Maria Faurholt-Jepsen, Jonas Busk, Morten Lindberg Tønning, Darius Rohani, Jakob Eyvind Bardram, Lars Vedel Kessing
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Daily mood and activity instability measures were calculated using the root squared successive difference method.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>In linear mixed effect regression models adjusted for age, sex, and work status, there were statistically significant lower levels of activity in patients with BD as compared with patients with UD overall, during euthymic states and during depressive states (<i>B</i>: −0.61, 95% CI: −0.98; −0.24, <i>p</i> = 0.001). There were no statistically significant differences in mood instability and activity instability between patients with BD and patients with UD overall, during euthymic states and during depressive states, when accounting for multiple testing (<i>p</i> > 0.012).</p>\n </section>\n \n <section>\n \n <h3> Limitations</h3>\n \n <p>Analyses were exploratory and post hoc. Findings should be interpreted with caution. 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引用次数: 0
摘要
背景：症状学中的情绪、活动和不稳定性在双相情感障碍（BD）和单相情感障碍（UD）中具有重要作用。目的是检查BD和UD患者在这些症状上的差异。方法：结合两项研究的数据，分别包括BD和UD患者，进行探索性分析。在6个月的时间里，患者每天都要提供基于智能手机的情绪和活动/能量评估。共有47例BD患者和59例UD患者被纳入分析。该数据集包含超过13,000名患者报告的情绪和活动评估。每日情绪和活动不稳定性测量采用平方根逐次差分法计算。结果：在调整了年龄、性别和工作状态的线性混合效应回归模型中，总体而言，在健康状态和抑郁状态下，BD患者的活动水平低于UD患者(B: -0.61, 95% CI: -0.98；-0.24, p = 0.001)。考虑到多重测试，BD患者和UD患者在情绪不稳定和活动不稳定方面的总体差异无统计学意义，在心境状态和抑郁状态期间（p > 0.012）。局限性：分析是探索性和事后分析。研究结果应谨慎解读。样本量不大。结论：BD患者的活动水平低于UD患者。两组之间的情绪和活动不稳定性没有差异。未来的研究包括更大的样本量应该调查BD和UD之间的差异。试验注册：ClinicalTrials.gov标识符：NCT03033420。
Mood, Activity, and Instability in Bipolar Disorder and Unipolar Disorder—An Exploratory Post Hoc Study Using Digital Data
Background
Mood, activity, and instability in symptomatology hold significant roles in bipolar disorder (BD) and unipolar disorder (UD). The objectives were to examine disparities in these symptoms among patients with BD and UD.
Methods
Data from two studies including patients with BD and UD, respectively, were combined for exploratory analyses. Patients provided daily smartphone-based evaluations of mood and activity/energy for a 6-month period. A total of 47 patients with BD and 59 patients with UD were included in the analyses. The dataset contains more than 13,000 patient-reported evaluations of mood and activity. Daily mood and activity instability measures were calculated using the root squared successive difference method.
Results
In linear mixed effect regression models adjusted for age, sex, and work status, there were statistically significant lower levels of activity in patients with BD as compared with patients with UD overall, during euthymic states and during depressive states (B: −0.61, 95% CI: −0.98; −0.24, p = 0.001). There were no statistically significant differences in mood instability and activity instability between patients with BD and patients with UD overall, during euthymic states and during depressive states, when accounting for multiple testing (p > 0.012).
Limitations
Analyses were exploratory and post hoc. Findings should be interpreted with caution. The sample size was modest.
Conclusion
Patients with BD presented with lower level of activity as compared with patients with UD. There were no differences in mood and activity instability between these groups. Future studies including larger sample sizes should investigate differences between BD and UD.
期刊介绍：
Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers.
Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.
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