Hematopoietic stem cell transplantation and cellular therapy in persons living with HIV.

IF 3.6 3区医学 Q2 INFECTIOUS DISEASES

Current Opinion in Infectious Diseases Pub Date : 2024-08-01 Epub Date: 2024-05-31 DOI:10.1097/QCO.0000000000001022

Paul G Rubinstein, Carlos Galvez, Richard F Ambinder

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引用次数: 0

Abstract

Purpose of review: Summarize the latest research of both stem cell transplantation and cellular therapy and present the implications with respect to persons with HIV (PWH), hematologic malignancies, and HIV-1 cure.

Recent findings: Allogeneic (alloSCT) and autologous (autoSCT) stem cell transplantation have been shown to be well tolerated and effective regardless of HIV-1 status. AlloSCT leads to a decrease in the HIV-1 latently infected reservoir orders of magnitude below that achieved with antiretroviral therapy (ART) alone. Utilization of CCR5Δ2/Δ32 donors in an alloSCT has resulted in HIV-1 cures. In the last 12 months, three cases of cure have been published, giving further insight into the conditions required for HIV-1 control. Other advances in the treatment of hematological cancers include chimeric antigen receptor T-cell (CART) therapy, which are active in PWH with lymphoma.

Summary: Here we discuss the advances in SCT and cellular therapy in PWH and cancer. Additionally, we discuss how these technologies are being utilized to achieve HIV-1 cure.

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艾滋病毒感染者的造血干细胞移植和细胞疗法。

综述的目的：总结干细胞移植和细胞疗法的最新研究，并介绍对艾滋病病毒感染者（PWH）、血液系统恶性肿瘤和HIV-1治愈的影响：最新研究结果：异体干细胞移植（alloSCT）和自体干细胞移植（autoSCT）已被证明耐受性良好且有效，与HIV-1状态无关。异体干细胞移植可使潜伏感染的HIV-1储库减少，其数量级低于单纯抗逆转录病毒疗法（ART）。在异体干细胞移植中使用 CCR5Δ2/Δ32 供体可治愈 HIV-1。在过去的 12 个月中，有三例治愈病例发表，让人们进一步了解了控制 HIV-1 所需的条件。血液癌症治疗的其他进展包括嵌合抗原受体 T 细胞疗法（CART），该疗法在患有淋巴瘤的 PWH 患者中十分活跃。此外，我们还讨论了如何利用这些技术实现 HIV-1 治愈。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Infectious Diseases 医学-传染病学

CiteScore

6.70

自引率

2.60%

发文量

121

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.