Critical Reviews in Biochemistry and Molecular Biology最新文献_第8页

RAGE and its ligands: from pathogenesis to therapeutics. RAGE及其配体:从发病机制到治疗方法。

IF 6.5 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2020-12-01 Epub Date: 2020-09-16 DOI: 10.1080/10409238.2020.1819194

Nitish Jangde, Rashmi Ray, Vivek Rai

{"title":"RAGE and its ligands: from pathogenesis to therapeutics.","authors":"Nitish Jangde, Rashmi Ray, Vivek Rai","doi":"10.1080/10409238.2020.1819194","DOIUrl":"https://doi.org/10.1080/10409238.2020.1819194","url":null,"abstract":"Receptor for advanced glycation end products (RAGE) is an immunoglobulin-like receptor present on cell surface. RAGE binds to an array of structurally diverse ligands, acts as a pattern recognition receptor (PRR) and is expressed on cells of different origin performing different functions. RAGE ligation leads to the initiation of a cascade of signaling events and is implicated in diseases, such as inflammation, cancer, diabetes, vascular dysfunctions, retinopathy, and neurodegenerative diseases. Because of the significant involvement of RAGE in the progression of numerous diseases, RAGE signaling has been targeted through use of inhibitors and anti-RAGE antibodies as a treatment strategy and therapy. Here in this review, we have summarized the physical and physiological aspects of RAGE biology in mammalian system and the importance of targeting this molecule in the treatment of various RAGE mediated pathologies. Highlights Receptor for advanced glycation end products (RAGE) is a member of immunoglobulin superfamily of receptors and involved in many pathophysiological conditions. RAGE ligation with its ligands leads to initiation of distinct signaling cascades and activation of numerous transcription factors. Targeting RAGE signaling through inhibitors and anti-RAGE antibodies can be promising treatment strategy.","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":"55 6","pages":"555-575"},"PeriodicalIF":6.5,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10409238.2020.1819194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38480453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Current perspectives on inhibitory SMAD7 in health and disease. 抑制SMAD7在健康和疾病中的当前观点。

IF 6.5 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2020-12-01 Epub Date: 2020-10-20 DOI: 10.1080/10409238.2020.1828260

Charlotte de Ceuninck van Capelle, Maureen Spit, Peter Ten Dijke

{"title":"Current perspectives on inhibitory SMAD7 in health and disease.","authors":"Charlotte de Ceuninck van Capelle, Maureen Spit, Peter Ten Dijke","doi":"10.1080/10409238.2020.1828260","DOIUrl":"https://doi.org/10.1080/10409238.2020.1828260","url":null,"abstract":"Transforming growth factor β (TGF-β) family members play an extensive role in cellular communication that orchestrates both early development and adult tissue homeostasis. Aberrant TGF-β family signaling is associated with a pathological outcome in numerous diseases, and in-depth understanding of molecular and cellular processes could result in therapeutic benefit for patients. Canonical TGF-β signaling is mediated by receptor-regulated SMADs (R-SMADs), a single co-mediator SMAD (Co-SMAD), and inhibitory SMADs (I-SMADs). SMAD7, one of the I-SMADs, is an essential negative regulator of the pleiotropic TGF-β and bone morphogenetic protein (BMP) signaling pathways. In a negative feedback loop, SMAD7 inhibits TGF-β signaling by providing competition for TGF-β type-1 receptor (TβRI), blocking phosphorylation and activation of SMAD2. Moreover, SMAD7 recruits E3 ubiquitin SMURF ligases to the type I receptor to promote ubiquitin-mediated proteasomal degradation. In addition to its role in TGF-β and BMP signaling, SMAD7 is regulated by and implicated in a variety of other signaling pathways and functions as a mediator of crosstalk. This review is focused on SMAD7, its function in TGF-β and BMP signaling, and its role as a downstream integrator and crosstalk mediator. This crucial signaling molecule is tightly regulated by various mechanisms. We provide an overview of the ways by which SMAD7 is regulated, including noncoding RNAs (ncRNAs) and post-translational modifications (PTMs). Finally, we discuss its role in diseases, such as cancer, fibrosis, and inflammatory bowel disease (IBD).","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":"55 6","pages":"691-715"},"PeriodicalIF":6.5,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10409238.2020.1828260","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38515378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Mammalian mitochondrial DNA replication and mechanisms of deletion formation. 哺乳动物线粒体DNA复制及缺失形成机制。

IF 6.5 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2020-12-01 Epub Date: 2020-09-24 DOI: 10.1080/10409238.2020.1818684

Maria Falkenberg, Claes M Gustafsson

引用次数: 30

NusG-dependent RNA polymerase pausing is a frequent function of this universally conserved transcription elongation factor. nusg依赖性RNA聚合酶暂停是这种普遍保守的转录延伸因子的常见功能。

IF 6.5 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2020-12-01 Epub Date: 2020-10-02 DOI: 10.1080/10409238.2020.1828261

Alexander V Yakhnin, Mikhail Kashlev, Paul Babitzke

{"title":"NusG-dependent RNA polymerase pausing is a frequent function of this universally conserved transcription elongation factor.","authors":"Alexander V Yakhnin, Mikhail Kashlev, Paul Babitzke","doi":"10.1080/10409238.2020.1828261","DOIUrl":"https://doi.org/10.1080/10409238.2020.1828261","url":null,"abstract":"Although transcription by RNA polymerase (RNAP) is highly processive, elongation can be transiently halted by RNAP pausing. Pausing provides time for diverse regulatory events to occur such as RNA folding and regulatory factor binding. The transcription elongation factors NusA and NusG dramatically affect the frequency and duration of RNAP pausing, and hence regulation of transcription. NusG is the only transcription factor conserved in all three domains of life; its homolog in archaea and eukaryotes is Spt5. This review focuses on NusG-dependent pausing, which is a common occurrence in Bacillus subtilis. B. NusG induces pausing about once per 3 kb at a consensus TTNTTT motif in the non-template DNA strand within the paused transcription bubble. A conserved region of NusG contacts the TTNTTT motif to stabilize the paused transcription elongation complex (TEC) in multiple catalytically inactive RNAP conformations. The density of NusG-dependent pause sites is 3-fold higher in untranslated regions, suggesting that pausing could regulate the expression of hundreds of genes in B. subtilis. We describe how pausing in 5' leader regions contributes to regulating the expression of B. subtilis genes by transcription attenuation and translation control mechanisms. As opposed to the broadly accepted view that NusG is an anti-pausing factor, phylogenetic analyses suggest that NusG-dependent pausing is a widespread mechanism in bacteria. This function of NusG is consistent with the well-established role of its eukaryotic homolog Spt5 in promoter-proximal pausing. Since NusG is present in all domains of life, NusG-dependent pausing could be a conserved mechanism in all organisms.","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":"55 6","pages":"716-728"},"PeriodicalIF":6.5,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10409238.2020.1828261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38544445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The molecular structure of long non-coding RNAs: emerging patterns and functional implications. 长链非编码rna的分子结构:新出现的模式和功能意义。

IF 6.5 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2020-12-01 Epub Date: 2020-10-12 DOI: 10.1080/10409238.2020.1828259

Isabel Chillón, Marco Marcia

引用次数: 44

From canonical to modified nucleotides: balancing translation and metabolism. 从标准核苷酸到修饰核苷酸:平衡翻译和代谢。

IF 6.5 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2020-12-01 Epub Date: 2020-09-16 DOI: 10.1080/10409238.2020.1818685

Federica Accornero, Robert L Ross, Juan D Alfonzo

{"title":"From canonical to modified nucleotides: balancing translation and metabolism.","authors":"Federica Accornero, Robert L Ross, Juan D Alfonzo","doi":"10.1080/10409238.2020.1818685","DOIUrl":"https://doi.org/10.1080/10409238.2020.1818685","url":null,"abstract":"Abstract Every type of nucleic acid in cells may undergo some kind of post-replicative or post-transcriptional chemical modification. Recent evidence has highlighted their importance in biology and their chemical complexity. In the following pages, we will describe new discoveries of modifications, with a focus on tRNA and mRNA. We will highlight current challenges and advances in modification detection and we will discuss how changes in nucleotide post-transcriptional modifications may affect cell homeostasis leading to malfunction. Although, RNA modifications prevail in all forms of life, the present review will focus on eukaryotic systems, where the great degree of intracellular compartmentalization provides barriers and filters for the level at which a given RNA is modified and will of course affect its fate and function. Additionally, although we will mention rRNA modification and modifications of the mRNA 5’-CAP structure, this will only be discussed in passing, as many substantive reviews have been written on these subjects. Here we will not spend much time describing all the possible modifications that have been observed; truly a daunting task. For reference, Bujnicki and coworkers have created MODOMICS, a useful repository for all types of modifications and their associated enzymes. Instead we will discuss a few examples, which illustrate our arguments on the connection of modifications, metabolism and ultimately translation. The fact remains, a full understanding of the long reach of nucleic acid modifications in cells requires both a global and targeted study of unprecedented scale, which at the moment may well be limited only by technology.","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":"55 6","pages":"525-540"},"PeriodicalIF":6.5,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10409238.2020.1818685","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38383196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Aromatase inhibitors. 芳香化酶抑制剂。

IF 6.5 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2020-11-25 DOI: 10.1007/978-3-7643-8693-1

J. Johnston

引用次数: 82

19-Noraldosterone. 19去羟甾酮。

IF 6.5 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2020-11-25 DOI: 10.1201/9781003068754-7

Y. Takeda

引用次数: 0

An updated perspective on the polymerase division of labor during eukaryotic DNA replication. 真核生物DNA复制过程中聚合酶分工的最新研究进展。

IF 6.5 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2020-10-01 Epub Date: 2020-09-03 DOI: 10.1080/10409238.2020.1811630

Thomas A Guilliam, Joseph T P Yeeles

引用次数: 28

Control of electron transfer by protein dynamics in photosynthetic reaction centers. 光合反应中心蛋白质动力学对电子转移的控制。

IF 6.5 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2020-10-01 Epub Date: 2020-09-03 DOI: 10.1080/10409238.2020.1810623

Michael Gorka, Dmitry A Cherepanov, Alexey Yu Semenov, John H Golbeck

{"title":"Control of electron transfer by protein dynamics in photosynthetic reaction centers.","authors":"Michael Gorka, Dmitry A Cherepanov, Alexey Yu Semenov, John H Golbeck","doi":"10.1080/10409238.2020.1810623","DOIUrl":"https://doi.org/10.1080/10409238.2020.1810623","url":null,"abstract":"Trehalose and glycerol are low molecular mass sugars/polyols that have found widespread use in the protection of native protein states, in both short- and long-term storage of biological materials, and as a means of understanding protein dynamics. These myriad uses are often attributed to their ability to form an amorphous glassy matrix. In glycerol, the glass is formed only at cryogenic temperatures, while in trehalose, the glass is formed at room temperature, but only upon dehydration of the sample. While much work has been carried out to elucidate a mechanistic view of how each of these matrices interact with proteins to provide stability, rarely have the effects of these two independent systems been directly compared to each other. This review aims to compile decades of research on how different glassy matrices affect two types of photosynthetic proteins: (i) the Type II bacterial reaction center from Rhodobacter sphaeroides and (ii) the Type I Photosystem I reaction center from cyanobacteria. By comparing aggregate data on electron transfer, protein structure, and protein dynamics, it appears that the effects of these two distinct matrices are remarkably similar. Both seem to cause a \"tightening\" of the solvation shell when in a glassy state, resulting in severely restricted conformational mobility of the protein and associated water molecules. Thus, trehalose appears to be able to mimic, at room temperature, nearly all of the effects on protein dynamics observed in low temperature glycerol glasses.","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":"55 5","pages":"425-468"},"PeriodicalIF":6.5,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10409238.2020.1810623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38343482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8