Current Oncology Reports最新文献

{"title":"Multimodal Imaging to Improve Patient Selection and Optimize Treatment Planning and Delivery for Patients Undergoing Reirradiation: A Scoping Review.","authors":"Arnaud Beddok, Laura Rozenblum, Valentin Calugaru, Loic Feuvret, Laurence Champion, Catherine Ala Eddine, Gilles Crehange, Georges El Fakhri, Irène Buvat","doi":"10.1007/s11912-025-01708-9","DOIUrl":"10.1007/s11912-025-01708-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>Advances in radiation therapy techniques that allow for better normal tissue sparing have made reirradiation (reRT) a more viable option for managing locoregional recurrences in various cancers. However, severe toxicity and a high risk of second recurrence persist, emphasizing the need for improved patient selection and treatment planning. This scoping review, registered in the PROSPERO database (CRD42023387364), followed PRISMA guidelines. A thorough search was conducted from 2012 to December 2023 in MEDLINE (via PubMed) and BioMed Central databases, focusing on studies that reported the value of multimodal imaging in enhancing patient selection and optimizing reRT planning. Inclusion criteria targeted studies involving MRI and PET imaging, with exclusions based on relevance, language, and quality.</p><p><strong>Recent findings: </strong>Of 363 records identified, 29 studies met inclusion criteria. Most focused on high-grade glioma (HGG, 48%), head and neck cancer (HNC, 31%), and pelvic cancer (21%). In HGG, ¹⁸F-FET PET and GdT1w-MRI linked larger, metabolically active volumes with shorter overall survival (OS). Radiomic signatures from pre-reRT PET/MRI, extracted from the planned reRT volume, were associated with post-reRT recurrence, reflecting the prognostic value of intratumoral heterogeneity. Multimodal imaging differentiated disease progression from post-treatment changes, aiding target delineation. Techniques like ¹¹C-MET PET, ¹⁸F-FET PET, and diffusion-weighted imaging for HGG, as well as ¹⁸F-FDG PET and dynamic contrast imaging for HNC, enhanced target definition and enabled dose-painting. MRI-guided reRT reduced urinary toxicity in prostate cancer through precise treatment adaptation. Multimodal imaging is essential for patient selection, target delineation, and adaptive reRT in recurrent cancers. Further research and standardization are needed to maximize its clinical impact.</p>","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Integrative Oncology in Patients Affected by Triple Negative Breast Cancer.","authors":"Shlomit Ein Gal, Samuel Mathis, Bhavana Pathak, Moshe Frenkel","doi":"10.1007/s11912-025-01711-0","DOIUrl":"10.1007/s11912-025-01711-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review examines the unmet needs of patients with triple-negative breast cancer (TNBC), the limitations of current treatment approaches, and the role of integrative modalities in symptom management, patient care, and quality-of-life enhancement. Despite advances in oncology, TNBC remains a clinical challenge due to its aggressive nature, intensive treatments, and disparities in access to care, leading to variable outcomes. This review summarizes recent progress in integrative oncology and its potential benefits for TNBC patients.</p><p><strong>Recent findings: </strong>TNBC patients face significant physical and psychosocial challenges, compounded by disparities in treatment and supportive care access. Continuous chemotherapy-based regimens often lead to accumulating symptoms, highlighting the need for integrative approaches. Evidence suggests that modalities such as nutritional counseling, physical activity programs, mind-body interventions (e.g., mindfulness, yoga) acupuncture and certain herbal remedies can help alleviate symptoms, improve well-being, and enhance resilience. A growing body of evidence supports the integration of these approaches into TNBC care to improve quality of life. The Society for Integrative Oncology has issued clinical practice guidelines recommending these modalities, yet challenges remain in optimizing personalized approaches and ensuring equitable access. Future research should focus on refining integrative strategies and increasing awareness of their benefits for TNBC patients.</p>","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adoptive T-Cell Therapy in Sarcomas.","authors":"Monika Kucharczyk, Emine Hatipoglu, Robin L Jones, Paul H Huang","doi":"10.1007/s11912-025-01706-x","DOIUrl":"https://doi.org/10.1007/s11912-025-01706-x","url":null,"abstract":"<p><strong>Purpose of review: </strong>To summarise and evaluate the latest adoptive T-cell therapies in sarcomas, focusing on therapeutic targets, efficacy, safety, and limitations.</p><p><strong>Recent findings: </strong>An increasing number of clinical trials are investigating adoptive T-cell therapies in sarcomas, most targeting NY-ESO-1 and MAGE-A4 through engineered T-cell receptors (TCR-T). The FDA approval of afamitresgene autoleucel for advanced synovial sarcoma and the breakthrough designation of letetresgene autoleucel for myxoid/round cell liposarcoma signify a major turning point. Chimeric antigen receptor T strategies target mainly B7H3, GD2, FGFR4, and HER2, with innovations including dual antigen targeting and safety switches. Tumour infiltrating lymphocyte therapy, including lifileucel, is under investigation with checkpoint inhibitors or oncolytic agents to enhance efficacy and manage toxicity. Adoptive T-cell therapy demonstrates early promise in sarcomas, particularly TCR-T therapy. Challenges include HLA restriction, tumour heterogeneity, and manufacturing complexity. Future strategies involving novel antigens, multi-targeting, and combinatorial regimens could broaden patient eligibility and improve therapeutic outcomes.</p>","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the Colorectal Cancer Maze: Unveiling Pathways To Diagnosis, Management, Pathophysiology and Prevention.","authors":"Khalid Ali Mohammed Al Kamzari, Constantina Constantinou","doi":"10.1007/s11912-025-01707-w","DOIUrl":"https://doi.org/10.1007/s11912-025-01707-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>Colorectal cancer is the third most prevalent cancer globally and the second leading cause of cancer-related mortality. It typically develops over years through the progression of benign polyps to malignancy, driven by genetic alterations-either spontaneous or inherited. This review summarizes current knowledge on colorectal cancer, including its epidemiology, risk factors, diagnostic methods, treatment strategies, preventative measures, and research developments, while identifying knowledge gaps to guide future studies.</p><p><strong>Recent findings: </strong>Colorectal cancer is influenced by numerous lifestyle-related risk factors, such as high-calorie diets, processed foods, red meat, smoking, obesity, and alcohol use. Colonoscopy, imaging tests, and biopsies remain essential for diagnosis, while the TNM staging system continues to guide therapeutic decisions. Treatment options range from early-stage surgical interventions to chemotherapy, radiotherapy, and targeted therapies in advanced stages, with neoadjuvant and adjuvant treatments offering improved outcomes. Experimental therapies, including regorafenib and cancer vaccines, are under investigation. Prevention strategies focus on healthy lifestyles and risk avoidance, alongside screening techniques including fecal occult blood tests, colonoscopy, and sigmoidoscopy. Screening programs emphasize individuals with genetic susceptibility, and clinical trials aim to enhance both screening and therapeutic approaches. Colorectal cancer poses a substantial global health challenge. Advances in diagnostics, treatment, and prevention are promising, but further research is needed to improve management strategies and address gaps in screening. Lifestyle changes and early detection through targeted screening remain critical for reducing the disease burden worldwide.</p>","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Trends in Artificial Intelligence in Neuro-Oncology.","authors":"Saahil Chadha, Durga V Sritharan, Thomas Hager, Rahul D'Souza, Sanjay Aneja","doi":"10.1007/s11912-025-01688-w","DOIUrl":"10.1007/s11912-025-01688-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>This article explores the evolving role of artificial intelligence (AI) in neuro-oncology, highlighting its potential to enhance diagnostic accuracy, predict patient outcomes, optimize treatment planning, and streamline clinical workflows.</p><p><strong>Recent findings: </strong>AI applications have led to significant advancements in automated tumor segmentation, molecular classification, risk stratification, treatment response evaluation, and computational pathology. AI-driven innovations have also accelerated drug discovery and leveraged natural language processing to generate structured clinical reports and extract actionable insights from unstructured data. AI has transformative potential in neuro-oncology; however, challenges like data quality, model generalizability, and clinical integration persist. Overcoming these barriers may involve new computational techniques and hardware efficiencies, as well as raising awareness, fostering interdisciplinary education, and expanding access to AI-driven tools.</p>","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":"951-962"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary Hematopoietic Malignancies: Considerations for Optimizing Diagnosis and Management.","authors":"Amy M Trottier, Lea Cunningham, Lucy A Godley","doi":"10.1007/s11912-025-01699-7","DOIUrl":"10.1007/s11912-025-01699-7","url":null,"abstract":"","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":"1019-1030"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining the Role of Postoperative Radio-Hormone Therapy in Prostate Cancer.","authors":"Harshitha Dudipala, Mai Dabbas, Kshitij Pandit, Sarika D Gurnani, Rana R McKay","doi":"10.1007/s11912-025-01694-y","DOIUrl":"10.1007/s11912-025-01694-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>Postoperative radio-hormone therapy plays a significant role in management of prostate cancer after radical prostatectomy (RP), particularly in efforts to reduce biochemical recurrence (BCR), distant metastasis, and improve overall survival. BCR rates can be upwards of 50-70% at 5 years, highlighting the need for optimized risk stratification and consideration of multimodal treatment approaches. The purpose of this review is to highlight evidence-based treatment recommendations, and call attention to the importance of personalized therapeutic strategies after RP.</p><p><strong>Recent findings: </strong>Both radiotherapy (RT) and ADT have been shown to optimize survival outcomes and to reduce disease progression in patients with persistent PSA, pathologic lymph-node positive disease, and adverse pathology. Early salvage RT (SRT) is typically a preferred treatment approach as it allows for treatment intensification only when clinically indicated, avoiding unnecessary radiation in men who may never recur. ADT is often added to external beam radiation therapy (EBRT) to enhance treatment efficacy, particularly in patients with high-risk features, though in selected lower-risk scenarios, radiation alone may be sufficient. Short-term ADT is appropriate for low-intermediate risk patients and long-term is appropriate for patients with advanced pathological features or nodal involvement. For certain high-risk pathologic findings, such as positive surgical margins and seminal vesicle invasion (T3b), adjuvant RT (aRT) may be indicated to optimize disease control. Overall, radio-hormone therapy plays a significant role in the postoperative setting by reducing the risk of recurrence and disease progression, and improving survival outcomes. There are several well-validated tools that may offer personalized risk assessments to identify which patients may most benefit from adjuvant or salvage therapies. Finally, the optimal use of such therapies continues to be investigated with ongoing trials.</p>","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":"975-985"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Treatment Strategies for Metastatic Disease of the Skeleton: Current Concepts.","authors":"Chloe Chose, Guston Zervoudakis, Thomas Karadimas, Thien Huong Huynh, Sean Lapp, Jonathan Henning, Ashley Lamba, David Joyce, Odion Binitie, Hakob Kocharyan, Vaiva Gustainyte, Mustafa Al-Roubaie, Alexander Lazarides","doi":"10.1007/s11912-025-01696-w","DOIUrl":"10.1007/s11912-025-01696-w","url":null,"abstract":"","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":"935-950"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines on Lifestyle Changes and Breast Cancer-where are we up to and how does this Apply to Black Women with Breast Cancer.","authors":"Sarah D Adomah, Susanne Cruickshank","doi":"10.1007/s11912-025-01691-1","DOIUrl":"10.1007/s11912-025-01691-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>Breast cancer remains a significant health concern globally, with lifestyle factors playing a crucial role in its prevention and management. This paper aims to summarize the current lifestyle guidelines for breast cancer for consistency and consensus of best practice and to explore their specific implications for Black women with breast cancer.</p><p><strong>Recent findings: </strong>There has been a growing body of data from both observational studies and some randomised controlled trials showing the relationship between diet, physical activity, body weight and cancer risk and outcomes. These has led to established national and international guidelines emphasizing the importance of lifestyle advice for survivors in reducing breast cancer risk and a drive for healthcare professionals to guide practice. However, the application and impact of these guidelines can vary across different populations, including Black women, who face unique challenges and disparities in breast cancer outcomes. Breast cancer survivors can benefit from counselling about lifestyle changes across the continuum from diagnosis, treatment through to survivorship. Guidelines recommending these changes for breast cancer survivors have been developed to guide healthcare professionals for consistency and best practice. Culturally sensitive approaches and targeted strategies are crucial to effectively reduce breast cancer disparities and improve survival rates in this population.</p>","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":"1031-1039"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the Needs of Breast Cancer Survivors.","authors":"Humaira Sarfraz, Fatima Tuz Zahra, Utsav Joshi, Tracey O'Connor","doi":"10.1007/s11912-025-01687-x","DOIUrl":"10.1007/s11912-025-01687-x","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer survivors experience unique treatment-related side effects that have long-standing and life-altering implications. These remain a challenging aspect both in terms of diagnosis and management for these patients.</p><p><strong>Objective: </strong>This article is a review of the latest key literature in the management of common side effects of treatment in breast cancer survivors namely infertility, vasomotor symptoms, sexual dysfunction, peripheral neuropathy, lymphedema, musculoskeletal symptoms, anthracycline-related cardiotoxicity, secondary malignancies, role of ctDNA, lifestyle modifications, strategies to maintain bone mineral density and addressing fear of cancer recurrence.</p><p><strong>Results: </strong>Recent research in the field has led to novel advancements for survivors planning a family, pharmacotherapeutic options for hot flashes, overcoming barriers such as adherence to therapy and management of long-term side effects, and a incorporating a multimodal approach to improve sexual health in women, neuropathy, musculoskeletal issues and lymphedema. There have been significant strides in the understanding and management of issues in breast cancer survivors. The increasing awareness and multimodal approach will continue to improve outcomes for survivors.</p>","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":"986-1001"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}