{"title":"Developments in Fungal Serology.","authors":"P Lewis White","doi":"10.1007/s12281-023-00462-4","DOIUrl":"10.1007/s12281-023-00462-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>The true incidence of fungal disease is hampered by conventionally poor diagnostic tests, limited access to advanced diagnostics, and limited surveillance. The availability of serological testing has been available for over two decades and generally underpins the modern diagnosis of the most common forms of fungal disease. This review will focus on technical developments of serological tests for the diagnosis of fungal disease, describing advances in clinical performance when available.</p><p><strong>Recent findings: </strong>Despite their longevity, technical, clinical, and performance limitations remain, and tests specific for fungal pathogens outside the main pathogens are lacking. The availability of LFA and automated systems, capable of running multiple different tests, represents significant developments, but clinical performance data is variable and limited.</p><p><strong>Summary: </strong>Fungal serology has significantly advanced the diagnosis of the main fungal infections, with LFA availability increasing accessibility to testing. Combination testing has the potential to overcome performance limitations.</p>","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":" ","pages":"1-12"},"PeriodicalIF":1.4,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10099008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10073755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Mayorga-Rodríguez, S. E. Reyes-Meza, Adriana del Carmen Rodríguez-Mena, D. G. Villanueva-Quintero, A. Pérez-Romero, Katia Alejandra Wheber Hidalgo
{"title":"Prevalence of Onychomycosis in Patients with Psoriasis","authors":"J. Mayorga-Rodríguez, S. E. Reyes-Meza, Adriana del Carmen Rodríguez-Mena, D. G. Villanueva-Quintero, A. Pérez-Romero, Katia Alejandra Wheber Hidalgo","doi":"10.1007/s12281-023-00457-1","DOIUrl":"https://doi.org/10.1007/s12281-023-00457-1","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"17 1","pages":"119 - 123"},"PeriodicalIF":1.4,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43558110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of HIV-Associated Cryptococcal Meningitis","authors":"Matt Osborn, A. Spec, Patrick B. Mazi","doi":"10.1007/s12281-023-00458-0","DOIUrl":"https://doi.org/10.1007/s12281-023-00458-0","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"1 1","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43312784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Invasive Aspergillosis and the Impact of Azole-resistance.","authors":"Davide Bosetti, Dionysios Neofytos","doi":"10.1007/s12281-023-00459-z","DOIUrl":"10.1007/s12281-023-00459-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>IA (invasive aspergillosis) caused by azole-resistant strains has been associated with higher clinical burden and mortality rates. We review the current epidemiology, diagnostic, and therapeutic strategies of this clinical entity, with a special focus on patients with hematologic malignancies.</p><p><strong>Recent findings: </strong>There is an increase of azole resistance in <i>Aspergillus</i> spp. worldwide, probably due to environmental pressure and the increase of long-term azole prophylaxis and treatment in immunocompromised patients (e.g., in hematopoietic stem cell transplant recipients). The therapeutic approaches are challenging, due to multidrug-resistant strains, drug interactions, side effects, and patient-related conditions.</p><p><strong>Summary: </strong>Rapid recognition of resistant <i>Aspergillus</i> spp. strains is fundamental to initiate an appropriate antifungal regimen, above all for allogeneic hematopoietic cell transplantation recipients. Clearly, more studies are needed in order to better understand the resistance mechanisms and optimize the diagnostic methods to identify <i>Aspergillus</i> spp. resistance to the existing antifungal agents/classes. More data on the susceptibility profile of <i>Aspergillus</i> spp. against the new classes of antifungal agents may allow for better treatment options and improved clinical outcomes in the coming years. In the meantime, continuous surveillance studies to monitor the prevalence of environmental and patient prevalence of azole resistance among <i>Aspergillus</i> spp. is absolutely crucial.</p>","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9706609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charles Gaulin, Zoey I. Harris, Rich Kodama, M. Shah, J. Blair, Yucai Wang, Yi Lin, J. Munoz
{"title":"Fungal Infections Associated with CD19-Targeted Chimeric Antigen Receptor T Cell Therapy","authors":"Charles Gaulin, Zoey I. Harris, Rich Kodama, M. Shah, J. Blair, Yucai Wang, Yi Lin, J. Munoz","doi":"10.1007/s12281-023-00460-6","DOIUrl":"https://doi.org/10.1007/s12281-023-00460-6","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"1 1","pages":"1-11"},"PeriodicalIF":1.4,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47590708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Ekeng, U. Emanghe, Adeyinka A. Davies, R. Oladele
{"title":"A Critical Review of Diagnostic Methods for Disseminated Histoplasmosis with Special Focus on Resource-Limited Settings","authors":"B. Ekeng, U. Emanghe, Adeyinka A. Davies, R. Oladele","doi":"10.1007/s12281-023-00454-4","DOIUrl":"https://doi.org/10.1007/s12281-023-00454-4","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"17 1","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43143923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of Fungal Osteoarticular Infections","authors":"M. Henry, Andy O. Miller","doi":"10.1007/s12281-023-00453-5","DOIUrl":"https://doi.org/10.1007/s12281-023-00453-5","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"17 1","pages":"25-35"},"PeriodicalIF":1.4,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52680165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Coccidioidomycosis in Pregnancy: an Update on Contributions to the Literature in the Past 5 Years","authors":"E. Niehaus, V. Wormser, A. Carey","doi":"10.1007/s12281-023-00452-6","DOIUrl":"https://doi.org/10.1007/s12281-023-00452-6","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"17 1","pages":"49-53"},"PeriodicalIF":1.4,"publicationDate":"2023-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48312289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic Challenges of Coccidioidomycosis in Solid Organ and Hematopoietic Stem Cell Transplant Recipients","authors":"Mohanad Al-Obiaidi, T. Zangeneh","doi":"10.1007/s12281-023-00449-1","DOIUrl":"https://doi.org/10.1007/s12281-023-00449-1","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"17 1","pages":"10-14"},"PeriodicalIF":1.4,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45184460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Strategies to Prevent Transmission of <i>Candida auris</i> in Healthcare Settings.","authors":"Suhail Ahmad, Mohammad Asadzadeh","doi":"10.1007/s12281-023-00451-7","DOIUrl":"10.1007/s12281-023-00451-7","url":null,"abstract":"<p><strong>Purpose of review: </strong><i>Candida auris</i>, a recently recognized yeast pathogen, has become a major public health threat due to the problems associated with its accurate identification, intrinsic and acquired resistance to antifungal drugs, and its potential to easily contaminate the environment causing clonal outbreaks in healthcare facilities. These outbreaks are associated with high mortality rates particularly among older patients with multiple comorbidities under intensive care settings. The purpose of this review is to highlight strategies that are being adapted to prevent transmission of <i>C. auris</i> in healthcare settings.</p><p><strong>Recent findings: </strong>Colonized patients shed <i>C. auris</i> into their environment which contaminates surrounding equipment. It resists elimination even by robust decontamination procedures and is easily transmitted to new patients during close contact resulting in outbreaks. Efforts are being made to rapidly identify <i>C. auris</i>-infected/<i>C. auris</i>-colonized patients, to determine its susceptibility to antifungals, and to perform effective cleaning and decontamination of the environment and isolation of colonized patients to prevent further transmission.</p><p><strong>Summary: </strong>Rapid and accurate identification of hospitalized patients infected/colonized with <i>C. auris</i>, rapid detection of its susceptibility patterns, and appropriate use of infection control measures can help to contain the spread of this highly pathogenic yeast in healthcare settings and prevent/control outbreaks.</p>","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"17 1","pages":"36-48"},"PeriodicalIF":2.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9150639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}