{"title":"Circulating Biomarkers in Sarcoma.","authors":"Taylor P Williams, Valerie P Grignol","doi":"10.1007/s11912-025-01692-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Biomarkers to evaluate, diagnose, and monitor cancer treatment can provide critical adjunct information to standard methods of cancer detection and monitoring. With over 100 different histologic subtypes, sarcomas are a group of tumors with a critical need for easily retrievable circulating biomarkers. This review presents the current progress in the field. We describe the myriad types of biomarkers, highlight the modalities of testing, and explore the clinical utility of specific biomarkers.</p><p><strong>Recent findings: </strong>Genomic circulating biomarkers include circulating tumor DNA and micro-RNA. Genomic expressions for different histologic subtypes of sarcoma are highlighted in this review. We also explore different oncogenes, their respective proteins, extracellular vesicles, and dysregulated metabolites as investigational circulating biomarkers for diagnostic and prognostic purposes. Soft tissue sarcomas are a category of cancers that lack a clinically validated circulating biomarker, and this review presents the ongoing research efforts to establish a genomic, proteomic, or metabolic biomarker.</p>","PeriodicalId":10861,"journal":{"name":"Current Oncology Reports","volume":" ","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Oncology Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11912-025-01692-0","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose of review: Biomarkers to evaluate, diagnose, and monitor cancer treatment can provide critical adjunct information to standard methods of cancer detection and monitoring. With over 100 different histologic subtypes, sarcomas are a group of tumors with a critical need for easily retrievable circulating biomarkers. This review presents the current progress in the field. We describe the myriad types of biomarkers, highlight the modalities of testing, and explore the clinical utility of specific biomarkers.
Recent findings: Genomic circulating biomarkers include circulating tumor DNA and micro-RNA. Genomic expressions for different histologic subtypes of sarcoma are highlighted in this review. We also explore different oncogenes, their respective proteins, extracellular vesicles, and dysregulated metabolites as investigational circulating biomarkers for diagnostic and prognostic purposes. Soft tissue sarcomas are a category of cancers that lack a clinically validated circulating biomarker, and this review presents the ongoing research efforts to establish a genomic, proteomic, or metabolic biomarker.
期刊介绍：
This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer.
We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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