Current Medical Research and Opinion最新文献

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A case of corticobasal syndrome possibly associated with anti-Yo antibodies. 一例可能与抗 Yo 抗体有关的皮质基底综合征。
IF 2.4 4区 医学
Current Medical Research and Opinion Pub Date : 2024-10-01 Epub Date: 2024-09-25 DOI: 10.1080/03007995.2024.2406888
Efthalia Angelopoulou, Vasilios C Constantinides, Evangelos Koumasopoulos, Evangelia Stanitsa, Efstratios-Stylianos Pyrgelis, Andreas Kyrozis, Elisabeth Kapaki, Leonidas Stefanis, Sokratis G Papageorgiou
{"title":"A case of corticobasal syndrome possibly associated with anti-Yo antibodies.","authors":"Efthalia Angelopoulou, Vasilios C Constantinides, Evangelos Koumasopoulos, Evangelia Stanitsa, Efstratios-Stylianos Pyrgelis, Andreas Kyrozis, Elisabeth Kapaki, Leonidas Stefanis, Sokratis G Papageorgiou","doi":"10.1080/03007995.2024.2406888","DOIUrl":"10.1080/03007995.2024.2406888","url":null,"abstract":"<p><strong>Introduction: </strong>Corticobasal syndrome (CBS) is a rare form of atypical parkinsonism, most commonly caused by neurodegenerative disorders. Autoimmune underlying conditions are extremely rare, and anti-Yo antibody-associated CBS has not been reported yet.</p><p><strong>Case report: </strong>Herein, we describe a case of a 68-year-old woman presenting with progressive dysarthria, gait instability and difficulty using her left hand with subacute deterioration during the last 3 months. Neurological examination revealed asymmetrical parkinsonism and pyramidal syndrome, reflex myoclonus and dystonia of her left upper limb, accompanied by apraxia of her left lower limb, fulfilling the criteria for possible CBS. Neuroimaging showed asymmetric frontoparietal atrophy, while cerebrospinal fluid and dopamine transporter imaging were normal. Prior to our evaluation, antineuronal autoantibody testing indicated positive anti-Yo antibodies. There was mild improvement after second IVIG cycle, and further investigation revealed no tumor.</p><p><strong>Conclusion: </strong>Although autoimmune etiology of this case cannot be certain, it highlights the potential expansion of the clinical spectrum of anti-Yo-associated paraneoplastic syndrome.</p>","PeriodicalId":10814,"journal":{"name":"Current Medical Research and Opinion","volume":" ","pages":"1737-1740"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of systemic inflammatory indices in predicting atrial fibrillation and its complications: a narrative review. 全身炎症指数在预测心房颤动及其并发症中的作用:综述。
IF 2.4 4区 医学
Current Medical Research and Opinion Pub Date : 2024-10-01 Epub Date: 2024-09-02 DOI: 10.1080/03007995.2024.2397074
Atefeh Ghareghani, Shahin Abbaszadeh, Mohammad Ali Takhshid
{"title":"The role of systemic inflammatory indices in predicting atrial fibrillation and its complications: a narrative review.","authors":"Atefeh Ghareghani, Shahin Abbaszadeh, Mohammad Ali Takhshid","doi":"10.1080/03007995.2024.2397074","DOIUrl":"10.1080/03007995.2024.2397074","url":null,"abstract":"<p><p>Atrial fibrillation (AF) is associated with increased morbidity and mortality. Inflammation and oxidative stress play critical roles in AF occurrence and its complications. Therefore, evaluating the circulating levels of inflammatory and oxidative stress biomarkers and their possible applications in AF diagnosis and management have been the focus of many efforts. The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and neutrophil-to-lymphocyte ratio (NLR) are two non-invasive, available, and established markers that serve as indicators of inflammation and oxidative stress. This review summarizes the current literature regarding alterations in the NLR, MHR, and other composite markers of systemic inflammation in AF patients. Moreover, this review discusses the clinical performance of these markers in predicting AF occurrence, recurrence, and disease outcomes. The PubMed, Scopus, and ScienceDirect online databases were searched for relevant studies using appropriate keywords, including \"atrial fibrillation\", \"monocyte to high-density lipoprotein cholesterol ratio\", and \"neutrophil to lymphocyte ratio\". The results of this review revealed the association of elevated levels of systemic inflammatory markers, specifically the NLR and MHR with AF and its complications. This finding indicates the potential role of subclinical inflammation in the development of AF, emphasizing its consideration in both the prevention and treatment of AF and associated complications. Despite these promising findings, the utilization of these markers in routine clinical settings faces challenges, including low specificity and sensitivity and varying cut-off values across different studies.</p>","PeriodicalId":10814,"journal":{"name":"Current Medical Research and Opinion","volume":" ","pages":"1657-1666"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Matching-adjusted indirect comparison of talquetamab vs selinexor-dexamethasone and vs belantamab mafodotin in patients with relapsed/refractory multiple myeloma. 对复发/难治性多发性骨髓瘤患者进行匹配调整后的间接比较:talquetamab与selinexor-dexamethasone和belantamab mafodotin。
IF 2.4 4区 医学
Current Medical Research and Opinion Pub Date : 2024-10-01 Epub Date: 2024-09-03 DOI: 10.1080/03007995.2024.2391553
Donna Reece, Joris Diels, Suzy Van Sanden, Lixia Pei, Eric Ammann, Christoph Heuck, Colleen Kane, Anil Londhe, Steve Peterson, Ajai Chari
{"title":"Matching-adjusted indirect comparison of talquetamab vs selinexor-dexamethasone and vs belantamab mafodotin in patients with relapsed/refractory multiple myeloma.","authors":"Donna Reece, Joris Diels, Suzy Van Sanden, Lixia Pei, Eric Ammann, Christoph Heuck, Colleen Kane, Anil Londhe, Steve Peterson, Ajai Chari","doi":"10.1080/03007995.2024.2391553","DOIUrl":"10.1080/03007995.2024.2391553","url":null,"abstract":"<p><strong>Objective: </strong>Talquetamab is the first GPRC5D-targeting bispecific antibody approved for the treatment of triple-class exposed (TCE) relapsed/refractory multiple myeloma (RRMM). This matching-adjusted indirect comparison (MAIC) study was conducted to compare the effectiveness of talquetamab vs selinexor-dexamethasone (sel-dex) and vs belantamab mafodotin (belamaf) in patients with TCE RRMM.</p><p><strong>Methods: </strong>An unanchored MAIC was performed using individual patient-level data from patients treated with subcutaneous talquetamab 0.4 mg/kg weekly (QW) and 0.8 mg/kg every other week (Q2W) from MonumenTAL-1 (NCT03399799/NCT04636552) and published summary data for sel-dex from STORM (NCT02336815) and belamaf from DREAMM-2 (NCT0325678). Patients from MonumenTAL-1 who met key eligibility criteria for STORM and DREAMM-2 were included. Outcomes of interest were overall response rate (ORR), complete response or better (≥CR), duration of response (DOR), progression-free survival (PFS), and overall survival (OS).</p><p><strong>Results: </strong>After adjustment for cross-trial differences, patients treated with both dosing schedules of talquetamab showed significantly better ORR, ≥CR, and DOR vs sel-dex and significantly higher ORR and ≥ CR vs belamaf; DOR was relatively similar to belamaf. PFS was significantly improved with talquetamab Q2W and numerically in favor of talquetamab QW vs sel-dex and significantly improved with both dosing schedules of talquetamab vs belamaf. OS was significantly improved with both dosing schedules of talquetamab vs sel-dex and was numerically in favor of both dosing schedules of talquetamab vs belamaf.</p><p><strong>Conclusion: </strong>These analyses show superior effectiveness of both talquetamab dosing schedules vs sel-dex and vs belamaf for most outcomes and highlight talquetamab as an effective treatment option for patients with TCE RRMM.</p>","PeriodicalId":10814,"journal":{"name":"Current Medical Research and Opinion","volume":" ","pages":"1769-1783"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of psilocybin in depressive disorders. 迷幻药在抑郁症中的作用。
IF 2.4 4区 医学
Current Medical Research and Opinion Pub Date : 2024-10-01 Epub Date: 2024-08-28 DOI: 10.1080/03007995.2024.2396536
Jadwiga Najib
{"title":"The role of psilocybin in depressive disorders.","authors":"Jadwiga Najib","doi":"10.1080/03007995.2024.2396536","DOIUrl":"10.1080/03007995.2024.2396536","url":null,"abstract":"<p><p>Depression is a serious psychiatric disorder with a high incidence of morbidity and mortality and psilocybin with psychotherapy has emerged as a promising potential in the treatment of depressive disorders. A review of psilocybin use in patients with depressive disorders is presented.A search was conducted investigating the use of psilocybin in patients with depressive disorders and treatment resistant depression <i>via</i> PubMed/MEDLINE, EMBASE, and Google Scholar in October 2023; all publication types were permitted and limited for English-language. Keyword search terms included: \"psilocybin\" or \"psychedelics\" and \"depression\", or \"major depressive disorder\", or \"treatment-resistant depression\". Controlled and uncontrolled clinical trials utilizing psilocybin with psychological support for major depressive disorder and treatment-resistant depression, as well as in patients with depression and cancer related anxiety have demonstrated immediate and sustained antidepressant and anxiolytic effects. Psilocybin has a favorable safety profile and was well-tolerated in clinical trials. Psilocybin's abuse potential is low and clinical research suggests the potential of psilocybin to produce rapid and lasting antidepressant effects up to 12 months post-treatment. Psilocybin may offer a valuable contribution as an option to the currently available pharmacological and psychotherapeutic agents for patients with major depressive disorders, treatment-resistant depression as well as for patients with depression and comorbid terminal cancer. Future studies are needed to demonstrate these findings and any synergistic interaction between psilocybin and the psychological support offered to patients during sessions.</p>","PeriodicalId":10814,"journal":{"name":"Current Medical Research and Opinion","volume":" ","pages":"1793-1808"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perception and knowledge of general practitioners on COPD management according to the GOLD23 document and reimbursement criteria for drugs prescription: an e-Delphi study. 根据 GOLD23 文件和药物处方报销标准,全科医生对慢性阻塞性肺病管理的看法和知识:一项电子德尔菲研究。
IF 2.4 4区 医学
Current Medical Research and Opinion Pub Date : 2024-10-01 Epub Date: 2024-09-19 DOI: 10.1080/03007995.2024.2399279
Ettore Marconi, Francesco Paolo Lombardo, Claudio Micheletto, Marzio Uberti, Fabiano Di Marco, Alessandro Rossi, Claudio Cricelli, Francesco Lapi
{"title":"Perception and knowledge of general practitioners on COPD management according to the GOLD23 document and reimbursement criteria for drugs prescription: an e-Delphi study.","authors":"Ettore Marconi, Francesco Paolo Lombardo, Claudio Micheletto, Marzio Uberti, Fabiano Di Marco, Alessandro Rossi, Claudio Cricelli, Francesco Lapi","doi":"10.1080/03007995.2024.2399279","DOIUrl":"10.1080/03007995.2024.2399279","url":null,"abstract":"<p><strong>Background: </strong>COPD management and therapy have been periodically revised to support a more patient-specific approach. Several concerns remain in primary care, such as the proper choice of initial treatment, medication adherence, and missing values for spirometry investigations. These concerns may be exacerbated by inconsistencies between the GOLD23 report and reimbursement criteria, as per the Italian NOTA99, especially for what concerns the assessment of disease severity and related treatment choice. We therefore examined the perception and knowledge of general practitioners (GPs) on COPD management and treatment.</p><p><strong>Methods: </strong>We conducted an exploratory e-Delphi study among 600 GPs. The study examined the COPD-related GP's access to spirometry evaluations in primary care clinics; knowledge on early recognition of COPD and related clinical concerns; perception of the clinical application of the NOTA99; the place in therapy of the triple LABA/LAMA/ICS combination.</p><p><strong>Results: </strong>Among 466 participating GPs (response rate: 70.3%; mean age 52, SD: 14.2; mean years of experience: 21.3, SD: 15) had a good level of knowledge about the GOLD 2023 document and the reimbursement criteria for COPD medications. Nevertheless, a low (34%) direct access to spirometry was reported, along with absence of consensus on the proper choice of initial treatment (especially of use of LABA/LAMA combination), and the re-evaluation of free-triple therapy LABA/LAMA/ICS through specialist's referral.</p><p><strong>Conclusions: </strong>This study captured the domains on which further training for GPs might be implemented to improve the management and treatment of COPD. An extension of this e-Delphi to a larger GPs' panel might further confirm these findings.</p>","PeriodicalId":10814,"journal":{"name":"Current Medical Research and Opinion","volume":" ","pages":"1821-1826"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost-effectiveness of CDK4/6 inhibitors in HR+/HER2- metastatic breast cancer: a systematic review and meta-analysis. CDK4/6抑制剂治疗HR+/HER2-转移性乳腺癌的成本效益:系统综述和荟萃分析。
IF 2.4 4区 医学
Current Medical Research and Opinion Pub Date : 2024-10-01 Epub Date: 2024-09-21 DOI: 10.1080/03007995.2024.2402074
Prajakta P Masurkar, Prachi Prajapati, Joanne Canedo, Swarnali Goswami, Sally Earl, Kaustuv Bhattacharya
{"title":"Cost-effectiveness of CDK4/6 inhibitors in HR+/HER2- metastatic breast cancer: a systematic review and meta-analysis.","authors":"Prajakta P Masurkar, Prachi Prajapati, Joanne Canedo, Swarnali Goswami, Sally Earl, Kaustuv Bhattacharya","doi":"10.1080/03007995.2024.2402074","DOIUrl":"10.1080/03007995.2024.2402074","url":null,"abstract":"<p><strong>Background: </strong>Cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors have emerged as a significant advancement in the treatment of HR+/HER2- metastatic breast cancer (MBC). Despite the clinical efficacy of CDK 4/6 inhibitors in HR+/HER2- metastatic breast cancer, there remains a significant gap in understanding their cost-effectiveness, particularly regarding the long-term economic impact and the key drivers of costs, when used in combination with endocrine therapy. This study aims to systematically review and conduct a meta-analysis of cost-effectiveness studies evaluating CDK4/6 inhibitors in treatment of HR+/HER2- advanced breast cancer and identify key drivers of costs of CDK4/6 inhibitors in combination with endocrine therapy.</p><p><strong>Methods: </strong>A comprehensive search of PubMed and Embase was conducted to identify peer-reviewed studies from February 2015 to March 2022 reporting cost-effectiveness of CDK4/6 inhibitors in MBC treatment. Incremental net benefits (INBs) were estimated, and meta-analysis was conducted. This review adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.</p><p><strong>Results: </strong>We identified 120 articles, of which 18 were eligible for systematic review and 16 for meta-analysis. None of the three CDK4/6 inhibitors had positive INB compared to endocrine/aromatase inhibitors therapy alone. The pooled INB was estimated at -$149,266.87 (95% Confidence Interval (CI) = -$196,961.54, -$101,572.20).</p><p><strong>Conclusion: </strong>The combination of CDK4/6 inhibitors and letrozole/endocrine therapy for the treatment of postmenopausal patients with advanced HR+/HER2 - MBC was not cost-effective.</p>","PeriodicalId":10814,"journal":{"name":"Current Medical Research and Opinion","volume":" ","pages":"1753-1767"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-world experience with clinical management of talquetamab in relapsed/refractory multiple myeloma: a qualitative study of US healthcare providers. 复发性/难治性多发性骨髓瘤患者使用他克莫司临床治疗的实际经验:一项针对美国医疗服务提供者的定性研究。
IF 2.4 4区 医学
Current Medical Research and Opinion Pub Date : 2024-10-01 Epub Date: 2024-08-23 DOI: 10.1080/03007995.2024.2387183
Carolina Schinke, Binod Dhakal, Sandra Mazzoni, Samantha Shenoy, Sara A Scott, Tiffany Richards, Hoa H Le, Amalia DeBrosse, Peter Okorozo, Rachel McDowell, Saurabh Patel, Jonathan Bunn, Kelly Hawks, Xinke Zhang, Cesar Rodriguez
{"title":"Real-world experience with clinical management of talquetamab in relapsed/refractory multiple myeloma: a qualitative study of US healthcare providers.","authors":"Carolina Schinke, Binod Dhakal, Sandra Mazzoni, Samantha Shenoy, Sara A Scott, Tiffany Richards, Hoa H Le, Amalia DeBrosse, Peter Okorozo, Rachel McDowell, Saurabh Patel, Jonathan Bunn, Kelly Hawks, Xinke Zhang, Cesar Rodriguez","doi":"10.1080/03007995.2024.2387183","DOIUrl":"10.1080/03007995.2024.2387183","url":null,"abstract":"<p><strong>Objective: </strong>Talquetamab is the first-in-class GPRC5DxCD3 bispecific antibody for relapsed/refractory multiple myeloma. Given limited real-world data, this study was conducted with US healthcare providers (HCPs) to understand real-world talquetamab dosing and symptom management.</p><p><strong>Methods: </strong>In February/March 2024, individual in-depth interviews (IDIs; <i>n</i> = 10) were conducted with HCPs administering talquetamab in real-world settings. A subsequent expert panel (<i>n</i> = 6) further discussed current practices.</p><p><strong>Results: </strong>The IDIs reported a variety of settings for step-up dosing (SUD), including inpatient (<i>n</i> = 5), outpatient (<i>n</i> = 3), and hybrid models (<i>n</i> = 2), with a trend toward shorter SUD length to reduce healthcare resource utilization. Most HCPs used a biweekly (Q2W) schedule in SUD (<i>n</i> = 7) and treatment phases (<i>n</i> = 8). Six participants explored reducing dose frequency to every 4 weeks (Q4W) in patients following positive disease response to treatment, considering patient convenience and relieving GPRC5D-related symptoms. Panelists recommended symptom management and prophylactic strategies, such as dexamethasone and nystatin mouthwash or zinc and vitamin B complex for oral symptoms, and topical steroids and cosmetic products for skin and nail symptoms.</p><p><strong>Conclusion: </strong>This study outlines current real-world practices for talquetamab. Findings indicate variation in the SUD care setting. The 0.8 mg/kg Q2W dosing schedule was most common, although switching to Q4W is a real-world symptom management strategy for some patients with responses to therapy. GPRC5D-related symptom management approaches are evolving; prophylactic use of dexamethasone and nystatin mouthwash or zinc and vitamin B complex may be effective strategies to alleviate oral symptoms. Further real-world evidence is needed to inform optimal dosing schedules while mitigating symptom impact.</p>","PeriodicalId":10814,"journal":{"name":"Current Medical Research and Opinion","volume":" ","pages":"1705-1711"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author language and communication preferences, and familiarity with global publication guidelines, for English-language industry-sponsored publications in Asia-Pacific: insights from a cross-sectional survey. 亚太地区英文行业赞助出版物的作者语言和交流偏好以及对全球出版准则的熟悉程度:一项横向调查的启示。
IF 2.4 4区 医学
Current Medical Research and Opinion Pub Date : 2024-10-01 Epub Date: 2024-08-29 DOI: 10.1080/03007995.2024.2396532
Alice Carruthers, Henry Chung, Rebecca Crawford, Joyce H Y Lee, Jonathan Lee
{"title":"Author language and communication preferences, and familiarity with global publication guidelines, for English-language industry-sponsored publications in Asia-Pacific: insights from a cross-sectional survey.","authors":"Alice Carruthers, Henry Chung, Rebecca Crawford, Joyce H Y Lee, Jonathan Lee","doi":"10.1080/03007995.2024.2396532","DOIUrl":"10.1080/03007995.2024.2396532","url":null,"abstract":"<p><strong>Objective: </strong>To understand current practices and challenges for collecting author feedback for English-language, industry-sponsored publications in Asia-Pacific (APAC), and the implications for adherence to international publication guidelines.</p><p><strong>Methods: </strong>A cross-sectional, internet-based survey of industry ('internal') authors (17 questions) and publication professionals (18 questions) supporting publications in APAC, conducted between November 18 and December 4, 2022.</p><p><strong>Results: </strong>Overall, 142 survey responses were received, of which 94 (66%) were complete and included in the analysis (33 internal authors, 61 publication professionals). Almost half (45%) of internal authors preferred a non-English language for providing feedback on publications, and most (70%) would use this language whenever possible. Internal authors favored written (91%) versus spoken (73%) English, and email was the preferred mode of communication. Publication professionals said they have observed qualitative differences when authors provide feedback in a preferred non-English language versus English. Many agreed that authors tend to provide more substantive or critical feedback when they can respond in their preferred non-English language. Internal authors had low self-assessed familiarity with key publication guidelines, while most publication professionals had a moderate or high self-assessed familiarity. The main barriers to application of publication guidelines, as rated by publication professionals, were that external authors in APAC are not familiar with global publication guidelines and do not always provide feedback/responses in writing.</p><p><strong>Conclusion: </strong>It is important to consider the diverse language, cultural, and communication preferences of individuals involved in English-language publication development in APAC, and to ensure that authors are aware of current publication guidelines and best practices.</p>","PeriodicalId":10814,"journal":{"name":"Current Medical Research and Opinion","volume":" ","pages":"1809-1819"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical manifestations, healthcare resource utilization, and costs among patients with long-chain fatty acid oxidation disorders: a retrospective claims database analysis. 长链脂肪酸氧化紊乱患者的临床表现、医疗资源利用率和成本:一项回顾性索赔数据库分析。
IF 2.3 4区 医学
Current Medical Research and Opinion Pub Date : 2024-09-18 DOI: 10.1080/03007995.2024.2405124
Erru Christy Yang,Zhenzhen Fang,Ruixin Tan,Yun Guo,Siyi He,Eliza Kruger,Justin Nedzesky,Deborah Marsden
{"title":"Clinical manifestations, healthcare resource utilization, and costs among patients with long-chain fatty acid oxidation disorders: a retrospective claims database analysis.","authors":"Erru Christy Yang,Zhenzhen Fang,Ruixin Tan,Yun Guo,Siyi He,Eliza Kruger,Justin Nedzesky,Deborah Marsden","doi":"10.1080/03007995.2024.2405124","DOIUrl":"https://doi.org/10.1080/03007995.2024.2405124","url":null,"abstract":"OBJECTIVELong-chain fatty acid oxidation disorders (LC-FAOD) are a group of rare genetic inborn errors of metabolism. Clinical manifestations may result in frequent healthcare visits, hospitalizations, and early death. This retrospective cohort study assessed manifestations, healthcare resource use (HRU), direct medical costs, and the impact of COVID-19 on HRU among patients with LC-FAOD.METHODSThe IQVIA PharMetrics Plus database was searched for pediatric (0-17 years) and adult (≥18 years) patients with confirmed LC-FAOD (ICD-10-CM Diagnosis Code E71.310) and ≥12 months continuous enrollment (CE) between January 2016-February 2020. A non-LC-FAOD general population cohort was randomly selected and matched using 1:20 exact matching on age, gender, payer type, and CE start year. Manifestations were identified via ICD-10 diagnosis codes (any billing position). Overall HRU and attributable costs were stratified by care setting. Pre-COVID-19 (March 2019-February 2020) and during COVID-19 (March 2020-February 2021) HRU was assessed among a subgroup of patients and the general population. Outcomes were evaluated among children and adults, respectively.RESULTS423 patients with LC-FAOD (47% female; 79.7% children) were included. Mean enrollment duration was 2.6 ± 1.2 years. 22.6% of children with LC-FAOD had at least one major clinical event (MCE), consisting of rhabdomyolysis (10.1%), hypoglycemia (9.8%), or cardiomyopathy (8.6%) versus 1.5% overall occurrence in the general population. Adults with LC-FAOD had higher incidence of MCEs (37.2%) than children with LC-FAOD. Annualized all-cause HRU in all care settings and mean total annualized medical costs (children: $17,082 vs $4,144; adults: $43,602 vs $3,949) were higher in patients with LC-FAOD versus the general population. Patients with LC-FAOD had substantially fewer healthcare visits during COVID-19 across care settings than during the pre-COVID-19 period.CONCLUSIONSLC-FAOD impart a high burden on patients. Extended hospital stays and increased outpatient management were especially pronounced for adults and for patients with ≥1 MCE, resulting in substantially higher medical costs than the general population.","PeriodicalId":10814,"journal":{"name":"Current Medical Research and Opinion","volume":"PP 1","pages":"1-40"},"PeriodicalIF":2.3,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Government's bold initiatives: tackling cervical cancer in India with determination and commitment. 政府的大胆举措:以坚定的决心和承诺应对印度的宫颈癌。
IF 2.4 4区 医学
Current Medical Research and Opinion Pub Date : 2024-09-01 Epub Date: 2024-08-16 DOI: 10.1080/03007995.2024.2388221
Rabin Devnath, Kalicharan Sharma
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