Current Gastroenterology Reports最新文献_第5页

Evolving Role of GLP-1 Therapies in Liver Disease. GLP-1在肝脏疾病治疗中的作用

Current Gastroenterology Reports Pub Date : 2025-06-06 DOI: 10.1007/s11894-025-00988-2

Mark Lindsay, Gretchen Arndt, Amanda Wieland, Thomas Jensen

引用次数: 0

Interleukin-23 Inhibitors for Inflammatory Bowel Disease: Pivotal Trials and Practical Considerations. 白细胞介素-23抑制剂治疗炎症性肠病：关键试验和实际考虑。

Current Gastroenterology Reports Pub Date : 2025-06-04 DOI: 10.1007/s11894-025-00987-3

Sarah Rotondo-Trivette, William Jennings, David Fudman

引用次数: 0

Current Perspectives on Colorectal Cancer Screening and Surveillance in the Geriatric Population. 老年人群结直肠癌筛查和监测的现状。

Current Gastroenterology Reports Pub Date : 2025-06-02 DOI: 10.1007/s11894-025-00985-5

Jahnavi Udaikumar, Rithish Nimmagadda, Sushrut Ingawale, Vindhya Vasini Lella, Keerthika Vijayakumar, Adam S Faye, Aasma Shaukat

{"title":"Current Perspectives on Colorectal Cancer Screening and Surveillance in the Geriatric Population.","authors":"Jahnavi Udaikumar, Rithish Nimmagadda, Sushrut Ingawale, Vindhya Vasini Lella, Keerthika Vijayakumar, Adam S Faye, Aasma Shaukat","doi":"10.1007/s11894-025-00985-5","DOIUrl":"10.1007/s11894-025-00985-5","url":null,"abstract":"Purpose of review: Colorectal cancer (CRC) is a leading cause of cancer-related mortality, with 44% of deaths occurring in individuals aged 75 years and older. With 78 million adults over 65 years projected by 2035, optimizing CRC screening and surveillance is crucial. This review examines guidelines, risks, and personalized approaches.Recent findings: CRC screening reduces incidence by 17-33% and mortality by 11-53%. Colonoscopy lowers mortality by 61% but has a 6.8% complication rate in those aged 75 years and older. The risk of gastrointestinal bleeding is 8.7 per 1,000 for polypectomy, and perforation occurs in 0.6 per 1,000. Frailty indices assess suitability, but surveillance guidelines lack clear discontinuation criteria. Screening should balance risk, complications, and health status. It may be cost-effective up to age 86 years in healthy individuals, but more research is needed to refine surveillance strategies and reduce overtreatment in older adults.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"34"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Mutations and Small Bowel Ulcerating Disease: Role in Diagnosis? 基因突变和小肠溃疡：在诊断中的作用？

Current Gastroenterology Reports Pub Date : 2025-05-21 DOI: 10.1007/s11894-025-00978-4

Rangesh Modi, Tanner Storozuk, Namrata Setia

{"title":"Genetic Mutations and Small Bowel Ulcerating Disease: Role in Diagnosis?","authors":"Rangesh Modi, Tanner Storozuk, Namrata Setia","doi":"10.1007/s11894-025-00978-4","DOIUrl":"10.1007/s11894-025-00978-4","url":null,"abstract":"Purpose of review: This review examines the role of genetic variations in the pathogenesis of small bowel (SB) ulcers associated with Crohn's disease (CD), NSAID enteropathy, and Cryptogenic Multifocal Ulcerous Stenosing Enteritis (CMUSE)/Chronic Non-Specific Ulcers of the Small Intestine (CNSU), aiming to address current diagnostic challenges.Recent findings: Advances in molecular genetics have revealed significant genetic contributors to SB ulceration. In CD, the NOD2 gene on chromosome 16 and several additional risk variants identified through genome-wide association studies (GWAS)-with key insights from the International Inflammatory Bowel Disease Genetics Consortium-have enhanced our understanding of the pathobiology of the disease. In NSAID enteropathy, polymorphisms in CYP enzymes have been associated with altered drug metabolism and gastrointestinal complications. However, the genetic mechanisms underlying deep ulcers in NSAID enteropathy, as well as CMUSE/CNSU, remain poorly understood. Genetic insights are crucial for understanding SB ulcerative diseases. Future research should focus on identifying specific genetic determinants to improve diagnostic accuracy and therapeutic strategies.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"33"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Success Rates for Endoscopic Placement of Post-Pyloric Nasoenteric Tube Underperform Expectations. 内镜下放置幽门后鼻肠管的成功率低于预期。

Current Gastroenterology Reports Pub Date : 2025-05-10 DOI: 10.1007/s11894-025-00965-9

Cristina Chiodi, Shesh Rai, Gerald Dryden

{"title":"Success Rates for Endoscopic Placement of Post-Pyloric Nasoenteric Tube Underperform Expectations.","authors":"Cristina Chiodi, Shesh Rai, Gerald Dryden","doi":"10.1007/s11894-025-00965-9","DOIUrl":"10.1007/s11894-025-00965-9","url":null,"abstract":"Purpose of review: Enteral nutrition plays a pivotal role in maintaining nutritional status and supporting recovery in hospitalized patients who are unable to meet their caloric requirements. The benefits of enteral nutrition include preserving gut integrity, reducing infection risks, and supporting immune function, which are vital in critically ill and post-operative patients. Nasoenteric feeding tubes often serve as important tools to deliver enteral nutrition efficiently, yet their optimal placement remains a subject of significant clinical consideration.Recent findings: Nasoenteric feeding tubes can be compromised by placement-related complications such as displacement, malpositioning, and tube-related discomfort. Our review of the relevant literature is complemented by review of our recent data. Our own clinical experience suggests that endoscopic placement of naso-enteric feeding tubes fails during the wire exchange process.Summary: This report reviews the importance of enteral nutrition for enhancing patient outcomes, documents findings from our retrospective study on endoscopically placed nasoenteric feeding tubes and focuses on the challenges and future advancements in nasoenteric feeding tube placement techniques.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"32"},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Refractory Post-Radiation Strictures: Lessons Learned from Long-term Follow-up after Combined Antegrade Retrograde Dilation. 严重难治性放射后狭窄：联合顺逆行扩张术后长期随访的经验教训。

Current Gastroenterology Reports Pub Date : 2025-05-07 DOI: 10.1007/s11894-025-00981-9

Mohamed Eisa, Amal Shine, Endashaw Omer, Matthew Heckroth, Michael Eiswerth, Vincent Nguyen, Benjamin Rogers, Paul Tennant, Stephen A McClave

{"title":"Severe Refractory Post-Radiation Strictures: Lessons Learned from Long-term Follow-up after Combined Antegrade Retrograde Dilation.","authors":"Mohamed Eisa, Amal Shine, Endashaw Omer, Matthew Heckroth, Michael Eiswerth, Vincent Nguyen, Benjamin Rogers, Paul Tennant, Stephen A McClave","doi":"10.1007/s11894-025-00981-9","DOIUrl":"https://doi.org/10.1007/s11894-025-00981-9","url":null,"abstract":"Purpose of review: Dysphagia with an identifiable stricture occurs frequently following chemoradiation therapy for head/neck cancer patients, some developing complete obliteration of the esophageal lumen. Combined Antegrade Retrograde Dilation (CARD) is designed to restore luminal patency. This paper reports how experience at one institution shaped a more effective strategy for the long-term management of this difficult patient population.Recent findings: Twenty patients, mean age 62.6 years, initially undergoing CARD procedure, subsequently required a total of 278 dilation sessions (average 13.9 sessions/patient) performed on average every 8.2 weeks (range 2.7-12.6). All patients achieved luminal patency. Complications occurred in 7 patients (35.0% of patients, 2.5% of all procedures) and included traumatic bleeding, pneumothorax, overt esophageal perforation, microscopic perforation with cervical osteomyelitis, and perforation at the gastrostomy site. Diet and dysphagia scores were ineffective at directing the schedule for maintenance dilation. The CARD procedure is effective at restoring initial esophageal patency, but must be followed closely with long-term maintenance dilation. Over a large number of dilations, complications are infrequent and difficult to predict. Their incidence may be reduced by use of prophylactic antibiotics, prior removal of a tracheoesophageal prosthesis, avoiding dilation of the gastrostomy tract, modest dilation goal, and scheduled \"stricture surveillance\" with dilations performed under fluoroscopic guidance.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gas-tly Interpretations: A Case-Based Approach to the Nuances of SIBO Breath Testing. 气体解释：基于案例的SIBO呼吸测试方法的细微差别。

Current Gastroenterology Reports Pub Date : 2025-05-01 DOI: 10.1007/s11894-025-00977-5

John A Damianos, Ayah Matar, Houssam Halawi

引用次数: 0

Dietary Relationships between Obesity and Inflammatory Bowel Diseases: A Narrative Review of Diets Which May Promote Both Diseases. 肥胖和炎症性肠病之间的饮食关系：可能促进这两种疾病的饮食综述

Current Gastroenterology Reports Pub Date : 2025-04-30 DOI: 10.1007/s11894-025-00980-w

Andrew Szilagyi, Jonathan Wyse, Jennifer Abdulezer

{"title":"Dietary Relationships between Obesity and Inflammatory Bowel Diseases: A Narrative Review of Diets Which May Promote Both Diseases.","authors":"Andrew Szilagyi, Jonathan Wyse, Jennifer Abdulezer","doi":"10.1007/s11894-025-00980-w","DOIUrl":"https://doi.org/10.1007/s11894-025-00980-w","url":null,"abstract":"Purpose of review: The pandemic of obesity preceded global spread of Inflammatory Bowel diseases by almost 2 decades. A pathogenic relationship has been described between obesity and inflammatory bowel diseases, but Crohn`s disease may be selectively impacted. The role of diet in pathogenesis has also gained significant support in the last few decades. This review explores dietary relationships to account for epidemiological observations. Quantifiable indices for diets have been described including a glycemic index, inflammatory indices and levels of food processing. Meta-analyses have been published which examine each for effects on obesity and co-morbidities as well as Crohn's disease and ulcerative colitis. This review suggests that ultra-processed foods provide the best link between obesity and Crohn's disease explaining epidemiological observations. However, the other 2 types of dietary indices likely contribute to ulcerative colitis as well as to co-morbidities related to both obesity and inflammatory bowel diseases. The term ultra-processed foods cover a large number of additives and extensive work is needed to define individual or combined harmful effects. Furthermore, the interactions among the 3 main indices need clarification in order to precisely apply therapeutic diets to both diseases (obesity and inflammatory bowel disease).","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Neuroimmune Axis in Gastrointestinal Disorders - An Underrecognized Problem. 胃肠道疾病中的神经免疫轴——一个未被认识的问题。

Current Gastroenterology Reports Pub Date : 2025-04-15 DOI: 10.1007/s11894-025-00973-9

Laura A Pace, Niwen Kong, Mohamed I Itani, James Hemp

引用次数: 0

Non-celiac Enteropathies. Non-celiac肠下垂。

Current Gastroenterology Reports Pub Date : 2025-04-14 DOI: 10.1007/s11894-025-00979-3

Kaitlyn Mi, Scarlett Cao, Dawn Adams

{"title":"Non-celiac Enteropathies.","authors":"Kaitlyn Mi, Scarlett Cao, Dawn Adams","doi":"10.1007/s11894-025-00979-3","DOIUrl":"https://doi.org/10.1007/s11894-025-00979-3","url":null,"abstract":"Purpose of review: Non-celiac enteropathies (NCE) can be due to a variety of causes. The workup for NCE includes history, physical, laboratory and histology review and can be difficult. Enteropathies can result in serious illness due to consequences of malabsorption including severe weight loss, nutritional deficiencies, and debilitating diarrhea. Recognition and support of these consequences while investigating underlying etiology is essential.Recent findings: Recent studies in NCEs have focused on improving diagnostic accuracy and predicting long-term outcomes in patients with NCEs. Further, literature has emphasized the importance of histological analysis, with a focus on differentiating between various enteropathies that cause villous atrophy, highlighting the complexity and need for personalized approaches in managing these conditions. Identification of etiologies of NCEs requires review of patients' detailed history, medications, and lab results. Common etiologies include immunodeficiencies, infectious, iatrogenic, and malignant causes. Using a systematic approach can lead to proper diagnosis and tailor treatment choices, benefiting patient outcomes. Supportive nutrition care should be initiated early when applicable to minimize morbidity.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11997019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0