Current Directions in Biomedical Engineering最新文献_第3页

Development of quality criteria for long-term testing of intracortical electrodes 皮质内电极长期试验质量标准的制定

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1105

Charlotte Sielaff, Ute Urban, Ulrich P. Froriep

引用次数: 0

Auditory Neurons on the Silk Road – spider silk for bridging the nerve-electrode-gap 丝绸之路上的听觉神经元——用来连接神经电极间隙的蜘蛛丝

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1062

Jana Schwieger, Verena Scheper, Thomas Lenarz, Peter M. Vogt, Sarah Strauß

{"title":"Auditory Neurons on the Silk Road – spider silk for bridging the nerve-electrode-gap","authors":"Jana Schwieger, Verena Scheper, Thomas Lenarz, Peter M. Vogt, Sarah Strauß","doi":"10.1515/cdbme-2023-1062","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1062","url":null,"abstract":"Abstract The cochlear implant (CI) restores hearing to patients with severe to profound sensorineural hearing loss by stimulating the spiral ganglion neurons (SGN). Due to the inner ear anatomy, a fluid-filled gap remains between the SGN and the electrode array. This gap impedes focused stimulation and thus optimized performance with the CI. Regenerating neurites may bridge this fluid-filled gap for a direct nerveelectrode- link but require a supportive matrix. Spider silk might be a suitable candidate for this support. Therefore, silk fibers were tested for biocompatibility with inner ear neuronal tissue, suitability as neurite outgrowth matrix and applicability to the CI-electrode array. Dragline silk from female Trichonephila spiders was woven around a frame and autoclaved. Spiral ganglia of young rats were prepared, cut and placed in a drop of medium on the parallel silk fibers for pre-cultivation to support adherence before remaining medium was added. After 5d of cultivation, cells were fixed and immunocytologically stained. For CIapplication, silk was wrapped around a silicone dummy and a one-sided spacer. Opposite the spacer, alginate-hydrogel was applied for silk-fixation and -shielding. After gelation, silk loops were cut in the middle to form protruding threads. Cells showed a high degree of migration and neurite regeneration along the silk fibers and in some cases the outgrown neurites directly contacted the silk. It was possible to fix the silk to the dummy as protruding fibers. The tested spider silk is compatible with the inner ear tissue in culture, supports cell growth and seems to be an attractive material for neurite contacting. Application to the CI as protruding fibers is possible, making it a promising candidate for structural support to bridge the nerve-electrode-gap.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Symmetry of Respiration Induced Upper Body Movements 呼吸的对称性引起上半身的运动

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1120

Bernhard Laufer, Sabine Krueger-Ziolek, Nour Aldeen Jalal, Knut Moeller, Paul D. Docherty, Fabian Hoeflinger, Leonhard Reindl

引用次数: 0

Design of a Flexible mechatronic system for mechanical impedance measurement of the wrist as one step towards robotic rehabilitation 腕部机械阻抗测量的柔性机电系统设计，作为机器人康复的第一步

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1164

Ornella Tortorici, Alireza Abbasimoshaei, Thorsten A. Kern, Arndt F. Schilling

{"title":"Design of a Flexible mechatronic system for mechanical impedance measurement of the wrist as one step towards robotic rehabilitation","authors":"Ornella Tortorici, Alireza Abbasimoshaei, Thorsten A. Kern, Arndt F. Schilling","doi":"10.1515/cdbme-2023-1164","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1164","url":null,"abstract":"Abstract Home rehabilitation is a great complement to inpatient rehabilitation, because it allows for more regular training, especially in rural areas, where the access to physiotherapists is limited. However, unsupervised training carries the risk of deviation from the prescribed protocol. An obvious solution is to introduce a technical means for rehabilitation and continuous monitoring of performance. This paper presents a robotic system for rehabilitation of three degrees of freedom of the wrist independently, implemented with only one actuator, optimizing the design and size of the system. The device provides measurements of joint torque-position dependence, allowing objective assessment of mechanical impedance and range of motion to evaluate the progress of rehabilitation. Derived from research on haptic devices, a measurement method was implemented to measure hand impedance in the high frequency range between 100 and 200 Hz using a combination of exciters and accelerometers in the handles. This allows continuous monitoring of gripping forces without the need for complex contact-based force sensors. In collaboration between the authors’ technical and medical universities, a set of two-level passive and active safety measures was implemented to ensure the safety of the system’s users. Therefore, the presented system shows the potential to evaluate the mechanical impedance of the wrist at both low and high frequencies and to monitor the progress during rehabilitation. In the next step, a baseline of wrist impedance will be measured in a target group of healthy volunteers in order to prepare for studies in motion-restricted subjects.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135427386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Randomized Registry Trials - efficient post market clinical follow-up for medical devices 随机注册试验:有效的医疗器械上市后临床随访

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1122

Matthias Leuchter, Stefan Siewert, Michael Stiehm, Andrea Bock, Klaus-Peter Schmitz, Sebastian Kaule, Ernst Klar

{"title":"Randomized Registry Trials - efficient post market clinical follow-up for medical devices","authors":"Matthias Leuchter, Stefan Siewert, Michael Stiehm, Andrea Bock, Klaus-Peter Schmitz, Sebastian Kaule, Ernst Klar","doi":"10.1515/cdbme-2023-1122","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1122","url":null,"abstract":"Abstract In spite of advances in the treatment of cardiovascular disease, there remains a significant need for high-quality evidence for clinical practice given the rising prevalence worldwide. Next to the increase of regulatory requirements, poor screening-to-recruitment ratios, lack of patient engagement, and long timelines for contracting and institutional review board (IRB) approval are leading to an outflow of clinical trials in the EU. Patient registries are a potentially rich source of data, especially for evaluating the course of rare diseases and effects of new treatments. In the sectors of regulatory assessments of medical devices they are greatly underused. Health-related real world data provide crucial support for regulatory decision-making, particularly post-market assessments of medical products. Registries can be used not only for observational studies, but also for conducting experimental study designs. Register-based randomized controlled trials (RRCTs) are of particular importance here, as they can combine the advantages of randomized controlled trials (RCT) and registers. The government's financial support and reduction of regulatory barriers to the implementation of registry-based RCT are incentive factors for manufacturers to let their medical devices (re-)certified. Furthermore, it is essential that the necessary criteria are already taken into account when setting up the German implant registry in order to enable future RRCTs. The presented work is an additional pleading for the use and extension of registries for all medical products.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"2012 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135428645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manufacture and extraction of PLLA films with incorporated metal ions 含金属离子PLLA薄膜的制备与提取

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1113

Thomas Eickner, Sabine Illner, Niels Grabow, Olga Hahn, Kirsten Peters, Brigitte Müller-Hilke, Anika Jonitz-Heincke, Rainer Bader, Tomas Fiedler

引用次数: 0

Optimization and evaluation of a mobile IMU-based ballistocardiography system 基于移动imu的ballocardiography系统的优化与评价

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1170

Lucas Klauth, Andreas Mühlen, Andreas Kitzig, Edwin Naroska, Gudrun Stockmanns

引用次数: 0

Outer ear reconstruction using 3D technology 利用3D技术进行外耳重建

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1001

György Wersényi, Balázs Gasz

引用次数: 1

Proof-of-Concept: Conceptual design and realisation of an educational augmented reality (AR) application for anaesthesia induction 概念验证:用于麻醉诱导的教育增强现实(AR)应用的概念设计和实现

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1063

Leonie Maleszka, Andreas Breuer-Kaiser, Marcel Schäfer, Karsten Lehn, Thomas Felderhoff

引用次数: 0

Deep.Neural.Signal.Pre-Processor - Towards Development of AI-enhanced End-to-End BCIs Deep.Neural.Signal。Pre-Processor -迈向ai增强型端到端BCIs

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1118

Leo Buron, Andreas Erbslöh, Karsten Seidl, Gregor Schiele, Karsten Seidl, Zia Ur-Rehman, Christian Klaes

引用次数: 0