Biomedical Applications of Some Schiff Base Metal Complexes Containing Imidazole/Thiophene Derivatives

Abstract

Imidazole-2-carboxaldehyde was condensed with 2-amino-3-carboxyethyl-4,5-dimethyl thiophene in 1:1 molar ratio yielded Schiff base. CoII, NiII, CuII and ZnII complexes of Schiff base were synthesized and characterized. The geometry exhibited by the complexes was proposed using magnetic and electronic spectral data. Thermal analysis was carried out to ascertain the thermal stability of the compounds. The fluorescence spectral analysis were investigated at different solvents for the Schiff base and its CuII complex. Using powder XRD measurements, the grain size was determined. The SEM images indicate the surface morphology of the complexes. The antibacterial and antifungal activities were screened by disk diffusion method designed by Kirby-Bauer. In vitro anticancer studies were carried out, by MTT assay for human cervical carcinoma cell line.