CoronavirusesPub Date : 2023-06-08DOI: 10.2174/2666796704666230608120444
S. Chadha, Sayali Mukherjee, Somali Sanyal
{"title":"A Review On The Role Of Nitric Oxide In The Pathophysiology And Management Of Sars- Cov-2 Disease","authors":"S. Chadha, Sayali Mukherjee, Somali Sanyal","doi":"10.2174/2666796704666230608120444","DOIUrl":"https://doi.org/10.2174/2666796704666230608120444","url":null,"abstract":"\u0000\u0000SARS-CoV-2, first emerged in December 2019 in Wuhan, China, and its rapid transmission led to the declaration of a pandemic by WHO. Nitric oxide is involved in SARS CoV-2 disease and its antiviral effects have prompted its use in the therapeutic management of SARS CoV-2. The effects of NO are concentration dependent. Local and controlled production of NO by the constitutive nitric oxide synthase appears beneficial, while overproduction due to inducible nitric oxide synthase may lead to cell destruction and tissue damage. The review discusses the role of nitric oxide in the pathogenesis of COVID-19 and its use as a probable therapeutic intervention preventing its progress to a more severe form.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85612084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CoronavirusesPub Date : 2023-05-08DOI: 10.2174/2666796704666230508140526
Afzal Hussain, A. Hussain
{"title":"Finding the potential inhibitory activity of Vilanterol Versus Budesonide towards SARS-CoV-2 Mpro: A molecular dynamics simulation approach","authors":"Afzal Hussain, A. Hussain","doi":"10.2174/2666796704666230508140526","DOIUrl":"https://doi.org/10.2174/2666796704666230508140526","url":null,"abstract":"The fast and widespread spread of a novel human coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), highlights the urgent need to identify a potential drug to combat COVID-19 infection. In this letter, we investigated drug repurposing as an appealing technique that can help with drug development by repurposing existing drugs to treat illnesses apart from their initial indications. The molecular dynamics (MD) simulations using GROMACS (200ns) were carried out for Vilanterol Versus Budesonide towards COVID-19 Mpro. The results indicated that the RMSD, RMSF, Radius of gyration, and Hydrogen-bond analysis favored Vilanterol over Budesonide. Animal investigations and reliable clinical trials will eventually be required to establish the potential preventive and therapeutic effects of these drugs.","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88420308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CoronavirusesPub Date : 2023-04-17DOI: 10.2174/2666796704666230417104522
Vivek Dave, Naveen Pallerla Reddy, P. Wal
{"title":"Tomato Flu! Is it Really Dangerous?","authors":"Vivek Dave, Naveen Pallerla Reddy, P. Wal","doi":"10.2174/2666796704666230417104522","DOIUrl":"https://doi.org/10.2174/2666796704666230417104522","url":null,"abstract":"\u0000\u0000In the modern era, the spread of new diseases makes humans panic in everyday life. Instead of panicking, proper prevention and awareness of the disease are required. Tomato flu is one of the emerging diseases in India, caused by the coxsackie Virus; this disease has led many people to panic. In this article, the Tomato flu is explained in detail, along with its treatment and prevention.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76895131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CoronavirusesPub Date : 2023-04-10DOI: 10.2174/2666796704666230410123425
{"title":"COVID-19: Mortality rate (in time) \u0000An Analysis of Publicly Available Data from 11 Countries to Calculate the Mortality Rate of COVID-19","authors":"","doi":"10.2174/2666796704666230410123425","DOIUrl":"https://doi.org/10.2174/2666796704666230410123425","url":null,"abstract":"\u0000\u0000In December 2019, a new virus, COVID-19, initially found in China, started spreading worldwide, resulting in a severe pandemic with 82 million confirmed infections at the end of 2020 and 288 million at the end of 2021. With 5.4 million reported deaths due to COVID-19 at the end of 2021, the apparent mortality rate is 2%, but the general agreement is that the reported numbers are incomplete. \u0000An analysis was made on the publicly available COVID-19 data from eleven countries (8 in Europe, 2 in North America and 1 in Africa) to obtain a mortality rate for COVID-19. The data from these countries also contained information about hospital admissions and were partly available in graphics, allowing the data to be downloaded. The size of the population varied from 5 million (Norway) to more than 300 million (USA).\u0000Data from an investigation of Sanquin, the Dutch blood bank, and the Belgian Red Cross on the presence of antibodies for the virus in their blood donors were used to estimate the number of infected people at the start of the pandemic. This estimate was combined with the number of hospital admissions to obtain a hospitalization rate. The resulting hospitalization rates for The Netherlands and Belgium were 1.49 % and 2.23 %, respectively. The hospitalization rates were used to calculate the total number of infected people during the pandemic, but analysis showed that the calculation is only valid until June 2021.\u0000Using the Dutch and Belgian hospitalization rates, the available data from The Netherlands, Belgium and the United Kingdom showed that COVID-19 mortality rates of 1.2% at the start of the pandemic decreased to 0.4 % in the spring of 2021. \u0000The resulting cumulative mortality rate in July 2021 showed agreement, within the uncertainty, for Germany, France, Switzerland, USA, Canada and South Africa, but with dependence on the use of the hospitalization rate. The mortality rate was below the uncertainty band in smaller countries like Denmark and Norway.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81520559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}