Current issues in pharmacy and medicine: science and practice最新文献

{"title":"Biological features of new 1,2,4-triazole derivatives (a literature review)","authors":"M. V. Ohloblina","doi":"10.14739/2409-2932.2022.1.252305","DOIUrl":"https://doi.org/10.14739/2409-2932.2022.1.252305","url":null,"abstract":"Modern chemistry of 1,2,4-triazoles is in need of the search for more rational ways of synthesizing biologically active substances. To date, a number of attractive alternatives to the classical methods for the synthesis of potentially biologically active derivatives among 1,2,4-triazoles are known. The above mentioned compounds demonstrate antimicrobial, antifungal, antioxidant, anti-inflammatory, antiviral activity, etc. Based on the results of literary sources generalization, a promising direction of scientific research was chosen.\u0000The aim of this work is to determine the direction of modern organic synthesis, clearly indicating the possibility of various chemical modeling of 1,2,4-triazoles and the peculiarities of using their derivatives.\u0000Materials and methods. The following methods were used in the work: synthetic, analytical, information retrieval, descriptive, generalization. The materials for the study comprised literary sources containing information on the relevance and prospects for further chemical modeling of 1,2,4-triazole.\u0000Results. A search, analysis and generalization of attractive alternatives to classical methods for the synthesis of potentially biologically active derivatives among 1,2,4-triazoles was carried out. Based on the study of a large amount of information and patent search over the past 10 years, about 700 sources of information have been found. They highlight the work of scientific teams from around the world devoted to screening studies of the antibacterial activity of new 3-aryl-5-mercapto-1,2,4-triazoles and tetra-O-acetyl-α-D-glucopyranosyl bromide; search for a number of new compounds among 4,5-diphenyl-4H-1,2,4-triazole-3-thiols with pronounced antibacterial activity against S. aureus and antifungal activity against Candida albicans; identification of new candidates among thiazolo[3,2-b]-1,2,4-triazol-5(6H)-one molecules with analgesic and anti-inflammatory activity; bringing moderate antimicrobial and fairly high antifungal activity of the above compounds.\u0000Conclusions. Processing, elements of systematization, comparison and generalization of modern information sources indicate rather high rates of biological activity of 1,2,4-triazole derivatives.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73249405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of biological properties of 1,2,4-triazole-containing compounds (literature review)","authors":"A. Khilkovets, V. Parchenko","doi":"10.14739/2409-2932.2022.1.252392","DOIUrl":"https://doi.org/10.14739/2409-2932.2022.1.252392","url":null,"abstract":"In the latest conditions of development and formation of the pharmaceutical industry, the introduction of new synthetic medicines requires continuous monitoring of the quality and safety of their use. For many years, synthetic drugs have remained an essential tool in the prevention and control of diseases of various etiologies. Among the synthetic class of substances, first of all, those that are low-toxic, safe, and effective deserve attention. In recent decades scientific publications prove the prospects of searching for new biologically active compounds among derivatives of 1,2,4-triazoles with fragments of various heterocyclic systems. Scientists claim that the combination of several structural fragments of heterocycles in one molecule leads to the emergence of new types of biological action, and sometimes to an increase in known pharmacological effects. At the same time, the synthesized compounds belong to the class of low-toxic or practically non-toxic substances.\u0000The aim of our work is to analyze foreign and native sources on the biological activity of 1,2,4-triazole derivatives.\u0000Conclusions. Among these derivatives, molecules that exhibit broad antifungal and antimicrobial activity, antitubercular, antiviral, actoprotective, antihypoxic, analgesic effects, etc. were found. After analyzing the known data, a number of «structure-action» regularities were established. The obtained results will be useful for further research work of scientists.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77647026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the quality of life indicators in patients with urate nephrolithiasis comorbid with metabolic syndrome","authors":"S. Bilai","doi":"10.14739/2409-2932.2022.1.244446","DOIUrl":"https://doi.org/10.14739/2409-2932.2022.1.244446","url":null,"abstract":"Kidney stone disease (KSD) is one of the most common urological diseases; however, until recently, there was no specific tools for the study of the influence of urate nephrolithiasis (UN) on the patients’ quality of life. The use of WISQOL quality of life questionnaire enabled quantitative evaluation of the subjective notion and enhanced the insight on the condition of a patient with UN in general, for measuring the broad scope of functions of health perception.\u0000The aim of the research is to study quality of life indicators in patients with UN comorbid with metabolic syndrome.\u0000Materials and methods. The study included 65 patients with UN and UN comorbid with MS. In the control group, there were 21 patients with UN who received traditional therapy. The comparison group comprised 21 patients with UN comorbid with MS, who received both traditional therapy and drugs that correct metabolic disorders. The main group consisted of 23 patients with UN comorbid with MS, who took quertin against the background of the traditional therapy and drugs that correct metabolic disorders. To assess the quality of life, the WISQOL questionnaire was used, which included 4 domains: social impact (SI), emotional impact (EI), health impact (HI) and impact on life activity (ILA). The patients’ condition was assessed before treatment and after 1.5–6.0 months.\u0000Results. After the treatment, main group patients demonstrated an increase of EI indicator; comparison group patients demonstrated an increase in EI, ILA, and HI indicators. The efficacy of quertin was confirmed by an increase in ILA, SI, and HI indicators.\u0000Conclusions. The levels of SI and HI were decreasing before treatment in patients with UN comorbid with MS from the comparison and the main groups. The use of quertin against the background of the traditional therapy and drugs that correct metabolic processes, significantly increased EI and ILA levels.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80432895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of TNF-α and INF-γ content in blood serum in connection with the marker profile of patients with acute hepatitis B at different degrees of severity of the disease","authors":"A. Khelemendyk","doi":"10.14739/2409-2932.2022.1.251211","DOIUrl":"https://doi.org/10.14739/2409-2932.2022.1.251211","url":null,"abstract":"The aim – is to analyze the dynamics of the content of TNF-α and INF-γ in the serum in connection with the marker profile of patients with acute hepatitis B at different degrees of severity of the disease.\u0000Materials and methods. 32 patients with AHB were examined in the dynamics of the disease with the determination of HBsAg, HBeAg, anti-HBs and anti-HBe, the content of TNF-α and IFN-γ by ELISA. Statistical processing was performed in Statistica 13 for Windows (StatSoft Inc., No. JPZ804I382130ARCN10-J).\u0000Results. Patients with severe (40.6 %) and moderate (37.5 %) courses of the disease predominate among patients with AHB. Severe course of AHB, compared with the moderate course, was characterized by higher levels of hyperbilirubinemia (P < 0.05), cytolytic syndrome (P < 0.05), hypoproteinemia (P < 0.05), and signs of hypocoagulation (P < 0.05). HBsAg (P < 0.05) was more often observed in patients with moderate and severe AHB (P < 0.05) in the absence of a difference in the frequency of seroconversion for HBeAg. Seroconversion of HBsAg/anti-HBs at 6 months was lowest after mild (66.7 %), compared with moderate (91.7 %) and severe (100.0 %) (P > 0.05) course of the disease. Regardless of the severity of AHB, the content of TNF-α was higher (P < 0.05) than in healthy individuals and highest in the severe course of the disease (P < 0.05). The content of INF-γ was higher than in healthy individuals (P < 0.05), regardless of the severity of the disease. TNF-α correlated with the severity of AHB (r = 0.57, P < 0.05), the level of total bilirubin (r = 0.65, P < 0.05), INR (r = 0.42, P < 0.05) and PI (r = -0.48, P < 0.05) at hospitalization.\u0000Conclusions. Patients with severe (40.6 %) and moderate (37.5 %) courses of the disease predominate among the hospitalized patients with AHB. At hospitalization, the content of TNF-α is highest in the severe course of the disease (P < 0.05). The content of INF-γ is higher than in healthy individuals (P < 0.05), regardless of the severity of the course of AHB. At hospitalization, all patients were positive for HBsAg and IgM anti-HBcorAg, the vast majority of patients for HBeAg. Positive HBsAg was more often (P < 0.05) in patients with a moderate course of AHB during discharge from the hospital. HBeAg was preserved in 28.6 % of patients with the mild course. Chronic HBV infection was observed in 3.6 % of patients with the mild course.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89185975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marketing research of the domestic market of antibiotics and chemotherapeutic drugs for use in dermatology","authors":"T. P. Zarichna, T. Brytanova, T. S. Raikova","doi":"10.14739/2409-2932.2022.1.251540","DOIUrl":"https://doi.org/10.14739/2409-2932.2022.1.251540","url":null,"abstract":"The aim of work is marketing research of the domestic market of antibiotics and chemotherapeutic drugs for use in dermatology.\u0000Materials and methods. To achieve this goal, electronic official sources of information and pharmacy websites were used. System-analytical, mathematical-statistical, and comparative methods of analysis were employed.\u0000Results. Analysis of the assortment structure of the domestic market of antibiotics and chemotherapeutic drugs for use in dermatology allowed us to establish that in this segment there are original drugs (30.4 %) and generics (69.6 %), monopreparations (84.1 %) and combined (15.9 %) ones. Drugs of the studied group are represented by various dosage forms, among which soft dosage forms dominate (85.4 %). When studying the corporate structure of this market segment, it was found that 56.6 % of drugs come from abroad from 12 countries of the world and 21 pharmaceutical companies, the leader of which is the United Kingdom (dij = 0.0758). The study of the level of competition showed that the greatest competition is observed among the manufacturers of acyclovir and mupirocin generics (Kvi = 0.89). Calculation of the liquidity ratio, which exceeds 0.5, confirms incomplete availability of these medicines for the population of Ukraine.\u0000Conclusions. A marketing study of the domestic market of antibiotics and chemotherapeutic drugs for use in dermatology was conducted. The assortment and corporate structures of this market segment are defined. The level of competitiveness of the pharmaceutical companies is analyzed, and the most successful ones are identified. The liquidity and solvency ratio was calculated, which allowed us to draw conclusions about the availability of these medicines for the population of Ukraine. In the future, in the healthcare system of Ukraine, an important direction should be outlined to improve the system of providing medical care to patients with dermatological diseases.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79487090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marketing analysis of the pharmaceutical market of antidiabetic drugs in Ukraine","authors":"A. Savych, B. Pavliuk","doi":"10.14739/2409-2932.2022.1.252509","DOIUrl":"https://doi.org/10.14739/2409-2932.2022.1.252509","url":null,"abstract":"Diabetes mellitus is an important public health issue. Statistics show a rapid growth in the number of patients each year, which increases the financial burden on the state’s economy. Therefore, systematic marketing monitoring of the pharmaceutical market of drugs for diabetes is appropriate and permanently relevant.\u0000The aim of the research was to study the pharmaceutical market of antidiabetic drugs in Ukraine as of the first quarter of 2022.\u0000Materials and methods. The nomenclature range of drugs was analyzed in accordance with the State Register and the Anatomical-Therapeutic-Chemical Classification. The objects of research were information on synthetic hypoglycemic drugs registered in Ukraine, as well as herbal medicines belonging to the category A10 “Antidiabetic drugs”. Analytical and comparative methods, as well as marketing analysis and generalization of information were applied.\u0000Results. The structure of the pharmaceutical market of medicines from category A10 “Antidiabetic drugs” is formed by mono-drugs, their share is 84.2 %, while combined drugs make 12.9 %, and only 2.9 % belongs to medicinal plant raw materials and their mixtures. Among mono-drugs, the most numerous by the number of trade names is the group of sulfonylureas and biguanides, the percentage of which is 33.9 %. The pharmaceutical market of antidiabetic drugs in Ukraine is import-dependent, as the share of foreign medicines from 24 importing countries is 59.3 %. Domestic manufacturers of drugs for type 2 diabetes are 10 pharmaceutical companies, among which production output is dominated by JSC “Farmak” – 31.9 %. Preparations based on medicinal plant raw materials are manufactured by PJSC “Liktravy” and PJSC Pharmaceutical Factory “Viola” in the form of mixtures and medicinal raw materials.\u0000Conclusions. The nomenclature ranges of drugs, which according to the ATC classification belong to the category A10 “Antidiabetic drugs”, are analyzed and the structure of the segment is described. The range of herbal antidiabetic drugs has been studied and their share in the structure of the pharmaceutical market of Ukraine has been determined. The prevalence of foreign-made drugs over domestic ones has been established.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76392553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of industrial technology of plant substance of cultivated parsnip herb thick extract","authors":"N. А. Symonenko, O. Shpychak","doi":"10.14739/2409-2932.2022.1.251976","DOIUrl":"https://doi.org/10.14739/2409-2932.2022.1.251976","url":null,"abstract":"The aim of the work is to develop the industrial technology of domestic phyto-substance of cultivated parsnip herb thick extract (CPHTE) with the aim of its further introduction into a tablet dosage form of cardioprotective action.\u0000Materials and methods. As an object of research, the experimental samples of parsnip herb (Pastinacae sativae herba) of the domestic selection of the Petryk variety, harvested on the experimental fields of the Institute of Vegetable and Melon Growing of the National Academy of Agrarian Sciences of Ukraine (Kharkiv region) were used to obtain the plant substance CPHTE (Pastinacae sativae herbae extractispissi).\u0000Results. The results of experimental research were used while development of a block scheme of the production technological process of plant substance CPHTE and an apparatus scheme tested in industrial conditions of LLC Pharmaceutical Company “Zdorovye” (Kharkiv, Ukraine) and control technological parameters for each stage of the technological process for manufacturing the developed thick extract have been established.\u0000Conclusions. The technology of the domestic plant substance CPHTE production, as well as the blocking scheme of the technological process, and the apparatus scheme tested in industrial conditions of LLC Pharmaceutical Company “Zdorovye” (Kharkiv) had been theoretically substantiated and experimentally developed. The results of the experiment were used in the development of methods for quality control projects and technological regulations for the developed plant substance.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85463001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study by GC-MS method of Thymus x citriodorus (Pers.) Schreb. var. “Silver Queen” extracts component composition","authors":"Ya. M. Steshenko, O. V. Mazulin","doi":"10.14739/2409-2932.2022.1.251416","DOIUrl":"https://doi.org/10.14739/2409-2932.2022.1.251416","url":null,"abstract":"The Thyme L. genus is quite common in Ukraine, herbal extracts are part of many effective herbal medicinal products that are widely used in modern phytocosmetology. Today, genus Thymus x citriodorus (Pers.) Schreb. var. “Silver Queen” is poorly studied but promising in terms of sufficient raw material base and BAS. Therefore, the GC-MS method of designating the component of the extract from herb splint is relevant.\u0000The aim of the work is to determine by the GC-MS method of the component alcohol extracts (1:10) compositions of Thymus x citriodorus (Pers.) Schreb. var. “Silver Queen” herbs from Ukrainian flora.\u0000Materials and methods. For the experimental studies, we used alcoholic extracts of Thymus х citriodorus (Pers.) Schreb. var. “Silver Queen” from herbs (1:10) harvested from Ukrainian flora. The component composition of extracts was analyzed using an Agilent 7890B gas chromatography with 5977B a mass – spectrometric detector.\u0000Results. By the GC-MS method were revealed up to 63 compounds. Two compounds were not identified. It is important to note, that seven biologically active compounds were revealed in a concentration over 5 %: oleic acid (10.35 ± 1.42 %), caryophyllene oxide (9.62 ± 0.97 %), matricarin (7.59 ± 0.86 %), trans-citral (6.35 ± 0.75 %), β-bisabolene (6.15 ± 0.75 %), thymol (5.46 ± 0.70 %).\u0000Conclusions. Taking into account by GC-MS method, it can be concluded that the studied species is relevant for further phytochemical study.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77246751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chromato-mass spectrometric study of valerian infusion with various extractants","authors":"V. Odyntsova, V. H. Korniievska, S. Panchenko, Yu. I. Korniievskyi, V. I. Kokitko","doi":"10.14739/2409-2932.2022.1.252374","DOIUrl":"https://doi.org/10.14739/2409-2932.2022.1.252374","url":null,"abstract":"Valerian Officinalis (Valeriana officinalis L.s.p.) is a collective species in Ukraine. It contains 13 species, including in the south of Ukraine grows valerian (V. stolonifera Czern.). At the present stage, it is confirmed that the calming and antispasmodic properties of valerian raw materials are due to the content of valepotriates, sesquiterpenoids and aromatic substances, in particular eugenol derivatives. That is why in many countries around the world a number of drugs have been created on their basis.\u0000The aim of our research is to determine the component composition of tinctures of tinctures of V. stolonifera Czern. made of 70 % alcohol and methanol using gas chromatography.\u0000Materials and methods. Raw materials (underground organs) Valerianae radices were harvested in March 2020 in Zaporizhzhia, Kantserivska Balka. Valerian tincture was prepared from fresh raw materials according to the method of making tinctures. The tincture was investigated on a gas chromatograph Agilent 7890B with mass spectrometric detector 5977B. The NIST14 mass spectrum library was used to identify the components.\u0000Results. 77 components were identified by gas chromatography in methanolic tincture of V. stolonifera Czern. roots, 13 components were isolated quantitatively. In the analysis of the chromatogram and the characteristic of the area of the peaks of the alcoholic tincture of V. stolonifera Czern. roots, 78 components were identified, 11 components were isolated quantitatively. At the comparative characteristic of chromatograms 39 components coincide. Of the main components, the largest content is: 13.413 RT methanolic 1(2H)-Naphthalenone, octahydro-4a,8a-dimethyl-7-(1-methylethyl)-, [4aR-(4a.α.,7.β.,8a.α.)] – 5.34 % 13.414 RT alcohol – 8.41 %; 11.943 RT methanolic Myrtenyl isovalerate – 3.88 %; 11,942 RT alcohol – 5.15 %; 15.362 RT methanolic Kessanyl acetate – 2.52 %; 15.360 RT Kessanyl acetate alcohol – 1.41 %.\u0000Conclusions. It was seen that valerian tinctures with methanol and alcohol extractant differ in both quantitative and qualitative composition analyzing the obtained data of gas chromatography. 39 Compounds were present in all tinctures; three of them were present in large quantities. According to the results of the study, data have been obtained that show that the best indicators of the quantitative and qualitative composition of the tincture of V. stolonifera Czern. were obtained using the extractant 70 % alcohol.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75836626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of pharmaceutical market of dietary supplements with green tea leaves extract","authors":"O. Maslov, S. Kolisnyk, M. Komisarenko, S. M. Poluian, M. Holik, T. Tomarovska","doi":"10.14739/2409-2932.2022.1.252651","DOIUrl":"https://doi.org/10.14739/2409-2932.2022.1.252651","url":null,"abstract":"The aim of work is to study the assortment of dietary supplements with green tea leaves extract on the modern pharmaceutical market to further search for ways to improve and optimize pharmaceutical supply.\u0000Materials and methods. The assortment of dietary supplements with green tea leaves extract was studied basing on the search of dietary supplements in pharmacies of Ukraine in the internet resources. For study of assortment of dietary supplements, the following methods were used: marketing, statistical, logic and graphic.\u0000Results. The assortment of dietary supplements with green tea leaves extract has been analyzed. The results showed that the leaders in the number of manufacturers in the analyzed group of dietary supplements are the United States, Ukraine, and Poland, their part is 61 %, 16 % and 8 %, respectively. In terms of assortment, the United States ranks first – 66 %. Dietary supplements are presented in 6 dosage forms, most of them are capsules (60 %). It was determined that monopreparations predominate in the pharmaceutical market and account for 77 %. The price segmentation of the market of dietary supplements with green tea leaves extract has been provided, the results showed that most of these are dietary supplements in the price range of 200–500 UAH. The study of the company structure made it possible to identify leaders among foreign companies; the top three companies included Now Foods (27 %), Swanson (20 %), Puritan’s Pride (14 %).\u0000Conclusions. There are 42 dietary supplements with green tea leaves extract at the beginning of 2022 in Ukraine. On the temporary pharmaceutical market of Ukraine 84 % of dietary supplements with green tea extract are presented by foreign manufacturers, mainly by monopreparations, in the form of capsules and in the price range from 200 to 500 UAH.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"170 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74907569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}