Current Heart Failure Reports最新文献

{"title":"Correction to: Cardiogenic Shock and Equity: Uncovering Mechanisms, Addressing Disparities, and Advancing Care.","authors":"Lourdes Vicent, Rafael Salguero-Bodes, Fernando Arribas Ynsaurriaga, Carlos Diaz-Arocutipa, Roberto Martín-Asenjo","doi":"10.1007/s11897-025-00736-7","DOIUrl":"10.1007/s11897-025-00736-7","url":null,"abstract":"","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":"22 1","pages":"45"},"PeriodicalIF":3.4,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Invasive Remote Monitoring in Heart Failure: Towards Wearable Devices and Artificial Intelligence Solutions : Short Title: Remote Monitoring and Wearable Devices in Heart Failure.","authors":"Camila S Pizarro, Bas B S Schots, Mark J Schuuring, Pim van der Harst, René van Es, Marish I F J Oerlemans","doi":"10.1007/s11897-025-00725-w","DOIUrl":"10.1007/s11897-025-00725-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review examines the potential benefits of non-invasive remote monitoring in patients with heart failure (HF), focusing on early detection of clinical deterioration and reducing hospitalizations. Key questions addressed include: Can remote monitoring prevent hospitalisations in patients with HF? Does it improve quality of life and promote self-care? Is it cost-effective? Can artificial intelligence (AI) facilitate its implementation?</p><p><strong>Recent findings: </strong>Monitoring with non-wearable and wearable devices reduces hospitalizations by detecting early signs of deterioration and enhancing self-care behaviour. While the initial investment can be high, the long-term cost-effectiveness is supported by reduced hospitalisations. AI is increasingly integrated into monitoring systems, enhancing predictive accuracy and personalized care. Remote monitoring reduces mortality and hospitalisations in patients with HF, with benefits in cost-effectiveness, and the potential to optimize care delivery by integrating AI. Future research should focus on identifying monitoring strategies for specific HF populations, such as patients with advanced HF.</p>","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":"22 1","pages":"44"},"PeriodicalIF":3.7,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12678519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Achievements in Gene Therapy Strategies and Delivery Systems in Preclinical and Clinical Models of Heart Failure.","authors":"Sarah Khan, Carol Wittlieb-Weber, Joseph W Rossano","doi":"10.1007/s11897-025-00734-9","DOIUrl":"10.1007/s11897-025-00734-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>Current treatment strategies for heart failure primarily aim to slow disease progression. In the case of rare genetic disorders with associated cardiomyopathies, management is largely supportive. Gene therapy offers a promising alternative that is potentially curative. This review explores gene therapy strategies, vector selection and relevant molecular targets. We also examine pre-clinical and clinical trials investigating gene therapy in cardiomyopathies.</p><p><strong>Recent findings: </strong>Clinical trials for several genetic disorders-including Danon disease, Fabry disease and Duchenne muscular dystrophy-have demonstrated encouraging results. However, with the use of viral vectors and associated immunogenicity eliciting a strong inflammatory response in some patients, there remains a substantial risk of morbidity and mortality. For rare diseases, gene therapy represents a potentially curative, one-time treatment strategy. As the field advances, further work is required to improve vector technology, reduce immunogenicity, decrease off-target effects and address the associated ethical considerations.</p>","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":"22 1","pages":"43"},"PeriodicalIF":3.7,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145630961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic-Electrophysiological Coupling in Heart Failure: from Bidirectional Decoupling to Therapeutic Recoupling.","authors":"Hong Yu, Shi-Yao Chang, Xin Tian, Hui Xiao, Jia-Jia Xu, Cai-Li Zhu, Lin Li, Li-Li Xu","doi":"10.1007/s11897-025-00731-y","DOIUrl":"10.1007/s11897-025-00731-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>Heart failure (HF) is a complex clinical syndrome of progressive cardiac dysfunction, posing a major global burden on public health. The coupling between cardiomyocyte electrophysiology and energy metabolism is critical for sustaining cardiac electromechanical function. This review aims to elucidate the role of disrupted metabolic-electrophysiological coupling in disease progression and summarize emerging therapeutic targets.</p><p><strong>Recent findings: </strong>Currently, drugs that correct electrical or metabolic issues are proving effective in patients, while theoretical research and preliminary experiments have corroborated electro-metabolic coupling and its regulatory crosstalk among metabolic signaling, electrical activity, and energy utilization. These foundational studies have established a viable basis for multi-target interventions in HF. Restoring the disrupted integration between metabolism and electrophysiology emerges as a promising strategic direction in HF therapy. Interventions targeting this integration, such as metabolic modulators and mitochondrially targeted agents, may suppress arrhythmias, reverse adverse remodeling, and improve contractile function. This integrated approach may ultimately lead to more effective treatments that improve clinical outcomes for HF patients.</p>","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":"22 1","pages":"42"},"PeriodicalIF":3.7,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145630934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Natriuretic Peptides: Corin and Furin As Phenotype-Specific Biomarkers and Therapeutic Gatekeepers in Heart Failure.","authors":"Dhruvil Vinaybhai Patel, Sanket Patel, Sankalp Acharya, Karanrajsinh Raol","doi":"10.1007/s11897-025-00732-x","DOIUrl":"10.1007/s11897-025-00732-x","url":null,"abstract":"<p><p>Heart failure (HF) remains a leading cause of morbidity and mortality worldwide, with a growing need for improved understanding of disease mechanisms and better strategies for risk stratification. Among the key systems involved in maintaining cardiovascular homeostasis is the natriuretic peptide pathway, which is dependent on two critical enzymes: Corin, a cardiac-restricted serine protease, and Furin, a ubiquitous convertase. These enzymes activate pro-atrial and pro-brain natriuretic peptides that facilitate natriuresis, vasodilation, and neurohormonal balance. Disruption of the corin-furin axis impairs peptide activation and contributes to the maladaptive processes that lead to the progression of heart failure (HF). While several studies have reported altered expression of corin and furin in different HF phenotypes, their value as clinical biomarkers remains limited. Current diagnostic performance shows only modest sensitivity and specificity compared to established markers such as BNP and NT-proBNP, and incremental benefit has yet to be demonstrated in clinical settings. Nonetheless, their ability to reflect upstream enzymatic processes offers important mechanistic insight into HF pathophysiology. Looking ahead, corin and furin may hold promise as adjunctive or mechanistic biomarkers to guide therapies targeting natriuretic peptide-related pathways. This review provides a critical overview of the physiological and pathological roles of corin and furin in heart failure and evaluates current evidence for their potential as biomarkers. It also discusses key limitations and highlights future directions for research and therapeutic translation.</p>","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":"22 1","pages":"41"},"PeriodicalIF":3.7,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145563226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiogenic Shock; Health Disparities; Equity; Mechanical Circulatory Support; Sex Differences; Multidisciplinary Care; Protocolized Care.","authors":"Lourdes Vicent, Rafael Salguero-Bodes, Fernando Arribas Ynsaurriaga, Carlos Diaz-Arocutipa, Roberto Martín-Asenjo","doi":"10.1007/s11897-025-00729-6","DOIUrl":"10.1007/s11897-025-00729-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review examines why substantial disparities persist in the management of cardiogenic shock (CS) despite advances in therapy and the existence of clinical guidelines. We synthesize structural, clinical, and ethical mechanisms that shape access to timely and advanced care and highlight equity-oriented solutions.</p><p><strong>Recent findings: </strong>Across contemporary cohorts, women, older adults, racial/ethnic minorities, and socioeconomically disadvantaged patients remain less likely to receive early coronary angiography, revascularization, or mechanical circulatory support (MCS) and experience longer inter-hospital transfer delays. Reported gaps typically range from ~ 20-40% lower use of guideline-recommended therapies compared with reference groups, independent of comorbidity and presentation severity. Drivers include implicit bias, variable institutional resources, uneven protocol activation, and discretionary triage under time pressure.  Equity in CS care cannot be achieved by protocols alone. It requires deliberate measurement, culturally responsive decision-making, and system-level accountability. Equity-minded implementation of protocolized care, regionalized hub-and-spoke networks, multidisciplinary shock teams, and disparity-sensitive metrics shows promise. Success in CS should be defined not only as survival but also as equitable inclusion in the full spectrum of recognition, triage, escalation, and shared decision-making.</p>","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":"22 1","pages":"40"},"PeriodicalIF":3.7,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145548674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Left Ventricular Reverse Remodeling in Heart Failure with Reduced Ejection Fraction.","authors":"Jeong Hwan Kim, Michael S Kiernan","doi":"10.1007/s11897-025-00719-8","DOIUrl":"10.1007/s11897-025-00719-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>While left ventricular (LV) remodeling has been associated with poor prognosis in heart failure with reduced ejection, a variable degree of LV remodeling can be reversed upon the removal of the initial insult and with appropriate therapies. Hence, better prediction of LV reverse remodeling would not only help prognostically, but also could illuminate potential therapeutic targets. Herein, we provide a comprehensive review on the latest evidence on the predictors of LV reverse remodeling.</p><p><strong>Recent findings: </strong>Several predictors of LV reverse remodeling have been identified including certain baseline parameters of underlying cardiomyopathy, myocardial structure and function assessed by multi-modality imaging, and biomarkers. Beyond improving clinical outcomes, many of the established and emerging heart failure therapies have been also demonstrated to promote reverse remodeling, likely reflective of the mechanistic underpinning of their therapeutics benefits. With the ongoing development of novel diagnostics and therapies of heart failure, our understanding of LV reverse remodeling continues to evolve. Furthermore, with the growing evidence between reverse remodeling and clinical outcomes, reverse remodeling may prove to be a clinically useful marker of myocardial recovery and potential therapeutic target.</p>","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":"22 1","pages":"39"},"PeriodicalIF":3.7,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145511894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endosomal Mechanisms in Heart Failure Pathophysiology.","authors":"Martijn F Hoes, Shujin Wang, Joost Jfp Luiken","doi":"10.1007/s11897-025-00728-7","DOIUrl":"10.1007/s11897-025-00728-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>To examine the role of endosomal dysfunction in heart failure pathophysiology and evaluate its potential as a therapeutic target, particularly focusing on its regulation of cardiac metabolism.</p><p><strong>Recent findings: </strong>Endosomal dysfunction, driven by v-ATPase disassembly and loss of acidification, emerges as a key contributor to metabolic perturbations in heart failure. This dysfunction leads to uncontrolled CD36 translocation, resulting in lipotoxicity and inflammatory signaling through CD36-TLR4 complex formation. These mechanisms are especially relevant in diabetic cardiomyopathy and heart failure with preserved ejection fraction. The endosomal system represents a promising therapeutic target in heart failure, though its contribution varies among patients and disease stages. Recent advances in molecular imaging and biomarker analysis enable better patient stratification, opening new avenues for personalized endosome-targeted therapies in heart failure treatment.</p>","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":"22 1","pages":"38"},"PeriodicalIF":3.7,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145502386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiprofessional Interventions for Frailty in Patients with Heart Failure: A Comprehensive Review.","authors":"Izabella Uchmanowicz, Maria Jędrzejczyk, Christopher S Lee, Loreena Hill, Cristiana Vitale, Quin E Denfeld, Ercole Vellone, Bernadetta Żółkowska, Sara Janczak, Asriel Juvenal Chamos, Marta Kałużna-Oleksy, Marta Wleklik, Magdalena Lisiak, Katarzyna Lomper","doi":"10.1007/s11897-025-00727-8","DOIUrl":"10.1007/s11897-025-00727-8","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Frailty is a prevalent and clinically significant condition affecting up to 45% of adults with heart failure (HF). Frailty reflects a state of reduced physiologic reserve and vulnerability to stressors, which profoundly influences health outcomes including health care utilization and survival. Frailty and HF interact through multiple overlapping pathophysiologic mechanisms, including chronic inflammation, neurohormonal abnormalities, and multiorgan dysfunction. This synergy, for the patient leads to poor physical performance, reduced independence, and a greater susceptibility to complications. RECENT FINDINGS: Evidence from recent clinical trials focused on frailty in HF underscores the potential benefits of multicomponent interventions combined with medication optimisation target physical dysfunction, poor nutrition, psychological disorders, and social isolation. Multidisciplinary care teams – including cardiologists, nurses, physical therapists, dieticians, occupational therapists, and social workers – can implement tailored strategies to reverse or slow the progression of frailty to improve health outcomes of patients with HF. Interventions such as resistance and balance training, individualised nutritional supplementation, medication review, cognitive and psychological support, and caregiver education have demonstrated a range of benefits in HF, from enhanced physical capacity and reduced hospital readmissions to improved health-related quality of life. Managing frailty in patients with HF requires a personalised, holistic and multicomponent approach. Successful intervention involves addressing not only physical dysfunction but also psychological, nutritional, and social factors that collectively undermine health and independence. Integrating multicomponent care into routine practice has the potential to improve clinical outcomes, reduce health care utilisation, and enhance the overall well-being of patients. Future research should aim to identify the most effective combinations of interventions, clarify mechanisms of action, and determine cost-efficiency in health care delivery. </p>","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":"22 1","pages":"37"},"PeriodicalIF":3.7,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12596338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145470816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidities - Integrating Complexity into Heart Failure Care.","authors":"Oliviana Geavlete, Christiane E Angermann, Ovidiu Chioncel","doi":"10.1007/s11897-025-00726-9","DOIUrl":"10.1007/s11897-025-00726-9","url":null,"abstract":"","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":"22 1","pages":"36"},"PeriodicalIF":3.7,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145451232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}