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引用次数: 0
摘要
综述目的：本文总结了凝血因子在心力衰竭病理生理学中的作用，包括D-二聚体、纤维蛋白原和纤维蛋白、凝血酶原、P-选择素、组织因子、组织凝血酶原激活物、von Willebrand因子、β-凝血酶原球蛋白、因子XI、组织凝血活酶、凝血酶原激活物抑制剂-1（PAI-1）、血栓调节蛋白、可溶性尿激酶型凝血酶原激活物受体（suPAR）和stuart-prower因子：最新研究结果：D-二聚体、P-选择素、凝血酶原、冯-威廉因子、组织纤溶酶原激活物、纤维蛋白原、suPAR、组织因子、血栓调节蛋白和因子 XI 在心力衰竭的病理生理学中发挥着重要作用。然而，β-凝血酶原球蛋白、组织凝血活酶、PAI-1 和 stuart-prower 因子与心力衰竭之间没有关联。凝血因子在心力衰竭的病理生理学中起着重要作用。因此，解释级联变化的潜在病理生理学机制与凝血级联因子的诊断、预后和治疗作用密切相关，有助于医生识别和治疗心衰。
The Role of Coagulation in Heart Failure: A Literature Review.
Purpose of review: This article summarizes the role of coagulation factors in the pathophysiology of heart failure including D-dimer, fibrinogen and fibrin, prothrombin, p-selectin, tissue factor, tissue plasminogen activator, von Willebrand factor, β-thromboglobulin, Factor XI, tissue thromboplastin, plasminogen activator inhibitor-1 (PAI-1), thrombomodulin, soluble urokinase-type plasminogen activator receptor (suPAR) and stuart-prower factor.
Recent findings: The D-dimer, P-selectin, prothrombin, von Willebrand factor, tissue plasminogen activator, fibrinogen, suPAR, tissue factor, thrombomodulin and Factor XI play significant roles the pathophysiology of heart failure. However, no associations were found between β-thromboglobulin, tissue thromboplastin, PAI-1 and stuart-prower factor in the context of heart failure. Coagulation factors play significant role in the pathophysiology of heart failure. Consequently, the underlying pathophysiological mechanisms that explain changes in the cascade are closely related to the diagnostic, prognostic and therapeutic roles of coagulation cascade factors, which help physicians identify and treat heart failure.
期刊介绍：
This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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