Current Atherosclerosis Reports最新文献

{"title":"Spontaneous Coronary Artery Dissection: Advances in Understanding and Management in Women.","authors":"Jocelyn Chai, Jacqueline Saw","doi":"10.1007/s11883-026-01408-0","DOIUrl":"https://doi.org/10.1007/s11883-026-01408-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute myocardial infarction (MI), particularly among young to middle-aged women without traditional cardiovascular risk factors. This review summarizes recent advances in the understanding, diagnosis, and management of SCAD.</p><p><strong>Recent findings: </strong>SCAD results from an intramural hematoma (IMH) or intimal tear causing separation of the coronary arterial wall and compression of the true lumen. Fibromuscular dysplasia is the most consistently associated arteriopathy, supporting a systemic vascular vulnerability. Genetic studies suggest a predominantly polygenic architecture, with variants such as PHACTR1 implicated in vascular signaling and endothelial regulation. Coronary angiography remains the diagnostic cornerstone, with intracoronary imaging aiding in uncertain cases, while emerging non-invasive modalities such as photon-counting computed tomography may refine non-invasive diagnosis. Conservative management is preferred in most stable patients because spontaneous healing is common and percutaneous coronary intervention carries procedural challenges. Persistent angina, coronary vasospasm, microvascular dysfunction, and psychological distress are increasingly recognized components of recovery. Multidisciplinary follow-up incorporating cardiac rehabilitation and psychological support is essential to address persistent symptoms and recovery after SCAD. SCAD is a distinct non-atherosclerotic cause of MI driven by an underlying arteriopathy and systemic vascular vulnerability, requiring individualized management, vascular screening, and multidisciplinary follow-up. Ongoing randomized trials and genomic studies aim to refine risk stratification, clarify optimal medication strategies, and improve long-term outcomes and recurrences.</p>","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"28 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimmune Dynamics in Diseases of the Arterial Wall: Mechanistic Foundations and Translational Prospects.","authors":"Qi Guo, Peter Holicek, Laura Tarnawski, Peder S Olofsson","doi":"10.1007/s11883-026-01418-y","DOIUrl":"https://doi.org/10.1007/s11883-026-01418-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>Peripheral nerves are increasingly recognized as regulators of vascular pathology, shaping arterial tone, inflammation, and structural remodeling. This review delineates how neural circuits interface with the aortic wall, considers sympathetic and sensory pathways in atherosclerosis and aneurysm pathophysiology, and discusses emerging experimental approaches and therapeutic strategies.</p><p><strong>Recent findings: </strong>Autonomic and sensory neural circuits are increasingly recognized as modulators of arterial disease. In experimental atherosclerosis, neuroimmune crosstalk shapes vascular inflammation and influences plaque stability. Limited available evidence from human and experimental studies suggest increased sympathetic innervation within aneurysm tissue. In preclinical models, aneurysm remodeling was linked with sympathetic input, and interventions that reduce noradrenergic signaling via sympathetic denervation or pharmacological adrenergic blockade attenuated disease severity. Improved understanding of the role for innervation in vascular pathophysiology may open therapeutic opportunities, including neuromodulation and pharmacological interventions. Clarifying sources of heterogeneity between models and clinical data can potentially refine therapeutic targets and patient selection, and advance opportunities for precision interventions. Peripheral neural circuits are integral to vascular homeostasis in health and disease, interfacing with blood vessels and regulating their physiology. Converging human and preclinical evidence implicates sympathetic innervation in disease development, and that dampening adrenergic signaling via denervation or adrenergic blockade may mitigate disease progression. This review discusses mechanistic neuroimmune crosstalk across atherosclerosis and aneurysm biology and outlines some potential translational opportunities. Together, the advances position neurovascular crosstalk as a potentially tractable axis for disease-modifying interventions.</p>","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"28 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of Cholesterol and Triglyceride Metabolism by Fatty acid Ethanolamides.","authors":"Sean S Davies, Reza Fadaei","doi":"10.1007/s11883-026-01417-z","DOIUrl":"10.1007/s11883-026-01417-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>This paper reviews the existing literature supporting a role for fatty acid ethanolamides including oleoylethanolamide and palmitoylethanolamide in regulating cholesterol and triglyceride metabolism and the mechanisms underlying these effects.</p><p><strong>Recent findings: </strong>Deletion of various fatty acid ethanolamide biosynthesis genes in cellular models and small animal models have provided additional evidence that endogenous biosynthesis of fatty acid ethanolamides regulates cholesterol and triglyceride metabolism, while new clinical trials using oleoylethanolamide and palmitoylethanolamide support their therapeutic potential to normalize lipid levels in individuals with cardiometabolic disease. Fatty acid ethanolamides are biosynthesized in the intestine, liver, and adipose tissue in response to metabolic stimuli like fasting and feeding. These fatty acid ethanolamides then act via receptors including PPARα, GPR119, and GPR55 to regulate cholesterol and triglyceride levels and promote the resolution of inflammation, thereby protecting against cardiometabolic diseases including metabolic-dysfunction associated steatotic liver disease and atherosclerotic cardiovascular disease.</p>","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"28 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CETP Renaissance with Obicetrapib.","authors":"Angela Pirillo, Alberico L Catapano","doi":"10.1007/s11883-026-01416-0","DOIUrl":"https://doi.org/10.1007/s11883-026-01416-0","url":null,"abstract":"","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"28 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression, Anxiety, and Bipolar Disorder and Atherosclerosis.","authors":"Emamuzo Otobo, Joseph D Nguyen, Fatima Saeed, Midori Torpoco Rivera, Sinead Sinnott, Puja K Mehta, Antonia V Seligowski, Shady Abohashem, Michael T Osborne","doi":"10.1007/s11883-026-01415-1","DOIUrl":"https://doi.org/10.1007/s11883-026-01415-1","url":null,"abstract":"","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"28 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Density Lipoprotein Assessment Revisited: A Review of Foundational Understanding and Recent Developments in Function, Particle Size, and Cardiometabolic Impact.","authors":"Anita Sherly A, Rukmini Mysore Srikantiah, Anand Rohatgi, Anupama Hegde, Sindhu H, Arun S","doi":"10.1007/s11883-026-01413-3","DOIUrl":"https://doi.org/10.1007/s11883-026-01413-3","url":null,"abstract":"","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"28 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Arterial Disease in Human Immunodeficiency Virus Infection.","authors":"Elizabeth Sarah Mayne, Susan Louw, Michael Freeman, Nicholas Funderburg, Ismail Cassimjee, Anthony Leland Hamilton Mayne","doi":"10.1007/s11883-026-01410-6","DOIUrl":"https://doi.org/10.1007/s11883-026-01410-6","url":null,"abstract":"","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"28 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Structural and Functional Journey of Apolipoprotein A-I Through the Human Body.","authors":"Samantha M Powell, Youngki You, Chinemerem P Ogbu, John T Melchior","doi":"10.1007/s11883-026-01405-3","DOIUrl":"https://doi.org/10.1007/s11883-026-01405-3","url":null,"abstract":"","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"28 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Disease and Dyslipidemia in Pediatric Type 1 Diabetes.","authors":"Grace K Kim, Preneet Cheema Brar, Nidhi Bansal","doi":"10.1007/s11883-026-01409-z","DOIUrl":"https://doi.org/10.1007/s11883-026-01409-z","url":null,"abstract":"","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"28 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13099778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Highlights of Cardiovascular Disease Prevention Studies Presented at the 2024 American Heart Association Scientific Sessions.","authors":"Melody Hermel, Abdul Mannan Khan Minhas, Colin Hinkamp, Maha Inam, Nikitha Murthy, Carly Waldman, Zohar Chai, Vashma Junaid, Adeel Khoja, Sana Sheikh, Leandro Slipczuk, Elizabeth Vaughan, Sandeep Mehta, Elizabeth Epstein, Salim S Virani","doi":"10.1007/s11883-026-01411-5","DOIUrl":"https://doi.org/10.1007/s11883-026-01411-5","url":null,"abstract":"","PeriodicalId":10875,"journal":{"name":"Current Atherosclerosis Reports","volume":"28 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}