Current Bioactive Compounds最新文献

{"title":"GCMS Analysis of Bioactive Compounds and Evaluation of Anti-parkinson\u0000Activity of Leaf Extract of Curculigo orchioides in Experimental Animals","authors":"U. D'Souza, Chandrashekar K.S., Shruthi R, Vasudev Pai","doi":"10.2174/0115734072285993240403110533","DOIUrl":"https://doi.org/10.2174/0115734072285993240403110533","url":null,"abstract":"\u0000\u0000Curculigo orchioides Gaertn, a plant belonging to the Hypoxidaceae\u0000family, is well-known for its traditional uses of all plant parts. This plant is commonly known\u0000as golden eye grass, black musli, Kali musli, or Kali Musali. Parkinson's disease is a neurodegenerative disorder that is commonly observed in older adults. It is caused by a variety of mechanisms, including neuroinflammation, which results in the loss of dopamine release when triggered\u0000and causes motor symptoms.\u0000\u0000\u0000\u0000Ethanolic extract was prepared by shade-drying the leaves, making them into a coarse\u0000powder, and the extract was prepared by maceration technique with the help of ethanol. GCMS\u0000analysis and Haloperidol-induced Parkinsonism study were carried out to evaluate the antiParkinson activity in albino Wistar rats. Ethanolic extract of Curculigo orchioides was subjected\u0000to GCMS analysis. The National Institute of Standards and Technology database was used to interpret the mass spectrum of the GC-MS. The screening models were catalepsy, rotarod and a few\u0000in vitro models, namely the estimation of catalase acetylcholinesterase levels. The animals were\u0000divided into 6 groups, namely control, disease, standard (levodopa), low dose (100 mg/kg p.o.),\u0000medium dose (200 mg/kg p.o.), high dose (400 mg/kg p.o.) groups having 6 animals each were\u0000used for rotarod and catalepsy models for 14 days\u0000\u0000\u0000\u0000The results obtained showed a dose-dependent increase in the anti-Parkinson activity.\u0000The evaluation of neuromuscular movements of the ethanolic leaf extract of Curculigo orchioides\u0000showed that the pre-treatment with different ranges of dose (100 mg/ml, 200 mg/kg, and 400\u0000mg/kg) suggested a dose-dependent significant increase in fall-off time when compared with both\u0000standard and disease groups GCMS analysis revealed the presence of flavonoids, Vitamin and\u0000fatty acid esters.\u0000\u0000\u0000\u0000The anti-Parkinson activity of Flavonoids has been reported previously. Hence, the\u0000activity may be attributed to kaempferol-3-O-glucuronide.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal Activity of Chitosan Nanocomposites against Candida albicans:\u0000A Systematic Review","authors":"P. Shakib, Shirzad Fallahi, G. Goudarzi, Shahram Ahmadi Somaghian, Sana Amiri, Sirus Nemati Delfan, Kourosh Cheraghipour","doi":"10.2174/0115734072297928240404074703","DOIUrl":"https://doi.org/10.2174/0115734072297928240404074703","url":null,"abstract":"\u0000\u0000This investigation aims to explore the potential anti-Candida albicans\u0000effects of Chitosan nanocomposites.\u0000\u0000\u0000\u0000Researchers searched several databases, including Scopus, PubMed, Science Direct,\u0000Cochrane, and Ovid, for articles published between 2000 and 2023 using specific keywords.\u0000\u0000\u0000\u0000Of the 5,600 studies that were first searched in the databases, after removing duplicates\u0000(700 cases) and applying inclusion and exclusion criteria, 43 studies were selected for evaluation\u0000after duplicate removal.\u0000\u0000\u0000\u0000According to studies, the anti-Candida albicans properties of chitosan nanocomposites\u0000are more than routine antifungals such as nystatin; therefore, it can be concluded that Chitosan\u0000nanocomposites can be used to deal with Candida albicans.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"62 1‐2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140695453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Characterization, Docking Studies, and In-vitro Cytotoxic\u0000Activity of Some Novel 2, 3 Disubstituted Naphthalene 1,4 Dione\u0000Derivatives","authors":"Dilipkumar S, Karthik V, Gowramma B, Magesh M, Kaviarasan L","doi":"10.2174/0115734072298465240403084903","DOIUrl":"https://doi.org/10.2174/0115734072298465240403084903","url":null,"abstract":"\u0000\u0000Many quinone derivatives as of now utilized for anticancer medications.\u0000Especially, 1,4-naphthoquinones are dynamic derivatives, and it was broadly utilized in unrefined\u0000substances in the drugs and agrochemicals industry.\u0000\u0000\u0000\u0000In this work, we planned and combined five different moieties into 2, 3\u0000disubstituted naphthalene-1,4-dione molecules. Various spectral studies distinguished the synthetic\u0000designs of the produced compounds. The naphthoquinone derivatives were exposed to the primary\u0000molecular descriptor by Molinspiration programming, and all the descriptor values are within\u0000the specified value.\u0000\u0000\u0000\u0000In this work, we planned and combined five different moieties into 2, 3\u0000disubstituted naphthalene-1,4-dione molecules. Various spectral studies distinguished the synthetic\u0000designs of the produced compounds. The naphthoquinone derivatives were exposed to the primary\u0000molecular descriptor by Molinspiration programming, and all the descriptor values are within\u0000the specified value.\u0000\u0000\u0000\u0000Each of the five naphthoquinone derivatives was docked against the\u0000Topoisomerase II utilizing Auto Dock program 4.2.5. (PDB: 3L4K). The docking tells us that the\u0000studied compounds possess significant to moderate inhibition toward the targeted enzymes.\u0000Among the studied compounds, compound L3 showed the most elevated binding score (-10.66\u0000kcal/mol with one H-bond) than the adriamycin (-9.58 kcal/mol with two H-bonds) and compound\u0000L2 (- 9.86 kcal/mol with two H-bonds). The derivatives were tried for in-vitro cytotoxicity\u0000studies against MCF - 7 by the SRB method. Among them, compounds L2 (28.42±3.1 μg/mL)\u0000and L3 (29.38±3.2 μg/mL) were the most significant ones when contrasted with the control Adriamycin\u0000(15.28±3.4 μg/mL).\u0000\u0000\u0000\u0000The current research indicates that the tested compounds show anticancer action\u0000against the MCF-7 breast cancer cell line. Thus, the study is an attempt to advance toward the\u0000identification of innovative anticancer drugs.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"1 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140697708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant Properties of Brassica Rapa L. Seeds and Immunostimulant Effect on Immunity Broilers Cells (Gallus Gallus Domesticus)","authors":"Soukaina Laaraj, Ibtisaam Ouahidi, Nada Al Moudani, A. Boukir, Samira Jaouhar, Safae Er Raouan, L. Aarab","doi":"10.2174/0115734072282302240402043805","DOIUrl":"https://doi.org/10.2174/0115734072282302240402043805","url":null,"abstract":"\u0000\u0000In the past few decades, researchers have focused on finding the benefits\u0000of natural substances derived from plants.\u0000\u0000\u0000\u0000This study aimed to evaluate the use of Brassica rapa seeds in poultry feed as an antioxidant\u0000and immunostimulant of host defenses.\u0000\u0000\u0000\u0000We prepared three extracts using ethanol, Ethyl Acetate, and water. Spectrophotometric\u0000methods determined the total phenolic and flavonoid content in the three extracts. Antioxidant\u0000activity was assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing/antioxidant\u0000power (FRAP), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS)\u0000radicals and β-Carotene bleaching methods. An assessment of their immunostimulant activities in\u0000vitro was performed on chicken immunity cell proliferation (splenocytes, thymocytes, and Bursa\u0000cells) and IgY production.\u0000\u0000\u0000\u0000We prepared three different extracts using ethanol, Ethyl Acetate, and water. The total phenolic and flavonoid content in the three extracts was determined by spectrophotometric methods.Antioxidant activity has been assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing/antioxidant power (FRAP), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radicals and β-Carotene bleaching methods. Assessment of their immunostimulant activities in vitro was tested on chicken immunity cell proliferation (splenocytes, thymocytes, and Bursa cells) and IgY production\u0000\u0000\u0000\u0000The total phenolic contents ranged from 462.5 to 794.8 mg /g of extract, the order of\u0000TPC was as follows: EtOAc > EtOH >Water. Flavonoid contents were, 63.7 mg in EtOH extract,\u000081.2 mg in EtOAc extract, and 108.7 mg/g Extract in aqueous extract. By DPPH, the IC50s of\u0000EtOH, EtOAc, and water, were 1.8μg/ml, 2.4μg/ml, and 1.5μg/ml, respectively. Using the Ferric-\u0000Reducing Antioxidant Power (FRAP), we remarked that the EtOH and EtOAc extracts have important\u0000antioxidant powers. The ABTS assay indicated that EtOH and water had the highest activities\u0000with IC50s of 0.19 and 0.07, respectively. Finally, by the β-carotene bleaching test, we observed\u0000that the IC50 of the EtOH, EtOAc, and water were 62.1 μg/mL; 72.7 μg/mL, and 45.8\u0000μg/mL, respectively. The results obtained indicate that Brassica aqueous extract stimulates humoral\u0000immunity by stimulating splenocyte (B and T-lymphocytes) and Bursa cell (B-lymphocyte)\u0000proliferation by more than 200% of response vs control. In addition, the aqueous extract highly\u0000stimulated the function of bursa cells by 208% of the reaction. In the same conditions, we recorded\u0000a stimulation of cellular immunity mediated by thymocytes by an increase in cell proliferation\u0000(352.7% of response) implicated in virus protection. These extracts also possessed an antimicrobial\u0000effect against diverse microorganisms such as coliforms and Staphylococcus. The FT-IR\u0000spectrum indicated that the hydroxyl group (phenol), hydroxybenzoic acid family, carbohydrate\u0000molecules such as glucopyranose, a carbonyl ester group, hydrocar","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"45 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140721616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential, Pharmacological Activities and Analytical Aspects\u0000of Liriodendrin in Medicine: Novel and Potential Therapy Options for the\u0000Treatment of Human Disorders and Associated Complications","authors":"K. Patel, D. Patel","doi":"10.2174/0115734072286081240326082701","DOIUrl":"https://doi.org/10.2174/0115734072286081240326082701","url":null,"abstract":"\u0000\u0000Natural products and their derived secondary metabolites play an important role in\u0000medicine and other allied health sectors. Liriodendrin is one of the main lignans of Boerhaavia\u0000diffusa roots. Liriodendrin is a lignin class phytochemical having numerous health beneficial\u0000properties in medicine, including anti-myocardial ischemia, anti-arrhythmic, anti-oxidant and anti-\u0000inflammatory potential. This present review aims to analyze the reported ethnomedicinal properties,\u0000pharmacological activities and analytical aspects of liriodendrin and identify the remaining\u0000gaps in medicinal fields for their future investigations. The pharmacological properties of liriodendrin\u0000have been described in the present paper in order to describe its better utilization in natural\u0000medicine in the future. Biological poptential and pharmacological activities of liriodendrin\u0000have been described in the present work with their analytical development in the scientific fields.\u0000In the present work, scientific data on liriodendrin were collected from different scientific databases\u0000such as PubMed, Springer, Google, Science Direct, and Google Scholar. They described\u0000their biological potential on the basis of the available scientific literature. Further, research and\u0000review articles from peer-reviewed journals were also searched during data collection. The present\u0000paper's scientific data signified the biological importance of liriodendrin in medicine, which\u0000has been isolated from Boerhaavia diffusa and other medicinal plants. Liriodendrin has biological\u0000potential against myocardial infarction, arrhythmias, lung injury, hepatic injury, antiinflammatory,\u0000ulcerative colitis, gastric injury, SARS-CoV-2 protease and intestinal inflammation.\u0000Further, its effectiveness in medicine was also due to its anti-convulsant activity, nitric oxide\u0000inhibitory potential, cytotoxicity, cytoprotective nature, anti-oxidant, and anti-microbial potential.\u0000The present paper's scientific data also described the metabolism and analytical development for\u0000their isolation, separation and identification in different samples. Detailed pharmacological activities\u0000of liriodendrin have been described here in the present work and highlighted its important\u0000pharmacological properties and analytical aspects. Liriodendrin is a valuable phytochemical of\u0000Boerhaavia diffusa, which has numerous biological applications in medicine. Further, this study\u0000can also validate the traditional and ethnobotanical use of the Boerhaavia diffusa and other plant\u0000material, which contain a significant amount of liriodendrin as an active phytochemical. Liriodendrin\u0000have huge biological potential far beyond its traditional uses in human complications.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"8 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140720662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eucalyptus globulus Labill. Essential Oil Effect on the Attachment of Oral\u0000Bacteria to Hydroxyapatite and Biofilm Formation","authors":"Kahina Hardou-Belhoucine, F. Brahmi, Daniel Grenier, Khokha Mouhoubi, K. Madani, L. Boulekbache‐Makhlouf","doi":"10.2174/0115734072296932240319060406","DOIUrl":"https://doi.org/10.2174/0115734072296932240319060406","url":null,"abstract":"\u0000\u0000Periodontal disease and dental caries are two oral illnesses that are significantly\u0000influenced by microorganisms, hence the usefulness of finding natural substances to\u0000inhibit them.\u0000\u0000\u0000\u0000This study aimed to assess the Eucalyptus globulus Labill. leaf and fruit essential oils\u0000effect against Streptococcus mutans, Streptococcus sobrinus, Aggregatibacter actinomycetemcomitans,\u0000Porphyromonas gingivalis, Fusobacterium nucleatum, and Candida albicans to study\u0000their anticariogenic and antiperiodonto pathogenic activities.\u0000\u0000\u0000\u0000these activities were evaluated according to the determination of minimum inhibitory\u0000concentration (MIC) and minimum bactericidal concentration (MBC), anti-biofilm effects, and\u0000the impact on the adhesion to hydroxyapatite, a main component of the tooth.\u0000\u0000\u0000\u0000both leaf and fruit essential oils showed strong antibacterial activity against anaerobic\u0000bacteria: F. nucleatum (MIC of 0.012 %) and P. gingivalis (MIC of 0.025 %). Anticarcinogenic\u0000activity also showed MIC values of 0.06 % against S. mutans and, 0.5 % against S. sobrinus, and\u0000appropriate antifungal activity against C. albicans. It is interesting to note that both oils showed a\u0000significant inhibitory property to biofilm formation by the different studied species and significantly\u0000reduced the adhesion capacity of S. mutans and S. sobrinus to the hydroxyapatite surface at\u0000very low concentrations of 0.12 and 0.5 % for S. mutans and S. sobrinus, respectively.\u0000\u0000\u0000\u0000These results highlight the strong potential of E. globulus essential oils as antimicrobial\u0000and antibiofilm agents, as well as their ability to inhibit bacterial adhesion, which is promising\u0000for the prevention of dental caries and plaque. This implies that E. globulus may be a new\u0000alternative source of substances of medicinal interest that can be used in the pharmaceutical industry\u0000to produce antimicrobial agents against dental caries and oral infectious diseases\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140751574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual and Dual Cytotoxicity of the Combination of Passiflora Caerulea Leaf Extract and Titanium Oxide Nanoparticles against A549, U937, and\u0000Hela Cells","authors":"L. Sindhura, Mohd. Nazneen Bobby, K. Srikanth, Helan Soundra Rani Michael, Abu Md Ashif Ikbal, Sabu Thomas, H. Kargarzadeh, Partha Palit","doi":"10.2174/0115734072294581240311064402","DOIUrl":"https://doi.org/10.2174/0115734072294581240311064402","url":null,"abstract":"\u0000\u0000The study addresses the underexplored realm of cytotoxicity evaluation\u0000involving binary mixtures of Passiflora caerulea leaf extracts and Titanium nanoparticles\u0000(TiO2NPs). The focus lies on understanding the combined effects of these components on cancer\u0000cells (A549, U937, and HeLa).\u0000\u0000\u0000\u0000In vitro cytotoxicity assessments were employed to evaluate the toxicity of P. caerulea\u0000leaf extracts, TiO2NPs, and their combination. The study utilized MTT, NRU, and LDH assays to\u0000measure cellular viability. Additionally, reactive oxygen species (ROS) and glutathione levels\u0000were assessed alongside the aforementioned assays.\u0000\u0000\u0000\u0000The toxicity percentage exhibited dose-dependent behavior for P. caerulea leaf extracts,\u0000TiO2NPs, and their combination. Interestingly, when P. caerulea leaf extract and TiO2NPs were\u0000combined, the reduction in cell viability was noticeably more than when the exposures were made\u0000separately. Moreover, the production of ROS was higher in the combined toxicity scenario, and a\u0000more pronounced decrease in glutathione levels was observed compared to individual exposures.\u0000\u0000\u0000\u0000The findings suggest that the combined effects of P. caerulea leaf extract and\u0000TiO2NPs induce greater cytotoxicity compared to their impacts. This underscores the potential for\u0000synergistic cytotoxicity in combined exposure scenarios, warranting further exploration of combined\u0000effects in future studies.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"19 S1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Malabar Nut (Justicia adhatoda L.) Leaves’ Phenolic\u0000Compounds by Alginate Emulsion-gelation Approach using Response\u0000Surface Methodology","authors":"Afaf Chebout, M. Chaalal, S. Ydjedd, Louiza Himed","doi":"10.2174/0115734072297243240304113132","DOIUrl":"https://doi.org/10.2174/0115734072297243240304113132","url":null,"abstract":"\u0000\u0000The encapsulation technique is an effective method for coating bioactive\u0000molecules and protecting them against various technological treatment conditions during production processing.\u0000\u0000\u0000\u0000The aim of this study was to optimize the encapsulation conditions of phenolic compounds extracted from Malabar nut (Justicia adhatoda L.) leaves by alginate emulsion-gelation\u0000approach using response surface methodology\u0000\u0000\u0000\u0000The ionotropic gelation method was used to encapsulate the phenolic compounds of\u0000Malabar nut (Justicia adhatoda L.) leaves. The optimization of this phenolic compounds encapsulation was carried out using response surface methodology through Box˗Behnken design. Four\u0000parameters with three levels (-1, 0, +1) were chosen including sodium alginate concentration\u0000(2 – 3 - 4%), calcium chloride concentration (4 - 6 - 8%), plant extract-alginate solution ratio\u0000(0.02 – 0.11 - 0.2 mg/ml), and gelation time (5 – 12.5 - 20 min). of the total phenolic and flavonoid contents encapsulation efficiency was assessed. Likewise, the antioxidant activity was evaluated using ferric-reducing power (FRP) and free radical scavenging activity (DPPH).\u0000\u0000\u0000\u0000The results of response surface methodology analysis using Box˗Behnken design\u0000showed that the optimal encapsulation conditions were 3.11% for alginate concentration, 5.74%\u0000for calcium chloride concentration, 0.1 mg/ml for the plant extract-alginate solution ratio, and\u000010.80 min for gelation time. Under these conditions, the optimum values of total phenolic and\u0000flavonoid encapsulation efficiency were 86.17% and 75.69%, respectively, 126.75 mg AAE/100\u0000g for ferric reducing power and 97.29% for DPPH. The experimental and prediction results have\u0000expressed a high significant level for all responses.\u0000\u0000\u0000\u0000The method revealed the validity of elaborated models through response surface\u0000methodology optimization processes for phenolic antioxidants encapsulation of Malabar nut\u0000(Justicia adhatoda L.) leaves extract.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"7 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140248582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Apigenin in Alleviating the Impact of Environmental Pollutants","authors":"K. Gaur, Y. Siddique","doi":"10.2174/0115734072296125240221061200","DOIUrl":"https://doi.org/10.2174/0115734072296125240221061200","url":null,"abstract":"\u0000\u0000Environmental pollutants pose a serious risk to human health and are a factor in the\u0000emergence of many diseases and disorders. In recent years, the research for efficient defence\u0000against these pollutants has focused much interest. Natural flavonoid apigenin in various fruits\u0000and vegetables has shown great defence against environmental toxins. This review aims to summarize\u0000the current knowledge regarding the protective effect of apigenin environmental pollutants\u0000and its underlying mechanisms. The study starts by summarizing the main industrial chemicals,\u0000environmental pollutants, water contaminants, and the health hazards they provide. The article\u0000discusses apigenin's bioactive attributes and focuses on its anti-inflammatory, detoxifying, and\u0000antioxidant activities. Previous studies have shown that apigenin supplementation can reduce oxidative\u0000stress, inflammation, DNA damage, and organ toxicity from pollutants. The molecular\u0000processes behind apigenin's anti-inflammatory effects are explored, including its interactions with\u0000important signaling networks. Additional research is required to assess its ideal dosage, bioavailability,\u0000and potential interactions with other drugs. Moreover, more human studies are required to\u0000evaluate the long-term advantages and safety of apigenin supplementation as a defence against\u0000the harmful health consequences of environmental contaminants.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"45 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140264464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Lipopeptide Biosurfactant Production with\u0000Anti-Inflammatory and Antimicrobial Activities","authors":"Salima Djafri-Dib, Yalaoui-Guellal Drifa, N. Amessis-Ouchemoukh, K. Madani, S. Ouchemoukh","doi":"10.2174/0115734072287039240214112330","DOIUrl":"https://doi.org/10.2174/0115734072287039240214112330","url":null,"abstract":"\u0000\u0000Biosurfactants are very important amphiphile compounds due to their\u0000interesting advantages such as low toxicity, biodegradability and also their many biological properties.\u0000\u0000\u0000\u0000In the present study, antimicrobial and anti-imflammatory activities were evaluated to\u0000determine the biological proprieties of biosurfactant BLA 2906 produced by Alcaligenes aquatilis\u0000YGD 2906 using different assays. Screening and optimization component concentrations in the\u0000medium were investigated using PBD and SRM to increase surfactant yield in term emulsification\u0000activity value (E24%).\u0000\u0000\u0000\u0000The halos of antifungal activity presented a mean value of 12.33 mm to 17.67 mm. For\u0000antibacterial activity, the diameter varied from 10.33 to 12.67 mm with a very important antiinflammatory\u0000activity using a protein denaturation method that showed a maximum inhibition of\u000092.79%.\u0000\u0000\u0000\u0000These results suggest that BLA 2906 may be used as a new therapeutic and antiinflammatory\u0000agent. The PBD selected 7 significant components out of the 14 screened. The\u0000RSM resulted in the production in terms of emulsification activity of 68.37% in the optimized\u0000medium.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"9 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140266315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}