Critical Reviews in Biochemistry and Molecular Biology最新文献

From serendipity to strategy: molecular glue degraders in cancer therapeutics. 从偶然发现到策略：分子胶降解剂在癌症治疗中的应用。

IF 6.4 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2025-10-01 DOI: 10.1080/10409238.2025.2564068

Sarah Darling, Ilirjana Bajrami, Stephen C West

{"title":"From serendipity to strategy: molecular glue degraders in cancer therapeutics.","authors":"Sarah Darling, Ilirjana Bajrami, Stephen C West","doi":"10.1080/10409238.2025.2564068","DOIUrl":"https://doi.org/10.1080/10409238.2025.2564068","url":null,"abstract":"Targeted protein degradation is an elegant therapeutic strategy that harnesses the cell's own degradation machinery to selectively eliminate target proteins. This approach marks a paradigm shift in drug discovery, moving beyond traditional occupancy-based inhibition toward target degradation, thereby silencing proteins that have historically resisted pharmacological intervention. Degrader molecules function by inducing proximity between target proteins and effectors, most commonly E3 ubiquitin ligases, triggering their ubiquitylation and proteasomal degradation. Molecular glue degraders - monovalent small molecules that promote these neo-interactions - have emerged as powerful tools in this space. Serendipity was once synonymous with molecular glue discovery, but increasing mechanistic understanding is now guiding their rational design. In this review, we trace their evolution from chance discovery, explore the biological mechanisms that underpin molecular glue activity, examine key examples that have advanced into the clinic, and discuss the challenges that remain in harnessing these compounds for broader therapeutic impact.","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":" ","pages":"1-31"},"PeriodicalIF":6.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial medicine in fatty acid oxidation disorders: insights from genetic discoveries and patient cell models. 线粒体医学在脂肪酸氧化障碍：从遗传发现和患者细胞模型的见解。

IF 6.4 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2025-09-26 DOI: 10.1080/10409238.2025.2564070

Rikke Katrine Jentoft Olsen

{"title":"Mitochondrial medicine in fatty acid oxidation disorders: insights from genetic discoveries and patient cell models.","authors":"Rikke Katrine Jentoft Olsen","doi":"10.1080/10409238.2025.2564070","DOIUrl":"https://doi.org/10.1080/10409238.2025.2564070","url":null,"abstract":"Mitochondrial fatty acid oxidation (mFAO) disorders are caused by genetic variants in mFAO enzymes, their electron transporters, and cofactors. The clinical spectrum is heterogeneous, ranging from multi-organ failure and early death to milder neuromuscular forms that often are triggered or exacerbated during catabolic stress. Advances in genetics and the inclusion of mFAO disorders in newborn screening programs have allowed timely diagnosis and dietary interventions to prevent tissue damage and even death. Current dietary treatment aims to prevent energy deficiency and reduce toxic metabolites, but does not significantly prevent neurological, cardiac, and skeletal muscular abnormalities, including rhabdomyolysis. This review summarizes the present knowledge obtained from human studies showing that disruption of mitochondrial bioenergetics and redox homeostasis may represent relevant mechanisms for understanding long-term tissue damage and the stress-induced disease pathology of mFAO disorders. Sources and mechanisms of reactive oxygen species (ROS) production are discussed, including knowledge gained from mutations in the Electron Transfer Flavoprotein (ETF) and ETF-Ubiquinone Oxidoreductase (ETF-QO) proteins. The ETF/ETF-QO site serves as a biophysical and biochemical linker between mFAO and OXPHOS, and its high capacity for ROS production makes it a key component of the respiratory chain and a source of ROS in mFAO disorders. Understanding mitochondrial disturbances and how secondary disturbances in mFAO cofactors integrate with redox regulation at the ETF/ETF-QO site will advance our understanding of not only mFAO disorders but also the many diseases entailing OXPHOS and mFAO deficiencies, such as neurological and cardiovascular diseases, and as such, be enlightening for mitochondrial medicine in general.","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":" ","pages":"1-25"},"PeriodicalIF":6.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular insights into nucleic acid triplexes: methodologies and biological applications. 分子洞察核酸三联体：方法和生物学应用。

IF 6.4 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2025-09-01 DOI: 10.1080/10409238.2025.2550728

Jack W Klose, Gerardo Urbina, Tara L Pukala

{"title":"Molecular insights into nucleic acid triplexes: methodologies and biological applications.","authors":"Jack W Klose, Gerardo Urbina, Tara L Pukala","doi":"10.1080/10409238.2025.2550728","DOIUrl":"https://doi.org/10.1080/10409238.2025.2550728","url":null,"abstract":"Triplex DNA structures form through the binding of a third oligonucleotide strand to the major groove of canonical double-stranded DNA at sites of extended polypurine sequence. Although they are known to be favored with certain sequence specificity and cellular conditions, including decreased pH and the presence of multivalent cations, there remains ambiguity in the structures and extent to which they form in vivo. Therefore, despite their biological relevance and many potential applications, the use of DNA triplexes in biotechnology has been limited to date. The focus of this review is to explore the intricacies of DNA triplex formation, as well as the current state of research into their functions and applications in molecular cell biology. The range of analytical, computational and synthetic chemistry techniques employed to investigate and enhance the stability of triplex assemblies is also reviewed. Understanding the structural properties that underpin triplex formation and activity, coupled with computational and synthetic methodologies to expand their utility, can unlock the potential of various triplex-forming oligonucleotides as a contemporary tool for regulating gene expression.","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":" ","pages":"1-25"},"PeriodicalIF":6.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breakthroughs in the development of antibiotics, antifungals and antiparasitics targeting the pathogens' respiratory chain. 针对病原体呼吸链的抗生素、抗真菌药和抗寄生虫药研发取得突破。

IF 6.4 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2025-08-22 DOI: 10.1080/10409238.2025.2545785

Jennifer M Sorescu, Martín A González-Montalvo, Ming Yuan, Joseph De Paolo-Boisvert, Corina Diana Ceapă, Rodolfo Garcia-Contreras, Oscar Flores-Herrera, Michael E Shea, Karina Tuz, Oscar X Juárez

{"title":"Breakthroughs in the development of antibiotics, antifungals and antiparasitics targeting the pathogens' respiratory chain.","authors":"Jennifer M Sorescu, Martín A González-Montalvo, Ming Yuan, Joseph De Paolo-Boisvert, Corina Diana Ceapă, Rodolfo Garcia-Contreras, Oscar Flores-Herrera, Michael E Shea, Karina Tuz, Oscar X Juárez","doi":"10.1080/10409238.2025.2545785","DOIUrl":"10.1080/10409238.2025.2545785","url":null,"abstract":"The aerobic respiratory chain is vital to bacterial and eukaryotic cell energy transformation. Embedded in the mitochondrial inner membrane and the bacterial plasma membrane, the respiratory chain couples sequential redox reactions with ion pumping, thereby generating the motive force that is used to drive ATP synthesis. Due to the essential role of oxidative phosphorylation in cellular life, the electron transport chain proteins, their cofactors, and ATP synthase components serve as a target for antibacterial, antifungal, and antiparasitic drugs. Whether by (1) inhibition of electron flow through transport chain complexes, (2) collapsing of the motive force, (3) competitive inhibition, or (4) blocking proton flow through the catalytic subunits of ATP synthase, small molecules can selectively inhibit bacterial, fungal, and parasitic life while not showing high toxicity in mammalian systems. Because of robust antimicrobial resistance against the traditional mechanisms of microbial control (cell wall integrity, protein synthesis, nucleotide and nucleic acid synthesis, etc.), the study of alternative targets, such as the respiratory chain, is prudent and timely. This review summarizes the current research on small molecule and peptide inhibition of the aerobic respiratory chain complexes, electron flow, and ion translocation in a series of human and plant pathogens.","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":" ","pages":"1-34"},"PeriodicalIF":6.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the multifaceted role of extracellular DNA (eDNA) of biofilm in bacterial physiology, biofilm formation, and matrixome architecture. 揭示生物膜细胞外DNA （eDNA）在细菌生理学、生物膜形成和基质组结构中的多方面作用。

IF 6.4 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2025-02-01 Epub Date: 2025-05-05 DOI: 10.1080/10409238.2025.2497270

Sonalin Rath, Shourat Fatma, Surajit Das

{"title":"Unraveling the multifaceted role of extracellular DNA (eDNA) of biofilm in bacterial physiology, biofilm formation, and matrixome architecture.","authors":"Sonalin Rath, Shourat Fatma, Surajit Das","doi":"10.1080/10409238.2025.2497270","DOIUrl":"10.1080/10409238.2025.2497270","url":null,"abstract":"Bacterial biofilms consist of bacterial communities embedded in a self-produced extracellular matrix (EM) known as the matrixome. The matrixome primarily comprises extracellular polymeric substances (EPS) and other elements. EPS encompassing exopolysaccharides, proteins, lipids, and nucleic acids plays a key role in maintaining structural integrity and is involved in various functions. Extracellular DNA (eDNA) released into the EM through various mechanisms, including cell lysis or autolysis, membrane vesicle-mediated release, phage-mediated release, active secretion, and Type VI secretion system (T6SS)-mediated eDNA release. Quorum sensing (QS), a vital signaling system during biofilm formation, also regulates the release of eDNA in a controlled manner by coordinating gene expression in response to cell density. Once released into the EM, eDNA interacts with EPS components, enhancing matrix stability, structural cohesion, and integrity. The present review comprehends the multifaceted roles of eDNA within the biofilm matrixome, highlighting its contribution to biofilm formation, stability, and functionality through various interactions and regulatory mechanisms. It also delves into the mechanisms of eDNA release and its interactions within the biofilm matrix. Understanding these complex roles of eDNA in regulating biofilm will provide insights into developing strategies to enhance the remediation of environmental pollutants and manage biofilm-associated problems in medical settings.","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":" ","pages":"1-32"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

B-cell lymphoma 6 in breast cancer: molecular mechanisms and clinical significance. b细胞淋巴瘤6在乳腺癌中的分子机制及临床意义。

IF 6.4 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2025-02-01 Epub Date: 2025-06-27 DOI: 10.1080/10409238.2025.2521319

Frank Louwen, Andreas Ritter, Nina-Naomi Kreis, Samira Catharina Hoock, Christine Solbach, Juping Yuan

{"title":"B-cell lymphoma 6 in breast cancer: molecular mechanisms and clinical significance.","authors":"Frank Louwen, Andreas Ritter, Nina-Naomi Kreis, Samira Catharina Hoock, Christine Solbach, Juping Yuan","doi":"10.1080/10409238.2025.2521319","DOIUrl":"10.1080/10409238.2025.2521319","url":null,"abstract":"Breast cancer is the most frequent malignancy and the most common cause of cancer-related death in women worldwide. Despite remarkable improvements in therapy, the prognosis of advanced breast cancer remains poor. Further investigations are mandatory to explore the molecular pathophysiology. Recent studies provide evidence that B-cell lymphoma 6 (BCL6) may play important roles in breast cancer progression. BCL6, a transcriptional suppressor, is critical in the initiation and maintenance of the germinal centers by regulating the formation and function of germinal center B cells, follicular helper T cells and follicular regulatory T cells. It is a well-known key oncogene in lymphomagenesis. In this narrative review, we have summarized the current knowledge of its expression levels in primary breast cancers, analyzed its pathophysiological functions in breast cancer cells, and discussed the underlying molecular mechanisms. The data highlight that elevated BCL6 is significantly related to malignant properties of breast cancer, including tumor size, grade, invasion, metastasis, recurrence, therapy resistance, and poor prognosis. Moreover, elevated BCL6 is tightly associated with cancerous cellular features, such as increased proliferation and survival, poor differentiation, augmented migration, and formation of cancer stem cells, through diverse molecular pathways. In particular, enhanced BCL6 is observed in triple negative breast cancer and linked to decreased progression-free survival of patients. These findings strongly suggest that BCL6 plays a key role in breast cancer development and that targeting BCL6 may be a novel strategy for the treatment of breast cancer.","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":" ","pages":"80-106"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ATG16L1 membrane recruitment in autophagy. ATG16L1膜在自噬中的募集。

IF 6.4 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2025-02-01 Epub Date: 2025-07-11 DOI: 10.1080/10409238.2025.2521321

Fujing Wei, Nan Qin, Yunling Chen, Zhenzhen Liu, Xiaozhu Zhao, Xiaoying Yu, Ziling Feng, Yu Wang, Aimin Yang, Hongjuan Cui

{"title":"ATG16L1 membrane recruitment in autophagy.","authors":"Fujing Wei, Nan Qin, Yunling Chen, Zhenzhen Liu, Xiaozhu Zhao, Xiaoying Yu, Ziling Feng, Yu Wang, Aimin Yang, Hongjuan Cui","doi":"10.1080/10409238.2025.2521321","DOIUrl":"10.1080/10409238.2025.2521321","url":null,"abstract":"Autophagy, a highly conserved catabolic pathway in eukaryotes, is essential for cellular survival during starvation and for maintaining cellular homeostasis. Central to autophagy is the de novo formation of double-membrane autophagosomes, which requires the orchestrated action of a set of autophagy-related (ATG) proteins. ATG16L1 is a core autophagy protein involved in distinct phases of autophagosome biogenesis, including membrane remodeling and the formation of phagophore-like membrane cups. It interacts with the ATG12-ATG5 conjugate to form the ATG12-ATG5-ATG16L1 complex, which functions as an E3-like enzyme to catalyze LC3 lipidation. The membrane targeting of the ATG12-ATG5-ATG16L1 complex is crucial for regulating autophagy and preventing ectopic membrane engagement. In this review, we summarize and discuss the potential mechanisms underlying ATG16L1 membrane recruitment, focusing on its intrinsic membrane-binding properties and partner-mediated recruitment pathways. We critically explore how these multiple mechanisms collectively ensure the proper localization and function of ATG16L1, thereby regulating the initiation of autophagy, LC3 lipidation, and the sequestration of bacteria during xenophagy.","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":" ","pages":"107-122"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sumner's legacy: a century of urease crystals and recent structural advances. 萨姆纳的遗产：一个世纪的脲酶晶体和最近的结构进展。

IF 6.4 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2025-02-01 Epub Date: 2025-07-17 DOI: 10.1080/10409238.2025.2533765

Robert P Hausinger

引用次数: 0

Protein targeting to the ER membrane: multiple pathways and shared machinery. 蛋白靶向内质网膜：多种途径和共享机制。

IF 6.4 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2025-02-01 Epub Date: 2025-05-16 DOI: 10.1080/10409238.2025.2503746

Wendy N Sánchez, Arnold J M Driessen, Christian A M Wilson

{"title":"Protein targeting to the ER membrane: multiple pathways and shared machinery.","authors":"Wendy N Sánchez, Arnold J M Driessen, Christian A M Wilson","doi":"10.1080/10409238.2025.2503746","DOIUrl":"10.1080/10409238.2025.2503746","url":null,"abstract":"The endoplasmic reticulum (ER) serves as a central hub for protein production and sorting in eukaryotic cells, processing approximately one-third of the cellular proteome. Protein targeting to the ER occurs through multiple pathways that operate both during and independent of translation. The classical translation-dependent pathway, mediated by cytosolic factors like signal recognition particle, recognizes signal peptides or transmembrane helices in nascent proteins, while translation-independent mechanisms utilize RNA-based targeting through specific sequence elements and RNA-binding proteins. At the core of these processes lies the Sec61 complex, which undergoes dynamic conformational changes and coordinates with numerous accessory factors to facilitate protein translocation and membrane insertion across and into the endoplasmic reticulum membrane. This review focuses on the molecular mechanisms of protein targeting to the ER, from the initial recognition of targeting signals to the dynamics of the translocation machinery, highlighting recent discoveries that have revealed unprecedented complexity in these cellular trafficking pathways.","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":" ","pages":"33-79"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catalase-peroxidase (KatG): a potential frontier in tuberculosis drug development. 过氧化氢酶-过氧化物酶（KatG）：结核病药物开发的潜在前沿。

IF 6.2 2区生物学

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2024-12-01 Epub Date: 2025-02-27 DOI: 10.1080/10409238.2025.2470630

Aimin Liu

{"title":"Catalase-peroxidase (KatG): a potential frontier in tuberculosis drug development.","authors":"Aimin Liu","doi":"10.1080/10409238.2025.2470630","DOIUrl":"10.1080/10409238.2025.2470630","url":null,"abstract":"Mycobacterium tuberculosis (Mtb) depends on the bifunctional enzyme catalase-peroxidase (KatG) for survival within the host. KatG exhibits both catalase and peroxidase activities, serving distinct yet critical roles. While its peroxidase activity is essential for activating the frontline tuberculosis drug isoniazid, its catalase activity protects Mtb from oxidative stress. This bifunctional enzyme is equipped with a unique, protein-derived cofactor, methionine-tyrosine-tryptophan (MYW), which enables catalase activity to efficiently disproportionate hydrogen peroxide in phagocytes. Recent studies reveal that the MYW cofactor naturally exists in a hydroperoxylated form (MYW-OOH) when cell cultures are grown under ambient conditions. New findings highlight a dynamic regulation of KatG activity, wherein the modification of the protein cofactor is removable-from MYW-OOH to MYW-at body temperature or in the presence of micromolar concentrations of hydrogen peroxide. This reversible modification modulates KatG's dual activities: MYW-OOH inhibits catalase activity while enhancing peroxidase activity, demonstrating the chemical accessibility of the cofactor. Such duality positions KatG as a unique target for tuberculosis drug development. Therapeutic strategies that exploit cofactor modification could hold promise, particularly against drug-resistant strains with impaired peroxidase activity. By selectively inhibiting catalase activity, these approaches would render Mtb more vulnerable to oxidative stress while enhancing isoniazid activation-a double-edged strategy for combating tuberculosis.","PeriodicalId":10794,"journal":{"name":"Critical Reviews in Biochemistry and Molecular Biology","volume":" ","pages":"434-446"},"PeriodicalIF":6.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0