Nitesh Kumar, Sejal Rajput, Ridham D Patel, Ashesha Yadav, Dr. Shanta Raj Lakshmi
{"title":"A Review on Environment-friendly Protocol for the Synthesis of Pyrazole Derivative","authors":"Nitesh Kumar, Sejal Rajput, Ridham D Patel, Ashesha Yadav, Dr. Shanta Raj Lakshmi","doi":"10.2174/0122133461316393240708085115","DOIUrl":"https://doi.org/10.2174/0122133461316393240708085115","url":null,"abstract":"\u0000\u0000Pyrazole derivatives are a significant group of heterocyclic compounds that have a diverse\u0000variety of biological activities and are used in several fields, such as medicines, agrochemicals, and\u0000materials research. Conventional methods for synthesizing pyrazole derivatives typically require\u0000severe reaction conditions, hazardous reagents, and environmentally harmful solvents, presenting\u0000considerable obstacles to achieving sustainable chemistry. This analysis specifically examines the\u0000latest progress made in creating environmentally friendly procedures for producing pyrazole derivatives.\u0000The study investigates different strategies in green chemistry, such as reactions without solvents,\u0000techniques including microwave and ultrasonic assistance, and using renewable resources and\u0000environmentally friendly catalysts. An in-depth analysis is conducted to evaluate the efficiency, selectivity,\u0000and environmental impact of these approaches. This review intends to comprehensively\u0000explore the potential for sustainable practices in synthesizing pyrazole derivatives by emphasizing\u0000advancements in green synthetic methods. It seeks to encourage further research and use of green\u0000chemistry concepts in heterocyclic chemistry.\u0000","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amir Samiei, Mohammad Ali Bodaghifard, M. Hamidinasab
{"title":"Green and Convenient Synthesis of Pharmaceutically Active Mono and\u0000Bis-dihydroquinazolines via a One-pot Multicomponent Reaction Under\u0000Sulfamic Acid Catalysis","authors":"Amir Samiei, Mohammad Ali Bodaghifard, M. Hamidinasab","doi":"10.2174/2213346110666230809141555","DOIUrl":"https://doi.org/10.2174/2213346110666230809141555","url":null,"abstract":"\u0000\u0000Multicomponent reactions (MCRs) and green chemistry are essential criteria for\u0000the development of efficient chemical syntheses for valuable organic compounds.\u0000\u0000\u0000\u0000The design, synthesis, and development of sustainable procedures for the production of novel\u0000biological and pharmaceutical molecules have gained high importance. Herein, an environmentally benign\u0000synthesis of mono- and bis-2,3-dihydroquinazolin-4(1H)-ones as pharmaceutically active compounds\u0000was carried out in good to high yields of 80-99% within 45-120 minutes.\u0000\u0000\u0000\u0000The desired products were synthesized via three-component and pseudo five-component condensations\u0000of isatoic anhydride, a primary amine (aniline or ammonium acetate), and an aldehyde/dialdehyde\u0000using sulfamic acid (20%) as a solid acidic catalyst under the solvent-free condition at 100°C.\u0000\u0000\u0000\u0000The easy work-up procedure, metal-free and environmentally benign catalyst, green reaction\u0000conditions for performing MCRs, and high yields of pure products are some advantages of the presented\u0000protocol.\u0000","PeriodicalId":10856,"journal":{"name":"Current Green Chemistry","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141230267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}