Relevance of Cardiovascular Exercise in Cancer and Cancer Therapy-Related Cardiac Dysfunction.

IF 3.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Heart Failure Reports Pub Date : 2024-06-01 Epub Date: 2024-05-02 DOI:10.1007/s11897-024-00662-0

Simon Wernhart, Tienush Rassaf

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引用次数: 0

Abstract

Purpose of the review: Cancer therapy-related cardiac dysfunction (CTRCD) has been identified as a threat to overall and cancer-related survival. Although aerobic exercise training (AET) has been shown to improve cardiorespiratory fitness (CRF), the relationship between specific exercise regimens and cancer survival, heart failure development, and reduction of CTRCD is unclear. In this review, we discuss the impact of AET on molecular pathways and the current literature of sports in the field of cardio-oncology.

Recent findings: Cardio-oncological exercise trials have focused on variations of AET intensity by using moderate continuous and high intensity interval training, which are applicable, safe, and effective approaches to improve CRF. AET increases CRF, reduces cardiovascular morbidity and heart failure hospitalization and should thus be implemented as an adjunct to standard cancer therapy, although its long-term effect on CTRCD remains unknown. Despite modulating diverse molecular pathways, it remains unknown which exercise regimen, including variations of AET duration and frequency, is most suited to facilitate peripheral and central adaptations to exercise and improve survival in cancer patients.

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心血管锻炼对癌症和癌症治疗相关心功能障碍的意义

综述的目的：癌症治疗相关心功能障碍（CTRCD）已被确定为对总体生存和癌症相关生存的威胁。虽然有氧运动训练（AET）已被证明能改善心肺功能（CRF），但具体的运动方案与癌症生存、心力衰竭发展和减少 CTRCD 之间的关系尚不清楚。在这篇综述中，我们将讨论 AET 对分子通路的影响，以及目前在心肺肿瘤学领域的运动文献：最近的研究结果：心因癌运动试验主要集中在通过使用中等强度的持续训练和高强度的间歇训练来改变 AET 的强度，这些都是适用、安全且有效的改善 CRF 的方法。AET 可提高 CRF，降低心血管疾病发病率和心衰住院率，因此应作为标准癌症治疗的辅助手段，但其对 CTRCD 的长期影响仍不得而知。尽管AET可调节多种分子通路，但哪种运动方案（包括AET持续时间和频率的变化）最适合促进外周和中枢对运动的适应并提高癌症患者的生存率，目前仍是未知数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Heart Failure Reports Medicine-Emergency Medicine

CiteScore

5.30

自引率

0.00%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.