Current Oncology Reports最新文献

Emerging Therapeutic Targets of Neuroendocrine Prostate Cancer.

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2025-02-27 DOI: 10.1007/s11912-025-01643-9

Xiaolin Zhu, Chien-Kuang C Ding, Rahul R Aggarwal

引用次数: 0

Beneath the Surface: The Emerging Role of Ultra-Processed Foods in Obesity-Related Cancer.

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2025-02-27 DOI: 10.1007/s11912-025-01654-6

Ioanna A Anastasiou, Dimitris Kounatidis, Natalia G Vallianou, Alexandros Skourtis, Krystalia Dimitriou, Ilektra Tzivaki, Georgios Tsioulos, Anastasia Rigatou, Irene Karampela, Maria Dalamaga

{"title":"Beneath the Surface: The Emerging Role of Ultra-Processed Foods in Obesity-Related Cancer.","authors":"Ioanna A Anastasiou, Dimitris Kounatidis, Natalia G Vallianou, Alexandros Skourtis, Krystalia Dimitriou, Ilektra Tzivaki, Georgios Tsioulos, Anastasia Rigatou, Irene Karampela, Maria Dalamaga","doi":"10.1007/s11912-025-01654-6","DOIUrl":"https://doi.org/10.1007/s11912-025-01654-6","url":null,"abstract":"Purposeof review: Ultra-processed foods (UPFs) are becoming more and more important in daily diets around the world; in some cases, they can account for as much as 60% of daily energy intake. Epidemiological evidence suggests that this shift toward high levels of food processing may be partially responsible for the global obesity epidemic and the rise in the prevalence of chronic diseases.Recent findings: Few prospective studies have examined the relationship between UPF consumption and cancer outcomes. According to currently available information, UPFs may increase the risk of cancer due to their obesogenic properties and exposure to substances that can cause cancer, such as certain food additives and pollution from product processing. The complex relationship between obesity and cancer involves factors such as immune dysregulation, altered adipokine and sex hormone levels, abnormal fatty acid metabolism, extracellular matrix remodeling, and chronic inflammation. Addressing cancer risk associated with UPF consumption could involve a multifaceted approach, including consumer behavior modification programs and robust public health regulations aimed at enhancing food environments. Improved knowledge of the potential dual negative impacts of UPFs on the environment and cancer risk is one of the priority areas we identify for future research and policy implications. Various approaches could be used to prevent cancers associated with UPF consumption, such as consumer behavior change programs and stricter public health regulations needed to improve the food environment. This review examines for the first time the potential role of UPFs in cancer risk associated with obesity, exploring underlying biological mechanisms and identifying key areas for future research and policy action, including the dual environmental and health impact of UPFs.","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De-escalation for Human Papillomavirus-Positive Oropharyngeal Cancer: A Look at the Prospective Evidence.

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2025-02-26 DOI: 10.1007/s11912-025-01652-8

Allen M Chen

{"title":"De-escalation for Human Papillomavirus-Positive Oropharyngeal Cancer: A Look at the Prospective Evidence.","authors":"Allen M Chen","doi":"10.1007/s11912-025-01652-8","DOIUrl":"https://doi.org/10.1007/s11912-025-01652-8","url":null,"abstract":"Purpose of review: Although it is now firmly established that the presence of human papillomavirus (HPV) expression in oropharyngeal cancer is associated with a favorable prognosis, the implications with respect to treatment remain uncertain. However, the recognition that HPV-positive oropharyngeal cancer is exquisitely sensitive to radiation and chemotherapy has raised questions regarding the appropriateness of historical treatment paradigms, and clinical trials have been conducted to assess whether patients can be treated with less intensive regimens. The fundamental goal of de-escalation is to preserve the high rates of cure and survival from traditional approaches while reducing the incidence of both short- and long-term side effects. However, the data reporting on de-escalation is relatively limited.Recent findings: While the evidence to date has been promising, the heterogeneity of the published studies particularly with trial design, de-escalation approach, inclusion criteria, and treatment selection has made drawing definitive conclusions difficult. The use of differing endpoints related to disease control and quality of life have also complicated the comparison of trials across the literature. Multiple uncertainties continue to exist with respect to the current state of de-escalation for HPV-positive oropharyngeal cancer, and how to consider the growing evidence in the context of clinical decision-making in the future is the subject of this review.","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ChatGPT in Oncology Diagnosis and Treatment: Applications, Legal and Ethical Challenges.

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2025-02-25 DOI: 10.1007/s11912-025-01649-3

Zihan Zhou, Peng Qin, Xi Cheng, Maoxuan Shao, Zhaozheng Ren, Yiting Zhao, Qiunuo Li, Lingxiang Liu

{"title":"ChatGPT in Oncology Diagnosis and Treatment: Applications, Legal and Ethical Challenges.","authors":"Zihan Zhou, Peng Qin, Xi Cheng, Maoxuan Shao, Zhaozheng Ren, Yiting Zhao, Qiunuo Li, Lingxiang Liu","doi":"10.1007/s11912-025-01649-3","DOIUrl":"https://doi.org/10.1007/s11912-025-01649-3","url":null,"abstract":"Purpose of review: This study aims to systematically review the trajectory of artificial intelligence (AI) development in the medical field, with a particular emphasis on ChatGPT, a cutting-edge tool that is transforming oncology's diagnosis and treatment practices.Recent findings: Recent advancements have demonstrated that ChatGPT can be effectively utilized in various areas, including collecting medical histories, conducting radiological & pathological diagnoses, generating electronic medical record (EMR), providing nutritional support, participating in Multidisciplinary Team (MDT) and formulating personalized, multidisciplinary treatment plans. However, some significant challenges related to data privacy and legal issues that need to be addressed for the safe and effective integration of ChatGPT into clinical practice. ChatGPT, an emerging AI technology, opens up new avenues and viewpoints for oncology diagnosis and treatment. If current technological and legal challenges can be overcome, ChatGPT is expected to play a more significant role in oncology diagnosis and treatment in the future, providing better treatment options and improving the quality of medical services.","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Nasopharyngeal Carcinoma Staging: from the 7th to the 9th Edition of the TNM System and Future Outlook.

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2025-02-25 DOI: 10.1007/s11912-025-01651-9

Binhao Wu, Xiaozhong Chen, Caineng Cao

{"title":"Advances in Nasopharyngeal Carcinoma Staging: from the 7th to the 9th Edition of the TNM System and Future Outlook.","authors":"Binhao Wu, Xiaozhong Chen, Caineng Cao","doi":"10.1007/s11912-025-01651-9","DOIUrl":"https://doi.org/10.1007/s11912-025-01651-9","url":null,"abstract":"Purpose of review: Nasopharyngeal carcinoma (NPC), characterized by its aggressive nature and sensitivity to radiation, demands accurate staging for optimal clinical outcomes. The purpose of this review was to provides a comprehensive overview of the evolution of the TNM staging system for NPC based on recent and previously published studies, with particular emphasis on the transition from the 7th to the 9th edition.Recent findings: The 9th edition introduces critical changes, particularly in the N and M classifications, to enhance prognostic accuracy. Our analysis also incorporates the burgeoning roles of biomarkers, especially Epstein-Barr virus (EBV)-DNA, and the potential of Artificial Intelligence (AI) in refining NPC staging. Each iteration of the TNM staging system for NPC has successfully enhanced the prognostic precision of NPC, with notable advancements from the 7th to the 9th edition. We also delves into the incorporation of biomarkers, such as EBV-DNA, and the potential of AI in refining staging accuracy. These innovations are anticipated to offer personalized prognoses and inform tailored treatment strategies for NPC patients in the future.","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal Stromal Tumors. 胃肠道间质瘤

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2025-02-22 DOI: 10.1007/s11912-025-01636-8

Gal Strauss, Suzanne George

引用次数: 0

Defining The Role for Hormone Therapy in Biochemically Recurrent Prostate Cancer: What Counts as a Win for Patients? 确定激素疗法在生化复发性前列腺癌中的作用：怎样才能让患者获胜？

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2025-02-22 DOI: 10.1007/s11912-025-01647-5

Lauren O'Loughlin, Melissa L Abel, Ravi A Madan, David J Einstein

{"title":"Defining The Role for Hormone Therapy in Biochemically Recurrent Prostate Cancer: What Counts as a Win for Patients?","authors":"Lauren O'Loughlin, Melissa L Abel, Ravi A Madan, David J Einstein","doi":"10.1007/s11912-025-01647-5","DOIUrl":"https://doi.org/10.1007/s11912-025-01647-5","url":null,"abstract":"Purpose of review: We evaluate unique clinical and drug development challenges in biochemically recurrent (BCR) prostate cancer. We examine risk stratification, critically appraise trials, and outline ongoing and future development of hormonal and non-hormonal options. We provide guidance for patient communication and examine how trial design may or may not reflect patient values.Recent findings: EMBARK established a potential role for enzalutamide with or without androgen deprivation therapy for certain patients with BCR, but questions remain about the study design and optimal usage. BCR is a heterogeneous condition with generally favorable long-term outcomes. Hormonal therapies are highly effective in suppressing-but not curing-micrometastatic disease, and are also highly effective when reserved for macrometastases, following surveillance. Ongoing studies are examining whether hormonal therapies add to metastasis-directed therapies and whether non-hormonal therapies may offer alternatives or combinations. Careful attention to trial design and endpoints will be essential for accurately measuring benefits and trade-offs.","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in the Diagnosis, Treatment, and Risk Stratification of Non-Muscle Invasive Bladder Cancer.

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2025-02-20 DOI: 10.1007/s11912-025-01645-7

Shayan Smani, Julien DuBois, Kai Zhao, Ryan Sutherland, Syed N Rahman, Peter Humphrey, David Hesse, Wei Shen Tan, Darryl Martin, Soum D Lokeshwar, Fady Ghali

{"title":"Advancements in the Diagnosis, Treatment, and Risk Stratification of Non-Muscle Invasive Bladder Cancer.","authors":"Shayan Smani, Julien DuBois, Kai Zhao, Ryan Sutherland, Syed N Rahman, Peter Humphrey, David Hesse, Wei Shen Tan, Darryl Martin, Soum D Lokeshwar, Fady Ghali","doi":"10.1007/s11912-025-01645-7","DOIUrl":"https://doi.org/10.1007/s11912-025-01645-7","url":null,"abstract":"Purpose of review: This review examines the evolving landscape of non-muscle invasive bladder cancer (NMIBC) management, focusing on risk stratification, novel therapeutic strategies, and the integration of biomarkers into clinical care.Recent findings: Emerging genomic markers such as FGFR3 and TERT promoter mutations show promise for diagnosis and personalized treatment. Advances in immunotherapy, including the use of pembrolizumab and nadofaragene firadenovec, offer options for BCG-unresponsive NMIBC, though challenges like cost and adverse effects remain. Current guidelines emphasize stratified care based on risk, balancing treatment intensity with recurrence and progression risks. While transurethral resection with intravesical therapy remains the standard for most NMIBC, early radical cystectomy is pivotal for select high-risk cases. Future directions highlight the need for biomarker-driven models to refine treatment paradigms, reduce overtreatment, and improve long-term outcomes. Continued clinical trials are essential to validate these approaches and address unmet needs in NMIBC care.","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of cancer in older adults: a systematic review of age-related differences in solid malignancies treatment.

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2025-02-15 DOI: 10.1007/s11912-025-01638-6

Esther Bastiaannet, Sophie Pilleron

{"title":"Epidemiology of cancer in older adults: a systematic review of age-related differences in solid malignancies treatment.","authors":"Esther Bastiaannet, Sophie Pilleron","doi":"10.1007/s11912-025-01638-6","DOIUrl":"https://doi.org/10.1007/s11912-025-01638-6","url":null,"abstract":"Purpose of review: We examined the latest epidemiological research on age-related differences in cancer treatment and selected outcomes, among patients with cancer aged 60 and above in comparison to younger patients.Recent findings: Colorectal, pancreatic and lung cancers were studied most often. Most studies were conducted in Europe or the United States of America (USA) within single centers. For unselected patients, older patients receive less treatment, and their survival, regardless of the metric used (cancer-specific survival or overall survival), was poorer than that of middle-aged patients. Age-related differences in treatment and outcomes were more pronounced in patients aged over 80 years. However, among patients selected for treatment, complications, adverse events rates and survival probabilities were comparable between older and younger patients. Treatment differences, especially the omission of therapy, were often smaller for good prognosis cancer types. The likelihood of receiving treatment decreased as age increases, regardless of the cancer types, treatment, countries and setting. More research on treatment in older patients with cancer, especially the frailest and the oldest, is urgently needed as there is still a lack of data to tailor treatment.","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Diet and Nutrition on Prostate Cancer - Food for Thought?

IF 4.7 2区医学

Current Oncology Reports Pub Date : 2025-02-15 DOI: 10.1007/s11912-025-01641-x

Rodrick Babakhanlou, Krisstina Gowin

引用次数: 0