Candidiasis and Other Emerging Yeasts.

IF 2.3 Q3 INFECTIOUS DISEASES

Current Fungal Infection Reports Pub Date : 2023-01-01 DOI:10.1007/s12281-023-00455-3

Megha Sharma, Arunaloke Chakrabarti

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引用次数: 7

Abstract

Purpose of review: The review presents a comprehensive and updated information on the contemporary status of invasive candidiasis (IC), other emerging yeast infections, and the challenges they present in terms of at-risk population, specific virulence attributes, and antifungal susceptibility profile.

Recent findings: With the advancement in medical field, there has been parallel expansion of vulnerable populations over the past two decades. This had led to the emergence of a variety of rare yeasts in healthcare settings, both Candida and non-Candida yeast causing sporadic cases and outbreaks. The advancements in diagnostic modalities have enabled accurate identification of rare Candida species and non-Candida yeast (NCY) of clinical importance. Their distribution and susceptibility profile vary across different geographical regions, thus necessitating surveillance of local epidemiology of these infections to improve patient outcomes.

Summary: The challenges in management of IC have been complicated with emergence of newer species and resistance traits. C. tropicalis has already overtaken C. albicans in many Asian ICUs, while C. auris is rising rapidly worldwide. Recent genomic research has reclassified several yeasts into newer genera, and an updated version of MALDI-TOF MS or ITS sequencing is necessary for accurate identification. Having a knowledge of the differences in predisposing factors, epidemiology and susceptibility profile of already established pathogenic yeasts, as well as new emerging yeasts, are imperative for better patient management.

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念珠菌病和其他新兴酵母菌。

综述目的:本综述提供了关于侵袭性念珠菌病(IC)和其他新发酵母菌感染的全面和最新信息，以及它们在高危人群、特定毒力属性和抗真菌敏感性方面所面临的挑战。最近的研究发现:近二十年来，随着医学领域的进步，弱势群体也在平行扩大。这导致在医疗机构中出现各种罕见酵母菌，念珠菌和非念珠菌引起零星病例和暴发。在诊断方式的进步，使准确鉴定罕见的念珠菌种类和非念珠菌(NCY)的临床重要性。它们的分布和易感性在不同的地理区域有所不同，因此有必要对这些感染的当地流行病学进行监测，以改善患者的预后。摘要:随着新物种和抗性性状的出现，IC管理面临的挑战变得更加复杂。在许多亚洲icu中，热带梭菌已经超过白色梭菌，而在世界范围内，耳梭菌正在迅速上升。最近的基因组研究已经将一些酵母重新分类为新的属，更新版本的MALDI-TOF MS或ITS测序是准确鉴定的必要条件。了解易感因素、流行病学和已建立的致病酵母以及新出现的酵母的易感性特征的差异，对于更好地管理患者是必不可少的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Fungal Infection Reports INFECTIOUS DISEASES-

CiteScore

3.10

自引率

7.10%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of fungal infections. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as advances in diagnosis, current and emerging management approaches, and genomics and pathogenesis. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. Commentaries from well-known figures in the field are also provided, and an international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research.