Current Issues in Molecular Biology最新文献_第2页

French Maritime Pine Bark Extract Alleviates Lung Injury by Regulating Inflammatory-Oxidative-Apoptotic Pathway and P2X7 Receptor Expression in LPS-Induced Sepsis. 法国海松皮提取物通过调节lps诱导脓毒症的炎症-氧化-凋亡通路和P2X7受体表达减轻肺损伤。

IF 3 3区生物学

Current Issues in Molecular Biology Pub Date : 2025-09-18 DOI: 10.3390/cimb47090770

Nergis Ulas, Seckin Ozkanlar, Serkan Yildirim, Omer Aydin, Yunusemre Ozkanlar

{"title":"French Maritime Pine Bark Extract Alleviates Lung Injury by Regulating Inflammatory-Oxidative-Apoptotic Pathway and P2X7 Receptor Expression in LPS-Induced Sepsis.","authors":"Nergis Ulas, Seckin Ozkanlar, Serkan Yildirim, Omer Aydin, Yunusemre Ozkanlar","doi":"10.3390/cimb47090770","DOIUrl":"10.3390/cimb47090770","url":null,"abstract":"Introduction: Sepsis is a dysregulated systemic immune response to infection which may result in mortality. It may also lead to organ injury, including injury to the lung. French maritime pine bark extract (MPBE) has been proposed to prevent/treat various inflammatory diseases due to its strong anti-inflammatory and antioxidant effects. This study evaluates the protective and therapeutic effects of MPBE on lung injury induced by intraperitoneal E. coli lipopolysaccharide (LPS) in rats.Materials and methods: The study design was as follows: Control, MPBE20, MPBE50, LPS, LPS+MPBE20 and LPS+MPBE50. Blood and lung tissue samples were collected 6 h after the LPS induction following a 10-day administration of MPBE.Results: LPS-induced sepsis was confirmed by the overproduction of IL-1β and TNF-α in bloodstream compared to the Control (p < 0.001). Lung injury was determined by severe histopathological changes and neutrophil infiltration in the lung tissue following intraperitoneal LPS injection. In lung tissue, MPBE improved the levels of P2X7R, TLR4, NLRP3, IL-1β, TNF-α, JNK, H2AX, 8-OHdG, MDA, GSH, Caspase-1 and Caspase-3, and pathological changes in MPBE+LPS groups compared to the LPS group.Conclusions: MPBE appears to regulate P2X7R signaling and the inflammatory-apoptotic pathway by protecting the lung from oxidative cell damage in LPS-induced sepsis in vivo.","PeriodicalId":10839,"journal":{"name":"Current Issues in Molecular Biology","volume":"47 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effect of Hepcidin on Sepsis-Associated Acute Kidney Injury via Activating the Nrf2/GPX4 Signaling Pathway. Hepcidin通过激活Nrf2/GPX4信号通路对脓毒症相关急性肾损伤的保护作用

IF 3 3区生物学

Current Issues in Molecular Biology Pub Date : 2025-09-18 DOI: 10.3390/cimb47090772

Liang-Bo Guo, Shao-Sheng Wu, Feng Xu, Xin-Xing Chen, Heng Fan

{"title":"Protective Effect of Hepcidin on Sepsis-Associated Acute Kidney Injury via Activating the Nrf2/GPX4 Signaling Pathway.","authors":"Liang-Bo Guo, Shao-Sheng Wu, Feng Xu, Xin-Xing Chen, Heng Fan","doi":"10.3390/cimb47090772","DOIUrl":"10.3390/cimb47090772","url":null,"abstract":"Background: Hepcidin not only sustains systemic iron homeostasis but also functions as an antimicrobial peptide. During this study, we sought to analyze the ability of hepcidin to protect against sepsis-associated acute kidney injury (SAKI) and elucidated its underlying mechanisms in mediating ferroptotic pathways.Methods: A SAKI mouse model was created via cecal ligation and puncture (CLP), along with an LPS-induced Human Kidney-2 (HK-2) cell model, to study the protective mechanism of hepcidin against SAKI. Through the analysis of renal injury biomarkers and ferroptosis-related molecules, combined with quantitative detection of nuclear factor-erythroid 2-related factor-2 (Nrf2) nuclear translocation and glutathione peroxidase 4 (GPX4), a regulatory protein of ferroptosis, we uncovered the hepcidin-mediated mechanisms underlying ferroptosis in SAKI.Results: Hepcidin significantly attenuated renal function impairment in mice with SAKI and reduced the sepsis-driven increase in inflammatory mediators. As sepsis was associated with enhanced renal ferroptosis, hepcidin exerted a therapeutic effect by mitigating ferroptosis to a degree comparable with that of the ferroptosis inhibitor Ferrostatin-1 (Fer-1). Furthermore, hepcidin conferred renoprotective effects in SAKI by promoting the nuclear translocation of Nrf2, which in turn mediated the upregulation of the downstream anti-ferroptotic protein GPX4. Importantly, the Nrf2 inhibitor ML385 abrogated both the hepcidin-induced nuclear translocation of Nrf2 and the subsequent increase in GPX4 expression.Conclusions: Protective effects of hepcidin against SAKI are mediated by the Nrf2/GPX4 ferroptosis pathway, underscoring its therapeutic potential for SAKI.","PeriodicalId":10839,"journal":{"name":"Current Issues in Molecular Biology","volume":"47 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential. 胰岛素样生长因子1 （IGF-1）在头发再生中的作用：机制途径和治疗潜力。

IF 3 3区生物学

Current Issues in Molecular Biology Pub Date : 2025-09-18 DOI: 10.3390/cimb47090773

Wang-Ju Hsieh, Wei-Yin Qiu, Ivona Percec, Tsong-Min Chang

{"title":"Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential.","authors":"Wang-Ju Hsieh, Wei-Yin Qiu, Ivona Percec, Tsong-Min Chang","doi":"10.3390/cimb47090773","DOIUrl":"10.3390/cimb47090773","url":null,"abstract":"IGF-1 (insulin-like growth factor 1) is a growth factor primarily secreted by dermal papilla cells on hair-bearing skin that stimulates hair follicle proliferation and vascularization, and promotes the transition to the anagen growth phase of the hair follicle by activating key pathways such as PI3K/Akt and MAPK/ERK. IGF-1 also inhibits apoptosis, prolongs the follicular growth phase, and boosts VEGF expression, which supports microcirculation and nutrient delivery to hair follicles. The combined effects of IGF-1 and other growth factors, including VEGF, KGF (FGF-7), and PDGF, further amplify its effects on follicular cell proliferation and tissue repair. IGF-1's ability to regulate the hair growth cycle and its interactions with other signaling pathways make it a compelling therapeutic target for hair loss disorders. Both preclinical models and clinical evidence highlight IGF-1 as a promising therapeutic option for conditions like androgenetic alopecia (AGA), where IGF-1 levels are typically diminished. While topical IGF-1 treatments have shown efficacy and safety with minimal systemic absorption, additional research is needed to improve delivery methods, such as liposomal gels and exosome-based carriers, and to evaluate long-term effects.","PeriodicalId":10839,"journal":{"name":"Current Issues in Molecular Biology","volume":"47 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Analysis of Solanum lycopersicum Sap Dark Proteome Reveals Ordered and Disordered Protein Abundance. 茄汁暗蛋白组分析揭示有序和无序蛋白丰度。

IF 3 3区生物学

Current Issues in Molecular Biology Pub Date : 2025-09-18 DOI: 10.3390/cimb47090769

Francisco Antonio Reyes-Soria, Francisco Guillén-Chable, Enrique Castaño de la Serna, Lorenzo Felipe Sánchez-Teyer, Miguel Angel Herrera-Alamillo, Alejandro Pereira-Santana, Luis Carlos Rodriguez-Zapata

{"title":"The Analysis of Solanum lycopersicum Sap Dark Proteome Reveals Ordered and Disordered Protein Abundance.","authors":"Francisco Antonio Reyes-Soria, Francisco Guillén-Chable, Enrique Castaño de la Serna, Lorenzo Felipe Sánchez-Teyer, Miguel Angel Herrera-Alamillo, Alejandro Pereira-Santana, Luis Carlos Rodriguez-Zapata","doi":"10.3390/cimb47090769","DOIUrl":"10.3390/cimb47090769","url":null,"abstract":"Protein identity and functional roles within the cell provide the landscape of proteomics and other high-throughput technologies. However, not all protein sequences are cataloged with an identity or a functional protein family. The lack of identity and functional role of a set of proteins are collectively named as the dark proteome. Key structural features are, for example, ordered sequences (with a defined structural arrangement) and disordered sequences (presenting one or more intrinsically disordered stretches). Here, we reanalyzed eight proteomic datasets and the subset of the \"unknown\" proteome of S. lycopersicum to describe if there is a relationship between disorder, length, and tissue-specific abundance of proteins with key structural features in the relation of ordered/disordered abundance in the protein sequences. Intriguingly, we unveil that from the S. lycopersicum proteome, the \"unknown\" subset represents around 10% only. We further cataloged dark proteome in terms of ordered and disordered sequences and found that proteins with disorder represent around 23% of the total \"unknown\" proteins. Also, we describe an amino acid composition and sequence length enrichment both, in the ordered and disordered fraction of the dark proteome. Finally, we describe that proteins within the dark proteome can be related to a specific location and abundance in an organ or tissue. An unknown protein sequence presenting a combination of specific length and degree of disorder can be explored with other biotechnological alternatives to improve responses or tolerate abiotic stress, also serving as sensors during development or ripening stages. These findings suggest an opportunity to study \"protein darkness\" in terms of disorder and functional associations.","PeriodicalId":10839,"journal":{"name":"Current Issues in Molecular Biology","volume":"47 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolome and Transcriptome Analyses of the Molecular Mechanism Underlying Light-Induced Anthocyanin Accumulation in Pepper (Capsicum annuum L.) Peel. 光诱导辣椒（Capsicum annuum L.）花青素积累的代谢组和转录组分析皮。

IF 3 3区生物学

Current Issues in Molecular Biology Pub Date : 2025-09-18 DOI: 10.3390/cimb47090774

Qinqin He, Liming He, Zongqin Feng, Yunyi Xiao, Qiucheng Qiu, Jiefeng Liu, Hanbing Han, Xinmin Huang

{"title":"Metabolome and Transcriptome Analyses of the Molecular Mechanism Underlying Light-Induced Anthocyanin Accumulation in Pepper (Capsicum annuum L.) Peel.","authors":"Qinqin He, Liming He, Zongqin Feng, Yunyi Xiao, Qiucheng Qiu, Jiefeng Liu, Hanbing Han, Xinmin Huang","doi":"10.3390/cimb47090774","DOIUrl":"10.3390/cimb47090774","url":null,"abstract":"Under light exposure, certain pepper cultivars synthesize large amounts of anthocyanins in their pericarps, with the illuminated areas exhibiting black coloration. However, research on light-induced anthocyanin formation in pepper fruit, particularly the related metabolites and genetic changes, remains limited. To identify the key genes involved in localized anthocyanin synthesis under light conditions, we investigated the black pericarps (light-exposed) and green pericarps of pepper variety MSCJ1 under illumination. Metabolomics analysis identified 579 metabolites in the black and green pepper pericarps, with 50 differentially accumulated metabolites. Petunidin-3-(6″-p-coumaroyl-glucoside) and delphinidin-3-p-coumaroyl-rutinoid accumulation represented the main factor underlying light-induced blackening of the pericarp. RNA-seq identified 121 differentially expressed genes that were significantly enriched in the flavonoid biosynthesis pathway. The genes for phenylalanine ammonia lyase (Capana09g002200, Capna09g002190), cinnamic acid hydroxylase (Capana06g000273), chalcone synthase (Capana05g002274), flavonoid 3-hydroxylase (Capana02g002586), flavonoid 3'-hydroxylase (MSTRG.15987), dihydroflavonol 4-reductase (Capana02g002763), anthocyanin synthase (Capana01g000365), UDP glucosyltransferase (Capana03g000135), and glutathione S-transferase (Capana02g002285) were key genes for anthocyanin synthesis and transport. Transcription factors bHLH (Capana09g001426, Capana09g001427), HSFB3 (Capana05g000086), and TCP4 (Capana07g002142) participated in the regulation of anthocyanin synthesis. These results broaden our understanding of the mechanism of light-induced anthocyanin synthesis in pepper peel.","PeriodicalId":10839,"journal":{"name":"Current Issues in Molecular Biology","volume":"47 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The First Complete Chloroplast Genome Sequence of the Cyrtomium hemionitis Fern. 第一个完整的卵细胞蕨叶绿体基因组序列。

IF 3 3区生物学

Current Issues in Molecular Biology Pub Date : 2025-09-18 DOI: 10.3390/cimb47090771

Junxi Zhao, Panpan Shi, Xiaoxuan Wang, Shuosheng Zhang, Haixian Zhan

{"title":"The First Complete Chloroplast Genome Sequence of the Cyrtomium hemionitis Fern.","authors":"Junxi Zhao, Panpan Shi, Xiaoxuan Wang, Shuosheng Zhang, Haixian Zhan","doi":"10.3390/cimb47090771","DOIUrl":"10.3390/cimb47090771","url":null,"abstract":"Cyrtomium hemionitis is a Cyrtomium fern with potential medicinal value; however, the lack of chloroplast genome data for this species limits its utilization and exploitation. In this study, the Illumina NovoSeq 6000 platform and SPAdes v3.14.1 were used to sequence and assemble the chloroplast genome of C. hemionitis. The chloroplast genome was 151,295 bp in length and exhibited a typical circular, double-stranded, quadripartite plastome architecture, with a GC content of 42.43%. Additionally, it included 30 high-frequency codons, 26 of which ended with A or U. In total, we annotated 130 coding genes, which included 88 protein-coding genes, 8 rRNA genes, and 34 tRNA genes. The IR (inverted repeat) boundaries of the genus Cyrtomium differed from those of common plants, with differences discovered in the JLB (large single-copy, inverted repeat b) and JLA (large single-copy, inverted repeat a) boundaries in this genus. Additionally, the phylogeny of this genus showed that C. hemionitis was more closely related to C. falcatum, whereas Dryopteris crassirhizoma was closely related to the genus Cyrtomium. These findings have significant implications for future research and can serve as a reference for the molecular evolution, systematic development, and utilization of C. hemionitis.","PeriodicalId":10839,"journal":{"name":"Current Issues in Molecular Biology","volume":"47 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of the First-in-Class Imipridone ONC201 and Standard Anticancer Therapies as a Rational Approach for Therapeutic Benefit. 一流的吡普利酮ONC201与标准抗癌药物联合使用作为治疗获益的合理途径

IF 3 3区生物学

Current Issues in Molecular Biology Pub Date : 2025-09-18 DOI: 10.3390/cimb47090775

Brahmi Shenoy, Miloni Mandani, Meena Chintamaneni, Sonal M Manohar

{"title":"Combination of the First-in-Class Imipridone ONC201 and Standard Anticancer Therapies as a Rational Approach for Therapeutic Benefit.","authors":"Brahmi Shenoy, Miloni Mandani, Meena Chintamaneni, Sonal M Manohar","doi":"10.3390/cimb47090775","DOIUrl":"10.3390/cimb47090775","url":null,"abstract":"The development of drugs for cancer treatment faces critical challenges due to the heterogeneity in cancers, metastatic nature of the disease, lack of efficacy, toxicity, and drug resistance. This makes it quite important to understand the complexities of cancer as well as the limitations of druggable targets. ONC201 (also known as dordaviprone/TIC10/ModeysoTM), a first-in-class member of the imipridone family, has been shown to kill cancer cells selectively. Recently, it has received FDA approval as the first and only treatment for recurrent H3K27M-mutant diffuse midline glioma. The unique pharmacophore, favorable therapeutic index, ability to induce TRAIL and the integrated stress response (ISR), activation of natural killer cells, and ability to diffuse across the blood-brain barrier are the unique characteristics of ONC201. ONC201 has shown effectiveness against various cancers, and this has been evident in many preclinical studies. ONC201 as a single agent, although useful, has some limitations, which could be addressed by using combination strategies. ONC201 has shown synergism with other drugs, leading to greater tumor cell death or reduced tumor growth. Next-generation imipridones, viz. ONC206 and ONC212, are more potent analogs of ONC201 and exhibit similar characteristics. In this review, we discuss the therapeutic potential of ONC201 and its analogs using combination strategies across different cancers.","PeriodicalId":10839,"journal":{"name":"Current Issues in Molecular Biology","volume":"47 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic Insights into the Abiotic Stress Adaptation of Salix Species: A Comprehensive Review of Physiological, Molecular, and Sex-Dimorphic Responses. 柳属植物对非生物胁迫适应的机制：生理、分子和两性二态反应的综合综述。

IF 3 3区生物学

Current Issues in Molecular Biology Pub Date : 2025-09-17 DOI: 10.3390/cimb47090767

Pengcheng Sun, Fangjing Fan, Yinggao Liu, Fuyuan Zhu

{"title":"Mechanistic Insights into the Abiotic Stress Adaptation of Salix Species: A Comprehensive Review of Physiological, Molecular, and Sex-Dimorphic Responses.","authors":"Pengcheng Sun, Fangjing Fan, Yinggao Liu, Fuyuan Zhu","doi":"10.3390/cimb47090767","DOIUrl":"10.3390/cimb47090767","url":null,"abstract":"As key species for ecological restoration, Salix spp. thrive in harsh environments, including high-altitude regions, arid zones, and saline-alkaline soils, demonstrating remarkable resilience to abiotic stressors. Recent advances in genomics, transcriptomics, and functional gene research have shed light on the mechanisms underlying Salix species' responses to drought, salinity, heavy metals, and low-temperature stresses. This review systematically synthesizes the physiological, biochemical, and molecular adaptations of Salix to abiotic stress, with a particular focus on underexplored areas such as sex-dimorphic regulation and integrated hormone-ROS signaling pathways. We emphasize the dynamic interplay between transcription factors, hormonal crosstalk, and ROS signaling that underpins the stress response, highlighting sex-specific variations that modulate adaptive capacity. Moreover, we discuss the synergistic roles of exogenous additives and rhizosphere microorganisms in enhancing stress resistance. This comprehensive analysis provides critical insights for breeding stress-resilient Salix cultivars and for future research into stress adaptation mechanisms in woody plants.","PeriodicalId":10839,"journal":{"name":"Current Issues in Molecular Biology","volume":"47 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Purification: Evolving Roles of Fusion Tags in Biotechnology. 超越纯化：融合标签在生物技术中的演变作用。

IF 3 3区生物学

Current Issues in Molecular Biology Pub Date : 2025-09-17 DOI: 10.3390/cimb47090768

Tsutomu Arakawa, Teruo Akuta

引用次数: 0

Mechanisms Linking Obesity with Non-Alcoholic Fatty Liver Disease (NAFLD) and Cardiovascular Diseases (CVDs)-The Role of Oxidative Stress. 肥胖与非酒精性脂肪性肝病（NAFLD）和心血管疾病（cvd）的联系机制——氧化应激的作用

IF 3 3区生物学

Current Issues in Molecular Biology Pub Date : 2025-09-16 DOI: 10.3390/cimb47090766

Fani-Niki Varra, Michail Varras, Viktoria-Konstantina Varra, Panagiotis Theodosis-Nobelos

{"title":"Mechanisms Linking Obesity with Non-Alcoholic Fatty Liver Disease (NAFLD) and Cardiovascular Diseases (CVDs)-The Role of Oxidative Stress.","authors":"Fani-Niki Varra, Michail Varras, Viktoria-Konstantina Varra, Panagiotis Theodosis-Nobelos","doi":"10.3390/cimb47090766","DOIUrl":"10.3390/cimb47090766","url":null,"abstract":"Obesity concerns a wide range of the population, tending to become a major factor for diseases' progression and fatality rate increases, with implications concerning the cardiovascular system's deterioration. Obesity is closely linked with metabolic derangements concerning lipid storage and circulation, and the cellular metabolism affecting most of the internal organs, especially liver and cellular function. In this current study, an analysis of the linking mechanisms between obesity, lipid deterioration, liver, and lipid tissue homeostasis will be performed, with special attention to the pathophysiological characteristics of these detrimental effects on the NAFLD (non-alcoholic fatty liver disease) and the cellular function of the endothelial blood cells, with special reference to the additional burdening of obesity on the autonomous nervous system signaling, and the resulting hypertension. Despite the very complex and pluripotent pathogenic mechanisms with which obesity is intervening in these processes, it could be safely deduced that metabolic and lipid transport manipulation could serve as a crucial factor towards the cellular and tissue function improvement, as the interlinkages in the mechanisms, although highly analyzed, have not been completely deciphered until now.","PeriodicalId":10839,"journal":{"name":"Current Issues in Molecular Biology","volume":"47 9","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12468255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0