羰基化合物与C - H酸在水中无催化剂Knoevenagel缩合

IF 1.1 Q3 CHEMISTRY, MULTIDISCIPLINARY
Goutam Brahmachari, Indrajit Karmakar, Mullicka Mandal, Bhagirath Mandal
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引用次数: 0

摘要

摘要/ Abstract摘要:本文建立了一种超声辅助无催化剂绿色方案,用于功能化芳香醛/isatin衍生物与取代丙二腈作为C-H酸在水中反应合成一系列不同取代的Knoevenagel缩合产物。该方法简单、直接、高效。该方法的主要优点是无催化剂合成方便,产率高,效率高,反应介质为水,产物易于分离,无需柱层析纯化,生态友好,操作简单。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ultrasound-Assisted Catalyst-Free Knoevenagel Condensation of Carbonyl Compounds with C – H Acids in Water
Abstract: An ultrasound-assisted catalyst-free green protocol has been developed for the synthesis of a series of diversely substituted Knoevenagel condensation products from the reaction between functionalized aromatic aldehydes/isatin derivatives and substituted malononitriles as the C-H acids in water at ambient conditions. The method is simple, straightforward, and highly efficient. The major advantages of this newly developed protocol are expedient catalyst-free synthesis, good to excellent yields, energy efficiency, use of water as reaction medium, easy isolation of products, no need for column chromatographic purification, eco-friendliness, and operational simplicity.
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来源期刊
Current Green Chemistry
Current Green Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
4.30
自引率
13.60%
发文量
6
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