Current Opinion in Infectious Diseases最新文献_第9页

IF 3.6 3区医学

Current Opinion in Infectious Diseases Pub Date : 2024-08-01 Epub Date: 2024-06-27 DOI: 10.1097/QCO.0000000000001031

引用次数: 0

Navigating the future: machine learning's role in revolutionizing antimicrobial stewardship and infection prevention and control. 领航未来：机器学习在抗菌药物管理和感染预防与控制革命中的作用。

IF 3.6 3区医学

Current Opinion in Infectious Diseases Pub Date : 2024-08-01 Epub Date: 2024-05-31 DOI: 10.1097/QCO.0000000000001028

John J Hanna, Richard J Medford

{"title":"Navigating the future: machine learning's role in revolutionizing antimicrobial stewardship and infection prevention and control.","authors":"John J Hanna, Richard J Medford","doi":"10.1097/QCO.0000000000001028","DOIUrl":"10.1097/QCO.0000000000001028","url":null,"abstract":"Purpose of review: This review examines the current state and future prospects of machine learning (ML) in infection prevention and control (IPC) and antimicrobial stewardship (ASP), highlighting its potential to transform healthcare practices by enhancing the precision, efficiency, and effectiveness of interventions against infections and antimicrobial resistance.Recent findings: ML has shown promise in improving surveillance and detection of infections, predicting infection risk, and optimizing antimicrobial use through the development of predictive analytics, natural language processing, and personalized medicine approaches. However, challenges remain, including issues related to data quality, model interpretability, ethical considerations, and integration into clinical workflows.Summary: Despite these challenges, the future of ML in IPC and ASP is promising, with interdisciplinary collaboration identified as a key factor in overcoming existing barriers. ML's role in advancing personalized medicine, real-time disease monitoring, and effective IPC and ASP strategies signifies a pivotal shift towards safer, more efficient healthcare environments and improved patient care in the face of global antimicrobial resistance challenges.","PeriodicalId":10880,"journal":{"name":"Current Opinion in Infectious Diseases","volume":" ","pages":"290-295"},"PeriodicalIF":3.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reexploring cytomegalovirus serology in allogeneic hematopoietic cell transplantation. 重新探讨异基因造血细胞移植中的巨细胞病毒血清学。

IF 3.6 3区医学

Current Opinion in Infectious Diseases Pub Date : 2024-08-01 Epub Date: 2024-06-10 DOI: 10.1097/QCO.0000000000001025

Léna Royston, Dionysios Neofytos

引用次数: 0

Update and approach to patients with brain abscess. 脑脓肿患者的最新情况和治疗方法。

IF 3.9 3区医学

Current Opinion in Infectious Diseases Pub Date : 2024-06-01 Epub Date: 2024-03-28 DOI: 10.1097/QCO.0000000000001014

Lars Haukali Omland, Henrik Nielsen, Jacob Bodilsen

{"title":"Update and approach to patients with brain abscess.","authors":"Lars Haukali Omland, Henrik Nielsen, Jacob Bodilsen","doi":"10.1097/QCO.0000000000001014","DOIUrl":"10.1097/QCO.0000000000001014","url":null,"abstract":"Purpose of review: The epidemiology of brain abscess has changed in recent decades. Moreover, acute and long-term management remains challenging with high risks of mortality and neurological sequelae. This review describes recent advances in epidemiology, diagnosis, and treatment of brain abscess.Recent findings: The incidence of brain abscess is increasing, especially among elderly individuals. Important predisposing conditions include dental and ear-nose-throat infections, immuno-compromise, and previous neurosurgery. Molecular-based diagnostics have improved our understanding of the involved microorganisms and oral cavity bacteria including anaerobes are the predominant pathogens. The diagnosis relies upon a combination of magnetic resonance imaging, neurosurgical aspiration or excision, and careful microbiological examinations. Local source control by aspiration or excision of brain abscess combined with long-term antimicrobials are cornerstones of treatment. Long-term management remains important and should address neurological deficits including epilepsy, timely diagnosis and management of comorbidities, and potential affective disorders.Summary: A multidisciplinary approach to acute and long-term management of brain abscess remains crucial and source control of brain abscess by neurosurgery should be pursued whenever possible. Numerous aspects regarding diagnosis and treatment need clarification. Nonetheless, our understanding of this complicated infection is rapidly evolving.","PeriodicalId":10880,"journal":{"name":"Current Opinion in Infectious Diseases","volume":" ","pages":"211-219"},"PeriodicalIF":3.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140317871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infectious mononucleosis: new concepts in clinical presentation, epidemiology, and host response. 传染性单核细胞增多症：临床表现、流行病学和宿主反应的新概念。

IF 3.9 3区医学

Current Opinion in Infectious Diseases Pub Date : 2024-06-01 Epub Date: 2024-03-26 DOI: 10.1097/QCO.0000000000001012

Patrick Naughton, Frances Enright, Brigid Lucey

{"title":"Infectious mononucleosis: new concepts in clinical presentation, epidemiology, and host response.","authors":"Patrick Naughton, Frances Enright, Brigid Lucey","doi":"10.1097/QCO.0000000000001012","DOIUrl":"10.1097/QCO.0000000000001012","url":null,"abstract":"Purpose of review: Infectious mononucleosis (IM) is an infectious disease that presents clinically in only a small percentage of individuals despite almost universal infection with the causative agent. Here, we review the latest concepts in the clinical presentation, epidemiology, and host response of this disease.Recent findings: Several recently published papers/reviews describe IM as a condition caused by one of several etiologic agents including, cytomegalovirus (HHV-5), Roseola virus (HHV-6) and Toxoplasmosis amongst others; this review focuses on IM as solely caused by the human herpes virus 4 (HHV-4). Since the initial discovery of the virus in the 1960s and its subsequent discovery as the primary etiologic agent for IM it has been associated with several human cancers and autoimmune disorders. Recent published findings show a correlation between HHV-4 and the autoimmune disorder, multiple sclerosis (MS), suggesting earlier IM could possibly act as a causative factor. Considering the important links being made with IM to so many cancers and autoimmune disorders it is surprising that a standard investigative procedure has yet to be determined for this disease. A standard approach to the investigation of IM would ensure more cases are diagnosed, particularly atypical cases, this would benefit epidemiological studies, and more immediately help practitioners distinguish viral from bacterial throat infections, enabling them to treat accordingly.Summary: The understanding of the latest concepts in clinical presentation, epidemiology and host response to IM would benefit greatly from the introduction of a standard procedure for its investigation and diagnosis.","PeriodicalId":10880,"journal":{"name":"Current Opinion in Infectious Diseases","volume":" ","pages":"157-163"},"PeriodicalIF":3.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fusarium species central nervous system infection. 镰刀菌中枢神经系统感染。

IF 3.9 3区医学

Current Opinion in Infectious Diseases Pub Date : 2024-06-01 Epub Date: 2024-03-18 DOI: 10.1097/QCO.0000000000001009

Nora Strong, Luis Ostrosky-Zeichner

引用次数: 0

Bacterial cholesterol-dependent cytolysins and their interaction with the human immune response. 依赖胆固醇的细菌细胞溶解素及其与人类免疫反应的相互作用。

IF 3.9 3区医学

Current Opinion in Infectious Diseases Pub Date : 2024-06-01 Epub Date: 2024-03-21 DOI: 10.1097/QCO.0000000000001010

Tristan C Sanford, Rodney K Tweten, Hunter L Abrahamsen

引用次数: 0

Central nervous system infections in the tropics. 热带地区的中枢神经系统感染。

IF 3.6 3区医学

Current Opinion in Infectious Diseases Pub Date : 2024-06-01 Epub Date: 2024-03-26 DOI: 10.1097/QCO.0000000000001015

Angel Miraclin T, Bhagteshwar Singh, Priscilla Rupali

{"title":"Central nervous system infections in the tropics.","authors":"Angel Miraclin T, Bhagteshwar Singh, Priscilla Rupali","doi":"10.1097/QCO.0000000000001015","DOIUrl":"10.1097/QCO.0000000000001015","url":null,"abstract":"Purpose of review: Emerging and re-emerging central nervous system (CNS) infections are a major public health concern in the tropics. The reasons for this are myriad; climate change, rainfall, deforestation, increased vector density combined with poverty, poor sanitation and hygiene. This review focuses on pathogens, which have emerged and re-emerged, with the potential for significant morbidity and mortality.Recent findings: In recent years, multiple acute encephalitis outbreaks have been caused by Nipah virus, which carries a high case fatality. Arboviral infections, predominantly dengue, chikungunya and Zika are re-emerging increasingly especially in urban areas due to changing human habitats, vector behaviour and viral evolution. Scrub typhus, another vector borne disease caused by the bacterium Orientia tsutsugamushi , is being established as a leading cause of CNS infections in the tropics.Summary: A syndromic and epidemiological approach to CNS infections in the tropics is essential to plan appropriate diagnostic tests and management. Rapid diagnostic tests facilitate early diagnosis and thus help prompt initiation and focusing of therapy to prevent adverse outcomes. Vector control, cautious urbanization and deforestation, and reducing disturbance of ecosystems can help prevent spread of vector-borne diseases. Regional diagnostic and treatment approaches and specific vaccines are required to avert morbidity and mortality.","PeriodicalId":10880,"journal":{"name":"Current Opinion in Infectious Diseases","volume":" ","pages":"201-210"},"PeriodicalIF":3.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of respiratory viral infections on nasopharyngeal pneumococcal colonization dynamics in children. 呼吸道病毒感染对儿童鼻咽肺炎球菌定植动态的影响。

IF 3.9 3区医学

Current Opinion in Infectious Diseases Pub Date : 2024-06-01 Epub Date: 2024-03-04 DOI: 10.1097/QCO.0000000000001008

Leigh M Howard, Carlos G Grijalva

{"title":"Impact of respiratory viral infections on nasopharyngeal pneumococcal colonization dynamics in children.","authors":"Leigh M Howard, Carlos G Grijalva","doi":"10.1097/QCO.0000000000001008","DOIUrl":"10.1097/QCO.0000000000001008","url":null,"abstract":"Purpose of review: Prevention of acute respiratory illnesses (ARI) in children is a global health priority, as these remain a leading cause of pediatric morbidity and mortality throughout the world. As new products and strategies to prevent respiratory infections caused by important pathogens such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza, respiratory syncytial virus and pneumococcus are advancing, increasing evidence suggests that these and other respiratory viruses and pneumococci may exhibit interactions that are associated with altered colonization and disease dynamics. We aim to review recent data evaluating interactions between respiratory viruses and pneumococci in the upper respiratory tract and their potential impact on pneumococcal colonization patterns and disease outcomes.Recent findings: While interactions between influenza infection and subsequent increased susceptibility and transmissibility of colonizing pneumococci have been widely reported in the literature, emerging evidence suggests that human rhinovirus, SARS-CoV-2, and other viruses may also exhibit interactions with pneumococci and alter pneumococcal colonization patterns. Additionally, colonizing pneumococci may play a role in modifying outcomes associated with respiratory viral infections. Recent evidence suggests that vaccination with pneumococcal conjugate vaccines, and prevention of colonization with pneumococcal serotypes included in these vaccines, may be associated with reducing the risk of subsequent viral infection and the severity of the associated illnesses.Summary: Understanding the direction and dynamics of viral-pneumococcal interactions may elucidate the potential effects of existing and emerging viral and bacterial vaccines and other preventive strategies on the health impact of these important respiratory pathogens.","PeriodicalId":10880,"journal":{"name":"Current Opinion in Infectious Diseases","volume":" ","pages":"170-175"},"PeriodicalIF":3.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Completion of multidose vaccine series in early childhood: current challenges and opportunities. 完成幼儿多剂量疫苗系列接种：当前的挑战与机遇。

IF 3.6 3区医学

Current Opinion in Infectious Diseases Pub Date : 2024-06-01 Epub Date: 2024-03-01 DOI: 10.1097/QCO.0000000000001007

Sarah Y Michels, Matthew F Daley, Sophia R Newcomer

{"title":"Completion of multidose vaccine series in early childhood: current challenges and opportunities.","authors":"Sarah Y Michels, Matthew F Daley, Sophia R Newcomer","doi":"10.1097/QCO.0000000000001007","DOIUrl":"10.1097/QCO.0000000000001007","url":null,"abstract":"Purpose of review: Completion of all doses in multidose vaccine series provides optimal protection against preventable infectious diseases. In this review, we describe clinical and public health implications of multidose vaccine series noncompletion, including current challenges to ensuring children receive all recommended vaccinations. We then highlight actionable steps toward achieving early childhood immunization goals.Recent findings: Although coverage levels are high for most early childhood vaccinations, rates of completion are lower for vaccinations that require multiple doses. Recent research has shown that lower family socioeconomic status, a lack of health insurance coverage, having multiple children in the household, and moving across state lines are associated with children failing to complete multidose vaccine series. These findings provide contextual evidence to support that practical challenges to accessing immunization services are impediments to completion of multidose series. Strategies, including reminder/recall, use of centralized immunization information systems, and clinician prompts, have been shown to increase immunization rates. Re-investing in these effective interventions and modernizing the public health infrastructure can facilitate multidose vaccine series completion.Summary: Completion of multidose vaccine series is a challenge for immunization service delivery. Increased efforts are needed to address remaining barriers and improve vaccination coverage in the United States.","PeriodicalId":10880,"journal":{"name":"Current Opinion in Infectious Diseases","volume":" ","pages":"176-184"},"PeriodicalIF":3.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11210715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0