Current Gastroenterology Reports最新文献_第4页

A Historical and Scientific Review of Anti-Reflux Surgery: Evolution, Evidence, and Future Directions. 抗反流手术的历史和科学回顾：演变、证据和未来方向。

IF 4.1

Current Gastroenterology Reports Pub Date : 2026-01-10 DOI: 10.1007/s11894-025-01031-0

Moustafa Elshafei, Sjaak Pouwels, Andreas Pascher, Jens Peter Hoelzen, Mazen A Juratli

{"title":"A Historical and Scientific Review of Anti-Reflux Surgery: Evolution, Evidence, and Future Directions.","authors":"Moustafa Elshafei, Sjaak Pouwels, Andreas Pascher, Jens Peter Hoelzen, Mazen A Juratli","doi":"10.1007/s11894-025-01031-0","DOIUrl":"10.1007/s11894-025-01031-0","url":null,"abstract":"Purpose of review: Gastroesophageal Reflux Disease (GERD) is a condition, which is frequently encountered by gastroenterologists, otorhinolaryngologists, surgeons and general physicians and requires a multidisciplinary treatment when there is a high symptom burden in patients. Besides lower oesophageal sphincter (LES) dysfunction there are several other risk factors that contribute to the development and symptoms (worsening) of GERD. While these lifestyle modifications and pharmacological therapies, particularly proton pump inhibitors (PPIs), are first-line treatments, a subset of patients requires surgical intervention due to refractory symptoms or complications. This review traces the evolution of anti-reflux surgery, examining its historical milestones, advancements, and future prospects.Recent findings: This review discusses the epidemiology of GERD, its pathophysiology, but also the development of Anti-Reflux Surgery (ARS). We will discuss the available evidence regarding different ARS procedures and will focus on individualised treatment for patients with GERD. In the treatment of patients with GERD we have to take into account that it might be challenging to personalise treatment and therefore optimise results. In this instance special considerations need to be taken for patients with GERD and obesity, patients with Barretts oesophagus, patients after bariatric and metabolic surgery (BMS) and patients with oesophageal motility disorders.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"28 1","pages":"4"},"PeriodicalIF":4.1,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing Acute Severe Ulcerative Colitis in 2025 and Beyond. 2025年及以后处理急性严重溃疡性结肠炎。

IF 4.1

Current Gastroenterology Reports Pub Date : 2026-01-07 DOI: 10.1007/s11894-025-01025-y

Manjeet Kumar Goyal, Syed Adeel Hassan, Jeffrey Aaron Berinstein

{"title":"Managing Acute Severe Ulcerative Colitis in 2025 and Beyond.","authors":"Manjeet Kumar Goyal, Syed Adeel Hassan, Jeffrey Aaron Berinstein","doi":"10.1007/s11894-025-01025-y","DOIUrl":"10.1007/s11894-025-01025-y","url":null,"abstract":"Purpose of review: Acute severe ulcerative colitis (ASUC) remains a high-risk condition with suboptimal clinical outcomes despite advancements in diagnostics, prognostication, and therapies. This review synthesizes recent evidence to address critical gaps in care, focusing on optimizing medical strategies to reduce colectomy rates and improve patient outcomes.Recent findings: Recent studies have identified novel biomarkers and predictive models for stratifying patients as high-risk for colectomy. Several emerging therapeutic strategies to optimize care have also been explored. Intensified infliximab dosing has not consistently shown improved clinical outcomes across all patients with ASUC, though it may benefit a subset of patients with unfavorable pharmacokinetics. Furthermore, Janus kinase inhibitors have shown promise in reducing colectomy rates, offering a potential alternative for select patients; however, supporting evidence remains preliminary. Despite these advancements, colectomy remains exceedingly common but continues to serve as a critical intervention to reduce complications and mortality. This underscores the therapeutic efficacy ceiling that still exists in our current approach to ASUC in 2025. Modern ASUC management prioritizes rapid risk stratification (using clinical, endoscopic, and biomarker data) and patient-tailored advanced therapy selection. Future strategies should focus on conducting rigorous trials of emerging agents in comparison to our current protocols, while integrating real-time, personalized, and dynamic prognostic tools to reduce heterogeneity in treatment response.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"28 1","pages":"3"},"PeriodicalIF":4.1,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Culinary Medicine: Current Status, Challenges and Opportunities. 儿童烹饪医学：现状、挑战和机遇。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-12-29 DOI: 10.1007/s11894-025-01024-z

Michelle Loy, Ashish Chogle, Hanna Tracy, Neha R Santucci, Khyati Mehta, Liane S Sadder, Rima Jibaly, Alain J Benitez, Maria R Mascarenhas

{"title":"Pediatric Culinary Medicine: Current Status, Challenges and Opportunities.","authors":"Michelle Loy, Ashish Chogle, Hanna Tracy, Neha R Santucci, Khyati Mehta, Liane S Sadder, Rima Jibaly, Alain J Benitez, Maria R Mascarenhas","doi":"10.1007/s11894-025-01024-z","DOIUrl":"10.1007/s11894-025-01024-z","url":null,"abstract":"Purpose of review: The health benefits of food are being increasingly recognized. Exposing children and parents to culinary medicine enables them to make healthy food choices with potential for long term health improvement. Here we review pediatric literature on culinary medicine, share results of a recent practice survey, and review strategies for program development and implementation including training opportunities.Recent findings: There is growing evidence of interest in culinary medicine in pediatrics. A pediatric culinary medicine practice survey directed to current practitioners in the USA showed great variability. Common challenges associated with the practice included sustained funding, program management needs and getting the message out to the right audience. Based on survey responses and current literature, we generated educational resources and practice recommendations to further knowledge on pediatric culinary medicine practice. Several opportunities exist for practitioners to further the field of pediatric culinary medicine by engaging in additional clinical practices, research, education, and advocacy.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"28 1","pages":"1"},"PeriodicalIF":4.1,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13055035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145849101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Building a Third SPACE Endoscopy Program Within a Community Hospital. 在社区医院内建立第三空间内窥镜检查项目。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-12-29 DOI: 10.1007/s11894-025-01017-y

Melvin Simien, Victoria Archibald

引用次数: 0

Diagnosis and Management of Food Protein-Induced Allergic Proctocolitis. 食物蛋白诱发过敏性直结肠炎的诊断与治疗。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-12-16 DOI: 10.1007/s11894-025-01022-1

Mahala Leney, Francesca Kahale, Victoria M Martin

{"title":"Diagnosis and Management of Food Protein-Induced Allergic Proctocolitis.","authors":"Mahala Leney, Francesca Kahale, Victoria M Martin","doi":"10.1007/s11894-025-01022-1","DOIUrl":"10.1007/s11894-025-01022-1","url":null,"abstract":"Purpose of review: Food protein-induced allergic proctocolitis (FPIAP) is a frequent cause of rectal bleeding in otherwise healthy infants. Although benign and self-limited, wide variation in diagnostic and management practices often leads to overdiagnosis, unnecessary dietary restriction, and disruption of breastfeeding. This review summarizes contemporary evidence to guide a pragmatic, challenge-anchored approach to diagnosis and management.Recent findings: Diagnosis of FPIAP remains clinical, based on symptom resolution after elimination and recurrence upon reintroduction of the trigger food; however, confirmatory challenges are seldom performed. Fecal calprotectin and other proposed biomarkers-such as eosinophil-derived neurotoxin, zonulin, and microbiome signatures-show poor reliability in infants and are not ready for clinical use. Management should prioritize the least restrictive diet - maternal dairy elimination for breastfed infants and extensively hydrolyzed formulas for formula-fed infants - only in challenge-proven FPIAP. Growing data support earlier reintroduction once colitis resolves, and early introduction of other allergens may reduce future IgE-mediated allergy risk. A standardized, challenge-confirmed framework minimizes over-restriction and supports continued breastfeeding. Future priorities include validation of non-invasive biomarkers and trials comparing timing and strategies for safe dietary reintroduction in FPIAP.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"76"},"PeriodicalIF":4.1,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD19 CAR-T Cell Therapy for Relapsed or Refractory Nodal and Gastrointestinal Follicular Lymphoma: Current Advances and Future Perspectives. CD19 CAR-T细胞治疗复发或难治性淋巴结和胃肠道滤泡性淋巴瘤：当前进展和未来展望

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-12-04 DOI: 10.1007/s11894-025-01028-9

Takuya Watanabe

{"title":"CD19 CAR-T Cell Therapy for Relapsed or Refractory Nodal and Gastrointestinal Follicular Lymphoma: Current Advances and Future Perspectives.","authors":"Takuya Watanabe","doi":"10.1007/s11894-025-01028-9","DOIUrl":"10.1007/s11894-025-01028-9","url":null,"abstract":"Purpose of review: Follicular lymphoma (FL) is the most common indolent B-cell lymphoma, yet primary gastrointestinal FL (GI-FL) remains poorly defined, and treatment of relapsed/refractory cases is controversial. This review aims to critically evaluate the role of CD19-directed chimeric antigen receptor (CAR) T-cell therapy in nodal and GI-FL, highlighting key clinical trials and the unique biological considerations of GI involvement.Recent findings: Pivotal trials such as ZUMA-5, ELARA, and TRANSCEND FL have demonstrated high overall and complete response rates with durable progression-free survival in patients with relapsed/refractory FL. Liso-cel in particular has shown a favourable efficacy-toxicity balance, including in patients with transformed disease or progression within 24 months (POD24). However, data specific to GI-FL are scarce, and emerging evidence suggests that its microenvironment, immune checkpoint expression, and mutational profile may influence CAR-T responses differently from nodal FL. CD19 CAR-T therapy represents a major therapeutic advance for relapsed/refractory FL and holds promise for patients with advanced or high-risk GI-FL. Nonetheless, the rarity of GI-FL, limited dedicated clinical data, and challenges such as treatment-related toxicities, costs, and accessibility warrant further prospective studies. Integrating biomarker-based patient selection and GI-FL-specific trial designs will be crucial to optimise the application of CAR-T therapy in this distinct subtype.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"75"},"PeriodicalIF":4.1,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rectal Prolapse in the Pediatric Population. 小儿直肠脱垂

Current Gastroenterology Reports Pub Date : 2025-12-01 Epub Date: 2024-11-23 DOI: 10.1007/s11894-024-00953-5

James K Moon, John D Stratigis, Aaron M Lipskar

{"title":"Rectal Prolapse in the Pediatric Population.","authors":"James K Moon, John D Stratigis, Aaron M Lipskar","doi":"10.1007/s11894-024-00953-5","DOIUrl":"10.1007/s11894-024-00953-5","url":null,"abstract":"Purpose of review: Rectal prolapse in the pediatric population presents a clinical challenge with wide variability in etiology, presentation, work-up and management. In this article, we reviewed the evidence supporting various medical and surgical treatment options as well as the recent trends amongst pediatric surgeons.Recent findings: Medical therapy is highly effective in most patients, with bowel management programs being particularly successful. Nonetheless, medically refractory disease, often seen in older children and in children with behavioral/psychiatric disorders, can be challenging. Sclerotherapy with ethanol or 5% phenol can be effective local treatments. 15% hypertonic saline, 50% dextrose, and Deflux are additional safe alternatives. Perianal procedures and perineal procedures are less invasive surgical options, but transabdominal rectopexy appears to be the favored treatment for disease refractory to local treatment. Transabdominal rectopexy with sigmoidectomy, the recommended operation in the adult population for patients with prolapse and constipation, appears only to be preferred in the pediatric population for postoperative recurrences.Recent findings: While outcomes of medical treatment for pediatric rectal prolapse are excellent, sclerotherapy and transabdominal rectopexy are effective options for refractory disease preferred by most pediatric surgeons.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Gut in Critical Illness. 危重疾病中的肠道。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-12-01 Epub Date: 2025-01-10 DOI: 10.1007/s11894-024-00954-4

Jayshil J Patel, Mark Barash

引用次数: 0

Inpatient Nutritional Considerations in Inflammatory Bowel Disease. 炎症性肠病住院患者的营养考虑。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-12-01 Epub Date: 2025-01-06 DOI: 10.1007/s11894-024-00958-0

Subin Chirayath, Janak Bahirwani, Akash Pandey, Zoe Memel, Sunhee Park, Yecheskel Schneider

{"title":"Inpatient Nutritional Considerations in Inflammatory Bowel Disease.","authors":"Subin Chirayath, Janak Bahirwani, Akash Pandey, Zoe Memel, Sunhee Park, Yecheskel Schneider","doi":"10.1007/s11894-024-00958-0","DOIUrl":"10.1007/s11894-024-00958-0","url":null,"abstract":"Purpose of review: This review aims to explain the causes, diagnosis, and treatment of malnutrition in hospitalized patients with inflammatory bowel disease (IBD), focusing on both adults and children.Recent findings: Malnutrition is common among IBD patients, affecting up to 85% of individuals, and is linked to higher rates of illness, death, and longer hospital stays. Recent studies highlight the importance of early detection using tools like the Subjective Global Assessment (SGA) and handgrip strength tests. Nutritional interventions-such as exclusive enteral nutrition (EEN) and parenteral nutrition (PN)-have proven effective in inducing remission and improving patient outcomes, especially in pediatric Crohn's disease. New evidence suggests that optimizing nutrition before and after surgery, as well as using immunonutrition, may reduce postoperative complications. Early identification and management of malnutrition in hospitalized IBD patients may be important for improving clinical outcomes. Using appropriate nutritional screening tools and creating personalized nutrition plans can help with recovery, decrease hospital stays, and improve quality of life. Further research is needed to develop standard protocols for nutritional assessment and treatment in this patient population.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"9"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastric Per-Oral Endoscopy Myotomy (G-POEM): Tips, Tricks, and Pitfalls. 胃经口腔内窥镜肌切开术（G-POEM）：诀窍、技巧和陷阱。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-12-01 Epub Date: 2024-11-06 DOI: 10.1007/s11894-024-00952-6

Grace E Kim, Mahnoor Khan, Sunil Amin, Amrita Sethi

引用次数: 0