Cytotechnology最新文献

{"title":"LncRNA NR2F1-AS1 is involved in osteogenic differentiation in fracture healing via miR-423-5p.","authors":"Yun Chen, Kun Huang, Wenjun Ji, Miao Huang, Jincheng Sima, Jin Li, Hao Song, Wei Xiong, Chao-Qun Ma","doi":"10.1007/s10616-025-00786-8","DOIUrl":"https://doi.org/10.1007/s10616-025-00786-8","url":null,"abstract":"<p><p>To investigate the function and mechanism of action of LncRNA NR2F1-AS1 involved in osteogenic differentiation process. An in vitro model was constructed by osteogenic differentiation-induced stimulation (OS) on the hFOB1.19 cell line. Real-time fluorescence quantitative PCR (RT-qPCR) was performed to detect the expression of NR2F1-AS1, miR-423-5p and osteogenic differentiation markers (RUNX2, OCN, OPN). Cell Counting Kit-8 (CCK8) method and flow cytometry were observed cell proliferation and apoptosis, respectively. Enzyme linked immunosorbent assay (ELISA) tested alkaline phosphatase (ALP) activity. Dual-Luciferase Report (DLR) assay and RNA immunoprecipitation (RIP) verified gene interactions. Bioinformatics methods predicted downstream target genes and their pathways of action. OS increased osteogenic differentiation markers and NR2F1-AS1 expression and decreased miR-423-5p levels. Transfection of si- NR2F1-AS1 promoted OS osteoblast apoptosis, but inhibited cell proliferation, ALP activity and osteogenic differentiation marker expression. NR2F1-AS1 is mostly present in the cytoplasm and is involved in the osteogenic differentiation process by down-regulating miR-423-5p. The use of miR-423-5p inhibitor can resist apoptosis induced by silencing NR2F1-AS1, promote osteoblast proliferation, activate ALP activity, and induce osteogenic differentiation process in osteoblasts. Bioinformatics prediction identified 82 target genes that might be involved in osteogenic differentiation, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis suggested that they were mainly associated with inter-synaptic formation and signaling. NR2F1-AS1 may promote osteoblast proliferation stimulate ALP activity, and induce osteogenic differentiation by down-regulating miR-423-5p.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s10616-025-00786-8.</p>","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 4","pages":"135"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FTO curbs trophoblast cell biological behaviors through repressing ALDH1A1 expression.","authors":"Lifang Liu, Hao Liu, Rui Jia, Xiaoyan Zhang, Xiaoxiao Lu","doi":"10.1007/s10616-025-00782-y","DOIUrl":"10.1007/s10616-025-00782-y","url":null,"abstract":"<p><p>Preeclampsia (PE) is one of the most common and serious documented gestational complications, and it is threatening the mother and the fetus, which is a notable burden on healthcare systems. Aldehyde dehydrogenase 1A1 (ALDH1A1), a cytosolic enzyme, shows vital physiological and pathophysiological functions in many areas. In the majority of cancer types, obesity-associated protein (FTO) is upregulated and exhibits an essential tumor-promoting role. We speculate that FTO and ALDH1A1 may play a significant role in the pathogenesis of PE by affecting the trophoblast cell biological behaviors. We analyzed differential expression genes (DEGs) in PE and non-PE groups in the GSE234726 dataset. The reverse-transcription quantitative polymerase chain reaction (qRT-PCR) and western blot assay were performed to test the mRNA and protein levels. The cell proliferation and apoptosis were examined using 5-Ethynyl-2'-deoxyuridine (EdU) and flow cytometry. The cell migration was investigated by wound healing assay and transwell assay. The ability of angiogenesis was tested by angiogenesis assay. The Spearman's rank correlation coefficient was used to analyze the correlation between ALDH1A1 expression and FTO expression. The m6A methylation site of ALDH1A1 mRNA was predicted using SRAMP website. The RNA immunoprecipitation (RIP) and m6A RNA immunoprecipitation (MeRIP) assay were performed to examine the binding relationship between ALDH1A1 and FTO. In PE, ALDH1A1 level is decreased. Silencing ALDH1A1 suppressed cell proliferation, migration, and angiogenesis and induced cell apoptosis. ALDH1A1 knockdown inhibited the expression of cyclin D1, anti-matrix metalloproteinase 9 (MMP9), and vascular endothelial growth factor (VEGF) and facilitated c-casp3 levels. The FTO expression was increased in PE placentas. Besides, the ALDH1A1 expression was negatively correlated with FTO levels, and FTO could target ALDH1A1. Mechanically, FTO repressed the biological behaviors of HTR-8/SVneo cells via ALDH1A1 down-regulation. FTO retards the HTR-8/SVneo cell biological function through knockdown of ALDH1A1. These results suggest that FTO and ALDH1A1 may play an important role in the pathogenesis of PE.</p>","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 4","pages":"124"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the impact of selegiline on the NF-kB/NLRP3/Caspase-1 signaling pathway in A549 lung epithelial cells exposed to lipopolysaccharide.","authors":"Mahin Dianat, Maryam Radan, Fereshteh Nejaddehbashi, Khojasteh Hoseinynejad, Narges Atefipour","doi":"10.1007/s10616-025-00799-3","DOIUrl":"https://doi.org/10.1007/s10616-025-00799-3","url":null,"abstract":"<p><p>Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are respiratory conditions associated with high mortality rates, primarily due to intense pulmonary inflammation. Lipopolysaccharide (LPS), an essential constituent of the wall of gram-negative bacteria, has the potential to trigger inflammation, ultimately leading to ALI. This study assessed the protective role of selegiline in mitigating LPS-induced inflammation in A549 cells. A549 cells were divided into seven groups: the negative control (PBS, 100 μM), the positive control (H₂O₂, 100 μM), the LPS group (1 µg/ml), groups treated with selegiline (Sel) (20, 30, and 40 μM) + LPS, and a group receiving Sel (40 μM). Parameters, including cell viability, iNOS activity, levels of SOD, CAT, and GPx, along with the pro-inflammatory cytokines IL-1β and TNF-α, as well as the protein expressions of NF-kB, NLRP3, and Caspase-1, were analyzed. Findings revealed that exposure to LPS increased oxidation and inflammation in A549 cells. Conversely, Sel markedly enhanced antioxidant capacity and diminished the iNOS activity, IL-1β, and TNF-α levels, as well as reduced the expression of inflammatory markers, including NF-kB, NLRP3, and Caspase-1 proteins. These results indicate that Sel may ameliorate LPS-induced pulmonary inflammation through its beneficial properties, including antioxidant and anti-inflammatory effects.</p>","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 4","pages":"140"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ELF3 regulates epithelial-mesenchymal transition through TPM1 and promotes the development of endometrial cancer.","authors":"Beibei Liu, Qiyun Liu, Yuan Liu, Zhenghua Xiong, Yong Hu","doi":"10.1007/s10616-025-00800-z","DOIUrl":"10.1007/s10616-025-00800-z","url":null,"abstract":"<p><p>Endometrial cancer (EC) is one of the common malignancies of the female reproductive system, and metastasis is critical to the progression and prognosis of EC. As a transcription factor, ELF3 is widely involved in the regulation of cancer cell growth and metastasis, but its role in EC is unclear. The purpose of this study was to explore the role and mechanism of ELF3 in regulating EC progression. In this study, we collected 8 pairs of EC tissue and normal paracancerous endometrial tissue, and injected human endometrial cancer cells (Ishikawa) into the left axilla of nude mice to construct a model of subcutaneous tumorigenesis in nude mice. The growth of Ishikawa cells and tumor tissues of EC nude mice was evaluated by CCK-8, clone formation assay, immunohistochemistry, etc., and the expression of related proteins and genes was detected by Western blot and RT-qPCR. In this study, it was found that the expression of ELF3 was up-regulated in EC, and knockdown of ELF3 could inhibit the proliferative activity and colony formation of EC cells, promote the expression of E-cadherin, inhibit the expression of N-cadherin and Vimentin, and reduce the epithelial-mesenchymal transition (EMT) of EC cells, thereby inhibiting the migration of EC cells to a certain extent and alleviating the development of EC in vivo. Mechanistically, ELF3 inhibits TPM1 transcription by binding to the promoter region of TPM1 gene, thereby inhibiting TPM1 expression, promoting EMT, proliferation and migration of EC cells, and accelerating the occurrence and development of EC in vivo. ELF3 promotes the development of EC through TPM1 regulation of EMT, and inhibition of ELF3 may become a potential new target for the treatment of EC.</p>","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 4","pages":"134"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the potential of mitochondrial transplantation: overcoming challenges and paving the way for routine therapeutic application.","authors":"Amaneh Mohammadi Roushandeh, Kazuo Tomita, Yoshikazu Kuwahara, Nima Najafi-Ghalehlou, Tomoaki Sato, Mehryar Habibi Roudkenar","doi":"10.1007/s10616-025-00805-8","DOIUrl":"https://doi.org/10.1007/s10616-025-00805-8","url":null,"abstract":"<p><p>Mitochondrial medicine has shown great promise as a therapeutic approach for treating currently incurable diseases. Preclinical studies highlight its safety and efficacy, but significant challenges remain in translating these therapies from bench to bedside. Key unresolved issues include understanding the mechanisms behind the reparative potential of transplanted mitochondria, such as their viability and functionality in an extracellular environment, especially under elevated calcium ion concentrations. Additionally, challenges related to mitochondrial sourcing, delivery methods, and ethical considerations need to be addressed for broader clinical adoption. This review analyses these challenges and explores strategies to overcome them, including refining mitochondrial sourcing, delivery techniques, and storage solutions. We also emphasise the need for rigorous ethical guidelines and regulatory frameworks to ensure safe and global implementation, paving the way for mitochondrial medicine's broader clinical use.</p>","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 4","pages":"139"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan-encapsulated <i>Gloriosa superba</i> nanoparticles suppress cervical cancer by inhibiting SKA3-mediated PI3K/AKT/mTOR pathway.","authors":"Rajarethinam Kumar, Saradhadevi Muthukrishnan, Aishwarya Rathinavel, Karthiyaini Rajendran, Gayathiri Gunasangkaran, Anjali K Ravi, Vijaya Anand Arumugam, Velayuthaprabhu Shanmugam, Marie Arockianathan Pushpam, Ashokkumar Kaliyaperumal, Gurusaravanan Packiaraj","doi":"10.1007/s10616-025-00809-4","DOIUrl":"https://doi.org/10.1007/s10616-025-00809-4","url":null,"abstract":"<p><p>The development of novel treatment strategies is essential to treat Cervical Cancer (CC) as it is the fourth-leading cancer among women. <i>Gloriosa superba</i> is a medicinal plant that retains various pharmacological activities. It possesses significant anticancer properties that have been previously studied. However, the anticancer efficacy of the nanocombination of <i>G. superba</i> tuber and seed has not yet been studied in CC. This study aimed to evaluate the anticancer efficacy of chitosan-encapsulated <i>G. superba</i> tuber nanoparticles and chitosan-encapsulated <i>G. superba</i> seed nanoparticles (CEGSTNs and CEGSSNs) via targeting the SKA3-mediated PI3K/AKT/mTOR pathway in CC. The CEGSTNs and CEGSSNs were synthesized and characterized by UV, DLS, zeta potential, FTIR, and TEM analysis. The anticancer efficacy on cell viability, proliferation, and apoptosis was investigated, and RT-PCR was used to measure the expression of the SKA3-mediated PI3K/AKT/mTOR pathway in HeLa cell lines. Furthermore, the acute toxicity assessment was conducted in Wistar rats, and body weights, haematological, and biomedical parameters, as well as histopathological studies, were performed. Characterisation techniques confirmed the synthesis of CEGSTNs and CEGSSNs. Both exhibited significant anticancer activity, induced apoptosis, and downregulated SKA3 expression, which inactivated the PI3K/AKT/mTOR pathway in HeLa cells. Acute toxicity analysis showed no toxicity or adverse effects in the treatment group. Overall, these results suggested that CEGSTNs have exhibited more anticancer efficacy than CEGSSNs. Moreover, CEGSTNs induced apoptosis and suppressed the proliferation of cells via the downregulation of the SKA3-mediated PI3K/AK/mTOR pathway.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s10616-025-00809-4.</p>","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 4","pages":"143"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12238432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulatory roles of bone morphogenetic protein 2 and asporin in osteo/cementoblast differentiation potential of human periodontal ligament stem cells: a multivariate model analysis.","authors":"Karina Gonzales Silvério, Gabriela Bessa Marconato Antunes, Bruno Cazotti Pereira, Francisco Naldo Gomes Filho, Nathalia Reiche Moreira, Renato Corrêa Viana Casarin, Enilson Antonio Sallum, Catharina Marques Sacramento","doi":"10.1007/s10616-025-00810-x","DOIUrl":"https://doi.org/10.1007/s10616-025-00810-x","url":null,"abstract":"<p><p>Understanding the molecular mechanisms regulating osteo/cementogenic differentiation is critical for optimizing cell-based strategies in periodontal regeneration. This study employed multivariate statistical modeling to investigate, in vitro, the interaction between bone morphogenetic protein 2 (BMP2) and asporin (ASPN) in human periodontal ligament stem cells (hPDLSCs) and its impact on mineralization potential. Four primary hPDLSC populations-two with high osteo/cementogenic potential (HOP) and two with low potential (LOP)-were cultured under standard (SDM) and osteo/cementogenic (OM) conditions. Mineralization was assessed using Alizarin Red Staining (AR-S) and alkaline phosphatase (ALP) activity, while gene expression of ASPN, BMP2, osteocalcin (OCN), and runt-related transcription factor 2 (RUNX2) was quantified by quantitative real-time polymerase chain reaction (qRT-PCR). BMP2 protein levels were measured using the Luminex system. Data analysis incorporated Principal Component Analysis (PCA), Linear Discriminant Analysis (LDA), Pearson correlations, correlation networks, and multivariate regression models in RStudio. HOP cells exhibited higher mineralization and BMP2 expression compared to LOP cells (p < 0.05). ASPN negatively correlated with BMP2 expression and mineralization, particularly in LOP cells (p < 0.01), reinforcing its inhibitory role. Multivariate modeling identified BMP2 as a key positive regulator of osteo/cementogenesis, while ASPN emerged as a significant inhibitory factor (p < 0.001). This study highlights the potential of multivariate models as powerful tools for uncovering molecular interactions and identifying novel therapeutic targets, paving the way for advancements in periodontal regeneration and cell-based therapies.</p><p><strong>Graphical abstract: </strong>Created in BioRender. Sacramento, C. (2025).</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s10616-025-00810-x.</p>","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 4","pages":"144"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of DO, agitation, aeration and copper concentration on lactate metabolism and charge heterogeneity for monoclonal antibody production by CHO cells in fed-batch culture.","authors":"Pei Yin, Huizhi Lin, Qian Zhou, Jing Tong, Meijin Guo","doi":"10.1007/s10616-025-00816-5","DOIUrl":"https://doi.org/10.1007/s10616-025-00816-5","url":null,"abstract":"<p><p>Understanding the impact of critical process parameters on CHO cell cultivation and critical quality attributes (CQAs) of monoclonal antibody is an essential requirement for robust process scale-up and technology transfer. The effect of process parameters on lactate metabolism is of particular interest as it has been shown to be associated with cell growth and productivity. Here, a comprehensive study is presented to investigate the impact of potentially critical process parameters (aeration rate, agitation speed, dissolved oxygen level and copper concentration) on process performance and CQAs. Results demonstrated that dissolved oxygen level has a dominate positive effect on lactate consumption. Scale-relevant parameters (aeration rate and agitation speed) and copper concentration have smaller but also significant positive influence on lactate consumption. Based on these results, it can be summarized that low dissolved oxygen, agitation and aeration rates plus low copper concentration, would lead to insufficient oxygen availability for cell respiration (hypoxia). Under this condition, cells would rely on anaerobic glycolysis to generate energy and hence promote lactate production. This study also revealed a linkage between hypoxic condition and antibody purity and charge heterogeneity. This work provides critical insights for lactate metabolic and product quality control through optimizing critical process parameters and medium component.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s10616-025-00816-5.</p>","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 4","pages":"145"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sevoflurane induces Ca²⁺ overload and EFHD1 upregulation, driving pyroptosis in SCLC cells.","authors":"Bin Chen, Lu Wang, Qiuyue Liu, Tao Liu, Linghai Li, Teng Ma, Wei Liu, Jun Ma","doi":"10.1007/s10616-025-00807-6","DOIUrl":"10.1007/s10616-025-00807-6","url":null,"abstract":"<p><p>Sevoflurane, a widely utilized inhalational anesthetic, has been shown in previous studies to inhibit the proliferation and invasion of non-small cell lung cancer (NSCLC) cells. However, whether sevoflurane affects the metastasis of small cell lung cancer (SCLC) cells remains unexplored. This study's primary objective was to investigate the mechanism by which sevoflurane induces calcium overload and EFHD1 upregulation, thereby contributing to pyroptosis in SCLC cells. NCI-H446 cells were treated with sevoflurane at concentrations of 0%, 0.6%, 3% and 15%. Cell proliferation was assessed using the CCK8 assay, while cell migration and invasion were analyzed using the Transwell assay. EFHD1 expression was determined by q-PCR and Western blot. Calcium content, ROS levels, and CCO content were measured using respective assay kits, and mitochondrial morphology was observed using transmission electron microscopy. Western blotting was performed to detect the expression of caspase-1 and GSDMD. All procedures were repeated under conditions of EFHD1 overexpression or silencing. Sevoflurane inhibited the proliferation, migration, and invasion of NCI-H446 cells, concurrently exerting a significant pro-pyroptotic effect. This was mediated by mitochondrial calcium overload, EFHD1 upregulation, and subsequent mitochondrial damage-induced pyroptosis. Sevoflurane significantly enhances pyroptosis in NCI-H446 cells, thereby potentially reducing cancer cell dissemination during surgery.</p>","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 4","pages":"150"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Circ-IGF1R plays a significant role in psoriasis via regulation of a miR-194-5p/CDK1 axis.","authors":"Yong Fang, Cailing E, Shixing Wu, Zudong Meng, Guifang Qin, Rongying Wang","doi":"10.1007/s10616-025-00772-0","DOIUrl":"https://doi.org/10.1007/s10616-025-00772-0","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s10616-021-00496-x.].</p>","PeriodicalId":10890,"journal":{"name":"Cytotechnology","volume":"77 4","pages":"153"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}