Current Atherosclerosis Reports最新文献_第4页

Beyond Cholesterol: Unraveling Residual Lipidomic Risk in Cardiovascular Health. 超越胆固醇：揭示残留脂质组学在心血管健康中的风险。

IF 5.7 2区医学

Current Atherosclerosis Reports Pub Date : 2025-03-17 DOI: 10.1007/s11883-025-01284-0

Matthew K Campbell, Nicholas W S Chew, Anurag Mehta

引用次数: 0

Built Environment and Cardiovascular Diseases - Insights from a Global Review. 建筑环境与心血管疾病——来自全球综述的见解。

IF 5.7 2区医学

Current Atherosclerosis Reports Pub Date : 2025-03-05 DOI: 10.1007/s11883-025-01282-2

Ali Aahil Noorali, Asma Altaf Hussain Merchant, Noreen Afzal, Rupshikha Sen, Vashma Junaid, Adeel Khoja, Sadeer Al-Kindi, Elizabeth M Vaughan, Unab I Khan, Nilofer F Safdar, Salim S Virani, Sana Sheikh

{"title":"Built Environment and Cardiovascular Diseases - Insights from a Global Review.","authors":"Ali Aahil Noorali, Asma Altaf Hussain Merchant, Noreen Afzal, Rupshikha Sen, Vashma Junaid, Adeel Khoja, Sadeer Al-Kindi, Elizabeth M Vaughan, Unab I Khan, Nilofer F Safdar, Salim S Virani, Sana Sheikh","doi":"10.1007/s11883-025-01282-2","DOIUrl":"10.1007/s11883-025-01282-2","url":null,"abstract":"Purpose of review: This narrative review aims to synthesize global literature on the relationship between cardiovascular diseases (CVD) and components of built environment (green spaces, walkability, food environment, accessibility and availability of recreational and healthcare facilities, and effects of air and noise pollution).Recent findings: Increased green space and neighborhood walkability are associated with lower CVD mortality and morbidity; however, benefits have shown differential effects by socioeconomic status (SES). Air pollution is a leading environmental risk factor contributing to CVDs, and it disproportionately impacts low SES populations and women. Findings on relationships between food environment and CVDs are inconsistent and limited. This global review reports on the multifactorial and complex relationship between built environment and higher CVD risk and poor CVD outcomes. Future research can address an unmet need to understand this relationship with further depth and breadth, and to investigate resulting health disparities.","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"27 1","pages":"36"},"PeriodicalIF":5.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quo Vadis after AEGIS: New Opportunities for Therapies Targeted at Reverse Cholesterol Transport? AEGIS后的现状：靶向逆转胆固醇转运的新治疗机会？

IF 5.7 2区医学

Current Atherosclerosis Reports Pub Date : 2025-02-26 DOI: 10.1007/s11883-025-01281-3

Nick S R Lan, Gerald F Watts

{"title":"Quo Vadis after AEGIS: New Opportunities for Therapies Targeted at Reverse Cholesterol Transport?","authors":"Nick S R Lan, Gerald F Watts","doi":"10.1007/s11883-025-01281-3","DOIUrl":"10.1007/s11883-025-01281-3","url":null,"abstract":"Purpose of review: High-density lipoprotein (HDL) is integral to reverse cholesterol transport (RCT), a process considered to protect against atherosclerotic cardiovascular disease (ASCVD). We summarise findings from the recent AEGIS-II trial and discuss new opportunities for HDL therapeutics targeted at RCT.Recent findings: Mendelian randomisation studies have suggested a causal association between the functional properties of HDL and ASCVD. However, the AEGIS-II trial of CSL112, an apolipoprotein A-I therapy that enhances cholesterol efflux, did not meet its primary endpoint. Exploratory analyses demonstrated that CSL112 significantly reduced ASCVD events among participants with a baseline low-density lipoprotein (LDL)-cholesterol ≥ 100 mg/dL, suggesting that RCT may depend on LDL-cholesterol levels. The role of HDL therapeutics in patients with familial hypercholesterolaemia, inherited low HDL-cholesterol and impaired HDL function, especially with inadequately controlled LDL-cholesterol, merits further investigation. The treatment of patients with monogenic defects in HDL metabolism remains a significant gap in care that needs further research.","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"27 1","pages":"35"},"PeriodicalIF":5.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Striving Towards Equity in Cardiovascular Genomics Research. 努力实现心血管基因组学研究的公平性。

IF 5.7 2区医学

Current Atherosclerosis Reports Pub Date : 2025-02-18 DOI: 10.1007/s11883-025-01277-z

Javier Jurado Vélez, Nekayla Anderson, Ivree Datcher, Christy Foster, Pamela Jackson, Bertha Hidalgo

{"title":"Striving Towards Equity in Cardiovascular Genomics Research.","authors":"Javier Jurado Vélez, Nekayla Anderson, Ivree Datcher, Christy Foster, Pamela Jackson, Bertha Hidalgo","doi":"10.1007/s11883-025-01277-z","DOIUrl":"10.1007/s11883-025-01277-z","url":null,"abstract":"Purpose of review: Our review emphasizes recent advancements and persisting gaps in cardiovascular genomics, particularly highlighting how emerging studies involving underrepresented populations have uncovered new genetic variants associated with cardiovascular diseases.Recent findings: Initiatives like the H3Africa project, the Million Veterans Program, and the All of Us Research Program are working to address this gap by focusing on underrepresented groups. Additionally, emerging research is centering on the interplay between genetic factors and socio-environmental determinants of health, which disproportionately impact marginalized communities. As cardiovascular genomics research grows, increasing the inclusion of underrepresented populations is essential for gaining a more comprehensive understanding of genetic variability. This will lead to more accurate and clinically meaningful strategies for preventing and treating cardiovascular diseases across all ancestral backgrounds and diverse populations.","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"27 1","pages":"34"},"PeriodicalIF":5.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-based Differences in Complications Following Percutaneous Coronary Interventions. 经皮冠状动脉介入术后并发症的性别差异

IF 5.7 2区医学

Current Atherosclerosis Reports Pub Date : 2025-02-17 DOI: 10.1007/s11883-025-01278-y

Mirvat Alasnag, Giulia Masiero, Sinjini Biswas, Ing Haan

{"title":"Sex-based Differences in Complications Following Percutaneous Coronary Interventions.","authors":"Mirvat Alasnag, Giulia Masiero, Sinjini Biswas, Ing Haan","doi":"10.1007/s11883-025-01278-y","DOIUrl":"10.1007/s11883-025-01278-y","url":null,"abstract":"Purpose of review: The role that sex plays in the incidence and outcomes of PCI related complications is not well understood. The purpose of this review is to highlight the commonly encountered peri-procedural complications and search for any sex differences in the published literature.Recent findings: Procedure related complications and long-term cardiovascular outcomes remain worse in women. The delayed presentation of women with coronary events and delayed referral for an invasive diagnostic angiogram and subsequent revascularization likely contribute to the worse outcomes. Whether the smaller vessel size, residual Syntax Score, and other biological factors impact periprocedural outcomes is controversial and warrants device and procedure specific research to identify sex differences. Modern day percutaneous revascularization has achieved very high acute procedural success rates and low complication rates with the advent of structured training programs, development of appropriate use criteria and refined devices and technologies in the catheterization laboratory. However, both procedure related complications and long-term cardiovascular outcomes remain worse in women.","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"27 1","pages":"33"},"PeriodicalIF":5.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Achieving More Optimal Lipid Control with Non-Statin Lipid Lowering Therapy. 通过非他汀类降脂治疗实现更优的脂质控制。

IF 5.7 2区医学

Current Atherosclerosis Reports Pub Date : 2025-02-15 DOI: 10.1007/s11883-025-01280-4

Stephen J Nicholls, Adam J Nelson

{"title":"Achieving More Optimal Lipid Control with Non-Statin Lipid Lowering Therapy.","authors":"Stephen J Nicholls, Adam J Nelson","doi":"10.1007/s11883-025-01280-4","DOIUrl":"10.1007/s11883-025-01280-4","url":null,"abstract":"Purpose of review: The use of statins has transformed approaches to the prevention of cardiovascular disease. However, many patients remain at a major risk of experiencing cardiovascular events, due to a range of factors including suboptimal control of low-density lipoprotein cholesterol (LDL-C). Accordingly, there is an ongoing need to develop additional strategies, beyond the use of statins, to achieve more effective reductions in cardiovascular risk.Recent findings: Genomic studies have implicated the causal role of LDL in atherosclerosis and identified that polymorphisms influencing factors involved in lipid metabolism influence both the level of LDL-C and cardiovascular risk. These findings have highlighted the potential for cardiovascular benefit from development of therapies targeting these factors and incremental benefit when used in combination with statins. Clinical trials have demonstrated that these new agents have favourable effects on both atherosclerotic plaque and cardiovascular events. Additional work has sought to improve intensification of statin therapy and adherence with lipid lowering therapy, to achieve more effective cardiovascular prevention via lipid lowering. Emerging therapies, beyond statins, have the potential to optimise lipid levels and play an effective role in the prevention of cardiovascular disease.","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"27 1","pages":"32"},"PeriodicalIF":5.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging Mobile Health and Wearable Technologies for the Prevention and Management of Atherosclerotic Cardiovascular Disease. 利用移动医疗和可穿戴技术预防和管理动脉粥样硬化性心血管疾病。

IF 5.7 2区医学

Current Atherosclerosis Reports Pub Date : 2025-02-11 DOI: 10.1007/s11883-024-01272-w

Pouria Alipour, Mawada El-Aghil, Ariel Foo, Zahra Azizi

{"title":"Leveraging Mobile Health and Wearable Technologies for the Prevention and Management of Atherosclerotic Cardiovascular Disease.","authors":"Pouria Alipour, Mawada El-Aghil, Ariel Foo, Zahra Azizi","doi":"10.1007/s11883-024-01272-w","DOIUrl":"10.1007/s11883-024-01272-w","url":null,"abstract":"Purpose of review: This review aims to assess the role of mobile health (mHealth) interventions and wearable technologies in the prevention and management of atherosclerotic cardiovascular disease (ASCVD). We sought to explore the benefits, challenges, and equity implications of these digital health modalities, with a focus on improving patient outcomes and reducing ASCVD risk.Recent findings: Recent studies have shown that mHealth interventions and wearable devices effectively promote healthy behaviors, offer real-time physiological monitoring, and aid in the early prevention of ASCVD by targeting key risk factors such as metabolic syndrome and sedentary lifestyles. These technologies hold great potential for improving patient engagement and enabling timely interventions. However, challenges such as technological constraints, high costs, and gaps in digital literacy significantly hinder their broader adoption, particularly among disadvantaged populations. In summary, our findings highlight the critical need for accessible, affordable, and inclusive digital health solutions to prevent and manage ASCVD, promoting more equitable healthcare delivery. To maximize these benefits, future research should focus on harnessing artificial intelligence and digital markers to improve early event prediction and develop personalized preventive strategies.","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"27 1","pages":"31"},"PeriodicalIF":5.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlights of Cardiovascular Disease Prevention Studies Presented at the 2024 American Heart Association Scientific Sessions. 在2024年美国心脏协会科学会议上提出的心血管疾病预防研究亮点。

IF 5.7 2区医学

Current Atherosclerosis Reports Pub Date : 2025-02-06 DOI: 10.1007/s11883-025-01276-0

Melody Hermel, Abdul Mannan Khan Minhas, Colin Hinkamp, Maha Inam, Nikitha Murthy, Zohar Chai, Vashma Junaid, Adeel Khoja, Sana Sheikh, Leandro Slipczuk, Elizabeth Vaughan, Sandeep Mehta, Elizabeth Epstein, Salim S Virani

{"title":"Highlights of Cardiovascular Disease Prevention Studies Presented at the 2024 American Heart Association Scientific Sessions.","authors":"Melody Hermel, Abdul Mannan Khan Minhas, Colin Hinkamp, Maha Inam, Nikitha Murthy, Zohar Chai, Vashma Junaid, Adeel Khoja, Sana Sheikh, Leandro Slipczuk, Elizabeth Vaughan, Sandeep Mehta, Elizabeth Epstein, Salim S Virani","doi":"10.1007/s11883-025-01276-0","DOIUrl":"10.1007/s11883-025-01276-0","url":null,"abstract":"Purpose of review: Focused review highlighting ten select studies presented at the 2024 American Heart Association (AHA) Scientific Sessions.Recent finding: Included studies assessed effects of intensive blood pressure control in patients with type 2 diabetes (BPROAD); decision support system for physicians to optimize early lipid lowering therapies after acute coronary syndrome (ZODIAC); efficacy and safety of zerlasiran, a short interfering RNA targeting lipoprotein(a) (ALPACAR); efficacy and safety of muvalaplin an oral disrupter of the assembly of lipoprotein(a) particles (KRAKEN); safety and efficacy of obicetrapib in patients with heterozygous familial hypercholesterolemia (BROOKLYN); efficacy and safety of lerodalcibep, a third generation PCSK9 inhibitor in heterozygous familial hypercholesterolemia subjects (LIBerate-HeFH_OLE); personalized app-based coaching to improve physical activity in patients with HFpEF compared to standard care (MyoMobile); semaglutide to improve cardiovascular outcomes in patients with a history of coronary artery bypass surgery and overweight or obesity (the SELECT trial); efficacy and safety of plozasiran in adults with genetically or clinically defined familial chylomicronemia syndrome at high risk of acute pancreatitis (PALISADE); and transcriptomic signatures and predictors of evolocumab added to maximum statin therapy based on intra-coronary plaque characteristics (YELLOW III). Research presented at the 2024 AHA Scientific Sessions emphasized innovative strategies in cardiovascular disease prevention and management.","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"27 1","pages":"30"},"PeriodicalIF":5.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid Lowering Therapy Utilization and Lipid Goal Attainment in Women. 妇女降脂治疗的应用和降脂目标的实现。

IF 5.7 2区医学

Current Atherosclerosis Reports Pub Date : 2025-01-28 DOI: 10.1007/s11883-025-01275-1

Julie A E van Oortmerssen, Janneke W C M Mulder, Marte F van der Bijl, Ruben J M Mijnster, Maryam Kavousi, Jeanine E Roeters van Lennep

{"title":"Lipid Lowering Therapy Utilization and Lipid Goal Attainment in Women.","authors":"Julie A E van Oortmerssen, Janneke W C M Mulder, Marte F van der Bijl, Ruben J M Mijnster, Maryam Kavousi, Jeanine E Roeters van Lennep","doi":"10.1007/s11883-025-01275-1","DOIUrl":"10.1007/s11883-025-01275-1","url":null,"abstract":"Purpose of review: The purpose of this review is to provide an overview of the current status of lipid-lowering therapy utilization and lipid goal attainment in women. We focus on lipid-lowering therapy in individuals with and without established atherosclerotic cardiovascular disease, as well as familial hypercholesterolemia. Additionally, this review aims to explore the underlying mechanisms driving these sex differences and to identify existing knowledge gaps in this area.Recent findings: Despite the proven efficacy of lipid-lowering therapy in both sexes, real-world studies indicate that women with comparable risk profiles are less likely than men to receive these treatments. Furthermore, women who are prescribed statins typically receive lower-intensity regimens than men and are less likely to achieve guideline-recommended low-density lipoprotein cholesterol goals. Despite advancements in lipid-lowering therapies, women compared to men, are systematically undertreated. This difference is influenced by patient-related, physician-related, and societal factors.","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"27 1","pages":"29"},"PeriodicalIF":5.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposomic Determinants of Atherosclerosis: Recent Evidence. 动脉粥样硬化的暴露性决定因素：最新证据。

IF 5.7 2区医学

Current Atherosclerosis Reports Pub Date : 2025-01-22 DOI: 10.1007/s11883-025-01274-2

Omar Hahad, Usman Sagheer, Khurram Nasir, Marin Kuntic, Andreas Daiber, Ana Navas-Acien, Kai Chen, Sanjay Rajagopalan, Sadeer Al-Kindi

{"title":"Exposomic Determinants of Atherosclerosis: Recent Evidence.","authors":"Omar Hahad, Usman Sagheer, Khurram Nasir, Marin Kuntic, Andreas Daiber, Ana Navas-Acien, Kai Chen, Sanjay Rajagopalan, Sadeer Al-Kindi","doi":"10.1007/s11883-025-01274-2","DOIUrl":"10.1007/s11883-025-01274-2","url":null,"abstract":"Purpose of review: The exposome refers to the total environmental exposures a person encounters throughout life, and its relationship with human health is increasingly studied. This non-systematic review focuses on recent research investigating the effects of environmental factors-such as air pollution, noise, greenspace, neighborhood walkability, and metallic pollutants-on atherosclerosis, a major cause of cardiovascular disease.Recent findings: Studies show that long-term exposure to airborne particulate matter can impair endothelial function and elevate adhesion molecule levels, leading to vascular damage. Nighttime traffic noise also negatively impacts endothelial health. On the other hand, living in areas with more greenspace and better neighborhood walkability is linked to reduced arterial stiffness, suggesting protective cardiovascular effects. Mechanisms involved include oxidative stress, inflammation, and sympathetic activation from air pollution and noise. Metallic pollutants, including lead, cadmium, and arsenic, are linked to early signs of atherosclerosis through mechanisms involving oxidative stress. However, the effects of specific pollutants and their interactions remain incompletely understood. There is a growing need to mitigate harmful environmental exposures, such as air pollution and noise, while promoting beneficial ones like greenspace, to improve cardiovascular health. Emerging technologies like remote sensing and artificial intelligence can help further our understanding of how the exposome influences cardiovascular outcomes. More research is necessary to clarify the impact of specific pollutants as well as their interactions and how they contribute to atherosclerosis.","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"27 1","pages":"28"},"PeriodicalIF":5.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0