches have become essential. Among these approaches, nanocarriers greatly facilitate the transport of drugs since the blood-brain barrier is an important obstacle to the penetration of drugs into the brain. Photosensitizers trigger activation after exposure to near-infrared radiation light of a suitable wavelength or laser light, resulting in the selective destruction of Aβ plaques. Photodynamic therapy and photothermal therapy have been investigated for their potential to inhibit Aβ plaques through photosensitizers. By encapsulating photosensitizers in nanocarriers, the limitations of photosensitizers can be overcome. By using these photosensitizers, near-infrared radiation fluorescence imaging can be used as a theranostic. In this review, potential treatment options for photodynamic therapy and photothermal therapy for Alzheimer's disease are summarised, and a simultaneous or combined approach is discussed, taking into account potential nanotheranostics.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Glycerophospholipid Metabolism in Epilepsy.","authors":"Zijian Li, Zhen Liang, Jing Zhang, Songyan Liu","doi":"10.2174/011570159X374966250319050052","DOIUrl":"https://doi.org/10.2174/011570159X374966250319050052","url":null,"abstract":"<p><p>Epilepsy is a prevalent and severe neurological condition characterized by recurring seizures. It impacts over 70 million individuals worldwide, posing a substantial challenge to public health and placing a heavy burden on society. Glycerophospholipids are an essential component of neuronal cell membranes. Their metabolism is strictly regulated, and maintaining their homeostasis is crucial for the optimal function of the nervous system. Research indicates that disruptions in glycerophospholipid metabolism are commonly detected in patients with epilepsy and animal models. However, the precise molecular mechanisms behind these disruptions remain unclear. Existing evidence indicates that neuroinflammation, oxidative stress, genetic mutations, and ion channel dysfunction are crucial factors contributing to glycerophospholipids imbalance and epilepsy. Further, therapeutic interventions targeting these pathological processes, such as regulating neuroinflammation and oxidative stress or restoring the balance of glycerophospholipid metabolism, may provide new avenues for epilepsy treatment. This review aims to provide an in-depth analysis of the potential mechanisms underlying the relationship between glycerophospholipid metabolism disorders and epilepsy, exploring potential therapeutic targets and diagnostic biomarkers.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese Multidisciplinary Expert Consensus on Orphan/Anticopper Drugs and Other Non-drug Management of Hepatolenticular Degeneration.","authors":"Ren Min Yang, Tao Feng, Wei Cai, Xu-En Yu, Gang Wang, Yong-Zhu Han, Cun-Xiu Fan, Qiang Xia, Hai-Bo Chen, Xiao-Ping Wang","doi":"10.2174/011570159X349587250311072553","DOIUrl":"https://doi.org/10.2174/011570159X349587250311072553","url":null,"abstract":"<p><strong>Background: </strong>This study aims to guide the diagnosis and treatment of hepatolenticular degeneration (also named Wilson's disease, WD) and aid multidisciplinary clinicians in making reasonable and personalized treatment regimens.</p><p><strong>Objectives: </strong>The authors aim to establish a systemic structure for Chinese Multidisciplinary Expert Consensus on Diagnosis and Treatment of Hepatolenticular Degeneration.</p><p><strong>Method: </strong>We collaborated with experts from relevant branches of the Chinese Medical Association and multiple disciplines, along with statistical experts, to formulate this consensus. It is based on advancements in basic and clinical research on Wilson's disease, both domestically and internationally.</p><p><strong>Results: </strong>It mainly consists of clinical manifestations, diagnosis, differential diagnosis, management, and prognosis in the context of Multi-Department treatment (MDT) in China.</p><p><strong>Conclusion: </strong>This Chinese consensus incorporates four decades of institutional experience with thousands of Chinese Wilson's disease (WD) inpatients, as well as decades of international inpatient cases from East to West. It is hoped that this consensus will garner broader attention from clinicians worldwide.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobehavioral Disorders and Cognitive Impairment in Methcathinone Exposure: A Systematic Review of Literature.","authors":"Yihan Wang, Ning Wang, Shuquan Zhao","doi":"10.2174/011570159X387589250318041633","DOIUrl":"https://doi.org/10.2174/011570159X387589250318041633","url":null,"abstract":"<p><strong>Background: </strong>Methcathinone, a synthetic cathinone derivative similar to amphetamine, has transitioned from a 1920s ephedrine precursor and Soviet-era antidepressant to a recreationally used substance since the 1970s-1980s, raising public health concerns due to its addiction potential and neurotoxicity-related health risks.</p><p><strong>Objective: </strong>This review comprehensively analyzes methcathinone's impact on adult offspring, synthesizing recent advancements and critiquing literature to pinpoint key findings, challenges, and future research directions.</p><p><strong>Method: </strong>The systematic review adhered to PRISMA guidelines and encompassed case series, prospective and retrospective studies, as well as short communications published in English. An electronic search was conducted on PubMed, Elsevier, and CNKI. The focus was on methcathinone and its neuropsychological disorders and physical health complications, specifically in adult offspring.</p><p><strong>Result: </strong>A total of 8 studies met the inclusion criteria, resulting in a dataset of methcathinone on neurobehavioral and cognitive functions. These studies mainly found that prenatal methcathinone exposure in rats led to delayed physical development and induced anxiety-like behavior in offspring, with changes observed in neurobehavioral tests and the concentration of serotonin and dopamine. Furthermore, neurochemical effects were identified, showing dose- and time-dependent increases in extracellular dopamine and serotonin concentrations, and neurotoxic potential towards brain dopamine neurons.</p><p><strong>Conclusion: </strong>This study concludes that methcathinone poses severe risks, including neurotoxicity for users and developmental harm for offspring, necessitating ongoing research to comprehend associated risks and inform public health interventions.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Current Research Landscape on the Machine Learning Application in Autism Spectrum Disorder: A Bibliometric Analysis From 1999 to 2023.","authors":"Xinyu Li, Wei Huang, Rongrong Tan, Caijuan Xu, Xi Chen, Qian Zhang, Sixin Li, Ying Liu, Huiwen Qiu, Changlong Bi, Hui Cao","doi":"10.2174/011570159X332833241222191422","DOIUrl":"https://doi.org/10.2174/011570159X332833241222191422","url":null,"abstract":"<p><strong>Background: </strong>Language deficits, restricted and repetitive interests, and social difficulties are among the characteristics of autism spectrum disorder (ASD). Machine learning and neuroimaging have also been combined to examine ASD. Utilizing bibliometric analysis, this study examines the current state and hot topics in machine learning for ASD.</p><p><strong>Objective: </strong>A research bibliometric analysis of the machine learning application in ASD trends, including research trends and the most popular topics, as well as proposed future directions for research.</p><p><strong>Methods: </strong>From 1999 to 2023, the Web of Science Core Collection (WoSCC) was searched for publications relating to machine learning and ASD. Authors, articles, journals, institutions, and countries were characterized using Microsoft Excel 2021 and VOSviewer. Analysis of knowledge networks, collaborative maps, hotspots, and trends was conducted using VOSviewer and CiteSpace.</p><p><strong>Results: </strong>A total of 1357 papers were identified between 1999 and 2023. There was a slow growth in publications until 2016; then, between 2017 and 2023, a sharp increase was recorded. Among the most important contributors to this field were the United States, China, India, and England. Among the top major research institutions with numerous publications were Stanford University, Harvard Medical School, the University of California, the University of Pennsylvania, and the Chinese Academy of Sciences. Wall, Dennis P. was the most productive and highest-cited author. Scientific Reports, Frontiers In Neuroscience Autism Research, and Frontiers In Psychiatry were the three productive journals. \"autism spectrum disorder\", \"machine learning\", \"children\", \"classification\" and \"deep learning\" are the central topics in this period.</p><p><strong>Conclusion: </strong>Cooperation and communication between countries/regions need to be enhanced in future research. A shift is taking place in the research hotspot from \"Alzheimer's Disease\", \"Mild Cognitive Impairment\" and \"cortex\" to \"artificial intelligence\", \"deep learning\", \"electroencephalography\" and \"pediatrics\". Crowdsourcing machine learning applications and electroencephalography for ASD diagnosis should be the future development direction. Future research about these hot topics would promote understanding in this field.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering T Cell Dynamics in Alzheimer's Disease Pathogenesis: Insights and Implications.","authors":"Qiqi Yang, Yunjie Qiu, Junjun Ni, Hui Li, Hong Qing","doi":"10.2174/011570159X350611250303044527","DOIUrl":"https://doi.org/10.2174/011570159X350611250303044527","url":null,"abstract":"<p><p>Neuroinflammation has emerged as a crucial factor in the pathogenesis of Alzheimer's disease (AD), paving the way for promising therapeutic interventions. Increasing evidence highlights the interplay between the peripheral immune system and the central nervous system (CNS) in driving neuroinflammation, with T lymphocytes playing a vital role in both regulatory and effector functions. Aberrant activation of T cells during the early stages of neuroinflammation perpetuates inflammatory responses by interacting with CNS glial cells and releasing pro-inflammatory mediators, such as IFN-γ, TNF-α, and IL-17. Studies have documented significant T cell activation and infiltration into the brain parenchyma in AD, contributing to disease progression. However, the specific mechanisms by which T cells mediate AD pathogenesis remain unclear. This comprehensive review synthesizes the current understanding of T cell involvement in AD pathology, emphasizing their aberrant activation, interactions with microglia, tau protein pathology, and the influence of gut microbiota. Finally, we propose potential treatment modalities for AD, highlighting the promise of T cellbased therapies currently under investigation in clinical trials. Understanding the critical role of T cells in intercellular communication and disease progression may enhance our comprehension of the pathophysiology of AD.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Trends and Evolution of Astrocytes in Depression and Antidepressant Treatment: A Bibliometric Analysis.","authors":"Shu-Man Pan, Zhe Li, Jing-Qi Zhou, Xiang Shang, Tian-Jia Gu, Xiao-Ming Sun, Zhen-Hua Zhu","doi":"10.2174/011570159X353752250227113751","DOIUrl":"https://doi.org/10.2174/011570159X353752250227113751","url":null,"abstract":"<p><strong>Background: </strong>Astrocytes have emerged as key players in the pathogenesis of depression and antidepressant treatment. However, comprehensive reviews in this field were absent. The bibliometric analysis can effectively illustrate research trends and hotspots of a specific domain through analysis of publications.</p><p><strong>Objective: </strong>We conducted a bibliometric analysis to overview the current hotspots and research trends of astrocytes in depression and antidepressant treatment.</p><p><strong>Methods: </strong>We collected publications' data from the science citation index expanded (SCI-E) of the Web of Science (WOS) database, and bibliometric analysis was applied through CiteSpace and VOSviewer software. Results were mapped via GraphPad Prism, Adobe Photoshop, and R software.</p><p><strong>Results: </strong>After analysis of 2896 publications, we analyzed the content of publications, most influential publications, productive journals, most cited journals, core authors, productive countries/regions, and institutions in this field. The cooperation of main countries and organizations was mapped. Most importantly, after a thorough analysis of keywords, we found neuroinflammation is a hot topic in this research field.</p><p><strong>Conclusions: </strong>The results of the bibliometric study prove neuroinflammation is a hot topic in this research field. Nowadays, many studies have investigated the role of astrocytes in depression and antidepressant treatment from the perspective of neuroinflammation. It is essential to pay more attention to elucidating the mechanisms of astrocyte-mediated neuroinflammation to identify potential targets for antidepressant development.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}