Acta Psychiatrica Scandinavica最新文献

{"title":"Reply to: Why does problem gambling in psychotic disorders pose such a challenge for comprehension?","authors":"Olivier Corbeil, Élizabeth Anderson, Laurent Béchard, Charles Desmeules, Maxime Huot-Lavoie, Lauryann Bachand, Sébastien Brodeur, Pierre-Hugues Carmichael, Christian Jacques, Marco Solmi, Isabelle Giroux, Michel Dorval, Marie-France Demers, Marc-André Roy","doi":"10.1111/acps.13730","DOIUrl":"10.1111/acps.13730","url":null,"abstract":"","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"151 1","pages":"102-104"},"PeriodicalIF":5.3,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of research examining mothers, infants, family and staff in psychiatric mother-baby units","authors":"Sam Adhikary,&nbsp;Kerri Gillespie,&nbsp;Hayley Kimball,&nbsp;Lyndall Healey,&nbsp;Olivia Webb,&nbsp;Abha Balram,&nbsp;Grace Branjerdporn","doi":"10.1111/acps.13727","DOIUrl":"10.1111/acps.13727","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This systematic review aimed to summarise and synthesise research conducted in psychiatric mother-baby units (MBUs) in relation to patients, their families, or staff, published from 1st January 2016 to 1st May 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Quantitative, qualitative, and mixed-method studies were included for review if they were published in peer-review journals in English and reported research on MBUs between January 2016 and May 2024. From the initial yield of 10,007 unique studies, 53 studies were included for review.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MBU research was found to more frequently investigate maternal characteristics rather than the benefits of MBU treatment compared to studies conducted prior to 2016. Most studies that did investigate impact of admission showed favourable results, however few follow-up studies and studies comparing MBU outcomes to other clinical settings were undertaken. Little research has been conducted to investigate the differential impacts of MBU admission on different diagnoses and long-term (&gt;1 year) patient outcomes. There was a dearth of research investigating partners of women in MBUs and few studies conducted on infant outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>MBUs were consistently found to improve mental health systems and mother-infant attachment in patients after admission. More research investigating patient support networks and child health, impact of diagnosis on outcomes, and studies with adequate follow-up are required.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"150 5","pages":"284-307"},"PeriodicalIF":5.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13727","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug survival and risk factors for ADHD medication discontinuation in adults: A Danish Nationwide Registry-based cohort study","authors":"Pelle Lau Ishøy,&nbsp;Kim Berg Engersgaard Johannessen,&nbsp;Tine Houmann,&nbsp;Eline Levin,&nbsp;Per Hove Thomsen","doi":"10.1111/acps.13724","DOIUrl":"10.1111/acps.13724","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Attention deficit hyperactivity disorder (ADHD) medication has proven effective for treating ADHD in adults, nonetheless previous studies have shown high rates of medication discontinuation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To assess drug survival and identify risk factors associated with discontinuation of ADHD medication.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A nationwide registry-based cohort study in Danish adults who redeemed a prescription for ADHD medication for the first time between 2010 and 2015. All patients were followed for 5 years from the first redeemed prescription. Discontinuation was defined as a gap of 12 months between redemptions. Logistic regression analysis with odds ratio (OR) and Kaplan Meier analysis were used to examine risk factors (sex, age, socioeconomic status, substance use disorders, and comorbidities) associated with discontinuation.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Twenty three thousand nine-hundred and sixteen patients with ADHD were identified. The 5-year overall drug survival was 29% in women vs. 23.5% in men. The risk of medication discontinuation was significantly higher in men compared to women, OR 1.26 (95% CI 1.19–1.34, &lt;i&gt;p&lt;/i&gt; &lt; 0.001). Adults aged 31–50 years had a significantly decreased risk of medication discontinuation compared to adults aged 18–30 years, OR 0.57 (95% CI 0.53–0.61, &lt;i&gt;p&lt;/i&gt; &lt; 0.001). Switching ADHD medication two times or three times or more significantly decreased the risk of discontinuation; OR 0.53 (95% CI 0.49–0.56, &lt;i&gt;p&lt;/i&gt; &lt; 0.001) and OR 0.26 (95% CI 0.23–0.30, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), respectively. Substance use disorders and certain comorbidities were associated with medication discontinuation. Eating disorders, OR 0.71 (95% CI 0.64–0.78, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), intellectual disabilities, OR 0.65 (95% CI 0.59–0.73, &lt;i&gt;p&lt;/i&gt; &lt; 0.001) and sleep disorders, OR 0.42 (95% CI 0.37–0.49, &lt;i&gt;p&lt;/i&gt; &lt; 0.001) were associated with continuation of ADHD medication.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The 5-year overall drug survival was longer in women compared to men. Women with ADHD; adults aged 31–50; and patients with comorbid eating disorder; intellectual disability; sleep disorder and medication switching were individually associated with continuation of ADHD medication. Various factors were associated with medication discontinuation. Discontinuation should be acknowledged as a comm","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"150 3","pages":"160-173"},"PeriodicalIF":5.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The conversation about family planning and desire for children in mental healthcare: Patients' perspective versus Professionals' perspective in a mixed methods study","authors":"Noralie N. Schonewille,&nbsp;Monique J. M. van den Eijnden,&nbsp;Ruveyda Sahin,&nbsp;Nini H. Jonkman,&nbsp;Anne A. M. W. van Kempen,&nbsp;Maria G. van Pampus,&nbsp;Fedde Scheele,&nbsp;Odile A. van den Heuvel,&nbsp;Birit F. P. Broekman","doi":"10.1111/acps.13725","DOIUrl":"10.1111/acps.13725","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Reproductive health and mental health are intertwined, but studies investigating family planning needs and desire for children in mental healthcare are scarce.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We studied the experiences of (former) patients, those with close relationships with the (former) patients (close ones) and mental health professionals (MHP) on discussing family planning and desire for children in mental healthcare. We combined quantitative (two nationwide surveys) and qualitative data (four focus groups) in a mixed-methods approach with sequential analytical design.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Combined data from focus groups (<i>n</i> = 19 participants) and two surveys (<i>n</i> = 139 MHPs and <i>n</i> = 294 (former) patients and close ones) showed that a considerable group of MHPs (64.0%), patients (40.9%) and close ones (50.0%) found that family planning should be discussed by a psychiatrist. However, several obstacles impeded a conversation, such as fear of judgment, lack of time and knowledge and limited opportunity for in-depth exploration of life themes in therapeutic relationships.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>To increase the autonomy of patients in discussing family planning, we suggest MHPs explore the desire to discuss family planning with all patients in the reproductive phase of life, prior to discussing contraceptive care. MHPs should receive education about psychiatric vulnerability in relation to family planning and desire for children, and patients and close ones should be empowered to initiate a conversation themselves.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"150 5","pages":"320-333"},"PeriodicalIF":5.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13725","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Call for action to address premature mortality due to physical illness in individuals with severe mental disorders","authors":"Laurent Boyer,&nbsp;Pierre-Michel Llorca,&nbsp;Guillaume Fond","doi":"10.1111/acps.13722","DOIUrl":"10.1111/acps.13722","url":null,"abstract":"&lt;p&gt;The study conducted by Tapio Paljärvi et al., titled “Cardiovascular mortality in bipolar disorder: population-based cohort study,” sheds crucial light on the alarming rates of cardiovascular disease mortality among individuals with bipolar disorder.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; The findings underscore a significant excess in mortality due to various cardiovascular causes, including coronary artery disease, cardiomyopathy, and hypertensive heart disease. This issue is part of a larger problem for people with severe mental illnesses (SMI), such as schizophrenia, bipolar disorders, and major depressive disorders. Individuals with SMI die up to 15 years earlier than the general population, and around 70% of this mortality gap is due to physical disorders.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Increased risk of physical disorders in those with mental disorders is due to reduced access to adequate physical health monitoring, care and prevention,&lt;span&gt;&lt;sup&gt;3-5&lt;/sup&gt;&lt;/span&gt; increased risk of adverse health behaviors&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; such as sedentary behavior, poor diet, and smoking, comorbid substance abuse, and side effects of psychiatric medications.&lt;span&gt;&lt;sup&gt;7&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Despite the availability of clinical practice guidelines and evidence-based interventions aimed at reducing excess mortality rates due to physical comorbidities in persons with SMI, the problem still persists. There is a crucial need to better understand how to implement clinical practice guidelines and evidence-based interventions successfully in the real world. Individuals with comorbid mental and physical disorders face specific challenges in service organization, requiring complex treatment and intense resource utilization.&lt;span&gt;&lt;sup&gt;8&lt;/sup&gt;&lt;/span&gt; The management of multimorbidity is recognized to be complex, with a high treatment burden in terms of understanding and self-managing the conditions, attending multiple appointments, and managing complex drug regimens.&lt;span&gt;&lt;sup&gt;9&lt;/sup&gt;&lt;/span&gt; Evidence suggests that a key part of the problem is the lack of integration of care across service settings. There is major fragmentation in how care is coordinated between family doctors and hospitals, between physical and mental health care, and across health and social care. As proposed by Tapio Paljärvi et al.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; and other authors,&lt;span&gt;&lt;sup&gt;10&lt;/sup&gt;&lt;/span&gt; person-centered and integrated care models are a critical step to support effective implementation approaches to translate evidence into practice.&lt;/p&gt;&lt;p&gt;However, despite local and innovative experiences in several countries, the large-scale implementation of integrated care models faces numerous barriers and conservatisms. These obstacles hinder progress and maintain the status quo, perpetuating major health inequalities in individuals with SMI. A call for action in Europe, similar to initiatives already established in the United States,&lt;span&gt;&lt;sup&gt;11&lt;/sup&gt;&lt;/span&gt; is necessary. Currently, there are two main types ","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"150 2","pages":"53-55"},"PeriodicalIF":5.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13722","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional associations between perinatal allopregnanolone and depression severity with postpartum gray matter volume in adult women","authors":"Megan M. Hare,&nbsp;Anita Barber,&nbsp;Scott A. Shaffer,&nbsp;Kristina M. Deligiannidis","doi":"10.1111/acps.13723","DOIUrl":"10.1111/acps.13723","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Perinatal depression (PND) is a debilitating condition affecting maternal well-being and child development. Allopregnanolone (ALLO) is important to perinatal neuroplasticity, however its relationship with depression severity and postpartum structural brain volume is unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We examined perinatal temporal dynamics and bidirectional associations between ALLO and depression severity and the association between these variables and postpartum gray matter volume, using a random intercept cross-lagged panel model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified a unidirectional predictive relationship between PND severity and ALLO concentration, suggesting greater depression severity early in the perinatal period may contribute to subsequent changes in ALLO concentration (<i>β</i> = 0.26, <i>p</i> = 0.009), while variations in ALLO levels during the perinatal period influences the development and severity of depressive symptoms later in the postpartum period (<i>β</i> = 0.38, <i>p</i> = 0.007). Antepartum depression severity (Visit 2, <i>β</i> = 0.35, <i>p</i> = 0.004), ALLO concentration (Visit 2, <i>β</i> = 0.37, <i>p</i> = 0.001), and postpartum depression severity (Visit 3, <i>β</i> = 0.39, <i>p</i> = 0.031), each predicted the right anterior cingulate volume. Antepartum ALLO concentration (Visit 2, <i>β</i> = 0.29, <i>p</i> = 0.001) predicted left suborbital sulcus volume. Antepartum depression severity (Visit 1, <i>β</i> = 0.39, <i>p</i> = 0.006 and Visit 2, <i>β</i> = 0.48, <i>p</i> &lt; 0.001) predicted the right straight gyrus volume. Postpartum depression severity (Visit 3, <i>β</i> = 0.36, <i>p</i> = 0.001) predicted left middle-posterior cingulate volume.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These results provide the first evidence of bidirectional associations between perinatal ALLO and depression severity with postpartum gray matter volume.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"150 5","pages":"404-415"},"PeriodicalIF":5.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant-associated diagnostic change from major depressive to bipolar disorder","authors":"Leonardo Tondo,&nbsp;Alessandro Miola,&nbsp;Marco Pinna,&nbsp;Martina Contu,&nbsp;Ross J. Baldessarini","doi":"10.1111/acps.13721","DOIUrl":"10.1111/acps.13721","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Anticipating diagnostic change from major depressive (MDD) to bipolar disorder (BD) can support better prognosis and treatment, especially of depression but is challenging and reported research results are inconsistent. We therefore assessed clinical characteristics associated with diagnostic change from MDD to BD with antidepressant treatments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We compared characteristics of 3212 initially MDD patients who became (hypo)manic during antidepressant treatment to those with stable MDD diagnoses as well as with cases of stable, spontaneous BD, using standard bivariate and multivariate statistics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among MDD patients, 6.69% [CI: 5.85–7.61] changed to BD, mostly type II (BD2, 76.7%). BD-converters had higher rates of familial mood disorders (74.1% vs. 57.1%) or BD (33.7% vs. 21.0%) and 2.8-years younger onset than stable MDD patients. They also had more prior depressive recurrences/year, years-of-illness, mood-stabilizer treatment, divorces, fewer children, more suicide attempts and drug-abuse, and higher intake cyclothymia, YMRS and MDQ scores. Predictors independently associated with diagnostic conversion were: more familial BD, depressions/year, unemployment, cyclothymic temperament, suicidal ideation or acts, and fewer children. BD-converters vs. spontaneous BD cases had significantly more suicide attempts, BD2 diagnoses, and affected relatives. Converting to vs. spontaneous BD1 was associated with more ADHD, more suicidal ideation or behavior, MDI course, and younger onset; converting to vs. spontaneous BD2 had more episodes/year, unemployment, ADHD, substance abuse, suicidal ideation or attempts, and more relatives with BD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Few (6.69%) initially MDD subjects converted to BD, most (76.7%) to BD2. Independent predictive associations with diagnostic change included: familial BD, more depressions/year, unemployment, cyclothymic temperament, suicidal behavior and fewer children. Notably, several characteristics were stronger among those changing to BD during antidepressant treatment vs. others with spontaneous BD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"150 3","pages":"126-137"},"PeriodicalIF":5.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141453794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep–wake variations of electrodermal activity in bipolar disorder","authors":"Clàudia Valenzuela-Pascual,&nbsp;Ariadna Mas,&nbsp;Roger Borràs,&nbsp;Gerard Anmella,&nbsp;Miriam Sanabra,&nbsp;Meritxell González-Campos,&nbsp;Marc Valentí,&nbsp;Isabella Pacchiarotti,&nbsp;Antoni Benabarre,&nbsp;Iria Grande,&nbsp;Michele De Prisco,&nbsp;Vincenzo Oliva,&nbsp;Anna Bastidas,&nbsp;Isabel Agasi,&nbsp;Allan H. Young,&nbsp;Marina Garriga,&nbsp;Andrea Murru,&nbsp;Filippo Corponi,&nbsp;Bryan M. Li,&nbsp;Peter de Looff,&nbsp;Eduard Vieta,&nbsp;Diego Hidalgo-Mazzei","doi":"10.1111/acps.13718","DOIUrl":"10.1111/acps.13718","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Affective states influence the sympathetic nervous system, inducing variations in electrodermal activity (EDA), however, EDA association with bipolar disorder (BD) remains uncertain in real-world settings due to confounders like physical activity and temperature. We analysed EDA separately during sleep and wakefulness due to varying confounders and potential differences in mood state discrimination capacities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We monitored EDA from 102 participants with BD including 35 manic, 29 depressive, 38 euthymic patients, and 38 healthy controls (HC), for 48 h. Fifteen EDA features were inferred by mixed-effect models for repeated measures considering sleep state, group and covariates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirteen EDA feature models were significantly influenced by sleep state, notably including phasic peaks (<i>p</i> &lt; 0.001). During wakefulness, phasic peaks showed different values for mania (<i>M</i> [SD] = 6.49 [5.74, 7.23]), euthymia (5.89 [4.83, 6.94]), HC (3.04 [1.65, 4.42]), and depression (3.00 [2.07, 3.92]). Four phasic features during wakefulness better discriminated between HC and mania or euthymia, and between depression and euthymia or mania, compared to sleep. Mixed symptoms, average skin temperature, and anticholinergic medication affected the models, while sex and age did not.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>EDA measured from awake recordings better distinguished between BD states than sleep recordings, when controlled by confounders.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"151 3","pages":"412-425"},"PeriodicalIF":5.3,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141416744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why does problem gambling in psychotic disorders pose such a challenge for comprehension?","authors":"Thalles Rodrigues Alves Leite,&nbsp;Tainá Conrado Ferreira,&nbsp;Lucas Lima Menezes Albuquerque,&nbsp;Fábio Gomes de Matos e Souza,&nbsp;Luísa Weber Bisol","doi":"10.1111/acps.13720","DOIUrl":"10.1111/acps.13720","url":null,"abstract":"","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"150 3","pages":"182-183"},"PeriodicalIF":5.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge graphs in psychiatric research: Potential applications and future perspectives","authors":"Sebastian Freidel,&nbsp;Emanuel Schwarz","doi":"10.1111/acps.13717","DOIUrl":"10.1111/acps.13717","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Knowledge graphs (KGs) remain an underutilized tool in the field of psychiatric research. In the broader biomedical field KGs are already a significant tool mainly used as knowledge database or for novel relation detection between biomedical entities. This review aims to outline how KGs would further research in the field of psychiatry in the age of Artificial Intelligence (AI) and Large Language Models (LLMs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a thorough literature review across a spectrum of scientific fields ranging from computer science and knowledge engineering to bioinformatics. The literature reviewed was taken from PubMed, Semantic Scholar and Google Scholar searches including terms such as “Psychiatric Knowledge Graphs”, “Biomedical Knowledge Graphs”, “Knowledge Graph Machine Learning Applications”, “Knowledge Graph Applications for Biomedical Sciences”. The resulting publications were then assessed and accumulated in this review regarding their possible relevance to future psychiatric applications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A multitude of papers and applications of KGs in associated research fields that are yet to be utilized in psychiatric research was found and outlined in this review. We create a thorough recommendation for other computational researchers regarding use-cases of these KG applications in psychiatry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This review illustrates use-cases of KG-based research applications in biomedicine and beyond that may aid in elucidating the complex biology of psychiatric illness and open new routes for developing innovative interventions. We conclude that there is a wealth of opportunities for KG utilization in psychiatric research across a variety of application areas including biomarker discovery, patient stratification and personalized medicine approaches.</p>\u0000 </section>\u0000 </div>","PeriodicalId":108,"journal":{"name":"Acta Psychiatrica Scandinavica","volume":"151 3","pages":"180-191"},"PeriodicalIF":5.3,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acps.13717","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141416743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}