Current Opinion in Organ Transplantation最新文献_第6页

Current Opinion in Organ Transplantation welcomes a new Editor-in-Chief. 器官移植最新观点》迎来了新任主编。

IF 2.2 4区医学

Current Opinion in Organ Transplantation Pub Date : 2024-02-01 Epub Date: 2024-01-04 DOI: 10.1097/MOT.0000000000001132

Sarah J Booth

引用次数: 0

Editorial introductions. 编辑介绍。

IF 2.2 4区医学

Current Opinion in Organ Transplantation Pub Date : 2024-02-01 Epub Date: 2024-01-04 DOI: 10.1097/MOT.0000000000001121

引用次数: 0

Optimizing the pediatric transplant candidate. 优化儿科移植候选者。

IF 2.2 4区医学

Current Opinion in Organ Transplantation Pub Date : 2024-02-01 Epub Date: 2023-10-12 DOI: 10.1097/MOT.0000000000001115

James E Squires, Vikram K Raghu, George V Mazariegos

{"title":"Optimizing the pediatric transplant candidate.","authors":"James E Squires, Vikram K Raghu, George V Mazariegos","doi":"10.1097/MOT.0000000000001115","DOIUrl":"10.1097/MOT.0000000000001115","url":null,"abstract":"Purpose of review: Advances in pediatric transplant parallel those in adult populations; however, there remain critical unique considerations and differences that require specialized knowledge and a specific skill set to optimize care afforded to the pediatric transplant candidate. We introduce general themes regarding optimization of the transplant candidate that are unique to children.Recent findings: The pathologies leading to pediatric organ transplant candidacy differ from adults and a precise understanding of the physiologies and natural histories of such diseases is critical for optimized care. Regardless of etiology, comorbidities including malnutrition, sarcopenia, and developmental delay are seen and often require disease and organ specific approaches to management. Additionally, an understanding of the concepts of developmental immunology and their relevance to transplant is critical.Summary: When looking to optimize pretransplant care, awareness of the pediatric-specific challenges by the transplant community in addition to organ- and age-specific management strategies enable the best outcomes for children awaiting solid organ transplantation.","PeriodicalId":10900,"journal":{"name":"Current Opinion in Organ Transplantation","volume":" ","pages":"43-49"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41194237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlling infections in hospitalized pretransplant candidates. 控制住院移植前患者的感染。

IF 2.2 4区医学

Current Opinion in Organ Transplantation Pub Date : 2024-02-01 Epub Date: 2023-11-14 DOI: 10.1097/MOT.0000000000001120

Marian G Lacy, Evgenii Filippov, Saman Nematollahi

{"title":"Controlling infections in hospitalized pretransplant candidates.","authors":"Marian G Lacy, Evgenii Filippov, Saman Nematollahi","doi":"10.1097/MOT.0000000000001120","DOIUrl":"10.1097/MOT.0000000000001120","url":null,"abstract":"Purpose of review: Infections in hospitalized patients awaiting solid organ transplantation can pose complicated diagnostic and therapeutic challenges. Goals of management include stabilizing the patient, treating or controlling infections, and decreasing the risk of reactivation of infection after transplant.Recent findings: Groups such as The Organ Procurement and Transplantation Network, American Society of Transplantation Infectious Diseases Community of Practice and the European Society of Clinical Microbiology and Infectious Diseases have updated their guidelines on screening and treatment of infection in transplant candidates. There are also recent developments in therapeutic options for tuberculosis, COVID-19, Clostridioides difficile colitis, bloodstream infections, and other common infections.Summary: Ideally, antimicrobial therapy should be complete prior to transplantation. In situations in which completion of therapy prior to transplant is not feasible, therapy may need to be prolonged or modified. In most situations, infections can be managed similarly to the general population, although some infections, particularly fungal and mycobacterial, require a different management approach. We review disease- and organ-specific management.","PeriodicalId":10900,"journal":{"name":"Current Opinion in Organ Transplantation","volume":" ","pages":"56-63"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138290599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing cardiac status in the preliver transplant candidate. 优化肝脏移植候选者的心脏状态。

IF 2.2 4区医学

Current Opinion in Organ Transplantation Pub Date : 2024-02-01 Epub Date: 2023-11-14 DOI: 10.1097/MOT.0000000000001119

Maxine W Stachel, Eugene C DePasquale

引用次数: 0

Treating rare tumors with liver transplantation. 肝移植治疗罕见肿瘤。

IF 2.2 4区医学

Current Opinion in Organ Transplantation Pub Date : 2024-02-01 Epub Date: 2023-10-18 DOI: 10.1097/MOT.0000000000001118

Andrew Melehy, Vatche Agopian

{"title":"Treating rare tumors with liver transplantation.","authors":"Andrew Melehy, Vatche Agopian","doi":"10.1097/MOT.0000000000001118","DOIUrl":"10.1097/MOT.0000000000001118","url":null,"abstract":"Purpose of review: The success of liver transplantation (LT) in treating unresectable hepatocellular carcinoma (HCC) has resulted in interest in LT for other oncologic conditions. Here, we discuss the role of LT for rare oncologic indications including metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs), hepatic epitheliod hemangioendothelioma (HEHE), fibrolamellar hepatocellular carcinoma (FLC), and hepatic angiosarcoma (HAS).Recent findings: Conditions reviewed have been documented indications for LT in the available literature. We summarize the experience of LT for these indications and proposed management guidelines.Summary: GEP-NETs with isolated metastases to the liver can be treated with LT with excellent long-term outcomes (10-year survival 88%) if strict selection criteria are used (low-intermediate grade, Ki-67% < 20%, complete resection of primary tumor, stable disease for 6 months, <50% hepatic involvement). HEHE is a rare hepatic tumor for which LT can be performed with reported 10-year survival around 70%. FLC is a distinct clinical entity to HCC and is optimally treated with surgical resection though experience with LT is described in observational series (5-year survival 50%, recurrence in 10%). HAS is a rapidly progressive tumor with a dismal prognosis with or without treatment, including LT.","PeriodicalId":10900,"journal":{"name":"Current Opinion in Organ Transplantation","volume":" ","pages":"30-36"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41233124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative surgical techniques in the intestine and multivisceral transplant. 创新的肠道和多器官移植手术技术。

IF 2.2 4区医学

Current Opinion in Organ Transplantation Pub Date : 2024-02-01 Epub Date: 2023-10-30 DOI: 10.1097/MOT.0000000000001098

Phillipe Abreu, Joao Manzi, Rodrigo Vianna

{"title":"Innovative surgical techniques in the intestine and multivisceral transplant.","authors":"Phillipe Abreu, Joao Manzi, Rodrigo Vianna","doi":"10.1097/MOT.0000000000001098","DOIUrl":"10.1097/MOT.0000000000001098","url":null,"abstract":"Purpose of review: This timely review delves into the evolution of multivisceral transplantation (MVT) over the past six decades underscoring how advancements in surgical techniques and immunosuppression have driven transformation, to provide insight into the historical development of MVT, shedding light on its journey from experimentation to a valuable clinical approach.Recent findings: The review presents contemporary enhancements in surgical methods within the context of intestinal transplantation. The versatility of MVT is emphasized, accommodating diverse organ combinations and techniques. Both isolated intestinal transplantation (IIT) and MVT have seen expanded indications, driven by improved parenteral nutrition, transplantation outcomes, and surgical innovations. Surgical techniques are tailored based on graft type, with various approaches for isolated transplantation. Preservation strategies and ostomy techniques are also covered, along with graft assessment advancements involving donor-specific antibodies.Summary: This review's findings underscore the remarkable evolution of MVT from experimental origins to a comprehensive clinical practice. The progress in surgical techniques and immunosuppression has broadened the spectrum of patients who can benefit from intestinal transplant, including both IIT and MVT. The expansion of indications offers hope to patients with complex gastrointestinal disorders. The detection of donor-specific antibodies in graft assessment advances diagnostic accuracy, ultimately improving patient outcomes.","PeriodicalId":10900,"journal":{"name":"Current Opinion in Organ Transplantation","volume":" ","pages":"88-96"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71411062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemodynamic monitoring in liver transplantation 'the hemodynamic system'. 肝移植血流动力学监测“血流动力学系统”。

IF 2.2 4区医学

Current Opinion in Organ Transplantation Pub Date : 2024-02-01 Epub Date: 2023-11-30 DOI: 10.1097/MOT.0000000000001125

Sherif Kandil, Ashraf Sedra

{"title":"Hemodynamic monitoring in liver transplantation 'the hemodynamic system'.","authors":"Sherif Kandil, Ashraf Sedra","doi":"10.1097/MOT.0000000000001125","DOIUrl":"10.1097/MOT.0000000000001125","url":null,"abstract":"Purpose of review: The purpose of this article is to provide a comprehensive review of hemodynamic monitoring in liver transplantation.Recent findings: Radial arterial blood pressure monitoring underestimates the aortic root arterial blood pressure and causes excessive vasopressor and worse outcomes. Brachial and femoral artery monitoring is well tolerated and should be considered in critically ill patients expected to be on high dose pressors. The pulmonary artery catheter is the gold standard of hemodynamic monitoring and is still widely used in liver transplantation; however, it is a highly invasive monitor with potential for serious complications and most of its data can be obtained by other less invasive monitors. Rescue transesophageal echocardiography relies on few simple views and should be available as a standby to manage sudden hemodynamic instability. Risk of esophageal bleeding from transesophageal echocardiography in liver transplantation is the same as in other patient populations. The arterial pulse waveform analysis based cardiac output devices are minimally invasive and have the advantage of real-time beat to beat monitoring of cardiac output. No hemodynamic monitor can improve clinical outcomes unless integrated into a goal-directed hemodynamic therapy. The hemodynamic monitoring technique should be tailored to the patient's medical status, surgical technique, and the anesthesiologist's level of expertise.Summary: The current article provides a review of the current hemodynamic monitoring systems and their integration in goal-directed hemodynamic therapy.","PeriodicalId":10900,"journal":{"name":"Current Opinion in Organ Transplantation","volume":" ","pages":"72-81"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pushing the limits of treatment for hepatocellular carcinoma. 推动肝细胞癌治疗的极限。

IF 2.2 4区医学

Current Opinion in Organ Transplantation Pub Date : 2024-02-01 Epub Date: 2023-11-30 DOI: 10.1097/MOT.0000000000001123

Michelle Jones-Pauley, David W Victor, Sudha Kodali

引用次数: 0

Molecular profiling in the management of hepatocellular carcinoma. 分子分析在肝细胞癌治疗中的应用。

IF 2.2 4区医学

Current Opinion in Organ Transplantation Pub Date : 2024-02-01 Epub Date: 2023-12-01 DOI: 10.1097/MOT.0000000000001124

Nadine Soliman, Ashish Saharia, Maen Abdelrahim, Ashton A Connor

引用次数: 0