Current Heart Failure Reports最新文献_第5页

Impact of Sex and Diabetes in Patients with Heart Failure. 性别和糖尿病对心力衰竭患者的影响

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-05-03 DOI: 10.1007/s11897-024-00666-w

Sara Álvarez-Zaballos, Manuel Martínez-Sellés

{"title":"Impact of Sex and Diabetes in Patients with Heart Failure.","authors":"Sara Álvarez-Zaballos, Manuel Martínez-Sellés","doi":"10.1007/s11897-024-00666-w","DOIUrl":"10.1007/s11897-024-00666-w","url":null,"abstract":"Purpose of review: Heart failure (HF) is a complex clinical syndrome with a growing global health burden. This review explores the intersection of HF, diabetes mellitus, and sex, highlighting epidemiological patterns, pathophysiological mechanisms, and treatment implications.Recent findings: Despite similar HF prevalence in men and women, diabetes mellitus (DM) appears to exert a more pronounced impact on HF outcomes in women. Pathophysiological differences involve cardiovascular risk factors, severe left ventricular dysfunction, and coronary artery disease, as well as hormonal influences and inflammatory markers. Diabetic cardiomyopathy introduces a sex-specific challenge, with women experiencing common adverse outcomes related to increased fibrosis and myocardial remodeling. Treatment strategies, particularly sodium-glucose cotransporter 2 inhibitors, exhibit cardiovascular benefits, but their response may differ in women. The link between HF and DM is bidirectional, with diabetes significantly increasing the risk of HF, and vice versa. Additionally, the impact of diabetes on mortality appears more pronounced in women than in men, leading to a modification of the traditional gender gap observed in HF outcomes. A personalized approach is crucial, and further research to improve outcomes in the complex interplay of HF, diabetes, and sex is needed.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"389-395"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profile and Prognostic Impact of Multimorbidity in Elderly Patients with Heart Failure: Are there Differences between Men and Women? 老年心力衰竭患者的多病特征和预后影响：男女之间是否存在差异？

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-07-03 DOI: 10.1007/s11897-024-00673-x

Rocío Del Pilar Falcón Fleytas, Osmar Antonio Centurión, Javier Galeano Figueredo, Hugo González Saldivar, Jorge E Martínez

{"title":"Profile and Prognostic Impact of Multimorbidity in Elderly Patients with Heart Failure: Are there Differences between Men and Women?","authors":"Rocío Del Pilar Falcón Fleytas, Osmar Antonio Centurión, Javier Galeano Figueredo, Hugo González Saldivar, Jorge E Martínez","doi":"10.1007/s11897-024-00673-x","DOIUrl":"10.1007/s11897-024-00673-x","url":null,"abstract":"Purpose of review: Heart failure (HF) represents a pathology in constant growth, but, despite the fact that a significant proportion of its population is comprised of elderly patients, they are not adequately represented in clinical trials or registries. They constitute a heterogeneous population with their particularities and interaction of the multiple comorbidities that characterize this age group, which makes the clinical course, prognosis and outcomes of the disease different.Recent findings: Compared to men, women with HF tend to be older, with a greater burden of non-cardiovascular comorbidities, less ischemic heart disease and preserved ventricular function in most cases. This fact translates into worse self-perceived quality of life, with lower hospitalization and mortality rates. Moreover, paradoxically, women are less likely to receive treatment recommended by clinical practice guidelines, including revascularization and device placement. As there are not enough representative studies of this population, the reasons for these results with better prognosis and relatively benign impact in the elderly female population are unknown, which is why it is necessary to continue with research in order to obtain greater evidence of the exposed gaps.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"337-343"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in Transthyretin Cardiac Amyloidosis: Unraveling the Complexities in Epidemiology, Pathophysiology, Diagnosis, and Treatment. 转甲状腺素心脏淀粉样变性的性别差异：揭开流行病学、病理生理学、诊断和治疗的复杂面纱》。

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-05-22 DOI: 10.1007/s11897-024-00667-9

Silvia Vilches, María Martínez-Avial, Irene Méndez, Cristina Gómez González, María Ángeles Espinosa

{"title":"Sex Differences in Transthyretin Cardiac Amyloidosis: Unraveling the Complexities in Epidemiology, Pathophysiology, Diagnosis, and Treatment.","authors":"Silvia Vilches, María Martínez-Avial, Irene Méndez, Cristina Gómez González, María Ángeles Espinosa","doi":"10.1007/s11897-024-00667-9","DOIUrl":"10.1007/s11897-024-00667-9","url":null,"abstract":"Transthyretin cardiac amyloidosis (ATTR-CA) is characterised by the deposition of transthyretin amyloid fibrils in the heart. ATTR-CA affects both men and women although there is evidence of sex differences in prevalence and clinical presentation. PURPOSE OF REVIEW: This review paper aims to comprehensively examine and synthesise the existing literature on sex differences in ATTR-CA. RECENT FINDINGS: The prevalence of ATTR-CA is higher in males although the male predominance is more apparent in older patients in the wild type form and in TTR genetic variants that predominantly result in a cardiac phenotype in the hereditary variant. Women tend to have less left ventricular hypertrophy (LVH) and a higher ejection fraction at clinical presentation which may contribute to a later diagnosis although the prognosis appears to be similar in both sexes. Female sex is a predictor of a good response to tafamidis 20 mg in TTR polyneuropathy but otherwise there are no data on sex differences in the efficacy of other treatments for ATTR-CA. It is crucial to define specific sex differences in ATTR-CA. A lower cut-off value for LVH in women may be needed to improve diagnosis. It is necessary to increase female representation in clinical trials to better understand possible sex differences in therapeutic management.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"344-353"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Pathophysiology, Prognosis and Treatment of Hypertension in Females from Pregnancy to Post-menopause: A Review. 从妊娠到绝经后女性高血压的病理生理学、预后和治疗：综述。

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI: 10.1007/s11897-024-00672-y

Simeng Li, Isabella Tan, Emily Atkins, Aletta E Schutte, Sonali R Gnanenthiran

{"title":"The Pathophysiology, Prognosis and Treatment of Hypertension in Females from Pregnancy to Post-menopause: A Review.","authors":"Simeng Li, Isabella Tan, Emily Atkins, Aletta E Schutte, Sonali R Gnanenthiran","doi":"10.1007/s11897-024-00672-y","DOIUrl":"10.1007/s11897-024-00672-y","url":null,"abstract":"Purpose of review: We summarise the physiological changes and risk factors for hypertension in females, potential sex-specific management approaches, and long-term prognosis.Key findings: Pregnancy and menopause are two key phases of the life cycle where females undergo significant biological and physical changes, making them more prone to developing hypertension. Gestational hypertension occurs from changes in maternal cardiac output, kidney function, metabolism, or placental vasculature, with one in ten experiencing pregnancy complications such as intrauterine growth restriction and delivery complications such as premature birth. Post-menopausal hypertension occurs as the protective effects of oestrogen are reduced and the sympathetic nervous system becomes over-activated with ageing. Increasing evidence suggests that post-menopausal females with high blood pressure (BP) experience greater risk of cardiovascular events at lower BP thresholds, and greater vulnerability to treatment-related adverse effects. Hypertension is a key risk factor for cardiovascular disease in females. Current BP treatment guidelines and recommendations are similar for both sexes, without addressing sex-specific factors. Future investigations into ideal diagnostic thresholds, BP control targets and treatment regimens in females are needed.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"322-336"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11333539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision Phenotyping of Heart Failure in People with HIV: Early Insights and Challenges. 艾滋病病毒感染者心力衰竭的精准表型分析：早期见解与挑战

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-06-28 DOI: 10.1007/s11897-024-00674-w

Eli Grunblatt, Matthew J Feinstein

{"title":"Precision Phenotyping of Heart Failure in People with HIV: Early Insights and Challenges.","authors":"Eli Grunblatt, Matthew J Feinstein","doi":"10.1007/s11897-024-00674-w","DOIUrl":"10.1007/s11897-024-00674-w","url":null,"abstract":"Purpose of review: People with HIV have an elevated risk of developing heart failure even with optimally controlled disease. In this review, we outline the various mechanisms through which HIV infection may directly and indirectly contribute to heart failure pathology and highlight the emerging relationship between HIV, chronic inflammation, and cardiometabolic disease.Recent findings: HIV infection leads to chronic inflammation, immune dysregulation, and metabolic imbalances even in those with well controlled disease. These dysregulations occur through several diverse mechanisms which may lead to manifestations of different phenotypes of heart failure in people with HIV. While it has long been known that people with HIV are at risk of developing heart failure, recent studies have suggested numerous complex mechanisms involving chronic inflammation, immune dysregulation, and metabolic derangement through which this may be mediated. Further comprehensive studies are needed to elucidate the precise relationship between these mechanisms and the development of different subtypes of heart failure in people with HIV.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"417-427"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertrophic Cardiomyopathy. 肥厚型心肌病。

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-03-15 DOI: 10.1007/s11897-024-00654-0

Jason N Dungu, Amy Hardy-Wallace, Anthony D Dimarco, Henry O Savage

{"title":"Hypertrophic Cardiomyopathy.","authors":"Jason N Dungu, Amy Hardy-Wallace, Anthony D Dimarco, Henry O Savage","doi":"10.1007/s11897-024-00654-0","DOIUrl":"10.1007/s11897-024-00654-0","url":null,"abstract":"Purpose of review: Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac condition with potential for severe complications including sudden cardiac death. Early diagnosis allows appropriate risk stratification and prompt intervention to minimise the potential for adverse outcomes. The implications of poorly coordinated screening are significant, either missing relatives at high-risk or burdening low-risk individuals with a diagnosis associated with reduced life expectancy. We aim to guide clinicians through the diagnostic pathway through to novel treatment options. Several conditions mimic the condition, and we discuss the phenocopies and how to differentiate from HCM.Recent findings: We summarise the latest developments informing clinical decision making in the modern era of myosin inhibitors and future gene editing therapies. Early identification will enable prompt referral to specialist centres. A diagnostic flowchart is included, to guide the general cardiology and heart failure clinician in important decision making regarding the care of the HCM patient and importantly their relatives at risk. We have highlighted the importance of screening because genotype-positive/phenotype-negative patients are likely to have the most to gain from novel therapies.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"428-438"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140136597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex and Gender-related Disparities in Clinical Characteristics and Outcomes in Heart Transplantation. 心脏移植临床特征和结果中与性别相关的差异。

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI: 10.1007/s11897-024-00670-0

Andrea Severo Sánchez, Javier González Martín, Javier de Juan Bagudá, Laura Morán Fernández, Christian Muñoz Guijosa, Fernando Arribas Ynsaurriaga, Juan Francisco Delgado, María Dolores García-Cosío Carmena

{"title":"Sex and Gender-related Disparities in Clinical Characteristics and Outcomes in Heart Transplantation.","authors":"Andrea Severo Sánchez, Javier González Martín, Javier de Juan Bagudá, Laura Morán Fernández, Christian Muñoz Guijosa, Fernando Arribas Ynsaurriaga, Juan Francisco Delgado, María Dolores García-Cosío Carmena","doi":"10.1007/s11897-024-00670-0","DOIUrl":"10.1007/s11897-024-00670-0","url":null,"abstract":"Purpose of review: Limited research has been conducted on sex disparities in heart transplant (HT). The aim of this review is to analyse the available evidence on the influence of sex and gender-related determinants in the entire HT process, as well as to identify areas for further investigation.Recent findings: Although women make up half of the population affected by heart failure and related mortality, they account for less than a third of HT recipients. Reasons for this inequality include differences in disease course, psychosocial factors, concerns about allosensitisation, and selection or referral bias in female patients. Women are more often listed for HT due to non-ischaemic cardiomyopathy and have a lower burden of cardiovascular risk factors. Although long-term prognosis appears to be similar for both sexes, there are significant disparities in post-HT morbidity and causes of mortality (noting a higher incidence of rejection in women and of malignancy and cardiac allograft vasculopathy in men). Additional research is required to gain a better understanding of the reasons behind gender disparities in eligibility and outcomes following HT. This would enable the fair allocation of resources and enhance patient care.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"367-378"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Coagulation in Heart Failure: A Literature Review. 凝血在心力衰竭中的作用：文献综述。

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-06-13 DOI: 10.1007/s11897-024-00671-z

Farhan Anjum, Mahrukh Gilani, Maryam Latif, Aqsa Sattar, Habiba Ashraf, Saira Rafaqat

{"title":"The Role of Coagulation in Heart Failure: A Literature Review.","authors":"Farhan Anjum, Mahrukh Gilani, Maryam Latif, Aqsa Sattar, Habiba Ashraf, Saira Rafaqat","doi":"10.1007/s11897-024-00671-z","DOIUrl":"10.1007/s11897-024-00671-z","url":null,"abstract":"Purpose of review: This article summarizes the role of coagulation factors in the pathophysiology of heart failure including D-dimer, fibrinogen and fibrin, prothrombin, p-selectin, tissue factor, tissue plasminogen activator, von Willebrand factor, β-thromboglobulin, Factor XI, tissue thromboplastin, plasminogen activator inhibitor-1 (PAI-1), thrombomodulin, soluble urokinase-type plasminogen activator receptor (suPAR) and stuart-prower factor.Recent findings: The D-dimer, P-selectin, prothrombin, von Willebrand factor, tissue plasminogen activator, fibrinogen, suPAR, tissue factor, thrombomodulin and Factor XI play significant roles the pathophysiology of heart failure. However, no associations were found between β-thromboglobulin, tissue thromboplastin, PAI-1 and stuart-prower factor in the context of heart failure. Coagulation factors play significant role in the pathophysiology of heart failure. Consequently, the underlying pathophysiological mechanisms that explain changes in the cascade are closely related to the diagnostic, prognostic and therapeutic roles of coagulation cascade factors, which help physicians identify and treat heart failure.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"277-291"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Sex in the Incidence of Heart Failure in Patients with Chronic Coronary Syndrome. 性别对慢性冠状动脉综合征患者心衰发生率的影响

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-05-04 DOI: 10.1007/s11897-024-00663-z

Ramón López-Palop, Pilar Carrillo, Íñigo Lozano

{"title":"Impact of Sex in the Incidence of Heart Failure in Patients with Chronic Coronary Syndrome.","authors":"Ramón López-Palop, Pilar Carrillo, Íñigo Lozano","doi":"10.1007/s11897-024-00663-z","DOIUrl":"10.1007/s11897-024-00663-z","url":null,"abstract":"Purpose of review: This review examines the available evidence concerning the incidence of heart failure in patients with chronic coronary syndrome, with a focus on gender differences.Recent findings: The incidence of heart failure in the context of chronic coronary syndrome presents conflicting data. Most of the available information stems from studies involving stable patients' post-acute coronary syndrome, revealing a wide range of incidence rates, from less than 3% to over 20%, observed over 5 years of follow-up. Regarding the gender differences in heart failure incidence, there is no consensus about whether women exhibit a higher incidence, particularly in the presence of evidence of obstructive coronary artery disease. However, in cases where obstructive coronary artery disease is absent, women may face a more unfavourable prognosis due to a higher prevalence of microvascular disease and heart failure with preserved ventricular function. The different profile of ischaemic heart disease in women difficult to establish differences in prognosis independently associated with female sex. Targeted investigations are essential to discern the incidence of heart failure in chronic coronary syndrome and explore potential gender-specific associations.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"354-366"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is There a Mitochondrial Protection via Remote Ischemic Conditioning in Settings of Anticancer Therapy Cardiotoxicity? 在抗癌治疗心脏毒性的情况下，远程缺血调节对线粒体有保护作用吗？

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-03-21 DOI: 10.1007/s11897-024-00658-w

Petra Kleinbongard, Ioanna Andreadou

引用次数: 0