Current Gastroenterology Reports最新文献

Fermented Durian Tempoyak as a Source of Probiotics for Colorectal Cancer Prevention through Gut Microbiome Modulation. 通过调节肠道微生物群，发酵榴莲可作为预防结直肠癌的益生菌来源。

Current Gastroenterology Reports Pub Date : 2026-05-07 DOI: 10.1007/s11894-026-01043-4

Wing Soon Ng, Nancy Choon-Si Ng, Rebecca Shin-Yee Wong, Bey Hing Goh

{"title":"Fermented Durian Tempoyak as a Source of Probiotics for Colorectal Cancer Prevention through Gut Microbiome Modulation.","authors":"Wing Soon Ng, Nancy Choon-Si Ng, Rebecca Shin-Yee Wong, Bey Hing Goh","doi":"10.1007/s11894-026-01043-4","DOIUrl":"https://doi.org/10.1007/s11894-026-01043-4","url":null,"abstract":"Purpose of review: Colorectal cancer (CRC) remains a major global and Malaysian public health concern, with increasing recognition of gut dysbiosis as a contributor to colorectal tumorigenesis. This review examines fermented durian tempoyak as a culturally relevant, probiotic-rich traditional food with potential application in CRC prevention through gut microbiome modulation.Recent findings: Dysbiosis may promote CRC through disruption of gut barrier integrity, chronic mucosal inflammation, immune dysregulation, reactive oxygen species (ROS)-mediated DNA damage, and altered microbial metabolism leading to carcinogenic metabolites such as secondary bile acids and hydrogen sulphide. Tempoyak commonly contains lactic acid bacteria, particularly Lactiplantibacillus plantarum, as well as Limosilactobacillus fermentum and Levilactobacillus brevis. Preclinical evidence suggests that related LAB strains can attenuate NF-κB, MAPK, STAT3, IL-17, and COX-2-associated inflammatory pathways, reduce immune-cell infiltration and oxidative stress, restore mucus and tight junction proteins, modulate bile acid metabolism, and reduce tumor burden in CRC or colitis-associated CRC models. Current evidence supports the mechanistic plausibility of tempoyak-associated LABs as microbiome-based agents for CRC chemoprevention. However, direct evidence using tempoyak-derived strains remains limited, and translation is constrained by strain-specific effects, microbial variability, sensory acceptability, safety and standardisation issues, and uncertain LAB viability after cooking. Future studies should prioritise strain characterisation, starter culture standardisation, probiotic stabilisation strategies, CRC-specific preclinical models, and well-designed human trials in high-risk populations.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Practical Guide to Incorporating Novel Barrett's Screening/Surveillance Tools into Clinical Practice. 将新型巴雷特筛查/监测工具纳入临床实践的实用指南。

Current Gastroenterology Reports Pub Date : 2026-04-06 DOI: 10.1007/s11894-026-01041-6

Brian E White, Alexandra L Strauss Starling

引用次数: 0

The Role of Endoscopic Ultrasound in the Diagnosis and Management of Congenital Gastrointestinal and Pancreaticobiliary Conditions. 超声内镜在先天性胃肠道和胰胆管疾病诊断和治疗中的作用。

Current Gastroenterology Reports Pub Date : 2026-03-30 DOI: 10.1007/s11894-026-01040-7

Inna Novak, Samuel Bitton

引用次数: 0

Gastrointestinal Complaints After Fundoplication: Rapid Review and Evidence Mapping. 用药后胃肠道不适：快速回顾和证据图谱。

Current Gastroenterology Reports Pub Date : 2026-03-21 DOI: 10.1007/s11894-026-01039-0

Alberto Aiolfi, Davide Bona, Francesco Cammarata, Moustafa Elshafei, Cristina Ogliari, Carmelo Scarpignato, Luigi Bonavina

引用次数: 0

Recent Endoscopic Technological Advancements in Crohn's Stricture Dilation. 克罗恩氏狭窄扩张的内镜技术进展。

Current Gastroenterology Reports Pub Date : 2026-03-16 DOI: 10.1007/s11894-026-01037-2

Andrei Savu, Michael Helou, Jamil Abdo, Scott Piechocki, Brandon Wuerth

引用次数: 0

Cutting Edge Access: Needle Knife Fistulotomy for Difficult Biliary Cannulation. 前沿通道：针刀造瘘术治疗胆道插管困难。

Current Gastroenterology Reports Pub Date : 2026-03-09 DOI: 10.1007/s11894-026-01038-1

Michael Helou, Ethan Steele, Andrei Savu, Allison Franz, David Liu, Nanlong Liu

{"title":"Cutting Edge Access: Needle Knife Fistulotomy for Difficult Biliary Cannulation.","authors":"Michael Helou, Ethan Steele, Andrei Savu, Allison Franz, David Liu, Nanlong Liu","doi":"10.1007/s11894-026-01038-1","DOIUrl":"10.1007/s11894-026-01038-1","url":null,"abstract":"Purpose of review: Endoscopic retrograde cholangiopancreatography is an advanced endoscopic procedure used mainly for the purpose of biliary intervention. During an ERCP a duodenoscope is used to assess the ampulla of Vater to inject contrast medium into the common bile duct through biliary cannulation. Biliary cannulation can be challenging, with studies showing unsuccessful biliary cannulation with standard technique greater than 10%. Needle-knife fistulotomy is a unique precut sphincterotomy technique that can assist with difficult biliary cannulation.Review of findings: Needle-knife fistulotomy has transitioned from a \"last-ditch\" technique to sometimes a primary approach in select patient populations by endoscopists. The major impetus for this change is due to consistent results showing a lower risk of post-ERCP pancreatitis compared to other pre-cut methods. This review article will go in-depth on the technique of needle-knife fistulotomy, the benefits and suspected complications of needle-knife fistulotomy compared to traditional sphincterotomy techniques and the evolution of NKF as a first-choice option for biliary cannulation.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12971757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Underwater Endoscopic Submucosal Dissection: Tips and Tricks. 水下内镜粘膜下解剖：提示和技巧。

Current Gastroenterology Reports Pub Date : 2026-03-03 DOI: 10.1007/s11894-026-01034-5

Mia Kamiya, Makoto Nishimura, Sayaka Nagao, Arameh Mousakhanian, Natalia Zbib, Jacques Beauvais, Shirley Jiang, Yohei Ogata

引用次数: 0

Dietary Therapy in Eosinophilic Esophagitis (EoE): A Practical Approach to Elimination. 饮食治疗嗜酸性食管炎（EoE）：一种实用的消除方法。

Current Gastroenterology Reports Pub Date : 2026-02-19 DOI: 10.1007/s11894-026-01036-3

Varan Perananthan, Diana L Snyder

引用次数: 0

Expanded Indications and Role of Pancreatic Cyst/Mass Ablation. 扩大了胰腺囊肿/肿块消融的适应症和作用。

Current Gastroenterology Reports Pub Date : 2026-02-17 DOI: 10.1007/s11894-026-01033-6

Brianna Hamilton, Christiaan Van Der Weiden, Ruth Bell, Nirav Thosani

引用次数: 0

Management of Recurrent Dysphagia after POEM and Heller Myotomy: Current Strategies and Future Directions. POEM和Heller肌切开术后复发性吞咽困难的处理：当前策略和未来方向。

Current Gastroenterology Reports Pub Date : 2026-02-14 DOI: 10.1007/s11894-026-01035-4

Ronald Casey Turner, Anh D Nguyen, Thomas Tielleman

引用次数: 0