{"title":"Analyzing Uttarakhand's COVID-19 Outbreak: Demographic Insights and Strategies for Future Pandemic Prevention","authors":"Gaurav Joshi, Akshara Pande, Omdeep Gupta, Anoop Nautiyal, Sanjay Jasola, Prashant Gahtori","doi":"10.2174/0126667975257267231213071226","DOIUrl":"https://doi.org/10.2174/0126667975257267231213071226","url":null,"abstract":"The Indian state of Uttarakhand, also known as \"Dev Bhoomi\" or the Abode of Gods, is snuggled in the lap of the Himalayas. It is endowed with an abundant natural hilly environment and occupies more people in total than Israel, Switzerland, Hong Kong, etc. In this report, we look closely at the impact of COVID-19 on both high land/ hilly and low land/ plain bhabar zones across the state. The data was retrieved from the Uttarakhand Government Covid-19 health bulletin for 12 months using the Python command line. The data analysis covers percentage positivity/COVID-19 positivity rate, recovery, deceased and doubling rate, along with a detailed statistical analysis. In the first wave, low-land- inhabitants residing in 4 districts, Dehradun, Haridwar, U. S. Nagar and Nainital, were found more vulnerable, with a peak positive case during the 21st – 26th week. On the other hand, the districts with exclusive hilly terrains, including Chamoli, Pauri Garhwal, and Rudraprayag, were found to be the least susceptible and reported a high number of positive cases between the 30th and 31st week. The highest recovery rate was found to be in the hilly district of Rudraprayag. The multiple regression with confirmed cases was explained in relation to deceased, recovered, other, and tested variables (R2 adj= 0.99). The analysis also revealed a very high doubling rate from the last week of May to the first week of Jun 2020. The reduced number of COVID-19 cases in high-altitude hilly districts may be associated with factors such as enhanced ventilation, improved arterial oxygen transport, and increased tissue oxygenation. The findings from this study offer insights that can contribute to future pandemic prevention efforts. Summarising the current study, we have suggested 5-point solutions for preventing the next pandemic. It's important to note that while this study suggests a potential link between these factors and lower COVID-19 cases, further research is needed to establish a conclusive connection.","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"52 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139175361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CoronavirusesPub Date : 2023-12-11DOI: 10.2174/0126667975272375231201073215
Monika Meghani, Shikha Sharma, Nitin Kumar, B. Sahoo
{"title":"In silico Molecular Docking of SARS-CoV-2 Surface Proteins with\u0000Benzimidazole Scaffolds: Strategy to Discover Lead Compounds","authors":"Monika Meghani, Shikha Sharma, Nitin Kumar, B. Sahoo","doi":"10.2174/0126667975272375231201073215","DOIUrl":"https://doi.org/10.2174/0126667975272375231201073215","url":null,"abstract":"\u0000\u0000The severe acute respiratory illness that was brought on because of the\u0000outbreak of COVID-19 caused by the SARS-CoV-2 infection has been designated as a public\u0000health emergency of worldwide concern. There is an immediate and pressing need to establish an\u0000effective therapeutic strategy to bring infections under control. COVID-19 viral spike glycoproteins and proteases both play important roles in the process of viral entrance as well as in the process of virus reproduction.\u0000\u0000\u0000\u0000Benzimidazole derivatives show antiviral activity against various RNA and DNA viruses\u0000and stop the early viral replication cycle. Based on this information, we designed eighteen new\u0000benzimidazole derivatives and screened them against the proteins S-glycoprotein 6VSB and papain-like protease 6W9C using molecular docking studies. Compounds that bind strongly to these\u0000proteins were evaluated again in an in vitro study.\u0000\u0000\u0000\u0000When docked with SARS-CoV-2 spike glycoprotein, the binding affinity of R1 and R7\u0000was –7.1 kcal/mol and -7.3 kcal/mol, respectively. This showed that they might be able to stop the\u0000SARS spike protein from binding to the ACE2 receptor on the human host, making it harder for the\u0000virus to get into the cells. The binding affinity of SARS-CoV-2 papain-like protease with R4, R14,\u0000and R15 was –6.7 kcal/mol, -6.5 kcal/mol, and –6.5 kcal/mol, respectively. COVID-19 could stop\u0000the protease from working by binding it.\u0000\u0000\u0000\u0000It was suggested, on the basis of the binding energy score, that these pharmacologically potent benzimidazole derivatives may be tested against SARS-CoV-2 and utilized in the production of efficient antiviral medicines\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138980642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}