Coronaviruses最新文献_第10页

A Review On The Role Of Nitric Oxide In The Pathophysiology And Management Of Sars- Cov-2 Disease 一氧化氮在Sars- Cov-2疾病病理生理和治疗中的作用综述

Coronaviruses Pub Date : 2023-06-08 DOI: 10.2174/2666796704666230608120444

S. Chadha, Sayali Mukherjee, Somali Sanyal

引用次数: 0

Finding the potential inhibitory activity of Vilanterol Versus Budesonide towards SARS-CoV-2 Mpro: A molecular dynamics simulation approach 维兰特罗与布地奈德对SARS-CoV-2 Mpro潜在抑制活性的分子动力学模拟方法

Coronaviruses Pub Date : 2023-05-08 DOI: 10.2174/2666796704666230508140526

Afzal Hussain, A. Hussain

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Tomato Flu! Is it Really Dangerous? 番茄流感!真的很危险吗?

Coronaviruses Pub Date : 2023-04-17 DOI: 10.2174/2666796704666230417104522

Vivek Dave, Naveen Pallerla Reddy, P. Wal

引用次数: 0

Coronavirus Disease (COVID-19): Features, Diagnosis, Treatments, and Impacts 冠状病毒病（COVID-19）：特征、诊断、治疗和影响

Coronaviruses Pub Date : 2023-04-17 DOI: 10.2174/2666796704666230417112151

Ayush Dogra, Bhawna Goyal

引用次数: 0

COVID-19: Mortality rate (in time) An Analysis of Publicly Available Data from 11 Countries to Calculate the Mortality Rate of COVID-19 COVID-19:死亡率(及时)对11个国家公开数据的分析，以计算COVID-19的死亡率

Coronaviruses Pub Date : 2023-04-10 DOI: 10.2174/2666796704666230410123425

{"title":"COVID-19: Mortality rate (in time) \u0000An Analysis of Publicly Available Data from 11 Countries to Calculate the Mortality Rate of COVID-19","authors":"","doi":"10.2174/2666796704666230410123425","DOIUrl":"https://doi.org/10.2174/2666796704666230410123425","url":null,"abstract":"\u0000\u0000In December 2019, a new virus, COVID-19, initially found in China, started spreading worldwide, resulting in a severe pandemic with 82 million confirmed infections at the end of 2020 and 288 million at the end of 2021. With 5.4 million reported deaths due to COVID-19 at the end of 2021, the apparent mortality rate is 2%, but the general agreement is that the reported numbers are incomplete. \u0000An analysis was made on the publicly available COVID-19 data from eleven countries (8 in Europe, 2 in North America and 1 in Africa) to obtain a mortality rate for COVID-19. The data from these countries also contained information about hospital admissions and were partly available in graphics, allowing the data to be downloaded. The size of the population varied from 5 million (Norway) to more than 300 million (USA).\u0000Data from an investigation of Sanquin, the Dutch blood bank, and the Belgian Red Cross on the presence of antibodies for the virus in their blood donors were used to estimate the number of infected people at the start of the pandemic. This estimate was combined with the number of hospital admissions to obtain a hospitalization rate. The resulting hospitalization rates for The Netherlands and Belgium were 1.49 % and 2.23 %, respectively. The hospitalization rates were used to calculate the total number of infected people during the pandemic, but analysis showed that the calculation is only valid until June 2021.\u0000Using the Dutch and Belgian hospitalization rates, the available data from The Netherlands, Belgium and the United Kingdom showed that COVID-19 mortality rates of 1.2% at the start of the pandemic decreased to 0.4 % in the spring of 2021. \u0000The resulting cumulative mortality rate in July 2021 showed agreement, within the uncertainty, for Germany, France, Switzerland, USA, Canada and South Africa, but with dependence on the use of the hospitalization rate. The mortality rate was below the uncertainty band in smaller countries like Denmark and Norway.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81520559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herbal Medicines Used for the Management of COVID-19 用于管理COVID-19的草药

Coronaviruses Pub Date : 2023-04-03 DOI: 10.2174/2666796704666230403101610

Virender Kumar, Y. Kumar, Rajat Huria, Suryadev Kumar, Tarun Kalson, Deepa Jangra, D. Kumar, Bharti Mangla

引用次数: 0

Moisturizer and COVID-19: Are We Missing a Trick? 保湿霜和COVID-19:我们错过了一个技巧吗?

Coronaviruses Pub Date : 2023-03-30 DOI: 10.2174/2666796704666230330083413

Srinivasan Tantravahi, Chenna R Galiveti

{"title":"Moisturizer and COVID-19: Are We Missing a Trick?","authors":"Srinivasan Tantravahi, Chenna R Galiveti","doi":"10.2174/2666796704666230330083413","DOIUrl":"https://doi.org/10.2174/2666796704666230330083413","url":null,"abstract":"\u0000\u0000Corona Virus Disease 2019 (COVID-19) is reported to be transmitted predominantly by respiratory droplets and fomites. The regular use of a mask can mitigate the airborne transmission of the Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2), but comprehensive prevention of the virus is possible only when the contact spread of the virus is also addressed. The recommended use of soap and hand sanitizer (alcoholic hand rub) is effective only until subsequent contact with the virus. Furthermore, regular and repeated application of these disinfectants is impractical and harmful to the skin. The damage to the outermost epidermal layers of the skin exposes the Angiotensin-converting enzyme 2 (ACE2) receptor rich keratinocytes, enhancing the scope for percutaneous transmission of virus. Moisturizers, composed of fatty acids, fatty alcohols, mineral oils, petrolatum, etc., are generally considered cosmetics used to maintain and enhance skin condition. At very low concentrations, several of these components are found to neutralize enveloped viruses, indicating their potential antiviral activity. Soaps also generally contain many of these constituents, making them effective against viruses. Petrolatum, a key component of occlusive moisturizers, is also said to enhance innate immunity. Additionally, moisturizers also alleviate inflammation and prevent skin dryness and damage. The periodic and regular application of an appropriate moisturizer on hand and palm can play a significant role in curtailing the transmission of infectious agents, including (SARS-CoV-2), and could act as an extra line of defense against microbial infections.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80150872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Possibility of use of SARS-CoV-2 Antiserum as an Alternative for Plasma Therapy 探索使用 SARS-CoV-2 抗血清替代血浆疗法的可能性

Coronaviruses Pub Date : 2023-03-29 DOI: 10.2174/2666796704666230329101950

Basavraj Nagoba, Ajay Gavkare, A. Rayate

引用次数: 0

Different Variants of SARS-COV-2: A Comprehensive Review on Mutation Patterns and Pathogenicity SARS-COV-2的不同变异:突变模式和致病性的综合综述

Coronaviruses Pub Date : 2023-03-28 DOI: 10.2174/2666796704666230328171636

M. F. Khan, Fahmina Rizvi, M. Khan, W. A. Ansari, Kajim Ali, Mohd Aamish Khan

{"title":"Different Variants of SARS-COV-2: A Comprehensive Review on Mutation Patterns and Pathogenicity","authors":"M. F. Khan, Fahmina Rizvi, M. Khan, W. A. Ansari, Kajim Ali, Mohd Aamish Khan","doi":"10.2174/2666796704666230328171636","DOIUrl":"https://doi.org/10.2174/2666796704666230328171636","url":null,"abstract":"\u0000\u0000Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a single-stranded and positive-sense RNA virus, is exhibiting a great degree of mutation acclimated to variable environments, posing a great threat to human life, with numerous SARS-CoV-2 variants. This review aims to analyze emerging strains of SARS-CoV-2, their mutational pattern, their impact on viral pathogenicity, and the identification of the targets for the development of vaccines and therapeutics against the virus. SARS-CoV-2 consists of four structural protein codes viz, peplomer protein (S), an envelope protein (E), nucleoprotein capsid (N), and matrix protein (M), that are involved in the ingression of the viral genome into the host cell by interacting with the host cell receptor, i.e., human angiotensin-converting enzyme 2 (ACE2) (only S protein is shown to bind to ACE-2 receptor). The review includes consequences of mutations- D614G (pre-dominant mutation), E484K, N501Y, K417N, L452R, P681H, del69/70, del157/158, Ins214EPE, and so forth, in alpha, beta, gamma, delta, omicron including other strains of SARS-CoV-2. Mutations include substitution, deletion, and insertion of amino acids in the spike glycoprotein of the SARS-CoV-2, resulting in antibody neutralization, immune escape, etc. As a consequence of modifications in the nucleotide sequence of the viral genome code pushed on by exposure to various environments, these new strains influence the pathogenicity of the virus.\u0000","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90352187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WITHDRAWN: The COVID-19 Pandemic: To Improve Public Acceptance, Don’t Keep Them in the Dark, Educate Them 撤回:COVID-19大流行:为了提高公众接受度，不要让他们蒙在鼓里，要教育他们

Coronaviruses Pub Date : 2023-03-08 DOI: 10.2174/2666796703666220607102238

Joseph M. Rosen, Jill R. Sensenig

引用次数: 0