Microwave-assisted Synthesis of Fluorinated Heterocycles

Abstract

The diverse biological applications of fluorinated heterocycles make them crucial chemical compounds. Several synthetic processes have been developed for their synthesis. Microwave-assisted synthesis has emerged as an important technique for generating fluorinated heterocycles in an eco-friendly and energy-efficient manner. It provides several benefits like less reaction time, high reaction yield, homogeneous heat distribution leading to lower side reaction, and better control of reaction temperature. Recently there has been significant progress in microwave use for heterocycle synthesis. This article discusses the applications of microwave irradiation in the synthesis of oxygen- and nitrogen-containing fluorinated heterocycles.