Current Neuropharmacology最新文献

{"title":"Research Trends and Evolution of Astrocytes in Depression and Antidepressant Treatment: A Bibliometric Analysis.","authors":"Shu-Man Pan, Zhe Li, Jing-Qi Zhou, Xiang Shang, Tian-Jia Gu, Xiao-Ming Sun, Zhen-Hua Zhu","doi":"10.2174/011570159X353752250227113751","DOIUrl":"https://doi.org/10.2174/011570159X353752250227113751","url":null,"abstract":"<p><strong>Background: </strong>Astrocytes have emerged as key players in the pathogenesis of depression and antidepressant treatment. However, comprehensive reviews in this field were absent. The bibliometric analysis can effectively illustrate research trends and hotspots of a specific domain through analysis of publications.</p><p><strong>Objective: </strong>We conducted a bibliometric analysis to overview the current hotspots and research trends of astrocytes in depression and antidepressant treatment.</p><p><strong>Methods: </strong>We collected publications' data from the science citation index expanded (SCI-E) of the Web of Science (WOS) database, and bibliometric analysis was applied through CiteSpace and VOSviewer software. Results were mapped via GraphPad Prism, Adobe Photoshop, and R software.</p><p><strong>Results: </strong>After analysis of 2896 publications, we analyzed the content of publications, most influential publications, productive journals, most cited journals, core authors, productive countries/regions, and institutions in this field. The cooperation of main countries and organizations was mapped. Most importantly, after a thorough analysis of keywords, we found neuroinflammation is a hot topic in this research field.</p><p><strong>Conclusions: </strong>The results of the bibliometric study prove neuroinflammation is a hot topic in this research field. Nowadays, many studies have investigated the role of astrocytes in depression and antidepressant treatment from the perspective of neuroinflammation. It is essential to pay more attention to elucidating the mechanisms of astrocyte-mediated neuroinflammation to identify potential targets for antidepressant development.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Akkermansia muciniphila on Mouse Models of Depression, Anxiety, and Stress: A Systematic Review and Meta-Analysis.","authors":"Leila Khalili, Gwoncheol Park, Ravinder Nagpal, Pradeep Bhide, Gloria Salazar","doi":"10.2174/011570159X360149250225041829","DOIUrl":"https://doi.org/10.2174/011570159X360149250225041829","url":null,"abstract":"<p><strong>Background: </strong>Akkermansia muciniphila (A. muciniphila), a bacterial species within the human gut microbiome, has shown beneficial effects on host health. Emerging research suggests that A. muciniphila also influences neurobehavioral domains through the microbiota-gut-brain axis. This meta-analysis evaluates A. muciniphila's impact on depression, anxiety, and stress in mouse models.</p><p><strong>Methods: </strong>We conducted a systematic search of PubMed, Science Direct, Embase, and Web of Science databases up to March 2024, identifying 15 eligible studies.</p><p><strong>Results: </strong>Supplementation with A. muciniphila, its outer membrane protein (Amuc_1100), and extracellular vesicles (EVs) alleviated anxiety, depressive-like behaviors, and enhanced memory in mice. Compared to controls, intervention groups exhibited reduced anxiety-like behaviors, including increased travel distance in the open-field test (OFT) and more time spent in the lightbox during the light-dark box (LDB) test and open arms in the elevated plus maze (EPM). Depression-like symptoms were reduced, with lower immobility time in the tail suspension and forced swim tests. Memory function also improved, and learning time was reduced in the Y-maze and Barnes circular maze tests. Serotonin levels increased significantly in the serum and hippocampus, while corticosterone levels decreased, though not significantly. The intervention reduced hippocampal and serum inflammatory markers (TNFα, IL1β, IL6) and altered gut microbiome composition, increasing Akkermansia, Roseburia, Caldicoprobacter, and Lachnospiraceae.</p><p><strong>Conclusion: </strong>This meta-analysis provides evidence supporting the health-promoting effects of A. muciniphila, one of the next-generation probiotics, in alleviating neuropsychiatric disorders. Given the high prevalence and clinical significance of depression, anxiety, and stress, further investigation into the therapeutic utility of A. muciniphila is warranted.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the Central Cholinergic Nervous System in Motor and Non-Motor Symptoms of Parkinson's Disease.","authors":"Si-Yuan Tian, Xin Cao, Guo-Jin Liu, Ying Zi, Hui-Xian Zhu, Yi-Miao Jiang, Wei-Wei Lou, Xiao-Xia Fang, Ling Shan, Zhan Liu, Qian-Xing Zhuang","doi":"10.2174/011570159X368923250313045859","DOIUrl":"https://doi.org/10.2174/011570159X368923250313045859","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a prevalent neurodegenerative disorder that is characterized by both motor and non-motor symptoms. Although dopamine agonists have been demonstrated to be efficacious in the treatment of motor symptoms, their capacity to enhance non-motor symptoms remains constrained. This suggests that additional neurotransmitter systems may be involved in the pathogenesis of PD-related symptoms. The cholinergic nervous system plays a pivotal role in the central nervous system, with various projection systems associated with diverse functions, including but not limited to learning, memory, attention, posture, balance, eye movement control, and adaptation. Nevertheless, the role of the cholinergic nervous system in the motor and non-motor impairments associated with PD remains uncertain. This review elucidates the location, projection, receptors, and effects of central cholinergic systems, as well as their role in both the motor symptoms and non-motor symptoms of PD. Additionally, it examines the crosstalk between cholinergic systems and dopaminergic systems in PD pathology. A deeper comprehension of the fundamental mechanisms of the cholinergic system in PD may facilitate the development of novel therapeutic strategies.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Effectiveness and Potential Pharmacological Mechanism of Minocycline for Spinal Cord Injury through Meta-Analysis and Network Pharmacology.","authors":"Cai-Wei Hu, Zhuo-Yao Li, Ke Zhu, Yu-Xiang Dai, Cheng Zhang, Yue-Li Sun, Qi Shi, Xue-Jun Cui, Min Yao","doi":"10.2174/1570159X23666250313104646","DOIUrl":"https://doi.org/10.2174/1570159X23666250313104646","url":null,"abstract":"<p><p>Spinal cord injury (SCI) has a catastrophic impact and lifelong functional incapacity on patients. Recent research has demonstrated the anti-inflammation and neuroprotection of minocycline, which were advantageous for treating disorders having an inflammatory foundation, including SCI. This study summarized the antioxidant, anti-inflammation, and neuro-restoration of minocycline. PubMed, Web of Science, Embase, and Chinese database were explored from their origin date to July 2022. Data extraction, methodological quality assessment, and study selection were conducted by 2 reviewers. Twenty-four studies were ultimately included. Overall, minocycline improved motor recovery after SCI, with Basso Beattie Bresnahan (BBB) scores in the treated group from the first week (15 studies, n = 378; MD = 2.34; 95% Confidence interval (CI), 1.31-3.36; p < 0.00001) to the fourth week (14 studies, n = 346; MD = 3.15; 95% Confidence Interval (CI), 2.07-4.23; p < 0.00001). Subgroup analysis showed function recovery was related to the mode of drug dose, animal race, and article quality. Network pharmacology identified 100 minocycline-related targets and 6720 SCI-related targets. Heat Shock Protein 90 Alpha Family Class A Member 1(HSP90AA1), Serine/Threonine kinase 1(Akt1), Steroid Receptor Coactivator (SRC), Epidermal growth factor receptor (EGFR) and Catenin (Cadherin-Associated Protein)-Beta 1 (CTNNB1) were key targets. 20 pathways were identified, including PI3K/Akt, MAPK and chemokine signaling pathway. Finally, molecular docking results showed B-cell CLL/lymphoma 2 (BCL2-6), CTNNB1, HSP90AA1, plasminogen activator urokinase (PLAU), and α protein kinase C alpha (PRCAKA) bound to minocycline better. This article concluded that minocycline was effective in treating SCI by improving neurological recovery and inhibiting oxidative stress, apoptosis, and inflammation.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on Neural Cell Culture Systems.","authors":"Ting Li, Xiaosong Qin, Qiang Ao","doi":"10.2174/011570159X360193250219082312","DOIUrl":"https://doi.org/10.2174/011570159X360193250219082312","url":null,"abstract":"<p><p>The nervous system, including the central nervous system and peripheral nervous system, has the most intricate structure and function among all systems in the human body. In studies of physiological and pathological functions, cell culture systems serve as an indispensable tool to simulate the nervous system in vivo. Two-dimensional (2D), three-dimensional (3D), and four-dimensional (4D) neural cell culture systems are used to assess the functional interconnectivity of neuronal tissues and have markedly advanced in recent years. Although 2D culture systems have predominated, they cannot accurately recapitulate the dynamic complexity of the in vivo environment, cell-cell communication, and nervous system structures. Consequently, studies have shifted to using 3D or 4D cell culture systems to achieve more realistic biochemical and biomechanical microenvironments. Nevertheless, many limitations persist in 3D or 4D culture systems, including difficulties in deciphering dynamic and reciprocal remodeling processes, as well as the spatiotemporal distributions of oxygen, nutrients, and metabolic waste. Here, we review 2D, 3D, and 4D culture systems, discuss the advantages and limitations of these techniques in modeling physiologically and pathologically relevant processes, and suggest directions for future research.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal Stress Increases the Risk of the FPR2-related Dysfunction in the Brain's Resolution of Inflammation: A Study on the Humanized APPNL-F/NL-F Mouse Model of Alzheimer's Disease.","authors":"Ewa Trojan, Jakub Frydrych, Władysław Lasoń, Agnieszka Basta-Kaim","doi":"10.2174/011570159X345385241004060055","DOIUrl":"https://doi.org/10.2174/011570159X345385241004060055","url":null,"abstract":"<p><strong>Introduction: </strong>Brain aging is a complex process involving genetic, neurodevelopmental, and environmental factors. Inherent features of this process are cellular senescence, the development of senescence-associated secretory phenotype (SASP), and prolonged inflammation.</p><p><strong>Methods: </strong>Recently, progress has been made in understanding the biological roles of FPR2 receptors and their ligands in the mechanism of inflammation resolution (RoI) in the brain. However, the number of studies comparing the influence of prenatal stress (PS) on RoI in physiological aging and neurodegenerative disorders pathology is very limited, and the data need to be more consistent. Here, we examined whether PS can condition the pattern of age-dependent cognitive and RoI changes in the prefrontal cortex and hippocampus in wild-type and hAPPNL-F/NL-F KI male mice.</p><p><strong>Results: </strong>We discovered that in aging, the memory deficits are accompanied by the limitation of the availability of pro-resolving FPR2 ligands, the rising proinflammatory microglia polarization, and inflammatory ligands mediated FPR2 overactivation. Moreover, the present study suggested the subtle role of the RoI deficits in creating brain cells' senescence and shifting the immunomodulators to the proinflammatory direction. PS has been revealed as a substantial factor modulating the profile of inflame-aging in a manner strongly determined by the age of animals and the brain structure under study, mainly in hAPPNL-F/NL-F KI male mice.</p><p><strong>Conclusion: </strong>Our results identify the FPR2 receptors as a driver regulating the RoI process in the brain and highlight that PS has diversified the picture of age-dependent neurodegenerative pathology.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATP1A3 Acts as a Potential Anti-oncogene in Glioblastoma via the Antagonizing Interaction with Small Nuclear Ribonucleoprotein Polypeptide G.","authors":"Shuang Zou, Bing Qin, Qi Chen, Zhiwei Shen, Qichang Liu, Xiangdong Zhu, Yulong Lan","doi":"10.2174/011570159X361656250128073206","DOIUrl":"https://doi.org/10.2174/011570159X361656250128073206","url":null,"abstract":"<p><strong>Background: </strong>The sodium pump α3 subunit (ATP1A3) is associated with various brain's physiological and pathological mechanisms. However, its molecular mechanisms and cellular targets in glioblastoma (GBM) are poorly understood.</p><p><strong>Methods: </strong>Bioinformatics and phosphor-proteomics analysis, target fishing experiment, confocal immunofluorescence, molecular cloning, and western blot techniques were carried out to elucidate probable downstream signaling pathways. Then GBM xenografts were established to assess potential molecular mechanisms of ATP1A3 associated with its in vivo anti-glioma impacts.</p><p><strong>Results: </strong>The mechanistic analyses indicated that the antagonism between ATP1A3 and small nuclear ribonucleoprotein polypeptide G (SNRPG) could suppress GBM growth. ATP1A3 inhibits SNRPGinduced GBM epithelial-mesenchymal transition, and SNRPG decreases ATP1A3 by increasing phosphorylation at S643. As a negative feedback loop, ATP1A3 overexpression causes a reduction of SNRPG-induced invasion-metastasis cascades via regulating KLF9. Furthermore, by using artificial intelligence (AI) techniques, we have also exerted the design and application of a synthetic peptide (ATP1A3-S643 peptide), which could be the potential inhibitor of ATP1A3 phosphorylation. To better explore the anti-glioma effect of ATP1A3 activation, a bioengineering nanomedicine capable of ondemand ATP1A3 activator delivery to the brain for GBM has also been developed in this work, which exhibited an improved therapeutic efficacy in the ATP1A3-targeted treatment of glioma.</p><p><strong>Conclusion: </strong>ATP1A3 is a potential anti-glioma treatment target, and its activation critically depends on its antagonizing interaction with SNRPG.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific Associations between Immune Parameters and Clinical Symptoms in First-episode Patients with Schizophrenia.","authors":"Anle Pan, Meihong Xiu, Jiahong Liu, Jing Yao, Yuanyuan Huang","doi":"10.2174/011570159X354419250217100855","DOIUrl":"https://doi.org/10.2174/011570159X354419250217100855","url":null,"abstract":"<p><strong>Introduction: </strong>Inflammation is linked to the pathophysiology of schizophrenia. The neutrophil- to-lymphocyte ratio (NLR), a measure of systemic inflammation, has been reported to be associated with schizophrenia. However, few studies have examined the sex-specific association between neutrophil-to-lymphocyte ratio (NLR) and clinical symptoms in schizophrenia. This study aimed to explore sex differences in NLR and its correlation with symptoms in first-episode schizophrenia (FES) patients.</p><p><strong>Method: </strong>Ninety-seven FES patients and 65 control subjects were recruited. The severity of clinical symptoms was assessed using the Positive and Negative Syndrome Scale (PANSS), and white blood cells were calculated. We performed a cross-sectional analysis comparing NLR in males and females in the patient and control groups. We explored its sex-specific associations with clinical symptoms in the patient group.</p><p><strong>Results: </strong>We found that neutrophil (NEU) counts and NLR were higher in male patients compared to female patients with schizophrenia. There were no significant differences in white blood cell counts and NLR in healthy controls. Linear regression analysis showed that NEU counts were associated with clinical symptoms in male patients, and NLR correlated with symptoms in female patients after controlling for age, onset age, and years of education.</p><p><strong>Conclusion: </strong>Our study suggests that NLR values and NEU counts were higher in male patients compared with female patients with schizophrenia and that the association between NLR or NEU and clinical symptoms was sex-specific.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dual Role of Microglia in Multiple Sclerosis and its Implications for Diagnostics and Repair.","authors":"Melissa T Goulart, Davi T U Queiroz, Fabíola M Ribeiro","doi":"10.2174/011570159X352356241126044933","DOIUrl":"https://doi.org/10.2174/011570159X352356241126044933","url":null,"abstract":"<p><p>Microglia play a crucial role in the development, immune surveillance, and repair of the central nervous system. These cells play a multifaceted role in multiple sclerosis (MS), with evidence suggesting that microglia can promote both active inflammation and remyelination. For instance, it has been shown that microglia can support the development of oligodendrocytes and phagocytose myelin debris, thus aiding in proper remyelination. However, microglia overactivation in MS lesions exacerbates neuroinflammation by releasing inflammatory cytokines and facilitating the activation of astrocytes and immune cells, promoting demyelination and, ultimately, driving MS pathology. In fact, it has been shown that there is a correlation between activated microglia patterns and the chronicity of MS. Thus, although it is difficult to be certain whether these cells are friends or foes, there is no doubt that microglia will be a relevant target for MS diagnosis and treatment in the future, when further research will help to clarify the role of these cells in MS. MRI and PET scan allow evaluation of microglia/macrophages biomarkers, facilitating the clinical assessment of a patient's disease stage. Moreover, new microglia-specific markers are being discovered, which will increase diagnostic precision, helping to identify active and chronic MS lesions. Because microglia are involved are in all MS phases, these cells are also an important drug target. In this review, we focus on the current understanding of the role of microglia in MS progression as well as on the evidence supporting both inflammatory and reparative functions of these cells. We will also review how microglia may yield new biomarkers for MS diagnosis and serve as a potential target for therapy.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Inflammation Profile of Cerebellar Ataxia.","authors":"Cuiling Tang, Qi Deng, Xinrong Yuan, Ziyan Ding, Jian Hu, Linliu Peng, Hongyu Yuan, Na Wan, Yiqing Gong, Siyu Ding, Yan Tan, Lijing Lei, Linlin Wan, Rong Qiu, Beisha Tang, Zhao Chen, Hong Jiang","doi":"10.2174/011570159X379620250225075810","DOIUrl":"https://doi.org/10.2174/011570159X379620250225075810","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study is to determine the characteristics of peripheral inflammatory profiles and their correlations with the clinical features in patients with cerebellar ataxia.</p><p><strong>Methods: </strong>We conducted a cross-sectional study on a cohort of 140 cerebellar ataxia patients, including 74 patients with spinocerebellar ataxia (SCA), 66 patients with multiple system atrophy with predominant cerebellar ataxia (MSA-C), and 145 healthy controls (HCs). Inflammatory profiles (PLT, MPV, NLR, PLR, MLR, SII, AISI and ESR) were measured in peripheral blood, and were compared by ANOVA and Kruskal-Wallis test. The receiver operating characteristic (ROC) curve and the area under curve (AUC) were performed to determine the sensitivity and specificity of the inflammatory markers. Spearman correlation and partial correlation analysis were performed to detect the association between inflammatory profiles and clinical scales in cerebellar ataxia.</p><p><strong>Results: </strong>Inflammatory profiles from peripheral blood showed significant difference between different groups. Significant variations were observed in MPV, NLR, MLR, SII, AISI and ESR between cerebellar ataxia and HCs groups (p<0.05). NLR and ESR in both SCA and MSA-C groups were increased compared with HCs (p<0.05). The difference of MHR between SCA and MSA-C groups was observed based on HDL variation (p<0.05). The combination of ESR and PLT distinguished SCA from MSA-C (AUC=0.800). In addition, MLR was significantly corelated with clinical scales, including SARA and ICARS in SCA group as well as UMSARS and FAB in MSA-C group (r>0.3/r<-0.3).</p><p><strong>Conclusion: </strong>Significant variation in peripheral inflammatory profiles was firstly identified in Chinese genetic ataxias and non-genetic cerebellar ataxia cohort, which showed the potential clinical correlations between peripheral inflammatory phenotype and severity of ataxia.</p>","PeriodicalId":10905,"journal":{"name":"Current Neuropharmacology","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}