Resmetirom for Steatotic Liver Disease: Does Data Support Widespread Use?

Q1 Medicine

Current Gastroenterology Reports Pub Date : 2025-07-22 DOI:10.1007/s11894-025-01002-5

Winston Dunn, Naim Alkhouri

引用次数: 0

Abstract

Metabolic dysfunction-associated steatohepatitis with significant fibrosis is the aggressive form of steatotic liver disease that can progress to cirrhosis and its complications. Resmetirom is a liver-directed thyroid hormone receptor beta agonist that recently received accelerated approval by the FDA based on the results of the MAESTRO trial that demonstrated reasonable safety and efficacy in achieving both MASH resolution and fibrosis regression based on histological assessment. In this review, we discuss the resmetirom clinical development program, the use of noninvasive tests to select and monitor patients for treatment, and different aspects of the utility of resmetirom in the real world.

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雷司替米治疗脂肪肝：数据支持广泛使用吗？

代谢功能障碍相关的脂肪性肝炎伴显著纤维化是脂肪性肝病的侵袭性形式，可发展为肝硬化及其并发症。Resmetirom是一种肝脏导向的甲状腺激素受体激动剂，最近获得了FDA的加速批准，基于MAESTRO试验的结果，该试验证明了基于组织学评估实现MASH解决和纤维化消退的合理安全性和有效性。在这篇综述中，我们讨论了雷司替罗的临床开发计划，使用无创测试来选择和监测患者的治疗，以及雷司替罗在现实世界中的不同方面的效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Gastroenterology Reports Medicine-Gastroenterology

CiteScore

7.80

自引率

0.00%

发文量

期刊介绍： As the field of gastroenterology and hepatology rapidly evolves, the wealth of published literature can be overwhelming. The aim of the journal is to help readers stay abreast of such advances by offering authoritative, systematic reviews by leading experts. We accomplish this aim by appointing Section Editors who invite international experts to contribute review articles that highlight recent developments and important papers published in the past year. Major topics in gastroenterology are covered, including pediatric gastroenterology, neuromuscular disorders, infections, nutrition, and inflammatory bowel disease. These reviews provide clear, insightful summaries of expert perspectives relevant to clinical practice. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.