Current Opinion in Oncology最新文献_第8页

Advances in testing for human papillomavirus -mediated head and neck cancer. 人类乳头瘤病毒介导的头颈癌检测进展。

IF 2.8 4区医学

Current Opinion in Oncology Pub Date : 2024-05-01 Epub Date: 2024-03-19 DOI: 10.1097/CCO.0000000000001029

Hisham Mehanna, Laia Alemany, Christian von Buchwald

{"title":"Advances in testing for human papillomavirus -mediated head and neck cancer.","authors":"Hisham Mehanna, Laia Alemany, Christian von Buchwald","doi":"10.1097/CCO.0000000000001029","DOIUrl":"10.1097/CCO.0000000000001029","url":null,"abstract":"Purpose of review: New evidence has recently emerged regarding the utility and benefits of dual p16 INKa (p16) and Human papillomavirus (HPV) status testing when determining the diagnosis and prognosis of patients with oropharyngeal cancer.Recent findings: HPV RNA polymerase chain reaction (PCR) is the most accurate diagnostic test. The other assays (HPV DNA PCR, HPV DNA/RNA in-situ hybridization (ISH) and p16) applied to formalin fixed tumour tissue have varying but high sensitivities and specificities. Dual p16 and HPV testing identifies discordant (p16+/HPV- or p16-/HPV+) results in 9.2% of cases, who have significantly poorer prognoses than p16+/HPV+, particularly in smokers. The proportion of discordant cases varies by region, and appears to be highest in regions with lowest attributable (p16+/HPV+) fractions. Dual testing improves prognostication for oropharyngeal cancer cases by identifying discordant cases and improving the prognostic power of the Tumour Node Metastasis (TNM) classification, especially in regions with high discordant rates.Summary: Dual testing is essential when considering patients for clinical trials of treatment de-escalation, and may be important when counselling patients on prognosis, especially in regions with high discordant rates and in smokers.","PeriodicalId":10893,"journal":{"name":"Current Opinion in Oncology","volume":" ","pages":"143-146"},"PeriodicalIF":2.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10990024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140173997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular and nutritional markers in head and neck cancer. 头颈癌的分子和营养标记。

IF 3.4 4区医学

Current Opinion in Oncology Pub Date : 2024-05-01 Epub Date: 2024-02-29 DOI: 10.1097/CCO.0000000000001034

Gerard Milano, Jocelyn Gal, René-Jean Bensadoun

{"title":"Molecular and nutritional markers in head and neck cancer.","authors":"Gerard Milano, Jocelyn Gal, René-Jean Bensadoun","doi":"10.1097/CCO.0000000000001034","DOIUrl":"10.1097/CCO.0000000000001034","url":null,"abstract":"Purpose of review: There is still a need of biomarkers in the induction and neoadjuvant settings for squamous cell carcinoma of the head and neck (SCCHN). The objective of this concise review article is to give an overview on both predictive and prognostic biomarkers potentially useful for the management of SCCHN.Recent findings: Human papilloma virus (HPV) positivity translated by the presence of the protein indicator p16 is synonymous of favorable prognosis SCCHN. However, there is some disparity for disease evolution among p16 positive SCCHN. A lack of correlation between immunohistochemistry (IHC) and precise quantification of active epidermal growth factor receptors (EGFRs) may explain the absence of link between EGFR expression performed by IHC and response to EGFR targeting therapies reported in SCCHN. Circulating tumor cells (CTCs) have the property to share the main somatic mutations and genetic rearrangements with the primary tumors. A particular potential interest lies on the possibility to predict patient outcome based on a single-CTC analysis.Summary: This short review indicates that key biological marker reflecting disease outcome is not yet emerging for a clinical use in SCCHN. Hopes can be put into the so-called liquid biopsies incorporating circulating tumor cells and circulating tumor DNA.","PeriodicalId":10893,"journal":{"name":"Current Opinion in Oncology","volume":" ","pages":"123-127"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stereotactic ablative radiation therapy in metastatic prostate cancer. 转移性前列腺癌的立体定向消融放射治疗。

IF 3.4 4区医学

Current Opinion in Oncology Pub Date : 2024-05-01 Epub Date: 2024-02-15 DOI: 10.1097/CCO.0000000000001025

Soha Bazyar, Heather Mannuel, Phuoc T Tran

{"title":"Stereotactic ablative radiation therapy in metastatic prostate cancer.","authors":"Soha Bazyar, Heather Mannuel, Phuoc T Tran","doi":"10.1097/CCO.0000000000001025","DOIUrl":"10.1097/CCO.0000000000001025","url":null,"abstract":"Purpose of review: The evolving role of stereotactic ablative radiation therapy (SABR) as metastasis-directed therapy (MDT) for oligometastatic prostate cancer (omPCa) will be discussed.Recent findings: Oligometastatic disease (OMD) is an intermediate state between localized and wide-spread malignant disease. OMD has recently been spotlighted given the increasing demonstration of clinical benefit from local therapies despite presence of metastatic disease and allure of the curative potential of MDT in select cases. Among the different forms of MDT, SABR has rapidly become a widely adopted treatment modality. Significant efforts in this space have focused on omPCa, owing to its relatively indolent biology, presence of a sensitive and specific serum biomarker and recent advances in molecular imaging. While most studies have evaluated the role of SABR MDT in hormone sensitive omPCa, new emerging clinical data also suggests benefits of SABR MDT for even castration-resistant disease.Summary: Treating omPCa with SABR MDT appears to generate an efficacy signal with minimal morbidity across both hormone-sensitive and castration-resistant disease. However, additional definitive omPCa trial data are needed. Future research efforts should investigate biomarkers for this heterogeneous disease space and the role of SABR MDT in combination with systemic agents to improve upon standard of care treatments.","PeriodicalId":10893,"journal":{"name":"Current Opinion in Oncology","volume":" ","pages":"180-185"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10990008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlighting recent progress in the treatment of men with advanced prostate cancer. 重点介绍治疗晚期前列腺癌患者的最新进展。

IF 3.4 4区医学

Current Opinion in Oncology Pub Date : 2024-03-13 DOI: 10.1097/cco.0000000000001035

Theodore Gourdin

引用次数: 0

Head and neck cancer patients treated with concomitant chemoradiotherapy involving the oral cavity and oropharynx: is another choice possible than prophylactic gastrostomy? 头颈部癌症患者同时接受涉及口腔和口咽的放化疗：除了预防性胃造口术，还有其他选择吗？

IF 3.4 4区医学

Current Opinion in Oncology Pub Date : 2024-03-08 DOI: 10.1097/cco.0000000000001031

Pierre Senesse, Jeanne Briant, Pierre Boisselier, René-Jean Bensadoun, Marie Vinches, Kerstin Faravel

引用次数: 0

Organ preservation in muscle-invasive urothelial bladder cancer. 肌层浸润性尿路膀胱癌的器官保留。

IF 3.4 4区医学

Current Opinion in Oncology Pub Date : 2024-03-08 DOI: 10.1097/cco.0000000000001038

Scot A Niglio, Juhi M Purswani, Peter B Schiff, Jonathan W Lischalk, William C Huang, Katie S Murray, Andrea B Apolo

引用次数: 0

Tripartite motif family - its role in tumor progression and therapy resistance: a review. 三方图案家族--在肿瘤进展和耐药性中的作用：综述。

IF 3.4 4区医学

Current Opinion in Oncology Pub Date : 2024-03-01 Epub Date: 2024-01-16 DOI: 10.1097/CCO.0000000000001021

Yongqi Zhang, Ying Guan, Shuxiang Wang, Chunyan Guan, Xiaoli Liu

引用次数: 0

Single agent vs combination immunotherapy in advanced melanoma: a review of the evidence. 晚期黑色素瘤的单药与联合免疫疗法：证据综述。

IF 3.4 4区医学

Current Opinion in Oncology Pub Date : 2024-03-01 Epub Date: 2024-01-02 DOI: 10.1097/CCO.0000000000001014

Nada Benhima, Rhizlane Belbaraka, Mireille D Langouo Fontsa

{"title":"Single agent vs combination immunotherapy in advanced melanoma: a review of the evidence.","authors":"Nada Benhima, Rhizlane Belbaraka, Mireille D Langouo Fontsa","doi":"10.1097/CCO.0000000000001014","DOIUrl":"10.1097/CCO.0000000000001014","url":null,"abstract":"Purpose of review: The aim of this review is to outline the current landscape of advanced melanoma treatment options, provide insights on selecting combination therapies within different clinical scenarios, capture clinical relevance of anti-programmed cell death protein 1 (PD-1) monotherapy, and explore the unmet needs with immune check-point inhibitors (ICI) in advanced melanoma.Recent findings: ICI based treatment consisted of single agent ICI or dual combination ICI-ICI is the standard of care of front-line treatment of metastatic or unresectable melanoma. PD-1 inhibitors (Pembrolizumab and Nivolumab) improved progression free survival (PFS) and overall survival (OS) compared to chemotherapy and cytotoxic T-lymphocyte associated protein 4 (CTLA-4) inhibitors (Ipilimumab and Tremelimumab). The dual ICI combination (Nivolumab and Ipilimumab) provided profound and durable responses better than monotherapy, and the longest overall survival ever achieved in advanced disease, including in patients with murine sarcoma viral oncogene homolog B (BRAF)-mutated disease, but at the cost of a high risk of severe toxicity. The new dual blockage of LAG-3 and PD-1 (Nivolumab-Relatlimab) emerges as a valid option with promising efficacy outcomes and a favourable toxicity profile. Mature survival data is still needed to capture the real benefit.Summary: These new plethora of options pose new challenges not only for optimal treatment sequencing strategies but especially for management of adverse effects, endorsing the need to integrate a holistic and personalized approach for patient care.","PeriodicalId":10893,"journal":{"name":"Current Opinion in Oncology","volume":" ","pages":"69-73"},"PeriodicalIF":3.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the role of cellular dormancy in cancer progression and recurrence. 揭示细胞休眠在癌症进展和复发中的作用。

IF 3.4 4区医学

Current Opinion in Oncology Pub Date : 2024-03-01 Epub Date: 2024-01-02 DOI: 10.1097/CCO.0000000000001013

Evelyne Collignon

{"title":"Unveiling the role of cellular dormancy in cancer progression and recurrence.","authors":"Evelyne Collignon","doi":"10.1097/CCO.0000000000001013","DOIUrl":"10.1097/CCO.0000000000001013","url":null,"abstract":"Purpose of review: Cellular dormancy is a major contributor to cancer progression and recurrence. This review explores recent findings on the molecular mechanisms implicated in cancer dormancy and investigates potential strategies to improve therapeutic interventions.Recent findings: Research on cancer dormancy reveals a complex and multifaceted phenomenon. Providing a latent reservoir of tumor cells with reduced proliferation and enhanced drug-tolerance, dormant cancer cells emerge from a clonally diverse population after therapy or at metastatic sites. These cells exhibit distinct transcriptional and epigenetic profiles, involving the downregulation of Myc and mechanistic target of rapamycin (mTOR) pathways, and the induction of autophagy. Senescence traits, under the control of factors such as p53, also contribute significantly. The tumor microenvironment can either promote or prevent dormancy establishment, notably through the involvement of T and NK cells within the dormant tumor niche. Strategies to combat dormancy-related relapse include direct elimination of dormant tumor cells, sustaining dormancy to prolong survival, or awakening dormant cells to re-sensitize them to antiproliferative drugs.Summary: Improving our understanding of cancer dormancy at primary and secondary sites provides valuable insights into patient care and relapse prevention.","PeriodicalId":10893,"journal":{"name":"Current Opinion in Oncology","volume":" ","pages":"74-81"},"PeriodicalIF":3.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered hormone expression induced genetic changes leads to breast cancer. 激素表达的改变诱发基因变化，从而导致乳腺癌。

IF 3.4 4区医学

Current Opinion in Oncology Pub Date : 2024-03-01 Epub Date: 2024-01-18 DOI: 10.1097/CCO.0000000000001019

Anchal Thakur, Navya Rana, Ranjit Kumar

{"title":"Altered hormone expression induced genetic changes leads to breast cancer.","authors":"Anchal Thakur, Navya Rana, Ranjit Kumar","doi":"10.1097/CCO.0000000000001019","DOIUrl":"10.1097/CCO.0000000000001019","url":null,"abstract":"Purpose of review: Breast cancer ranks first among gynecological cancer in India. It is associated with urbanization, changes in lifestyle and obesity. Hormones also play a crucial role in the development of breast cancer. Steroid hormones play critical role in development of breast cancer.Recent finding: Breast cancer is caused due to alteration in different hormone expressions leading to genetic instability. Loss or gains of functions due to genetic instability were associated with the alterations in housekeeping genes. Up-regulation in c-myc, signal transducer and activator of transcription (STAT), CREB-regulated transcription coactivator (CRTC), and eukaryotic translation initiation factor 4E (eIF4E) may cause the development of breast cancer. Peptide hormones are commonly following the phosphoinositide 3-kinases (PI3K) pathway for activation of cell cycle causing uncontrolled proliferation. Although steroid hormones are following the Ras/Raf/mitogen-activated protein kinase (MEK) pathway, their hyper-activation of these pathways causes extracellular-signal-regulated kinase (ERK) and MAPK activation, leading to carcinogenesis.Summary: Alteration in cell cycle proteins, oncogenes, tumor suppressor genes, transcription and translation factors lead to breast cancer. Apoptosis plays a vital role in the elimination of abnormal cells but failure in any of these apoptotic pathways may cause tumorigenesis. Hence, a complex interplay of hormonal and genetic factors is required to maintain homeostasis in breast cells. Imbalance in homeostasis of these hormone and genes may lead to breast cancer.","PeriodicalId":10893,"journal":{"name":"Current Opinion in Oncology","volume":" ","pages":"115-122"},"PeriodicalIF":3.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0