Current Bioactive Compounds最新文献

{"title":"Iron(III) Monoglycerolate: A Potential Hemostatic Agent for Topical Application","authors":"Tat’yana Khonina, Alexander Safronov, M. Bulatova, L. Larionov, Irina Antropova, M. Dobrinskaya, N. Izmozherova, D. Tishin, Semyon Alekseenko, E. Bogdanova, Maxim Karabanalov, O. Chupakhin","doi":"10.2174/0115734072295011240425080837","DOIUrl":"https://doi.org/10.2174/0115734072295011240425080837","url":null,"abstract":"\u0000\u0000Glycerolates of biogenic elements are of interest because of their pharmacological\u0000activity. Some of them are used as active substances in agents for topical application\u0000and as biocompatible precursors in sol-gel synthesis of bioactive materials.\u0000\u0000\u0000\u0000In this work, morphostructural feature, ability to hydrolyze, and the pharmacological\u0000activity of previously synthesized iron(III) monoglycerate were studied.\u0000\u0000\u0000\u0000Analytical techniques, including SEM, TEM, XRD, TGA, IR spectroscopy, DLS and\u0000ELS, were used. Hemostatic activity was studied in vivo, and primary toxicological studies were\u0000carried out on experimental animals. Antimicrobial activity was studied using the agar diffusion\u0000method.\u0000\u0000\u0000\u0000When dispersed in glycerol, solid crystalline iron(III) monoglycerolate transforms into\u0000an amorphous state, forming aggregates with an average particle size of 250 nm (according to\u0000DLS data). It slowly hydrolyzes in water at room temperature, while hydrolysis does not take\u0000place in an aqueous glycerol media. Iron(III) monoglycerolate is nontoxic and exhibits pronounced\u0000hemostatic activity and low antibacterial activity (relative to the strain S. аureus).\u0000\u0000\u0000\u0000Iron(III) monoglycerolate can be considered a potential hemostatic agent, showing\u0000promise for topical application in medical and veterinary practice, as well as a novel biocompatible\u0000precursor in the sol-gel synthesis of practically useful substances.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140996530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer Activity and GC-MS Profiling of Bioactive Constituents in the Methanolic Extracts of Spatoglossum variabile and Gracilaria corticata","authors":"S. Sruthi, Shahjahan A, Kumaran K, Dannie Macrin, Vijay Murali RM, K.N. Aruljothi","doi":"10.2174/0115734072296835240409124751","DOIUrl":"https://doi.org/10.2174/0115734072296835240409124751","url":null,"abstract":"\u0000\u0000Marine algae stand out as repositories of bioactive metabolites, widely\u0000harnessed in treating diverse diseases. Given the often-challenging side effects associated with\u0000conventional cancer treatments, researchers are increasingly turning their attention to marine algae\u0000as a promising source for discovering novel and potent anticancer compounds. In this study,\u0000we meticulously explored the potential anticancer activity of Spatoglossum variabile and\u0000Gracilaria corticata sourced from the Indian Ocean.\u0000\u0000\u0000\u0000Marine algae are rich in bioactive metabolites that are extensively used to treat various diseases. Researchers have considered marine algae for novel and promising anticancer compounds due to the adverse effects of standard cancer treatments\u0000\u0000\u0000\u0000The secondary metabolites were extracted using methanol solvent according\u0000to the standard protocol. The extract was subjected to GC-MS analysis and evaluated for\u0000its short- and long-term cytotoxicity and anti-proliferative ability in the HCT116 cell line using\u0000MTT, clonogenic, and trypan blue dye exclusion assays, respectively.\u0000\u0000\u0000\u0000The methanolic extract of Spatoglossum variabile contained 21 unique\u0000anticancer compounds, except for the other bioactive compounds. The results indicate that increasing\u0000the concentration of algal extracts decreased the cell viability significantly, with an IC50\u0000of 51.49 μg/mL and 37.50 μg /mL in the HCT116 cell line. The results showed a significant reduction\u0000in colorectal cancer colony formation and a gradual reduction in cell proliferation. These\u0000results underscore the potential for targeted, low-toxicity biomedicines due to their selective cytotoxicity\u0000against cancer cells.\u0000\u0000\u0000\u0000The extract was subjected to GC-MS analysis and evaluated for its short- and long-term cytotoxicity and anti-proliferative ability in HCT116 cell line using MTT, clonogenic, and trypan blue dye exclusion assays, respectively.\u0000\u0000\u0000\u0000Our findings show that Spatoglosuum variabile & Gracilaria corticata extracts contain\u0000various bioactive compounds, display long-term and short-term cytotoxicity and antiproliferative\u0000effects, which indicates that their constituent compounds might be further refined\u0000into effective anti-colorectal cancer medications.\u0000\u0000\u0000\u0000The methanolic extract of Spatoglossum variabile contained 21 unique anti-cancer compounds, in addition to other bioactive compounds. The results indicate that increasing the concentration of algal extracts decreased the cell viability significantly, with an IC50 of 51.49 µg/mL and 37.50 µg /ml in the HCT116 cell line. The results showed a significant reduction in colony formation and a gradual reduction in cell proliferation\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xanthone Derivatives: A Pharmacological Panorama of Versatility","authors":"Anuradha Mehra, Rekha Sangwan, Emmanuel Owusu","doi":"10.2174/0115734072278162240406123303","DOIUrl":"https://doi.org/10.2174/0115734072278162240406123303","url":null,"abstract":"\u0000\u0000Xanthones are a class of naturally occurring compounds found in various plant\u0000sources. Over the years, studies have revealed therapeutic impending xanthones in treating and\u0000managing several ailments, including cancer, inflammation, and microbial infections. Xanthones\u0000exert their therapeutic effects through various mechanisms, such as anti-inflammatory, antioxidant,\u0000and anti-proliferative activities. It has also been found that xanthones induce apoptosis, inhibit\u0000cell proliferation, and arrest cell cycles by modulating several signaling pathways. This review\u0000objective is to deliver an inclusive overview of the therapeutic essence of xanthones and\u0000their potential use as a natural remedy for managing and treating various diseases.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GCMS Analysis of Bioactive Compounds and Evaluation of Anti-parkinson\u0000Activity of Leaf Extract of Curculigo orchioides in Experimental Animals","authors":"U. D'Souza, Chandrashekar K.S., Shruthi R, Vasudev Pai","doi":"10.2174/0115734072285993240403110533","DOIUrl":"https://doi.org/10.2174/0115734072285993240403110533","url":null,"abstract":"\u0000\u0000Curculigo orchioides Gaertn, a plant belonging to the Hypoxidaceae\u0000family, is well-known for its traditional uses of all plant parts. This plant is commonly known\u0000as golden eye grass, black musli, Kali musli, or Kali Musali. Parkinson's disease is a neurodegenerative disorder that is commonly observed in older adults. It is caused by a variety of mechanisms, including neuroinflammation, which results in the loss of dopamine release when triggered\u0000and causes motor symptoms.\u0000\u0000\u0000\u0000Ethanolic extract was prepared by shade-drying the leaves, making them into a coarse\u0000powder, and the extract was prepared by maceration technique with the help of ethanol. GCMS\u0000analysis and Haloperidol-induced Parkinsonism study were carried out to evaluate the antiParkinson activity in albino Wistar rats. Ethanolic extract of Curculigo orchioides was subjected\u0000to GCMS analysis. The National Institute of Standards and Technology database was used to interpret the mass spectrum of the GC-MS. The screening models were catalepsy, rotarod and a few\u0000in vitro models, namely the estimation of catalase acetylcholinesterase levels. The animals were\u0000divided into 6 groups, namely control, disease, standard (levodopa), low dose (100 mg/kg p.o.),\u0000medium dose (200 mg/kg p.o.), high dose (400 mg/kg p.o.) groups having 6 animals each were\u0000used for rotarod and catalepsy models for 14 days\u0000\u0000\u0000\u0000The results obtained showed a dose-dependent increase in the anti-Parkinson activity.\u0000The evaluation of neuromuscular movements of the ethanolic leaf extract of Curculigo orchioides\u0000showed that the pre-treatment with different ranges of dose (100 mg/ml, 200 mg/kg, and 400\u0000mg/kg) suggested a dose-dependent significant increase in fall-off time when compared with both\u0000standard and disease groups GCMS analysis revealed the presence of flavonoids, Vitamin and\u0000fatty acid esters.\u0000\u0000\u0000\u0000The anti-Parkinson activity of Flavonoids has been reported previously. Hence, the\u0000activity may be attributed to kaempferol-3-O-glucuronide.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal Activity of Chitosan Nanocomposites against Candida albicans:\u0000A Systematic Review","authors":"P. Shakib, Shirzad Fallahi, G. Goudarzi, Shahram Ahmadi Somaghian, Sana Amiri, Sirus Nemati Delfan, Kourosh Cheraghipour","doi":"10.2174/0115734072297928240404074703","DOIUrl":"https://doi.org/10.2174/0115734072297928240404074703","url":null,"abstract":"\u0000\u0000This investigation aims to explore the potential anti-Candida albicans\u0000effects of Chitosan nanocomposites.\u0000\u0000\u0000\u0000Researchers searched several databases, including Scopus, PubMed, Science Direct,\u0000Cochrane, and Ovid, for articles published between 2000 and 2023 using specific keywords.\u0000\u0000\u0000\u0000Of the 5,600 studies that were first searched in the databases, after removing duplicates\u0000(700 cases) and applying inclusion and exclusion criteria, 43 studies were selected for evaluation\u0000after duplicate removal.\u0000\u0000\u0000\u0000According to studies, the anti-Candida albicans properties of chitosan nanocomposites\u0000are more than routine antifungals such as nystatin; therefore, it can be concluded that Chitosan\u0000nanocomposites can be used to deal with Candida albicans.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140695453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Characterization, Docking Studies, and In-vitro Cytotoxic\u0000Activity of Some Novel 2, 3 Disubstituted Naphthalene 1,4 Dione\u0000Derivatives","authors":"Dilipkumar S, Karthik V, Gowramma B, Magesh M, Kaviarasan L","doi":"10.2174/0115734072298465240403084903","DOIUrl":"https://doi.org/10.2174/0115734072298465240403084903","url":null,"abstract":"\u0000\u0000Many quinone derivatives as of now utilized for anticancer medications.\u0000Especially, 1,4-naphthoquinones are dynamic derivatives, and it was broadly utilized in unrefined\u0000substances in the drugs and agrochemicals industry.\u0000\u0000\u0000\u0000In this work, we planned and combined five different moieties into 2, 3\u0000disubstituted naphthalene-1,4-dione molecules. Various spectral studies distinguished the synthetic\u0000designs of the produced compounds. The naphthoquinone derivatives were exposed to the primary\u0000molecular descriptor by Molinspiration programming, and all the descriptor values are within\u0000the specified value.\u0000\u0000\u0000\u0000In this work, we planned and combined five different moieties into 2, 3\u0000disubstituted naphthalene-1,4-dione molecules. Various spectral studies distinguished the synthetic\u0000designs of the produced compounds. The naphthoquinone derivatives were exposed to the primary\u0000molecular descriptor by Molinspiration programming, and all the descriptor values are within\u0000the specified value.\u0000\u0000\u0000\u0000Each of the five naphthoquinone derivatives was docked against the\u0000Topoisomerase II utilizing Auto Dock program 4.2.5. (PDB: 3L4K). The docking tells us that the\u0000studied compounds possess significant to moderate inhibition toward the targeted enzymes.\u0000Among the studied compounds, compound L3 showed the most elevated binding score (-10.66\u0000kcal/mol with one H-bond) than the adriamycin (-9.58 kcal/mol with two H-bonds) and compound\u0000L2 (- 9.86 kcal/mol with two H-bonds). The derivatives were tried for in-vitro cytotoxicity\u0000studies against MCF - 7 by the SRB method. Among them, compounds L2 (28.42±3.1 μg/mL)\u0000and L3 (29.38±3.2 μg/mL) were the most significant ones when contrasted with the control Adriamycin\u0000(15.28±3.4 μg/mL).\u0000\u0000\u0000\u0000The current research indicates that the tested compounds show anticancer action\u0000against the MCF-7 breast cancer cell line. Thus, the study is an attempt to advance toward the\u0000identification of innovative anticancer drugs.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140697708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant Properties of Brassica Rapa L. Seeds and Immunostimulant Effect on Immunity Broilers Cells (Gallus Gallus Domesticus)","authors":"Soukaina Laaraj, Ibtisaam Ouahidi, Nada Al Moudani, A. Boukir, Samira Jaouhar, Safae Er Raouan, L. Aarab","doi":"10.2174/0115734072282302240402043805","DOIUrl":"https://doi.org/10.2174/0115734072282302240402043805","url":null,"abstract":"\u0000\u0000In the past few decades, researchers have focused on finding the benefits\u0000of natural substances derived from plants.\u0000\u0000\u0000\u0000This study aimed to evaluate the use of Brassica rapa seeds in poultry feed as an antioxidant\u0000and immunostimulant of host defenses.\u0000\u0000\u0000\u0000We prepared three extracts using ethanol, Ethyl Acetate, and water. Spectrophotometric\u0000methods determined the total phenolic and flavonoid content in the three extracts. Antioxidant\u0000activity was assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing/antioxidant\u0000power (FRAP), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS)\u0000radicals and β-Carotene bleaching methods. An assessment of their immunostimulant activities in\u0000vitro was performed on chicken immunity cell proliferation (splenocytes, thymocytes, and Bursa\u0000cells) and IgY production.\u0000\u0000\u0000\u0000We prepared three different extracts using ethanol, Ethyl Acetate, and water. The total phenolic and flavonoid content in the three extracts was determined by spectrophotometric methods.Antioxidant activity has been assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing/antioxidant power (FRAP), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radicals and β-Carotene bleaching methods. Assessment of their immunostimulant activities in vitro was tested on chicken immunity cell proliferation (splenocytes, thymocytes, and Bursa cells) and IgY production\u0000\u0000\u0000\u0000The total phenolic contents ranged from 462.5 to 794.8 mg /g of extract, the order of\u0000TPC was as follows: EtOAc > EtOH >Water. Flavonoid contents were, 63.7 mg in EtOH extract,\u000081.2 mg in EtOAc extract, and 108.7 mg/g Extract in aqueous extract. By DPPH, the IC50s of\u0000EtOH, EtOAc, and water, were 1.8μg/ml, 2.4μg/ml, and 1.5μg/ml, respectively. Using the Ferric-\u0000Reducing Antioxidant Power (FRAP), we remarked that the EtOH and EtOAc extracts have important\u0000antioxidant powers. The ABTS assay indicated that EtOH and water had the highest activities\u0000with IC50s of 0.19 and 0.07, respectively. Finally, by the β-carotene bleaching test, we observed\u0000that the IC50 of the EtOH, EtOAc, and water were 62.1 μg/mL; 72.7 μg/mL, and 45.8\u0000μg/mL, respectively. The results obtained indicate that Brassica aqueous extract stimulates humoral\u0000immunity by stimulating splenocyte (B and T-lymphocytes) and Bursa cell (B-lymphocyte)\u0000proliferation by more than 200% of response vs control. In addition, the aqueous extract highly\u0000stimulated the function of bursa cells by 208% of the reaction. In the same conditions, we recorded\u0000a stimulation of cellular immunity mediated by thymocytes by an increase in cell proliferation\u0000(352.7% of response) implicated in virus protection. These extracts also possessed an antimicrobial\u0000effect against diverse microorganisms such as coliforms and Staphylococcus. The FT-IR\u0000spectrum indicated that the hydroxyl group (phenol), hydroxybenzoic acid family, carbohydrate\u0000molecules such as glucopyranose, a carbonyl ester group, hydrocar","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140721616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential, Pharmacological Activities and Analytical Aspects\u0000of Liriodendrin in Medicine: Novel and Potential Therapy Options for the\u0000Treatment of Human Disorders and Associated Complications","authors":"K. Patel, D. Patel","doi":"10.2174/0115734072286081240326082701","DOIUrl":"https://doi.org/10.2174/0115734072286081240326082701","url":null,"abstract":"\u0000\u0000Natural products and their derived secondary metabolites play an important role in\u0000medicine and other allied health sectors. Liriodendrin is one of the main lignans of Boerhaavia\u0000diffusa roots. Liriodendrin is a lignin class phytochemical having numerous health beneficial\u0000properties in medicine, including anti-myocardial ischemia, anti-arrhythmic, anti-oxidant and anti-\u0000inflammatory potential. This present review aims to analyze the reported ethnomedicinal properties,\u0000pharmacological activities and analytical aspects of liriodendrin and identify the remaining\u0000gaps in medicinal fields for their future investigations. The pharmacological properties of liriodendrin\u0000have been described in the present paper in order to describe its better utilization in natural\u0000medicine in the future. Biological poptential and pharmacological activities of liriodendrin\u0000have been described in the present work with their analytical development in the scientific fields.\u0000In the present work, scientific data on liriodendrin were collected from different scientific databases\u0000such as PubMed, Springer, Google, Science Direct, and Google Scholar. They described\u0000their biological potential on the basis of the available scientific literature. Further, research and\u0000review articles from peer-reviewed journals were also searched during data collection. The present\u0000paper's scientific data signified the biological importance of liriodendrin in medicine, which\u0000has been isolated from Boerhaavia diffusa and other medicinal plants. Liriodendrin has biological\u0000potential against myocardial infarction, arrhythmias, lung injury, hepatic injury, antiinflammatory,\u0000ulcerative colitis, gastric injury, SARS-CoV-2 protease and intestinal inflammation.\u0000Further, its effectiveness in medicine was also due to its anti-convulsant activity, nitric oxide\u0000inhibitory potential, cytotoxicity, cytoprotective nature, anti-oxidant, and anti-microbial potential.\u0000The present paper's scientific data also described the metabolism and analytical development for\u0000their isolation, separation and identification in different samples. Detailed pharmacological activities\u0000of liriodendrin have been described here in the present work and highlighted its important\u0000pharmacological properties and analytical aspects. Liriodendrin is a valuable phytochemical of\u0000Boerhaavia diffusa, which has numerous biological applications in medicine. Further, this study\u0000can also validate the traditional and ethnobotanical use of the Boerhaavia diffusa and other plant\u0000material, which contain a significant amount of liriodendrin as an active phytochemical. Liriodendrin\u0000have huge biological potential far beyond its traditional uses in human complications.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140720662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eucalyptus globulus Labill. Essential Oil Effect on the Attachment of Oral\u0000Bacteria to Hydroxyapatite and Biofilm Formation","authors":"Kahina Hardou-Belhoucine, F. Brahmi, Daniel Grenier, Khokha Mouhoubi, K. Madani, L. Boulekbache‐Makhlouf","doi":"10.2174/0115734072296932240319060406","DOIUrl":"https://doi.org/10.2174/0115734072296932240319060406","url":null,"abstract":"\u0000\u0000Periodontal disease and dental caries are two oral illnesses that are significantly\u0000influenced by microorganisms, hence the usefulness of finding natural substances to\u0000inhibit them.\u0000\u0000\u0000\u0000This study aimed to assess the Eucalyptus globulus Labill. leaf and fruit essential oils\u0000effect against Streptococcus mutans, Streptococcus sobrinus, Aggregatibacter actinomycetemcomitans,\u0000Porphyromonas gingivalis, Fusobacterium nucleatum, and Candida albicans to study\u0000their anticariogenic and antiperiodonto pathogenic activities.\u0000\u0000\u0000\u0000these activities were evaluated according to the determination of minimum inhibitory\u0000concentration (MIC) and minimum bactericidal concentration (MBC), anti-biofilm effects, and\u0000the impact on the adhesion to hydroxyapatite, a main component of the tooth.\u0000\u0000\u0000\u0000both leaf and fruit essential oils showed strong antibacterial activity against anaerobic\u0000bacteria: F. nucleatum (MIC of 0.012 %) and P. gingivalis (MIC of 0.025 %). Anticarcinogenic\u0000activity also showed MIC values of 0.06 % against S. mutans and, 0.5 % against S. sobrinus, and\u0000appropriate antifungal activity against C. albicans. It is interesting to note that both oils showed a\u0000significant inhibitory property to biofilm formation by the different studied species and significantly\u0000reduced the adhesion capacity of S. mutans and S. sobrinus to the hydroxyapatite surface at\u0000very low concentrations of 0.12 and 0.5 % for S. mutans and S. sobrinus, respectively.\u0000\u0000\u0000\u0000These results highlight the strong potential of E. globulus essential oils as antimicrobial\u0000and antibiofilm agents, as well as their ability to inhibit bacterial adhesion, which is promising\u0000for the prevention of dental caries and plaque. This implies that E. globulus may be a new\u0000alternative source of substances of medicinal interest that can be used in the pharmaceutical industry\u0000to produce antimicrobial agents against dental caries and oral infectious diseases\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140751574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual and Dual Cytotoxicity of the Combination of Passiflora Caerulea Leaf Extract and Titanium Oxide Nanoparticles against A549, U937, and\u0000Hela Cells","authors":"L. Sindhura, Mohd. Nazneen Bobby, K. Srikanth, Helan Soundra Rani Michael, Abu Md Ashif Ikbal, Sabu Thomas, H. Kargarzadeh, Partha Palit","doi":"10.2174/0115734072294581240311064402","DOIUrl":"https://doi.org/10.2174/0115734072294581240311064402","url":null,"abstract":"\u0000\u0000The study addresses the underexplored realm of cytotoxicity evaluation\u0000involving binary mixtures of Passiflora caerulea leaf extracts and Titanium nanoparticles\u0000(TiO2NPs). The focus lies on understanding the combined effects of these components on cancer\u0000cells (A549, U937, and HeLa).\u0000\u0000\u0000\u0000In vitro cytotoxicity assessments were employed to evaluate the toxicity of P. caerulea\u0000leaf extracts, TiO2NPs, and their combination. The study utilized MTT, NRU, and LDH assays to\u0000measure cellular viability. Additionally, reactive oxygen species (ROS) and glutathione levels\u0000were assessed alongside the aforementioned assays.\u0000\u0000\u0000\u0000The toxicity percentage exhibited dose-dependent behavior for P. caerulea leaf extracts,\u0000TiO2NPs, and their combination. Interestingly, when P. caerulea leaf extract and TiO2NPs were\u0000combined, the reduction in cell viability was noticeably more than when the exposures were made\u0000separately. Moreover, the production of ROS was higher in the combined toxicity scenario, and a\u0000more pronounced decrease in glutathione levels was observed compared to individual exposures.\u0000\u0000\u0000\u0000The findings suggest that the combined effects of P. caerulea leaf extract and\u0000TiO2NPs induce greater cytotoxicity compared to their impacts. This underscores the potential for\u0000synergistic cytotoxicity in combined exposure scenarios, warranting further exploration of combined\u0000effects in future studies.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}