可见光促进生物活性N, N-杂环的合成

IF 1.1 Q3 CHEMISTRY, MULTIDISCIPLINARY
Sasadhar Majhi, I. Saha
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引用次数: 2

摘要

杂环化合物是一类有价值的结构基序,在医药化学、生物活性天然产物化学以及合成有机化学等领域占有重要地位。氮杂环化合物是一类非常重要的化合物,广泛应用于农业化学、材料科学和生物活性复合物分子的合成,在现代药物设计中也发挥着重要作用。在N-杂环中,生物活性N, N-杂环在药物的发现和开发过程中起着至关重要的作用。苯并咪唑、恶二唑、吡唑、吡唑啉、吡啶嗪、嘧啶、噻二唑、三唑等是一类重要的N、N杂环化合物,具有重要的生理生物活性和广泛的合成用途。例如,含有恶二唑核的化合物如苯胺A和B显示细胞毒性。含有1,3,4-恶二唑和吡嗪骨架的Zibotentan已被FDA接受用于治疗前列腺癌,而含有1,2,4-噻二唑骨架的头孢唑普兰(SCE-2787)是一种强大的商业抗生素。因此,改进高效、方便、环保的合成方案以形成具有药学意义的N,N-杂环一直是人们关注的焦点。在此背景下,可见光辅助合成生物活性N,N-杂环对可持续发展具有重要影响,因为它是一种清洁、可再生、丰富的能源,在工业上的应用前景广阔。因此,本文旨在对可见光促进生物活性N,N-杂环的合成的认识进行综述,并进一步促进更多相关新策略的开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Visible light-promoted synthesis of bioactive N, N-heterocycles
Heterocycles are a valuable type of structural motifs which occupy a major space in the area of medicinal, pharmaceutical, and bioactive natural product chemistry as well as synthetic organic chemistry. Most frequently, nitrogen heterocycles represent a highly significant type of compounds that are extensively employed in agrochemistry, materials science, and synthesis of bioactive complex molecules and it also has a profound role in modern drug design. Among N-heterocycles, bioactive N, N-heterocycles play a crucial role in the drug discovery and development process. Benzimidazoles, oxadiazoles, pyrazoles, pyrazolines, pyridazines, pyrimidines, thiadiazoles, triazoles, etc. are important classes of N, N-heterocycles due to their significant physiological and biological activities as well as versatile synthetic utility. For example, compounds containing an oxadiazole core such as phidianidines A and B display cytotoxicity. Zibotentan including 1,3,4-oxadiazole and pyrazine skeletons was accepted for the treatment of prostate cancer by the FDA, and cefozopran (SCE-2787) comprising 1,2,4-thiadiazole core is a powerful commercial antibiotic. So, there is continuing considerable attention to the improvement of efficient, convenient, and eco-friendly synthetic protocols for the formation of pharmaceutically relevant N,N-heterocycles. In this context, visible light-assisted synthesis of bioactive N,N-heterocycles has a great impact on sustainable development as it constitutes a clean, renewable, and abundant energy source, as well as its encouraging application in industry. Hence, this review aims to deal with the understanding of the visible light-promoted synthesis of bioactive N,N-heterocycles and further stimulate the development of more new relevant strategies.
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来源期刊
Current Green Chemistry
Current Green Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
4.30
自引率
13.60%
发文量
6
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