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Synthetic approaches to enhance biological carbon capture 增强生物碳捕获的合成方法
IF 7 2区 工程技术
Current opinion in biotechnology Pub Date : 2025-10-01 Epub Date: 2025-08-28 DOI: 10.1016/j.copbio.2025.103350
Zhiyi Li , David L Lanster , Ahmed H Badran
{"title":"Synthetic approaches to enhance biological carbon capture","authors":"Zhiyi Li ,&nbsp;David L Lanster ,&nbsp;Ahmed H Badran","doi":"10.1016/j.copbio.2025.103350","DOIUrl":"10.1016/j.copbio.2025.103350","url":null,"abstract":"<div><div>Biologically driven strategies to remove carbon dioxide from the atmosphere are gaining traction as long-term means for atmospheric correction. Many ongoing research efforts focus on enhancing the Calvin<em>–</em>Benson<em>–</em>Bassham (CBB) cycle with notable focus on the rate-limiting enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), aiming to alter its catalytic efficiency, substrate specificity, or cognate regulatory pathways. Beyond these strategies, novel approaches to provide energy to the CBB cycle or synthetic pathways for <em>in vivo</em> autotrophy have opened the door to engineerable carbon-negative biosynthesis. Finally, recent complementary studies that go beyond the CBB cycle to develop entirely new carbon fixation pathways have shown promise in addressing bottlenecks in efficiency and scalability of natural systems. In this perspective, we highlight many of these recent efforts to develop synthetic biology and bioengineering frameworks aimed at improving carbon capture efficiency, biomass productivity, and sustainable energy integration in living systems.</div></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":"95 ","pages":"Article 103350"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering microbial exopolysaccharides for food applications. 食品用工程微生物胞外多糖。
IF 7 2区 工程技术
Current opinion in biotechnology Pub Date : 2025-10-01 Epub Date: 2025-08-06 DOI: 10.1016/j.copbio.2025.103339
Jannis Broeker, Jochen Schmid
{"title":"Engineering microbial exopolysaccharides for food applications.","authors":"Jannis Broeker, Jochen Schmid","doi":"10.1016/j.copbio.2025.103339","DOIUrl":"10.1016/j.copbio.2025.103339","url":null,"abstract":"<p><p>Microbial exopolysaccharides for direct food applications remain rare due to significant financial and regulatory hurdles. However, exopolysaccharides without direct food approval have recently been employed in various indirect food-related uses. This review highlights microbial exopolysaccharides with strong potential for both direct and indirect food applications and outlines engineering strategies to optimize their biotechnological production. For sucrase-based polysaccharides, enzyme engineering aimed at controlling molecular weight has shown strong potential for generating novel functional properties. In the case of synthase-based polysaccharides, leveraging epimerases or exploiting the natural promiscuity of the synthase enzyme emerges as a particularly promising approach. For heteropolysaccharides, this review presents some rare examples of successful engineering and heterologous expression in chassis organisms, while also identifying key challenges that still limit efficient optimization.</p>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":"95 ","pages":"103339"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the prebiotic potential of polyphenols in gut health and metabolism. 揭示多酚在肠道健康和代谢中的益生元潜力。
IF 7 2区 工程技术
Current opinion in biotechnology Pub Date : 2025-10-01 Epub Date: 2025-08-07 DOI: 10.1016/j.copbio.2025.103338
Katherine Petersen, Thomas J Mansell
{"title":"Unveiling the prebiotic potential of polyphenols in gut health and metabolism.","authors":"Katherine Petersen, Thomas J Mansell","doi":"10.1016/j.copbio.2025.103338","DOIUrl":"10.1016/j.copbio.2025.103338","url":null,"abstract":"<p><p>Polyphenols are a diverse class of plant metabolites with noted health benefits, such as antioxidant, anticancer, and antidiabetic effects. Recently, these compounds have gained interest for their ability to manipulate the composition of the human gut microbiome through distinct mechanisms, including microbial metabolism, enzymatic biotransformation, and antimicrobial effects. For example, many gut microbes express β-glucosidases or polyphenol catabolizing enzymes (PAZymes), which could enable the use of these compounds in competitive niches. This review explores recent research on the enzymes that interact with these substrates, the mechanisms by which polyphenols modulate the gut microbiome, and the use of polyphenolic compounds as next-generation prebiotics for the benefit of the human host.</p>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":"95 ","pages":"103338"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upstream considerations for gas fermentation processes 气体发酵过程的上游考虑
IF 7 2区 工程技术
Current opinion in biotechnology Pub Date : 2025-10-01 Epub Date: 2025-07-29 DOI: 10.1016/j.copbio.2025.103337
Michael G Resch , Alex Badgett , Jens O Krömer , Esteban Marcellin
{"title":"Upstream considerations for gas fermentation processes","authors":"Michael G Resch ,&nbsp;Alex Badgett ,&nbsp;Jens O Krömer ,&nbsp;Esteban Marcellin","doi":"10.1016/j.copbio.2025.103337","DOIUrl":"10.1016/j.copbio.2025.103337","url":null,"abstract":"<div><div>Gas fermentation enables the production of fuels, chemicals, and foods from gaseous carbon sources and could serve as a technology for valorizing carbon that may otherwise be emitted to the atmosphere. In this review, we focus on upstream feedstock considerations: the supply of carbon and the supply of electrical power. Electrical power serves a dual role, providing both process energy and biochemical redox potential (via hydrogen or reduced intermediates). We define gas fermentation as bioprocesses involving gaseous feedstocks metabolized by microbes, distinct from microbial electrosynthesis. Trends in CO<sub>2</sub> point sources and low-carbon electricity systems are analyzed, highlighting opportunities and challenges for future deployment. This review synthesizes current knowledge and identifies key R&amp;D priorities for process integration at industrial scale.</div></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":"95 ","pages":"Article 103337"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From animal tissue to engineered cells: biotechnological advances in sulfated glycosaminoglycan production 从动物组织到工程细胞：硫代糖胺聚糖生产的生物技术进展
IF 7 2区 工程技术
Current opinion in biotechnology Pub Date : 2025-10-01 Epub Date: 2025-08-14 DOI: 10.1016/j.copbio.2025.103340
Aditi Dey Tithi , Yuefan Song , Hana Zeghal , Mattheos Koffas
{"title":"From animal tissue to engineered cells: biotechnological advances in sulfated glycosaminoglycan production","authors":"Aditi Dey Tithi ,&nbsp;Yuefan Song ,&nbsp;Hana Zeghal ,&nbsp;Mattheos Koffas","doi":"10.1016/j.copbio.2025.103340","DOIUrl":"10.1016/j.copbio.2025.103340","url":null,"abstract":"<div><div>Biotechnological strategies are rapidly advancing the production of sulfated glycosaminoglycans (GAGs), such as chondroitin sulfate and heparin, offering animal-free alternatives with greater safety and structural control. This article examines key developments across microbial, enzymatic, and synthetic platforms, highlighting innovations in metabolic engineering, sulfotransferase optimization, and cofactor regeneration. Case studies in both chondroitin and heparin biosynthesis illustrate how systems biology and protein design are addressing long-standing bottlenecks. We also discuss current limitations and future directions needed to realize scalable, clinically relevant GAG bioproduction.</div></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":"95 ","pages":"Article 103340"},"PeriodicalIF":7.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biotechnological solutions for critical mineral recovery from unconventional feedstocks 从非常规原料中回收关键矿物的生物技术解决方案
IF 7.1 2区 工程技术
Current opinion in biotechnology Pub Date : 2025-10-01 Epub Date: 2025-07-25 DOI: 10.1016/j.copbio.2025.103336
Hannah S Zurier , Scott Banta , Dan M Park , David W Reed , Allison Z Werner
{"title":"Biotechnological solutions for critical mineral recovery from unconventional feedstocks","authors":"Hannah S Zurier ,&nbsp;Scott Banta ,&nbsp;Dan M Park ,&nbsp;David W Reed ,&nbsp;Allison Z Werner","doi":"10.1016/j.copbio.2025.103336","DOIUrl":"10.1016/j.copbio.2025.103336","url":null,"abstract":"<div><div>Secure and sustainable metal recovery from unconventional feedstocks is needed to meet the mineral demands of energy, defense, and electronic technologies. Here, we highlight the potential to leverage nature’s ability to extract and differentiate metal ions in biotechnologies that could become the next generation of mining and refining. We describe bulk and trace processes and then discuss the advances and opportunities of two key bioprocesses: microbially mediated solubilization of metal ions from solid matrices (termed ‘bioleaching’) and bio-based separation of solubilized ions via selective adsorption to proteins. Both biotechnologies have advantages such as reduced energy input for leaching low-grade feedstocks and reduced organic solvent demand for separating ions with similar physiochemical properties but require more development for industrial scale recovery from unconventional feedstocks. Innovation in biological science and engineering may bring timely solutions to key challenges toward recovering critical minerals from unconventional feedstocks.</div></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":"95 ","pages":"Article 103336"},"PeriodicalIF":7.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergizing gene editing and cellular agriculture for a sustainable and healthy food future 协同基因编辑和细胞农业，创造可持续和健康的食品未来
IF 7.1 2区 工程技术
Current opinion in biotechnology Pub Date : 2025-08-01 Epub Date: 2025-07-08 DOI: 10.1016/j.copbio.2025.103334
Jacob T Liberty , Haijiao Lin , Yona Sipos , Olivia C Ihedioha , Magdaline J Kwaji
{"title":"Synergizing gene editing and cellular agriculture for a sustainable and healthy food future","authors":"Jacob T Liberty ,&nbsp;Haijiao Lin ,&nbsp;Yona Sipos ,&nbsp;Olivia C Ihedioha ,&nbsp;Magdaline J Kwaji","doi":"10.1016/j.copbio.2025.103334","DOIUrl":"10.1016/j.copbio.2025.103334","url":null,"abstract":"<div><div>The intersection of gene editing and cellular agriculture is transforming food production by offering sustainable, ethical alternatives to conventional agriculture. Cellular agriculture uses tissue engineering and fermentation technologies to produce animal-free food, whereas gene editing tools like CRISPR-Cas9 optimize cellular efficiency, nutritional value, and sustainability. While some researchers emphasize the environmental and food security benefits, others raise concerns about high costs, regulatory challenges, and consumer acceptance. This paper critically examines existing literature, compares breakthroughs and controversies, and provides an expert perspective on the challenges and opportunities in gene-edited cellular agriculture. By tackling key scientific, economic, regulatory, and ethical issues, this article presents a roadmap for responsibly advancing these technologies and integrating them into global food systems. To our knowledge, this is the first work to explore how gene editing and cellular agriculture can be synergized to advance sustainability, food security, and global health.</div></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":"94 ","pages":"Article 103334"},"PeriodicalIF":7.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biotechnological advances in algae-based foods: applications in nutrition and microbiome health 藻类食品的生物技术进展：在营养和微生物群健康方面的应用
IF 7.1 2区 工程技术
Current opinion in biotechnology Pub Date : 2025-08-01 Epub Date: 2025-07-07 DOI: 10.1016/j.copbio.2025.103335
Sora Yu , Yasuo Yoshikuni
{"title":"Biotechnological advances in algae-based foods: applications in nutrition and microbiome health","authors":"Sora Yu ,&nbsp;Yasuo Yoshikuni","doi":"10.1016/j.copbio.2025.103335","DOIUrl":"10.1016/j.copbio.2025.103335","url":null,"abstract":"<div><div>Algae are a sustainable, nutrient-rich resource with growing potential in food biotechnology. Their ability to thrive in diverse environments makes them a promising alternative to conventional crops. Rich in proteins, essential fatty acids, and bioactive compounds, algae support the development of functional foods, including plant-based meat and seafood alternatives. Advances in synthetic biology and fermentation have enhanced algal nutrient profiles and enabled novel applications. Algae-derived polysaccharides, such as alginate, fucoidan, laminarin, and porphyran, exhibit prebiotic effects by modulating the gut microbiota and promoting SCFA production. Enzymatic hydrolysis efficiently produces bioactive oligosaccharides, while engineered microbial systems support scalable production. Algae also enable synbiotic food development by serving as both prebiotic substrates and probiotic carriers.</div></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":"94 ","pages":"Article 103335"},"PeriodicalIF":7.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing the potential of microbial methane utilization for chasing sustainability 利用微生物利用甲烷的潜力来追求可持续性
IF 7.1 2区 工程技术
Current opinion in biotechnology Pub Date : 2025-08-01 Epub Date: 2025-07-04 DOI: 10.1016/j.copbio.2025.103332
Marina G Kalyuzhnaya , Jin Wang , Amy C Rosenzweig
{"title":"Harnessing the potential of microbial methane utilization for chasing sustainability","authors":"Marina G Kalyuzhnaya ,&nbsp;Jin Wang ,&nbsp;Amy C Rosenzweig","doi":"10.1016/j.copbio.2025.103332","DOIUrl":"10.1016/j.copbio.2025.103332","url":null,"abstract":"<div><div>Microbial methane utilization (known as methanotrophy) serves as a gatekeeper of methane emissions in numerous ecosystems. Methanotrophy became a platform for the production of biofuels, value-added chemicals, and novel molecules from natural or renewable gas. Methanotroph- driven Methanotroph-driven processes enable novel solutions for bioremediation, biomining of minerals, methane mitigation, and agriculture. All applications rely on in-depth understanding of methanotroph biochemistry, genetics, physiology, and ecological fitness.</div><div>Here, we review recent advances in the enzymology of methane utilization and methanotroph carbon assimilation pathways as well as progress toward engineering both native and synthetic methanotrophs. New bioreactor approaches to overcoming methane and oxygen mass transfer limitations are also described. Continued research in these areas is critical to future success in methanotroph optimization for industrial processes.</div></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":"94 ","pages":"Article 103332"},"PeriodicalIF":7.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From bench to biofactory: high-throughput technologies and automated workflows to accelerate biomanufacturing 从实验室到生物工厂：高通量技术和自动化工作流程加速生物制造
IF 7.1 2区 工程技术
Current opinion in biotechnology Pub Date : 2025-08-01 Epub Date: 2025-06-11 DOI: 10.1016/j.copbio.2025.103320
Christopher J Petzold , Aindrila Mukhopadhyay
{"title":"From bench to biofactory: high-throughput technologies and automated workflows to accelerate biomanufacturing","authors":"Christopher J Petzold ,&nbsp;Aindrila Mukhopadhyay","doi":"10.1016/j.copbio.2025.103320","DOIUrl":"10.1016/j.copbio.2025.103320","url":null,"abstract":"<div><div>Microbial production of target molecules has advanced significantly in recent years driven by innovations in enzyme engineering, DNA synthesis, and genomic editing. However, to access the massive potential of microbial production, a vast parametric space remains to be investigated to optimize these biobased processes for a robust bioeconomy. Here, we review the current state of the art, some key challenges and possible solutions. We see a critical role of automation, high-throughput technologies, self-driving and cloud labs, and data management to enable Artificial Intelligence/Machine Learning and mechanistic models to overcome the design space challenges and accelerate the development of novel bio-based solutions. Accurate models will expedite the development and scale-up of engineered microbes for a range of final products from many starting materials.</div></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":"94 ","pages":"Article 103320"},"PeriodicalIF":7.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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