1,2,4-三唑类化合物的生物学特性分析(文献综述)

A. Khilkovets, V. Parchenko
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引用次数: 1

摘要

在制药业发展和形成的最新条件下,引入新的合成药物需要对其使用的质量和安全进行持续监测。多年来,合成药物一直是预防和控制各种病因疾病的重要工具。在合成类物质中,首先是那些低毒、安全、有效的物质值得关注。近几十年来,科学出版物证明了在含有各种杂环体系片段的1,2,4-三唑衍生物中寻找新的生物活性化合物的前景。科学家声称,杂环的几个结构片段在一个分子中的结合会导致新的生物作用类型的出现,有时会增加已知的药理作用。同时,所合成的化合物属于低毒或几乎无毒的物质。本研究的目的是分析国内外有关1,2,4-三唑衍生物的生物活性。在这些衍生物中,发现了具有广泛的抗真菌和抗菌活性、抗结核、抗病毒、活性保护、抗缺氧、镇痛等作用的分子。通过对已知数据的分析,建立了一系列“结构-作用”规律。所得结果对科学家们进一步的研究工作是有用的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of biological properties of 1,2,4-triazole-containing compounds (literature review)
In the latest conditions of development and formation of the pharmaceutical industry, the introduction of new synthetic medicines requires continuous monitoring of the quality and safety of their use. For many years, synthetic drugs have remained an essential tool in the prevention and control of diseases of various etiologies. Among the synthetic class of substances, first of all, those that are low-toxic, safe, and effective deserve attention. In recent decades scientific publications prove the prospects of searching for new biologically active compounds among derivatives of 1,2,4-triazoles with fragments of various heterocyclic systems. Scientists claim that the combination of several structural fragments of heterocycles in one molecule leads to the emergence of new types of biological action, and sometimes to an increase in known pharmacological effects. At the same time, the synthesized compounds belong to the class of low-toxic or practically non-toxic substances. The aim of our work is to analyze foreign and native sources on the biological activity of 1,2,4-triazole derivatives. Conclusions. Among these derivatives, molecules that exhibit broad antifungal and antimicrobial activity, antitubercular, antiviral, actoprotective, antihypoxic, analgesic effects, etc. were found. After analyzing the known data, a number of «structure-action» regularities were established. The obtained results will be useful for further research work of scientists.
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