DARU Journal of Pharmaceutical Sciences最新文献

{"title":"Oral calcitriol in hematopoietic recovery and survival after autologous stem cell transplantation: a randomized clinical trial.","authors":"Kosar Raoufinejad,&nbsp;Ahmad Reza Shamshiri,&nbsp;Shahrzad Pezeshki,&nbsp;Bahram Chahardouli,&nbsp;Molouk Hadjibabaie,&nbsp;Zahra Jahangard-Rafsanjani,&nbsp;Kheirollah Gholami,&nbsp;Mehdi Rajabi,&nbsp;Mohammad Vaezi","doi":"10.1007/s40199-019-00306-y","DOIUrl":"https://doi.org/10.1007/s40199-019-00306-y","url":null,"abstract":"<p><strong>Background: </strong>Calcitriol, the active metabolite of vitamin D, is an essential regulator in the hematopoiesis and immunity. However, knowledge revealing its influence on the immune and hematologic reconstitution after hematopoietic stem cell transplantation (HSCT) in clinical trials is very limited.</p><p><strong>Objectives: </strong>The effects of calcitriol on short-term and long-term hematopoietic recovery, relapse-free survival (RFS) and overall survival (OS) in multiple myeloma, Hodgkin's and non-Hodgkin's lymphoma following autologous peripheral blood HSCT were assessed.</p><p><strong>Methods: </strong>Eighty patients (age: 18-68 years) in complete remission were allocated 1:1 to two groups by balanced block randomization. Calcitriol 0.25 μg or placebo capsule was administered three times daily from transplantation to day 30. Absolute neutrophil count (ANC), absolute lymphocyte count (ALC), and platelet count (PC) were determined daily from transplantation to day 30. White blood cell count (WBC), PC, and hemoglobin concentration (HC) of days 180 and 365 were extracted from clinic files. A thorough examination for oral mucositis (OM) was completed daily during hospital stay. Adverse drug reactions (ADRs) as well as two-year RFS and OS were evaluated.</p><p><strong>Results: </strong>Median time to ANC engraftment (≥0.5 × 10³/μl: 10.0 vs. 11.0 days; P = 0.98) and PC engraftment (≥20.0 × 10³/μl: both 14.0 days; P = 0.58) was similar between groups. However, the median time to ALC recovery was significantly shorter in the calcitriol group (≥0.5 × 10³/μl: 13.0 vs. 20.0 days; P < 0.001). Moreover, ALC recovery rates on day 15 (≥0.5 × 10³/μl: 82.1% vs. 42.5%; P < 0.001) and on day 30 (≥1.0 × 10³/μl: 91.7% vs. 57.5%; P = 0.001) was significantly higher with calcitriol. WBC, PC, and HC on days 180 and 365 were not significantly different between groups. None of the OM indices were modulated by calcitriol. All the ADRs were non-serious and mild, possibly or unlikely related to the intervention. In a median of 29 months follow-up, RFS was significantly better in the calcitriol group (77.0%, SE = 7.0% vs. 59.0%, SE = 8.0%; P = 0.03), albeit the OS was not affected (87.0%, SE = 5.0% vs. 92.0%, SE = 4.0%; P = 0.72).</p><p><strong>Conclusion: </strong>Calcitriol could improve ALC recovery and RFS as a safe option post-HSCT. Graphical abstract Oral calcitriol 0.25 µg three times daily from transplantation to day 30 improved lymphocytes recovery and two-year relapse-free survival as a safe option in 80 patients of autologous hematopoietic stem cell transplantation in comparison with placebo.</p>","PeriodicalId":10888,"journal":{"name":"DARU Journal of Pharmaceutical Sciences","volume":"27 2","pages":"709-720"},"PeriodicalIF":3.6,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40199-019-00306-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49675388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of computational tools for the designing of Oleuropein loaded nanostructured lipid carrier for brain targeting through nasal route","authors":"Sucharitha Palagati, Satyanarayana Sv, B. Kesavan","doi":"10.1007/s40199-019-00304-0","DOIUrl":"https://doi.org/10.1007/s40199-019-00304-0","url":null,"abstract":"","PeriodicalId":10888,"journal":{"name":"DARU Journal of Pharmaceutical Sciences","volume":"133 1","pages":"695 - 708"},"PeriodicalIF":3.6,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73778443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in the delivery of disulfiram: a critical analysis of promising approaches to improve its pharmacokinetic profile and anticancer efficacy","authors":"M. Farooq, M. Aquib, Daulat Haleem Khan, Z. Hussain, Anam Ahsan, M. Baig, D. Wande, Muhammad Masood Ahmad, H. Ahsan, Jiang Jiajie, Bo Wang","doi":"10.1007/s40199-019-00308-w","DOIUrl":"https://doi.org/10.1007/s40199-019-00308-w","url":null,"abstract":"","PeriodicalId":10888,"journal":{"name":"DARU Journal of Pharmaceutical Sciences","volume":"124 1","pages":"853 - 862"},"PeriodicalIF":3.6,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79494157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review of clinical studies with herbal medicine on polycystic ovary syndrome (PCOS)","authors":"A. Moini Jazani, Hamidreza Nasimi Doost Azgomi, Alireza Nasimi Doost Azgomi, R. Nasimi Doost Azgomi","doi":"10.1007/s40199-019-00312-0","DOIUrl":"https://doi.org/10.1007/s40199-019-00312-0","url":null,"abstract":"","PeriodicalId":10888,"journal":{"name":"DARU Journal of Pharmaceutical Sciences","volume":"78 2 1","pages":"863 - 877"},"PeriodicalIF":3.6,"publicationDate":"2019-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77417869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats","authors":"R. Ebrahimi, M. Sepand, S. Seyednejad, A. Omidi, Mostafa Akbariani, M. Gholami, O. Sabzevari","doi":"10.1007/s40199-019-00309-9","DOIUrl":"https://doi.org/10.1007/s40199-019-00309-9","url":null,"abstract":"","PeriodicalId":10888,"journal":{"name":"DARU Journal of Pharmaceutical Sciences","volume":"33 1","pages":"721 - 733"},"PeriodicalIF":3.6,"publicationDate":"2019-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77048825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional, complementary and alternative medicine in children constipation: a systematic review","authors":"Maryam Sadat Paknejad, Monireh Sadat Motaharifard, Shahdis Barimani, Payam Kabiri, M. Karimi","doi":"10.1007/s40199-019-00297-w","DOIUrl":"https://doi.org/10.1007/s40199-019-00297-w","url":null,"abstract":"","PeriodicalId":10888,"journal":{"name":"DARU Journal of Pharmaceutical Sciences","volume":"50 20","pages":"811 - 826"},"PeriodicalIF":3.6,"publicationDate":"2019-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40199-019-00297-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72489081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting kidneys by superparamagnetic allopurinol loaded chitosan coated nanoparticles for the treatment of hyperuricemic nephrolithiasis","authors":"Gurpreet Kandav, D. Bhatt, D. Jindal","doi":"10.1007/s40199-019-00300-4","DOIUrl":"https://doi.org/10.1007/s40199-019-00300-4","url":null,"abstract":"","PeriodicalId":10888,"journal":{"name":"DARU Journal of Pharmaceutical Sciences","volume":"56 1","pages":"661 - 671"},"PeriodicalIF":3.6,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90435518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of probiotics supplementation on glucose and oxidative stress in type 2 diabetes mellitus: a meta-analysis of randomized trials","authors":"Edris Ardeshirlarijani, Ozra Tabatabaei-Malazy, S. Mohseni, M. Qorbani, B. Larijani, R. Baradar Jalili","doi":"10.1007/s40199-019-00302-2","DOIUrl":"https://doi.org/10.1007/s40199-019-00302-2","url":null,"abstract":"","PeriodicalId":10888,"journal":{"name":"DARU Journal of Pharmaceutical Sciences","volume":"5 1","pages":"827 - 837"},"PeriodicalIF":3.6,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87663599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellulose nanofibers from lignocellulosic biomass of lemongrass using enzymatic hydrolysis: characterization and cytotoxicity assessment.","authors":"P. Kumari, Gauri Pathak, Ruby Gupta, D. Sharma, A. Meena","doi":"10.1007/s40199-019-00303-1","DOIUrl":"https://doi.org/10.1007/s40199-019-00303-1","url":null,"abstract":"","PeriodicalId":10888,"journal":{"name":"DARU Journal of Pharmaceutical Sciences","volume":"24 1","pages":"683 - 693"},"PeriodicalIF":3.6,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81825327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved activity and expression of recombinant human factor IX by propeptide engineering","authors":"J. Vatandoost, M. Bos","doi":"10.1007/s40199-019-00299-8","DOIUrl":"https://doi.org/10.1007/s40199-019-00299-8","url":null,"abstract":"","PeriodicalId":10888,"journal":{"name":"DARU Journal of Pharmaceutical Sciences","volume":"1 1","pages":"653 - 660"},"PeriodicalIF":3.6,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83739025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}