Current Advances in Chemistry and Biochemistry Vol. 9最新文献

Fabrication of Xanthan Gum: Gelatin (Xnt:Gel) Hybrid Composite Hydrogels for Investigating Skin Wound Healing Efficacy 黄原胶:明胶(Xnt:凝胶)复合水凝胶的制备及其对皮肤创面愈合效果的研究

Current Advances in Chemistry and Biochemistry Vol. 9 Pub Date : 2021-07-08 DOI: 10.9734/bpi/cacb/v9/2241f

Mohammad Mahfuz Ali Khan Shawan, N. Islam, Shahin Aziz, N. Khatun, S. Sarker, Mozammel Hossain, Tareq Hossan, M. Morshed, Marzan Sarkar, Md. Salman Shakil, M. Rahman, M. Begum, Md. Ashraful Hasan

{"title":"Fabrication of Xanthan Gum: Gelatin (Xnt:Gel) Hybrid Composite Hydrogels for Investigating Skin Wound Healing Efficacy","authors":"Mohammad Mahfuz Ali Khan Shawan, N. Islam, Shahin Aziz, N. Khatun, S. Sarker, Mozammel Hossain, Tareq Hossan, M. Morshed, Marzan Sarkar, Md. Salman Shakil, M. Rahman, M. Begum, Md. Ashraful Hasan","doi":"10.9734/bpi/cacb/v9/2241f","DOIUrl":"https://doi.org/10.9734/bpi/cacb/v9/2241f","url":null,"abstract":"Fabrication of hybrid hydrogels to improve biological properties or to decrease the disadvantages of biomaterials has been a popular approach. With the background of snowballing threat of skin wound to public health and economy, this study was undertaken utilizing xanthan gum (Xnt), citric acid (C), gelatin (Gel), glutaraldehyde (G) and HPLC-grade water to fabricate a series of composite hydrogels i.e. Xnt, Xnt:C, Xnt:Gel(3):G, Xnt:C:Gel(3):G, Xnt:Gel(5):G, Xnt:C:Gel(5):G for investigating their wound healing efficacy in experimental rat skin wound model. Physicochemical characterization revealed that all the composite hydrogels contained more than 90% water. The hydrogels displayed swelling ability, biodegradability, good polymeric networks and porosity. Fourier Transform Infrared Spectroscopy (FT-IR) studies confirmed the presence of bound water and free, intra and inter molecular bound hydrogen bonded OH and NH in the hydrogels. All the hydrogels showed significant wound healing potency in experimental deep second degree skin burns in rats compared to controls. 20 days post-application of hydrogels, Xnt:Gel(3):G, Xnt:Gel(5):G and Xnt:C:Gel(5):G-treated wounds showed better recovery compared to other composite hydrogels. The highest wound contraction of these hydrogel composites might be due to presence of Gel in the formulations. We conclude that, Xnt:Gel(3):G, Xnt:Gel(5):G and Xnt:C:Gel(5):G might be effective wound dressing material.","PeriodicalId":10902,"journal":{"name":"Current Advances in Chemistry and Biochemistry Vol. 9","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81969260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Efficient Electrochemical Approach for the Characterization of Interfacial Strength of Nano Titania-silica Composite Coating on Titanium Implants 一种表征钛植入体纳米二氧化钛复合涂层界面强度的高效电化学方法

Current Advances in Chemistry and Biochemistry Vol. 9 Pub Date : 2021-07-08 DOI: 10.9734/bpi/cacb/v9/2847f

S. Mathai

引用次数: 0

Determining the Removal, Recovery, and Recycles of Au(III) from Aqueous Au(III) Solution Using Immobilized Pseudomonas Cells by Biomineralization and Thiourea Oxidation 生物矿化和硫脲氧化固定化假单胞菌细胞测定Au(III)水溶液中Au(III)的去除、回收和循环

Current Advances in Chemistry and Biochemistry Vol. 9 Pub Date : 2021-07-08 DOI: 10.9734/bpi/cacb/v9/10666d

T. Tsuruta

{"title":"Determining the Removal, Recovery, and Recycles of Au(III) from Aqueous Au(III) Solution Using Immobilized Pseudomonas Cells by Biomineralization and Thiourea Oxidation","authors":"T. Tsuruta","doi":"10.9734/bpi/cacb/v9/10666d","DOIUrl":"https://doi.org/10.9734/bpi/cacb/v9/10666d","url":null,"abstract":"Recently, some researchers have investigated the recovery of gold using microbial cells, such as bacteria, fungi, yeasts, and algae. However, there is little information on which kind of microorganisms has a high gold adsorbing ability. We have reported various species and strains of bacteria, actinomycetes, fungi, and yeasts were screened for their ability to adsorb gold from a solution containing hydrogen tetrachloroaurate (III). Hydrogen tetrachloroaurate (III) is used for medical and ceramic materials. The effect of pH, external gold concentration, cell amounts on gold biosorption, and the time course of gold biosorption by Pseudomonas maltophilia cells, which adsorbed large amounts of gold from a solution containing hydrogen tetrachloroaurate (III), were reported in detail. In this chapter, in order to approve the amount of gold recovery much higher, the removal of gold (III) by biosorption and biomineralization from aqueous systems using microbial cells, gold (III) removal by those using microbial cells was investigated. Additionally, the oxidative recovery of gold after reduced gold(0) by the oxidation using aqueous thiourea solution, and recycles of gold reduction-oxidation cycles.","PeriodicalId":10902,"journal":{"name":"Current Advances in Chemistry and Biochemistry Vol. 9","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81010507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Potentiality of Lipase in the Bioconversion Processes of Vegetable Oils from the Amazon 脂肪酶在亚马逊地区植物油生物转化过程中的潜力

Current Advances in Chemistry and Biochemistry Vol. 9 Pub Date : 2021-07-08 DOI: 10.9734/bpi/cacb/v9/9172d

André Luis Willerding, Cassiane Minelli-Oliveira, Luiz Antônio de Oliveira

引用次数: 0

Fine Tune Balance of Hydrophobic-hydrophylic Relationship of Amphiphilic Compounds by Partial Reduction and Methylation 部分还原和甲基化对两亲化合物疏亲关系的微调平衡

Current Advances in Chemistry and Biochemistry Vol. 9 Pub Date : 2021-07-08 DOI: 10.9734/bpi/cacb/v9/9584d

D. Iga, D. Popescu, V. Niculescu

引用次数: 0

A Comparative Analysis of Dissolution Profiles of Furosemide Tablets Available in the Argentinean Market (Part 2) 阿根廷市场上速尿片溶出度的比较分析(二)

Current Advances in Chemistry and Biochemistry Vol. 9 Pub Date : 2021-07-08 DOI: 10.9734/bpi/cacb/v9/2661f

Y. Han, Laura D. Simionato, Romina G. Calvo, M. B. Mattei, A. Segall

{"title":"A Comparative Analysis of Dissolution Profiles of Furosemide Tablets Available in the Argentinean Market (Part 2)","authors":"Y. Han, Laura D. Simionato, Romina G. Calvo, M. B. Mattei, A. Segall","doi":"10.9734/bpi/cacb/v9/2661f","DOIUrl":"https://doi.org/10.9734/bpi/cacb/v9/2661f","url":null,"abstract":"The rate and the extent of drug dissolution and its absorption depend on the characteristics of the active pharmaceutical ingredient (API) as well as the dosage form properties. In this work dissolution profiles of furosemide tablets of nine commercial products marketed in Argentine were evaluated. All Brands fulfill the specifications of dissolution test of USP. Comparison of dissolution profiles were carried out by model-dependent and model independent approaches. The Weibull model provided the best kinetic curve adjustment. Brands IV, VI and IX had the best fitting, with the maximum determination coefficient and the smallest AIC values. Results obtained via model-independent approach show that there was not significative difference in Dissolution efficiency between the reference product and Brands II, III and IV and in Mean dissolution time between the reference product and Brands II, III, IV and V. Using fit factors, only Brands I and III were similar. It has been demonstrated in vivo bioequivalence of furosemide market products interchangeability with generics should be avoided.","PeriodicalId":10902,"journal":{"name":"Current Advances in Chemistry and Biochemistry Vol. 9","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76383352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemoprotective Studies of Some Preservatives against Spoilage Microorganisms Associated with Stored Roselle Juice and Their Resultant Effects on the Juice’s pH and Ascorbic Acid 几种防腐剂对玫瑰茄汁腐败微生物的化学保护研究及其对果汁pH和抗坏血酸的影响

Current Advances in Chemistry and Biochemistry Vol. 9 Pub Date : 2021-07-08 DOI: 10.9734/bpi/cacb/v9/2505e

L. O. Ajala, O. Ogunlowo, M. Okafor, V. Onwukeme, S. Ezem

{"title":"Chemoprotective Studies of Some Preservatives against Spoilage Microorganisms Associated with Stored Roselle Juice and Their Resultant Effects on the Juice’s pH and Ascorbic Acid","authors":"L. O. Ajala, O. Ogunlowo, M. Okafor, V. Onwukeme, S. Ezem","doi":"10.9734/bpi/cacb/v9/2505e","DOIUrl":"https://doi.org/10.9734/bpi/cacb/v9/2505e","url":null,"abstract":"Four different prepared extracts from roselle (Hibiscus sabdariffa Linn.) calyxes were stored differently with chemical preservatives (sodium benzoate, sodium metabisulphite, boric acid, and citric acid) for eight weeks. A control, sample without preservative was also stored for the same period. They were understudied weekly for changes in the pH, ascorbic acid content, and microbial population. The research was carried out to studying the influence of the chemical preservatives on the pH, vitamin C, and microbial population of the extract during storage. Up to the first three weeks of storage, the vitamin C contents of the entire juices were not statistically different (p = 0.05) except, sample preserved with sodium benzoate. In the same manner, with exception of samples stored without preservative and with sodium metabisulphite, other samples were not significantly different (p = 0.05) with respect to pH. With exception of the control, spoilage started between third and sixth week of storage while sodium metabisulphite inhibited the growth of microbes till the end of the studied week. Generally, the results from this study revealed a decrease in pH (increase in acidity), a reduction in ascorbic acid content and an increase in microbial population as the storage time was extended in the entire samples but more explicit in the sample stored without preservative. The rate of change of pH and percentage reduction in ascorbic acid with respect to storage time in the sample without preservative increased tremendously compared to other juices stored with preservatives. This study showed that the chemical preservatives prohibited rapid loss of vitamin C and inhibited the growth of microorganisms that might have caused spoilage of this juice during storage. The use of chemical preservatives to prolong the shelf-life of this juice is therefore advocated so as to make it more available round the year.","PeriodicalId":10902,"journal":{"name":"Current Advances in Chemistry and Biochemistry Vol. 9","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85679499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione—L-Dopa Codrug against H2O2-Induced Cellular Toxicity: A Recent Study 调节凋亡细胞死亡和谷胱甘肽-左旋多巴联合药物对h2o2诱导的细胞毒性的神经保护作用:最新研究

Current Advances in Chemistry and Biochemistry Vol. 9 Pub Date : 2021-07-08 DOI: 10.9734/bpi/cacb/v9/10081d

S. Franceschelli, P. Lanuti, Alessio Ferrone, D. M. Gatta, L. Speranza, M. Pesce, A. Grilli, I. Cacciatore, E. Ricciotti, A. Stefano, S. Miscia, M. Felaco, A. Patruno

{"title":"Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione—L-Dopa Codrug against H2O2-Induced Cellular Toxicity: A Recent Study","authors":"S. Franceschelli, P. Lanuti, Alessio Ferrone, D. M. Gatta, L. Speranza, M. Pesce, A. Grilli, I. Cacciatore, E. Ricciotti, A. Stefano, S. Miscia, M. Felaco, A. Patruno","doi":"10.9734/bpi/cacb/v9/10081d","DOIUrl":"https://doi.org/10.9734/bpi/cacb/v9/10081d","url":null,"abstract":"Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons mainly in the substantia nigra. The L-3,4-dihydroxyphenylalanine (LD) is the gold standard drug currently used to manage Parkinson’s disease (PD) and to control its symptoms. However, LD could cause disease neurotoxicity due to the generation of pro-oxidant intermediates deriving from its autoxidation. In order to overcome this limitation, we have conjugated LD to the natural antioxidant glutathione (GSH) to form a codrug (GSH-LD). Here we investigated the effect of GSH-LD on H2O2-induced cellular toxicity in undifferentiated and differentiated lymphoma U-937 and dopaminergic neuroblastoma SH-SY5Y cell lines, used respectively as models to study the involvement of macrophages/microglia and dopaminergic neurons in PD. We analyzed the effect of GSH-LD on apoptosis and cellular oxidative stress, both considered strategic targets for the prevention and treatment of neurodegenerative diseases. Compared to LD and GSH, GSH-LD had a stronger effect in preventing hydrogen peroxide (H2O2) induced apoptosis in both cell lines. Moreover, GSH-LD was able to preserve cell viability, cellular redox status, gluthation metabolism and prevent reactive oxygen species (ROS) formation, in a phosphinositide 3-kinase (PI3K)/kinase B (Akt)-dependent manner, in a neurotoxicity cellular model. Our findings indicate that the GSH-LD codrug offers advantages deriving from the additive effect of LD and GSH and it could represent a promising candidate for PD treatment. The significance of our observations need to be validated in further studies investigating the neuroprotective effects of GSH-LD in PD in in vivo animal models and its ability to penetrate effectively the BBB.","PeriodicalId":10902,"journal":{"name":"Current Advances in Chemistry and Biochemistry Vol. 9","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84341640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 100% Aqueous Mobile Phase HPLC-photodiode Array Detection of Tetracycline and Its 4-epimer, 4-epi-tetracycline 100%水相流动相高效液相色谱-光电二极管阵列检测四环素及其4-表聚体，4-表四环素

Current Advances in Chemistry and Biochemistry Vol. 9 Pub Date : 2021-07-08 DOI: 10.9734/bpi/cacb/v9/1741c

N. Furusawa

引用次数: 0

Description of a Harmless Method for Determining Trenbolone Acetate Together with 17B-Trenbolone in Beef 牛肉中醋酸Trenbolone和17B-Trenbolone的无害化测定方法描述

Current Advances in Chemistry and Biochemistry Vol. 9 Pub Date : 2021-07-08 DOI: 10.9734/bpi/cacb/v9/1742c

N. Furusawa

引用次数: 0