Current Green Chemistry最新文献_第4页

Green Synthesis of Bioactive Heterocycles - Part 1B 生物活性杂环的绿色合成——第1B部分

IF 2.2

Current Green Chemistry Pub Date : 2023-04-01 DOI: 10.2174/221334611001230406103842

引用次数: 1

Meet the Co Editor 会见联合编辑

IF 2.2

Current Green Chemistry Pub Date : 2023-04-01 DOI: 10.2174/221334611001230406092420

G. Brahmachari

引用次数: 0

A new, ecological and stability-indicating method by HPLC for the quantification of moxifloxacin in tablets 高效液相色谱法测定莫西沙星片中莫西沙星的含量

IF 2.2

Current Green Chemistry Pub Date : 2023-03-31 DOI: 10.2174/2213346110666230331085433

A. Kogawa, Thaisa Alves Celedonio da Silva, João Roberto da Silva Júnior

{"title":"A new, ecological and stability-indicating method by HPLC for the quantification of moxifloxacin in tablets","authors":"A. Kogawa, Thaisa Alves Celedonio da Silva, João Roberto da Silva Júnior","doi":"10.2174/2213346110666230331085433","DOIUrl":"https://doi.org/10.2174/2213346110666230331085433","url":null,"abstract":"\u0000\u0000A new, ecological, and stability-indicating method by HPLC was developed for the quantification of moxifloxacin in tablets. A C18 column at 33°C, purified water acidified with 0.2% phosphoric acid and ethanol (74:26,v/v), flow rate at 1.0 mLmin-1, injection volume of 5 µL, and detection at 290 nm was used.\u0000\u0000\u0000\u0000Moxifloxacin (MOX), a fluoroquinolone antimicrobial, does not present a physical-chemical analytical method for tablets form described in an official compendium. On the other hand, the literature shows some methods for evaluating MOX by HPLC. However, they bring opportunities for improvement.\u0000\u0000\u0000\u0000The method was linear (2-12 μgmL-1), selective, accurate (100.86%), precise (RSD<2%), and robust.\u0000\u0000\u0000\u0000The retention time for moxifloxacin in tablets was approximately 4.4 minutes.\u0000\u0000\u0000\u0000A Inertsil ODS-4 (150 x 4.6 mm, 5 μm, GL SciencesTM) column at 33 °C, purified water acidified with 0.2 % phosphoric acid and ethanol (74: 26, v/v) as mobile phase, flow rate at 1.0 mL min-1, injection volume of 5 µL and detection at 290 nm were used.\u0000\u0000\u0000\u0000To sum up, a method based on the principles of green analytical chemistry was successfully developed and validated for the quantification of moxifloxacin in tablets.\u0000\u0000\u0000\u0000Keywords: HPLC, green analytical chemistry, method validation, tablets, fluoroquinolone, moxifloxacin.\u0000","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42239147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemo-enzymatic synthesis of rivastigmine intermediate by Locally Isolated Soil Fungus Fusarium graminearum 本地分离土壤真菌禾谷镰刀菌化学酶促合成利瓦斯汀中间体

IF 2.2

Current Green Chemistry Pub Date : 2023-03-30 DOI: 10.2174/2213346110666230330105603

Suneelkumar Muragesh M Basingia, M. Siddesh

{"title":"Chemo-enzymatic synthesis of rivastigmine intermediate by Locally Isolated Soil Fungus Fusarium graminearum","authors":"Suneelkumar Muragesh M Basingia, M. Siddesh","doi":"10.2174/2213346110666230330105603","DOIUrl":"https://doi.org/10.2174/2213346110666230330105603","url":null,"abstract":"\u0000\u0000Biocatalytic and bioconversion processes are increasingly playing key roles in the development of pharmaceutical enantiopure drugs. This work describes a process for the production of a key chiral intermediate N-ethyl-N-methyl-carbamic acid-3-(1S-hydroxy-ethyl)-phenyl ester which can be further converted into rivastigmine. (S)-rivastigmine is a chiral drug for the treatment of mild to moderate dementia of Alzheimer’s type. A fungi Fusarium graminearum isolated locally from soil samples was used for regioselective reduction of an acetophenone derivative. The various parameters (pH, temperature, and agitation) of the growth condition were optimized for the culture. The reaction under fermentative condition for 48 hours at a temperature of 30 °C with an agitation speed of 200rpm with 82% final yield was found to be an optimal condition for the overall bioreduction process of the ketone employed in this study. Further, the product is obtained on a gram scale using the selected fungi in a fermentative reduction approach.\u0000\u0000\u0000\u0000Biocatalytic and bioconversion processes are increasingly playing key roles in the development of pharmaceutical enantiopure drugs\u0000\u0000\u0000\u0000synthesis of rivastigmine intermediate by Locally Isolated Soil Fungus Fusarium graminearum by chemo enzymatic process using the growing organism\u0000\u0000\u0000\u0000screening of fungi from soil by plate dilution method, for bior-eduction of specific ketones.\u0000\u0000\u0000\u0000The reaction time of 48 h set as optimal because the maximum conversion of the substrate with desired stereo selectivity of 98\u0000","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46239537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Synthesis of Bioactive Heterocycles 生物活性杂环化合物的绿色合成

IF 2.2

Current Green Chemistry Pub Date : 2023-03-01 DOI: 10.2174/221334610903230102122357

Bubun Banerjee

引用次数: 1

Drugs Designed for Degradation in the Environment Post Use 设计用于使用后在环境中降解的药物

IF 2.2

Current Green Chemistry Pub Date : 2023-03-01 DOI: 10.2174/2213346110666230301102856

M. Sydnes

引用次数: 1

Minireview on the Mechanism for the Production of 5-hydroxymethylfurfural from Biomass 生物质生产5-羟甲基糠醛机理综述

IF 2.2

Current Green Chemistry Pub Date : 2023-02-28 DOI: 10.2174/2213346110666230228141023

K. Yan, Yongjian Zeng, Zhiwei Jiang, Di Hu, Ruichao Guo

引用次数: 0

A Decenary Update on the Deep Eutectic Solvents in Heterocyclic Scaffold Synthesis-A Green Solvent Approach 杂环支架合成中深共晶溶剂的十年新进展——绿色溶剂方法

IF 2.2

Current Green Chemistry Pub Date : 2023-02-13 DOI: 10.2174/2213346110666230213113824

Kantharaju Kamanna, Krishnappa B Badiger, Aravind D. Kamath

{"title":"A Decenary Update on the Deep Eutectic Solvents in Heterocyclic Scaffold Synthesis-A Green Solvent Approach","authors":"Kantharaju Kamanna, Krishnappa B Badiger, Aravind D. Kamath","doi":"10.2174/2213346110666230213113824","DOIUrl":"https://doi.org/10.2174/2213346110666230213113824","url":null,"abstract":"\u0000\u0000Deep eutectic solvents (DESs) are a mixture of two or more chemicals (hydrogen bond donors and acceptors) that are solid at room temperature, but combined at a unique molar ratio, presenting a melting point recession and becoming liquid. These solvents emerged as an alternative to hazardous solvents employed in various organic transformations and fulfilled the green chemistry concept. The convenience of synthesis, recyclability, inexpensiveness, non-toxicity, high solvent capacity, high biodegradation, low volatile organic character, and environmentally benign nature give DESs an edge over other solvents. Due to the numerous benefits to present environmental concerns and the necessity to replace hazardous solvents, the DESs solvent system is appealing to chemists in recent decades. The most important role played by the DESs showed component interactions via covalent or ionic bonds, and is thus considered a good candidate to replace ionic liquids or traditional solvents. The present review article focuses mainly on recent highlights of DESs, preparation, properties and applications to various heterocyclic molecule construction for the period 2012 to 2022.\u0000","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48887098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative Chlorination: A Sustainable Alternative for the Preparation of Chloroarenes 氧化氯化法:制备氯芳烃的可持续选择

IF 2.2

Current Green Chemistry Pub Date : 2023-02-13 DOI: 10.2174/2213346110666230213113910

Vitor S. C. de Andrade, M. de Mattos

引用次数: 0

Green Synthetic Approach: A well-organized Eco-Friendly Tool for Synthesis of Bio-active Fused Heterocyclic Compounds 绿色合成方法:一个组织良好的生态友好的合成生物活性融合杂环化合物的工具

IF 2.2

Current Green Chemistry Pub Date : 2023-01-20 DOI: 10.2174/2213346110666230120154516

C. Mukhopadhyay, Rajiv Karmakar

{"title":"Green Synthetic Approach: A well-organized Eco-Friendly Tool for Synthesis of Bio-active Fused Heterocyclic Compounds","authors":"C. Mukhopadhyay, Rajiv Karmakar","doi":"10.2174/2213346110666230120154516","DOIUrl":"https://doi.org/10.2174/2213346110666230120154516","url":null,"abstract":"\u0000\u0000Heterocyclic chemistry is a highly significant and exciting segment of organic chemistry because of its high biological and pharmacological activities. An environmentally benign and synthetically proficient way of synthesis of fused heterocycles is the major goal of modern organic synthesis by developing greener synthetic strategies. Green synthetic approaches address our future challenges for the development of a bioactive heterocycle framework with maximum productivity and minimum side products. A few decades ago, novel tools for manufacturing fused heterocycles had a huge impact on organic chemistry. Subsequently, the preparation of fused heterocycles through a synthetically efficient and environmentally benign route is the important purpose of modern synthetic chemistry.\u0000\u0000\u0000\u0000This review consists of green synthetic strategies for the synthesis of N/O-containing various bio-active fused heterocyclic compounds using modern organic transformations including: cyclocondensation, cycloaddition, one-pot, multi-components, and other modular reactions. Some greener unconventional techniques such as ultrasound and microwave-assisted method, green solvent and solvent-free reaction medium are important modes adopted towards sustainability.\u0000\u0000\u0000\u0000This review aims to reflect the sustainability scope in green approaches to the synthesis of N/O-containing bio-active fused heterocyclic compounds so that economically and environmentally viable synthetic methodologies may be selectively identified and applied in academia and industries.\u0000\u0000\u0000\u0000In this review, we have discussed the recent advancements in green and eco-friendly tools for the synthesis of N/O-based bio-active fused heterocyclic compounds that will lead to further research in this field.\u0000","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47532407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0