Current Gastroenterology Reports最新文献_第6页

New Kids on the Block: IL-23 Inhibitors in IBD Management. IL-23抑制剂在IBD治疗中的应用

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-10-22 DOI: 10.1007/s11894-025-01020-3

Jacob Jones, Jeevin Sandhu, Kara Jones, David Dulaney, Anish Patel

引用次数: 0

Enteral Nutrition in Critical Care: Pathogenesis, Complications, and the Therapeutic Promise of Mediterranean-Style Diets. 肠内营养在重症监护：发病机制，并发症，和地中海式饮食的治疗前景。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-10-22 DOI: 10.1007/s11894-025-01018-x

Wafaa F Abusudah, R B Singh, Jan Fedacko, Ghizal Fatima, Athanasios Alexiou, Marios Papadakis, Safaa A Faheem, Gaber El-Saber Batiha

{"title":"Enteral Nutrition in Critical Care: Pathogenesis, Complications, and the Therapeutic Promise of Mediterranean-Style Diets.","authors":"Wafaa F Abusudah, R B Singh, Jan Fedacko, Ghizal Fatima, Athanasios Alexiou, Marios Papadakis, Safaa A Faheem, Gaber El-Saber Batiha","doi":"10.1007/s11894-025-01018-x","DOIUrl":"10.1007/s11894-025-01018-x","url":null,"abstract":"Purpose of review: This review reframes enteral nutrition in critically ill patients as a targeted therapy rather than simple support. It asks whether Mediterranean-style, bioactive-rich formulas containing omega-3 fatty acids, polyphenols, and glutamine can modulate key pathways in sepsis, endothelial dysfunction, and fibrotic remodeling, and whether ICU feeding should be personalized by disease severity, immune profile, and genetic factors.Recent findings: Recent evidence shows these bioactive agents have potent anti-inflammatory, antioxidant, and nutrigenomic effects. They influence cytokine signaling, oxidative stress, and endothelial-to-mesenchymal transition, offering molecular targets for attenuating organ injury. Personalized, metabolism-guided enteral nutrition enriched with Mediterranean bioactive foods may improve tolerance, reduce organ dysfunction, and enhance recovery by directly modulating pathological gene programs. Integrating nutrigenomics into ICU care could transform feeding practices. The review calls for clinical trials to validate these approaches and establish evidence-based guidelines linking diet composition to genetic responses and patient outcomes.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"69"},"PeriodicalIF":4.1,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145344037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Recent Advances in Colon-targeted Drug Delivery Systems: from Traditional Methods to Advanced Technologies. 探索结肠靶向药物输送系统的最新进展：从传统方法到先进技术。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-10-13 DOI: 10.1007/s11894-025-01019-w

Nidhi Agrawal, Mohammad Akbar Siddiqui, Sakshi Gupta, Meenakshi Jaiswal, S K Lanjhiyana

{"title":"Exploring Recent Advances in Colon-targeted Drug Delivery Systems: from Traditional Methods to Advanced Technologies.","authors":"Nidhi Agrawal, Mohammad Akbar Siddiqui, Sakshi Gupta, Meenakshi Jaiswal, S K Lanjhiyana","doi":"10.1007/s11894-025-01019-w","DOIUrl":"10.1007/s11894-025-01019-w","url":null,"abstract":"Purpose of review: This review examines various colon-targeted drug delivery systems (CTDDS) and their implications for the treatment of colonic disorders.Recent findings: Recent studies have demonstrated substantial advancements in CTDDS by the development of pH-dependent, enzyme-responsive, and time-controlled formulations designed for enhancing site-specific delivery and reducing systemic adverse effects. Advanced methodologies, such as ligand or receptor-mediated targeting and multifunctional systems that incorporate various triggering mechanisms, are demonstrating encouraging outcomes in improving therapeutic efficacy. Furthermore, innovative methods like pressure, osmotic-controlled systems, and 3D printing technologies are also being explored for their ability to ensure precise drug release in the colonic region. CTDDS enables localized, controlled therapy, which has the potential to enhance colonic disease outcomes. Integrating the knowledge of the colon's physiology with new delivery technologies may help future research and facilitate the development of more effective treatments.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"67"},"PeriodicalIF":4.1,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traction Techniques for Endoscopic Submucosal Dissection (ESD): Organ-Specific Best Practices and Western Outcomes. 内镜下粘膜剥离（ESD）的牵引技术：器官特异性最佳实践和西方结果。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-10-10 DOI: 10.1007/s11894-025-01015-0

Emmanuel Palomera-Tejeda, Farhan Kawsar, Salmaan Jawaid

{"title":"Traction Techniques for Endoscopic Submucosal Dissection (ESD): Organ-Specific Best Practices and Western Outcomes.","authors":"Emmanuel Palomera-Tejeda, Farhan Kawsar, Salmaan Jawaid","doi":"10.1007/s11894-025-01015-0","DOIUrl":"10.1007/s11894-025-01015-0","url":null,"abstract":"Purpose of review: ESD adoption in Western countries has been limited by longer procedure times, higher complication rates, and a steeper learning curve than in Eastern centers. This review examines the rationale for traction in Western practice, compares outcomes of traction-assisted versus conventional ESD, and outlines best practices for common techniques.Recent findings: Traction methods such as clip-with-line, clip-and-snare, internal elastic devices, double-scope, and novel single-operator tools function as a \"third hand\" to improve submucosal visualization and dissection. Meta-analyses show that traction shortens procedure time (~20 minutes), increases R0 resection rates, and may reduce perforation risk-benefits most evident in the esophagus and colon. Western data are emerging: an expert U.S. center found no major differences with selective use, whereas Japanese RCTs and European guidelines support routine traction in defined settings. Traction addresses key challenges in Western ESD. Mastery of multiple methods allows tailored use, shortens the learning curve, and improves efficiency and safety.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"65"},"PeriodicalIF":4.1,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolving Indications of Esophageal Peroral Endoscopic Myotomy (E-POEM): A Review of Expanding Applications in Esophageal Pathologies. 食管经口内窥镜肌切开术适应症的演变：食管病理扩展应用综述。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-10-10 DOI: 10.1007/s11894-025-01016-z

Yervant Ichkhanian, John M DeWitt

引用次数: 0

Endoscopic Management of Complicated Small Bowel Crohn's Disease. 复杂小肠克罗恩病的内镜治疗。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-09-29 DOI: 10.1007/s11894-025-01014-1

Bo Shen

{"title":"Endoscopic Management of Complicated Small Bowel Crohn's Disease.","authors":"Bo Shen","doi":"10.1007/s11894-025-01014-1","DOIUrl":"10.1007/s11894-025-01014-1","url":null,"abstract":"Purpose of review: Complicated Crohn's disease in the small bowel is often associated with structural complications, particularly strictures. Endoscopy plays a key role in the diagnosis, disease monitoring, and therapy of small bowel CD. This article will provide state-of-the-art endoscopic treatment modalities for small bowel complications in CD.Recent findings: Endoscopic therapy for small bowel disease can be delivered through upper endoscopy, push enteroscopy, ileocolonoscopy, device-assisted enteroscopy, intraoperative enteroscopy, and ileoscopy. In addition to persistent medical therapy, endoscopic treatment is performed using bare- or drug-coated balloon dilation, electrocision, and mechanical stricturectomy. Isolated ileocecal valve CD with associated stricture and adjacent fistulas comprises a unique phenotype of CD, mimicking the clinical presentation and disease course of achalasia at the gastroesophageal junction. Ileocecal valve CD can be treated with stricturectomy and fistulotomy. Endoscopy also has a major role in the treatment of surgery-associated anastomotic complications (such as stricture, bleeding, and leaks). Endoscopic treatment should be attempted in patients with short (<4-5) small bowel strictures on top of medical therapy. Isolated ileocecal valve CD represents a unique phenotype of CD consisting of inflammation, stricture, and fistula at and around the valve, which is amenable for endoscopic therapy.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"64"},"PeriodicalIF":4.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portal Hypertensive Colopathy: Diagnostic Challenges and Management in Cirrhosis. 门脉高压性结肠病：肝硬化的诊断挑战和治疗。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-09-19 DOI: 10.1007/s11894-025-01012-3

Jiasheng Henry Guo, Angelo H Paredes

{"title":"Portal Hypertensive Colopathy: Diagnostic Challenges and Management in Cirrhosis.","authors":"Jiasheng Henry Guo, Angelo H Paredes","doi":"10.1007/s11894-025-01012-3","DOIUrl":"10.1007/s11894-025-01012-3","url":null,"abstract":"Purpose of review: This review summarizes the current understanding of portal hypertensive colopathy (PHC), highlights the clinical and endoscopic presentation, treatment options to be considered and areas for future investigation.Recent findings: Portal hypertensive colopathy (PHC) is an underrecognized consequence of portal hypertension in cirrhosis. It frequently presents with subtle gastrointestinal symptoms, such as iron deficiency anemia or intermittent rectal bleeding, and is often misattributed to more common etiologies like hemorrhoids or diverticular disease. PHC is a diagnosis made endoscopically and is characterized by erythema of the colonic mucosa, vascular lesions and colon varices. Management focuses on portal pressure reduction, endoscopic colon therapies and intra-vascular procedures. Due to a lack diagnostic criteria, the true prevalence of PHC is unknown but has been reported to be up to 71% among cirrhotic patients. The management of acute bleeding from PHC is based on case reports, case series and expert opinion. PHC should be considered in all cirrhotic patients with unexplained lower GI bleeding or chronic anemia. A high index of suspicion is required in order to make a timely and accurate diagnosis.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"63"},"PeriodicalIF":4.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Of Endpoints and Equipoise: Reforming Clinical Trials in Colorectal Polyp Resection. 终点和平衡：改革结肠直肠息肉切除术的临床试验。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-09-18 DOI: 10.1007/s11894-025-01013-2

Zachary L Smith, Nauzer Forbes, Srivats Madhavan, Heiko Pohl, Jacob M Schauer, Ingo Steinbrück, Daniel von Renteln

{"title":"Of Endpoints and Equipoise: Reforming Clinical Trials in Colorectal Polyp Resection.","authors":"Zachary L Smith, Nauzer Forbes, Srivats Madhavan, Heiko Pohl, Jacob M Schauer, Ingo Steinbrück, Daniel von Renteln","doi":"10.1007/s11894-025-01013-2","DOIUrl":"10.1007/s11894-025-01013-2","url":null,"abstract":"Purpose of review: To review and assess current design approaches in endoscopic mucosal resection (EMR) trials, identify areas where traditional methodologies may limit relevance or generalizability, and propose a forward-looking framework that incorporates methodological innovations aligned with clinical and stakeholder priorities.Recent findings: Despite major procedural advances in EMR, trial design has evolved more slowly - employing binary endpoints, limited patient and clinician input, and enrollment models often led by high-volume proceduralists. Critical design innovations, such as ordinal recurrence classifications, composite outcomes ranked by clinical severity, and proceduralist-aware statistical models can help to overcome these limitations. Introducing methodology such as generalized pairwise comparisons yielding a win ratio, while useful for analyzing hierarchical composite endpoints (HCEs), represent just one facet of a broader strategy. Drawing from innovations in cardiovascular and other procedural disciplines, this review highlights how diverse design elements can be adapted to the EMR space. Improving EMR trials demands a shift in trial architecture. By combining stakeholder-informed outcome hierarchies, advanced analytic methods, and strategies to mitigate operator bias, a modern framework capable of producing more meaningful, reproducible, and generalizable evidence is possible. This evolution in design reflects a necessary progression for procedural trials and sets the stage for a new standard in colorectal polyp resection research.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"62"},"PeriodicalIF":4.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal Ultrasound for Monitoring Colonic Inflammation in Inflammatory Bowel Disease. 肠超声监测炎症性肠病的结肠炎症。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-08-12 DOI: 10.1007/s11894-025-01010-5

Rishika Chugh, Phillip Gu, Michael Todd Dolinger

{"title":"Intestinal Ultrasound for Monitoring Colonic Inflammation in Inflammatory Bowel Disease.","authors":"Rishika Chugh, Phillip Gu, Michael Todd Dolinger","doi":"10.1007/s11894-025-01010-5","DOIUrl":"10.1007/s11894-025-01010-5","url":null,"abstract":"Purpose of review: Traditional abdominal ultrasound for monitoring inflammatory bowel disease is known as Intestinal ultrasound (IUS). This is a non-invasive, point-of-care imaging tool that is utilized to visualize the bowel wall and its layers. IUS was initially used for assessment of small bowel Crohn's disease (CD) but has now proven to be just as accurate for colonic disease.Recent findings: IUS can detect disease activity in both ulcerative colitis (UC) and colonic CD with high sensitivity and specificity when compared to colonoscopy. The sonographic parameter of bowel wall thickness (BWT) is key for detecting disease activity. The ease and reproducibility of IUS allows for rapid assessment of treatment response in both outpatient and inpatient settings with changes seen as early as 48 h after initiating appropriate treatment. IUS has proven to be useful in special populations, including pregnancy and pediatrics, where traditional methods of monitoring are less feasible or of higher risk. IUS is a useful tool for objective assessment of colonic disease activity in colonic UC or CD.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"61"},"PeriodicalIF":4.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Cholecystectomy on Colorectal Cancer Risk: A Comprehensive Review on Risk Factors and the Association. 胆囊切除术对结直肠癌风险的影响：危险因素及其相关性的综合综述。

IF 4.1

Current Gastroenterology Reports Pub Date : 2025-08-11 DOI: 10.1007/s11894-025-01008-z

Parsa Lorestani, Ferdos Faghihkhorasani, Homina Saffar, Behnam Darabi, Yasaman Tavakoli, Amir Mohammad Lorestani, Mohammad Ghiasi, Kimia Jazi

{"title":"The Impact of Cholecystectomy on Colorectal Cancer Risk: A Comprehensive Review on Risk Factors and the Association.","authors":"Parsa Lorestani, Ferdos Faghihkhorasani, Homina Saffar, Behnam Darabi, Yasaman Tavakoli, Amir Mohammad Lorestani, Mohammad Ghiasi, Kimia Jazi","doi":"10.1007/s11894-025-01008-z","DOIUrl":"10.1007/s11894-025-01008-z","url":null,"abstract":"Purpose of review: This review examines the debated association between cholecystectomy and colorectal cancer risk. The goal is to evaluate biological mechanisms, epidemiological evidence, and related risk factors to better understand this potential association.Recent findings: Cholecystectomy may increase CRC risk through altered bile acid metabolism and gut microbiota changes, particularly in the right colon. Epidemiological studies, however, yield mixed outcomes: some show a heightened CRC risk following surgery, especially in women and for proximal colon cancers, while others find no notable link or even a lower risk compared to individuals with untreated gallstones. No clear consensus exists on the cholecystectomy-CRC link. Biological evidence hints at a possible connection, yet epidemiological findings are inconsistent, calling for more prospective research to resolve this uncertainty. Until conclusive answers emerge, high-risk patients' post-cholecystectomy may benefit from enhanced CRC screening and lifestyle adjustments, influencing future clinical and research directions.","PeriodicalId":10776,"journal":{"name":"Current Gastroenterology Reports","volume":"27 1","pages":"59"},"PeriodicalIF":4.1,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0