{"title":"一氧化氮在Sars- Cov-2疾病病理生理和治疗中的作用综述","authors":"S. Chadha, Sayali Mukherjee, Somali Sanyal","doi":"10.2174/2666796704666230608120444","DOIUrl":null,"url":null,"abstract":"\n\nSARS-CoV-2, first emerged in December 2019 in Wuhan, China, and its rapid transmission led to the declaration of a pandemic by WHO. Nitric oxide is involved in SARS CoV-2 disease and its antiviral effects have prompted its use in the therapeutic management of SARS CoV-2. The effects of NO are concentration dependent. Local and controlled production of NO by the constitutive nitric oxide synthase appears beneficial, while overproduction due to inducible nitric oxide synthase may lead to cell destruction and tissue damage. The review discusses the role of nitric oxide in the pathogenesis of COVID-19 and its use as a probable therapeutic intervention preventing its progress to a more severe form.\n","PeriodicalId":10815,"journal":{"name":"Coronaviruses","volume":"22 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Review On The Role Of Nitric Oxide In The Pathophysiology And Management Of Sars- Cov-2 Disease\",\"authors\":\"S. Chadha, Sayali Mukherjee, Somali Sanyal\",\"doi\":\"10.2174/2666796704666230608120444\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nSARS-CoV-2, first emerged in December 2019 in Wuhan, China, and its rapid transmission led to the declaration of a pandemic by WHO. Nitric oxide is involved in SARS CoV-2 disease and its antiviral effects have prompted its use in the therapeutic management of SARS CoV-2. The effects of NO are concentration dependent. Local and controlled production of NO by the constitutive nitric oxide synthase appears beneficial, while overproduction due to inducible nitric oxide synthase may lead to cell destruction and tissue damage. The review discusses the role of nitric oxide in the pathogenesis of COVID-19 and its use as a probable therapeutic intervention preventing its progress to a more severe form.\\n\",\"PeriodicalId\":10815,\"journal\":{\"name\":\"Coronaviruses\",\"volume\":\"22 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Coronaviruses\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/2666796704666230608120444\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coronaviruses","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2666796704666230608120444","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A Review On The Role Of Nitric Oxide In The Pathophysiology And Management Of Sars- Cov-2 Disease
SARS-CoV-2, first emerged in December 2019 in Wuhan, China, and its rapid transmission led to the declaration of a pandemic by WHO. Nitric oxide is involved in SARS CoV-2 disease and its antiviral effects have prompted its use in the therapeutic management of SARS CoV-2. The effects of NO are concentration dependent. Local and controlled production of NO by the constitutive nitric oxide synthase appears beneficial, while overproduction due to inducible nitric oxide synthase may lead to cell destruction and tissue damage. The review discusses the role of nitric oxide in the pathogenesis of COVID-19 and its use as a probable therapeutic intervention preventing its progress to a more severe form.
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