Current Oncology Reports最新文献_第2页

From Detection to Cure - Emerging Roles for Urinary Tumor DNA (utDNA) in Bladder Cancer. 从检测到治愈--尿液肿瘤 DNA (utDNA) 在膀胱癌中的新作用。

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI: 10.1007/s11912-024-01555-0

Joshua A Linscott, Hiroko Miyagi, Prithvi B Murthy, Sijie Yao, G Daniel Grass, Aram Vosoughi, Hongzhi Xu, Xuefeng Wang, Xiaoqing Yu, Alice Yu, Logan Zemp, Scott M Gilbert, Michael A Poch, Wade J Sexton, Philippe E Spiess, Roger Li

{"title":"From Detection to Cure - Emerging Roles for Urinary Tumor DNA (utDNA) in Bladder Cancer.","authors":"Joshua A Linscott, Hiroko Miyagi, Prithvi B Murthy, Sijie Yao, G Daniel Grass, Aram Vosoughi, Hongzhi Xu, Xuefeng Wang, Xiaoqing Yu, Alice Yu, Logan Zemp, Scott M Gilbert, Michael A Poch, Wade J Sexton, Philippe E Spiess, Roger Li","doi":"10.1007/s11912-024-01555-0","DOIUrl":"10.1007/s11912-024-01555-0","url":null,"abstract":"Purpose of review: This review sought to define the emerging roles of urinary tumor DNA (utDNA) for diagnosis, monitoring, and treatment of bladder cancer. Building from early landmark studies the focus is on recent studies, highlighting how utDNA could aid personalized care.Recent findings: Recent research underscores the potential for utDNA to be the premiere biomarker in bladder cancer due to the constant interface between urine and tumor. Many studies find utDNA to be more informative than other biomarkers in bladder cancer, especially in early stages of disease. Points of emphasis include superior sensitivity over traditional urine cytology, broad genomic and epigenetic insights, and the potential for non-invasive, real-time analysis of tumor biology. utDNA shows promise for improving all phases of bladder cancer care, paving the way for personalized treatment strategies. Building from current research, future comprehensive clinical trials will validate utDNA's clinical utility, potentially revolutionizing bladder cancer management.","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141246934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Options: How to Choose Therapy in Frontline Metastatic Melanoma. 多种选择：如何选择前线转移性黑色素瘤的治疗方法？

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI: 10.1007/s11912-024-01547-0

Lucy Boyce Kennedy, April K S Salama

引用次数: 0

Screening and Testing for Homologous Recombination Repair Deficiency (HRD) in Breast Cancer: an Overview of the Current Global Landscape. 乳腺癌同源重组修复缺陷（HRD）的筛查和检测：全球现状概览。

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2024-08-01 Epub Date: 2024-06-01 DOI: 10.1007/s11912-024-01560-3

Gordon R Daly, Sindhuja Naidoo, Mohammad Alabdulrahman, Jason McGrath, Gavin P Dowling, Maen M AlRawashdeh, Arnold D K Hill, Damir Varešlija, Leonie Young

{"title":"Screening and Testing for Homologous Recombination Repair Deficiency (HRD) in Breast Cancer: an Overview of the Current Global Landscape.","authors":"Gordon R Daly, Sindhuja Naidoo, Mohammad Alabdulrahman, Jason McGrath, Gavin P Dowling, Maen M AlRawashdeh, Arnold D K Hill, Damir Varešlija, Leonie Young","doi":"10.1007/s11912-024-01560-3","DOIUrl":"10.1007/s11912-024-01560-3","url":null,"abstract":"Purpose of review: Homologous recombination repair deficiency (HRD) increases breast cancer susceptibility and influences both prophylactic and active management of breast cancer. This review evaluates HRD testing and the therapeutic implications of HRD in a global context.Recent findings: Ongoing research efforts have highlighted the importance of HRD beyond BRCA1/2 as a potential therapeutic target in breast cancer. However, despite the improved affordability of next-generation sequencing (NGS) and the discovery of PARP inhibitors, economic and geographical barriers in access to HRD testing and breast cancer screening do not allow all patients to benefit from the personalized treatment approach they provide. Advancements in HRD testing modalities and targeted therapeutics enable tailored breast cancer management. However, inequalities in access to testing and optimized treatments are contributing to widening health disparities globally.","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevention of Post-Mastectomy Pain Syndrome: A Review of Recent Literature on Perioperative Interventions. 预防乳房切除术后疼痛综合征：关于围手术期干预措施的最新文献综述。

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI: 10.1007/s11912-024-01553-2

Rachel R Wu, Simon Katz, Jing Wang, Lisa V Doan

引用次数: 0

An Annual Symposium on Disparities in Milwaukee, WI, with a 2023 Focus on Older Adults with Cancer. 威斯康星州密尔沃基市差异问题年度研讨会，2023 年重点关注患癌症的老年人。

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2024-08-01 Epub Date: 2024-05-27 DOI: 10.1007/s11912-024-01525-6

Sailaja Kamaraju, June McKoy, Grant R Williams, Nikesha Gilmore, Christina Minami, Kathryn Bylow, Helena Rajalingam, Chandler S Cortina, Angela Beckert, Melinda Stolley, Dan Bullock, Razelle Kurzrock, Aminah Jatoi

{"title":"An Annual Symposium on Disparities in Milwaukee, WI, with a 2023 Focus on Older Adults with Cancer.","authors":"Sailaja Kamaraju, June McKoy, Grant R Williams, Nikesha Gilmore, Christina Minami, Kathryn Bylow, Helena Rajalingam, Chandler S Cortina, Angela Beckert, Melinda Stolley, Dan Bullock, Razelle Kurzrock, Aminah Jatoi","doi":"10.1007/s11912-024-01525-6","DOIUrl":"10.1007/s11912-024-01525-6","url":null,"abstract":"Purpose of review: Cancer-related inequities are prevalent in Wisconsin, with lower survival rates for breast, colorectal, and lung cancer patients from marginalized communities. This manuscript describes the ongoing efforts at the Medical College of Wisconsin and potential pathways of community engagement to promote education and awareness in reducing inequities in cancer care.Recent findings: While some cancer inequities are related to aggressive disease biology, health-related social risks may be addressed through community-academic partnerships via an open dialogue between the community members and academic faculty. To develop potential pathways of community-academic partnerships, an annual Cancer Disparities Symposium concept evolved as a pragmatic and sustainable model in an interactive learning environment. In this manuscript, we describe the programmatic development and execution of the annual Cancer Disparities Symposium, followed by highlights from this year's meeting focused on geriatric oncology as discussed by the speakers.","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Localized Melanoma in the Anti-PD-1 Era. 抗PD-1时代的局部黑色素瘤治疗。

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2024-08-01 Epub Date: 2024-06-06 DOI: 10.1007/s11912-024-01556-z

Elan Novis, Alexander C J van Akkooi

{"title":"Management of Localized Melanoma in the Anti-PD-1 Era.","authors":"Elan Novis, Alexander C J van Akkooi","doi":"10.1007/s11912-024-01556-z","DOIUrl":"10.1007/s11912-024-01556-z","url":null,"abstract":"Purpose of review: The management of cutaneous melanoma has rapidly progressed over the past decade following the introduction of effective systemic therapies. Given the large number of recent clinical trials which have dramatically altered the management of these patients, an updated review of the current evidence regarding the management of localized melanoma is needed.Recent findings: The role of effective systemic therapies in earlier stages (I-III) melanoma, both in adjuvant and neoadjuvant settings is rapidly changing the role of surgery in the management cutaneous melanoma, particularly regarding surgical safety margins for wide local excision (WLE), the role of sentinel lymph node biopsy (SLNB) and the extent of lymph node dissections. The randomized phase 2 SWOG1801 trial has demonstrated superiority of neoadjuvant-adjuvant anti-PD1 therapy in improving event-free survival by 23% at 2-years over adjuvant anti-PD-1 therapy only. Furthermore, the PRADO trial has suggested a more tailored approach both the extent of surgery as well as adjuvant therapy can safely and effectively be done, depending on the response to initial neoadjuvant immunotherapy. These results await validation and it is expected that in 2024 the phase 3 Nadina trial (NCT04949113) will definitively establish neo-adjuvant combination immunotherapy as the novel standard. This will further redefine the management of localized melanoma. The use of effective systemic therapies will continue to evolve in the next decade and, together with new emerging diagnostic and surveillance techniques, will likely reduce the extent of routine surgery for stage I-III melanoma.","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11300549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141260475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation and Melanoma: Where Are We Now? 辐射与黑色素瘤：我们现在在哪里？

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2024-08-01 Epub Date: 2024-06-01 DOI: 10.1007/s11912-024-01557-y

Roy Bliley, Adam Avant, Theresa M Medina, Ryan M Lanning

引用次数: 0

Use of Circulating Tumor DNA to Guide Decision-making in Adjuvant Colon Cancer. 利用循环肿瘤 DNA 指导结肠癌辅助治疗决策。

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2024-08-01 Epub Date: 2024-06-06 DOI: 10.1007/s11912-024-01565-y

Zachary Gottschalk, Stacey A Cohen

引用次数: 0

Immunological Checkpoint Blockade in Anal Squamous Cell Carcinoma: Dramatic Responses Tempered By Frequent Resistance. 肛门鳞状细胞癌的免疫检查点阻断疗法：频繁的抗药性抑制了剧烈的反应

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI: 10.1007/s11912-024-01564-z

Thejus Jayakrishnan, Devvrat Yadav, Brandon M Huffman, James M Cleary

{"title":"Immunological Checkpoint Blockade in Anal Squamous Cell Carcinoma: Dramatic Responses Tempered By Frequent Resistance.","authors":"Thejus Jayakrishnan, Devvrat Yadav, Brandon M Huffman, James M Cleary","doi":"10.1007/s11912-024-01564-z","DOIUrl":"10.1007/s11912-024-01564-z","url":null,"abstract":"Purpose of review: Squamous cell carcinoma of the anus (SCCA) is an HPV-associated malignancy that has limited treatment options. Immunotherapy has expanded these options and here we review current and emerging immunotherapeutic approaches.Recent findings: Multiple studies of single-agent anti-PD1/PD-L1 immunotherapy have demonstrated a modest response rate of approximately 10% to 15%. While a minority of patients (~5%) with SCCA experience durable complete responses, most advanced SCCAs are resistant to anti-PD1/PD-L1 monotherapy. Given the need for more broadly effective immunotherapies, novel strategies, such as adaptive cell therapies and therapeutic vaccination, are being explored. To reduce the recurrence risk of localized high-risk SCCA, strategies combining immunotherapy with chemoradiation are also being investigated. While a small subset of patients with SCCA have prolonged responses to PD1-directed immunotherapy, the majority do not derive clinical benefit, and new immunotherapeutic strategies are needed. Better understanding of the immune microenvironment and predictive biomarkers could accelerate therapeutic advances.","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicities from BRAF and MEK Inhibitors: Strategies to Maximize Therapeutic Success. BRAF 和 MEK 抑制剂的毒性：最大限度提高治疗成功率的策略。

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2024-08-01 Epub Date: 2024-06-08 DOI: 10.1007/s11912-024-01544-3

Mike Wang, Ryan J Sullivan, Meghan J Mooradian

引用次数: 0