CosmeticsPub Date : 2024-04-04DOI: 10.3390/cosmetics11020057
Nareekan Yanasan, Worrapon Wangkananon, S. Natakankitkul, Kanokwan Kiattisin
{"title":"Nanoemulsions Containing Passiflora quadrangularis L. Fruit Extracts for Cosmetic Application and Skin Efficacy Study","authors":"Nareekan Yanasan, Worrapon Wangkananon, S. Natakankitkul, Kanokwan Kiattisin","doi":"10.3390/cosmetics11020057","DOIUrl":"https://doi.org/10.3390/cosmetics11020057","url":null,"abstract":"This study aimed to determine the anti-collagenase, anti-elastase, and anti-hyaluronidase activities of Passiflora quadrangularis fruit extracts (epicarp, mesocarp, endocarp, and seed), develop stable nanoemulsions, and evaluate the efficacy of the nanoemulsions containing extracts in human volunteers. The results indicated that the epicarp and seed extracts exhibited collagenase, elastase, and hyaluronidase inhibition effects. Gallic acid was identified in the extracts, with the highest concentration found in the endocarp extract (1449.35 mg gallic acid/g extract) followed by the seed extract (839.63 mg gallic acid/g extract). The endocarp and seed extracts demonstrated good stability at different temperatures. Consequently, these extracts were selected for incorporation into nanoemulsions due to their high yield, excellent anti-tyrosinase and anti-aging activity, and good stability, making them suitable for cosmetic products. The nanoemulsions were prepared using the ultrasonication method, resulting in a particle size of 133.1 ± 0.8 nm, a polydispersity index of 0.33 ± 0.03, and a zeta potential of −61.8 ± 0.6 mV, indicating good stability. The nano-serum containing extracts was non-irritating and safe for the skin. Skin evaluation among human volunteers after 60 days of application revealed improvements in skin hydration and reduction in wrinkles. In conclusion, nanoemulsions containing P. quadrangularis fruit extracts have the potential to be effective cosmetic products.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140743411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-04-03DOI: 10.3390/cosmetics11020055
A. Courtney, John C Su
{"title":"Wigs and Alopecia Areata: Psychosocial Impact and Economic Considerations","authors":"A. Courtney, John C Su","doi":"10.3390/cosmetics11020055","DOIUrl":"https://doi.org/10.3390/cosmetics11020055","url":null,"abstract":"Alopecia areata (AA) presents a challenging and unpredictable condition associated with substantial psychosocial and financial burdens. A chronic, relapsing form of non-scarring hair loss, it affects approximately 0.1–0.2% of the population worldwide with a lifetime risk of 1.0% to 2.1%. The psychosocial implications of AA, including its association with depression, anxiety, social phobia, employment disruption, and relationship challenges are well described . Significant economic costs of AA include those of healthcare, lost income, transportation, psychotherapy, and cosmetic accessories (wigs and hairpieces). However, wigs and hairpieces can contribute to enhanced self-esteem, confidence, and overall quality of life (QOL) in AA patients; these positive outcomes correlating with satisfaction in appearance. This article explores the role of wigs in addressing the aesthetic and emotional impact of AA, emphasizing their importance as potential coping mechanisms for individuals facing hair loss whilst also acknowledging possible barriers to their use. Different types of wigs and hairpieces, their respective advantages and disadvantages, and methods of attachment are thoroughly discussed, providing a comprehensive overview for both patients and healthcare professionals. Considering the economic impact of AA, this article explores the cost of wigs in Australia and available financial assistance programs. Wigs can play a pivotal role in rapidly addressing the multifaceted challenges posed by AA, offering time for psychosocial adaptation and delayed response to medical therapies. This review aims to provide valuable insights to inform evidence-based, practical, and personalized counselling of patients with AA and enable shared decision making about the utility of wigs and other cosmetic interventions for hair loss. Further research is warranted to explore differences in the optimal utilization of wigs between diverse sub-populations with AA.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140749036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-04-03DOI: 10.3390/cosmetics11020056
Eleni Andreou, Efstathios Rallis, Sophia Hatziantoniou, V. Kefala
{"title":"Permanent Makeup (PMU) Removal with Plant Origin Extracts","authors":"Eleni Andreou, Efstathios Rallis, Sophia Hatziantoniou, V. Kefala","doi":"10.3390/cosmetics11020056","DOIUrl":"https://doi.org/10.3390/cosmetics11020056","url":null,"abstract":"Permanent makeup (PMU) is a popular application for the correction of face and body imperfections. It can be applied over the facial area to correct the shape and color of eyebrows, to the eyelids to create permanent eyeliner shapes, and the lips to create permanent lipliner and lip shading features. Furthermore, its “medical” use on the scalp and men’s facial hair area to camouflage hair follicles and to cover hairless areas makes it popular for hair transplants. No matter how useful these procedures are, there are always mistakes and the factor of bad application which raises the number of patients who want to “remove” it or “correct” it on their face or body. In order to find a non-laser solution for PMU removal, we investigated the decolorization capacity of common plants and plant origin extracts on mouse models. Two methods were used for PMU decolorization. The first one included the use of traditional tattooing with needles combined with plant origin extracts applied over the tattooed area. The second one included the use of electroporation technology application with the combination of plant origin materials to remove the PMU colorants over the tattooed area. In both cases, the permanent makeup colorants for eyebrows, eyeliners, and lipliners were applied in vivo.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140746199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-04-03DOI: 10.3390/cosmetics11020054
Jenny Allen, K. Dodou
{"title":"Current Knowledge and Regulatory Framework on the Use of Hyaluronic Acid for Aesthetic Injectable Skin Rejuvenation Treatments","authors":"Jenny Allen, K. Dodou","doi":"10.3390/cosmetics11020054","DOIUrl":"https://doi.org/10.3390/cosmetics11020054","url":null,"abstract":"Dermal injections of hyaluronic acid gel for aesthetic skin rejuvenation are becoming increasingly popular nowadays. Although these products are classified as medical devices, the regulations on their administration by licensed practitioners are still weak, whereas their manufacturers increasingly highlight and advertise the cellular effects that underpin the efficacy of these injections. In this review, we discuss all current knowledge on the mode of action of dermally injected hyaluronic acid and the potential toxicological implications, especially from crosslinked gels, in conjunction with the current global regulations. We also highlight the urgent need for further research to elucidate the therapeutic implications and underscore the imperative need for robust regulatory frameworks to safeguard public health. We conclude that dermal injections of hyaluronic acid have several therapeutic implications that warrant further research and that strict regulations must be applied to their manufacture/quality control and the required qualifications of licensed aesthetic injectors.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140750333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unlocking the Potential: A Comprehensive Analysis of the Technological Properties and Consumer Perception of Shampoo Enriched with Patchouli Extract and Allantoin","authors":"Ugnė Žlabienė, Erlita Bartkutė, Jurga Bernatonienė","doi":"10.3390/cosmetics11020053","DOIUrl":"https://doi.org/10.3390/cosmetics11020053","url":null,"abstract":"Amidst a growing shift towards eco-friendly choices in personal care products, the challenge of formulating herbal shampoos with efficacy comparable to synthetic counterparts persists. This study investigates the potential of incorporating patchouli extract and allantoin as additives in anti-dandruff shampoo formulations, assessing their impact on the technological properties of the product. With limited research on their efficacy, our investigation contributes valuable insights to the development of effective and consumer-friendly shampoos targeting dandruff concerns. Physicochemical characteristics (pH, surface tension, texture) were evaluated, alongside specific quality assessments such as wetting time, dirt dispersion, foaming, and cleaning action, in in vivo consumer research. Shampoo formulations incorporating 0.5% Patchoul’Up™ and 1% allantoin exhibited acceptable properties. However, the addition of plant-derived ingredients resulted in a beneficial decrease in surface tension (5.87%). Nevertheless, a decrease in cohesiveness (18%) over a 5-month period resulted in rheological changes, indicating potential instability (p < 0.05). While the consumer evaluation aligns with laboratory findings, continuous research is essential to ensure stability and validate the anti-dandruff potential of the formulation, both in vitro and in vivo. This involves expanding the number of volunteers, with a specific focus on individuals experiencing dandruff concerns, to assess the shampoo’s efficacy and impact on diverse user experiences.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140753585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-04-02DOI: 10.3390/cosmetics11020051
Rania Hamed, Baraah Jehad Abu Nahia, A. Alkilani, Yasmeen Al-Adhami, Rana Obaidat
{"title":"Recent Advances in Microneedling-Assisted Cosmetic Applications","authors":"Rania Hamed, Baraah Jehad Abu Nahia, A. Alkilani, Yasmeen Al-Adhami, Rana Obaidat","doi":"10.3390/cosmetics11020051","DOIUrl":"https://doi.org/10.3390/cosmetics11020051","url":null,"abstract":"Microneedling, also known as percutaneous collagen induction, using microneedling devices and fabricated microneedle patches, has been widely employed in cosmetic applications for acne scar treatment, skin care, hair loss, melasma, skin rejuvenation, and skin cancer. The micro-channels formed by microneedling through the stratum corneum facilitate the delivery of cosmetic agents and stimulate collagen and elastin production by inducing the wound-healing cascade, keeping the skin shiny and wrinkle-free. Several cosmetic agents, such as ascorbic acid, hyaluronic acid, retinoids, niacinamide, and peptides, have been delivered by microneedling. This review aims to highlight the use of microneedling devices and fabricated microneedle patches in facilitating the delivery of cosmetic agents through the skin layers. Moreover, the differences between the microneedling devices, commonly used alone or in combinational treatments with topical formulations, are explored. Furthermore, the safety of microneedling in terms of skin irritation, pain sensation, skin or systemic infection, and chemical and biological materials used in the fabrication of microneedles is discussed.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140753485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-04-02DOI: 10.3390/cosmetics11020052
S. Coiai, Elisa Passaglia, Alice Telleschi, Werner Oberhauser, M. Coltelli, F. Cicogna
{"title":"A Sustainable Multistage Process for Immobilizing Bioactive Compounds on Layered Double Hydroxides","authors":"S. Coiai, Elisa Passaglia, Alice Telleschi, Werner Oberhauser, M. Coltelli, F. Cicogna","doi":"10.3390/cosmetics11020052","DOIUrl":"https://doi.org/10.3390/cosmetics11020052","url":null,"abstract":"Hybrid systems with antioxidant properties have been developed by integrating bioactive compounds derived from plant resources with layered double hydroxides (LDHs). Anion exchange has been used to substitute intercalated nitrate anions in Mg-Al LDH with carboxylate anions derived from trans-ferulic acid, rosmarinic acid, and 18β-glycyrrhetinic acid. These organic compounds are known for their powerful antioxidant, anti-inflammatory and antimicrobial properties and are highly suitable for cosmetics, biomedicine, and food packaging. To enhance sustainability, a multistage procedure has been developed with the aim of recovering unexchanged carboxylate anions from residual reaction water, ensuring an environmentally friendly and easily scalable preparation process. The process, adapted for each of the three molecules, allows the production of a consistently high-quality hybrid product containing an organic fraction ranging from 10 to 48% by weight, depending on the specific molecule used. The immobilization of organic compounds has occurred either within the layers of LDH through intercalation or on the external surface through adsorption. Good antioxidant capacity has been exhibited by these powdered hybrid systems, as assessed through both the DPPH and linoleic acid/β-carotene tests. Sustainable production practices are enabled by this innovative approach, which also opens avenues for the development of advanced materials for diverse applications across various industries.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140752796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-04-01DOI: 10.3390/cosmetics11020050
Samuel Fiuza, Tiago Marques, Irving Padin, Maria Teresa Carvalho, Nélio Veiga, Juliana Campos Hasse Fernandes, G. Fernandes, P. Couto
{"title":"Histological, Clinical Assessment, and Treatment of a Permanent Filler Complication in the Upper Lip: A Case Report with 16-Year Follow-Up","authors":"Samuel Fiuza, Tiago Marques, Irving Padin, Maria Teresa Carvalho, Nélio Veiga, Juliana Campos Hasse Fernandes, G. Fernandes, P. Couto","doi":"10.3390/cosmetics11020050","DOIUrl":"https://doi.org/10.3390/cosmetics11020050","url":null,"abstract":"There is a considerable increase in the use of substances and medical procedures aimed at changing the esthetics of the face, particularly the appearance of the lips. Permanent fillers such as polydimethylsiloxane, also called liquid silicone, are widely used, but their application for facial esthetics is currently obsolete. Silicone belongs to this polymer family; its viscosity is determined by its degree of polymerization. Liquid injectable silicone is odorless, colorless, non-volatile, and oily to the touch. The substance is not altered by storage at room temperature and is not carcinogenic or teratogenic. However, the long-term complications remain a reality, as they can occur decades after the application. Thus, the goal of this case report was to present a complication after 16 years of treatment using liquid silicone. This case report involved a 52-year-old male with a complication of bilateral permanent filler in the upper lip performed 16 years ago, its surgical removal, and histological analysis. The patient had the first appointment at the University Dental Clinic—Universidade Católica Portuguesa (Viseu, Portugal) in April 2022, dissatisfied with his upper lip’s esthetic appearance and shape. He was not a smoker or diabetic but had hypertension and hypercholesterolemia and was medicated with Losartan, Hydrochlorothiazide, and Pitavastatin. No relevant findings were observed in the extraoral examination; he had bruxism and a good periodontal condition. The patient had an asymptomatic bilateral mass, hard to palpation, located on the upper lip due to permanent lip filling performed to increase its volume in 2006 associated with non-related generalized granules of Fordyce. The treatment options presented just observation or complete material removal in two surgical steps, which was the patient’s choice. Then, the first surgical procedure was performed under local anesthesia on the right side of the lip, one carpule of Lidocaine 2% with adrenaline 1:100,000, with a chalazion clamp, a diode laser for hemorrhagic control, and a simple suture. In this procedure, three fragments were biopsied: a cuboid measuring 1 × 1 × 0.8 cm and an irregular one consisting of two fragments that at one end of the piece were in continuity with each other, one measuring 1.6 × 0.5 × 0.4 cm and the other 2.5 × 0.6 × 0.5 cm. A similar macroscopic appearance in all the material, white in color, irregular surface, elastic, white section surface, or slightly fasciculate. The patient was medicated with Tylenol 500 mg thrice a day for two days. With 20-day intervals, the sutures from the first surgery were removed, as well as the foreign body from the upper lip on the left side, following the same surgical technique and medication. Histologically, it was possible to identify a chronic inflammatory, lymphoplasmacytic, and granulomatous reaction, with foreign body giant cells’ reaction, in relation to non-polarizable exogenous material due to the reaction to silicone. Th","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140781169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-03-31DOI: 10.3390/cosmetics11020049
Federica Trovato, Stefano Ceccarelli, Simone Michelini, Giordano Vespasiani, Stefania Guida, Hassan Ibrahim Galadari, Steven Paul Nisticò, Laura Colonna, Giovanni Pellacani
{"title":"Advancements in Regenerative Medicine for Aesthetic Dermatology: A Comprehensive Review and Future Trends","authors":"Federica Trovato, Stefano Ceccarelli, Simone Michelini, Giordano Vespasiani, Stefania Guida, Hassan Ibrahim Galadari, Steven Paul Nisticò, Laura Colonna, Giovanni Pellacani","doi":"10.3390/cosmetics11020049","DOIUrl":"https://doi.org/10.3390/cosmetics11020049","url":null,"abstract":"The growing interest in maintaining a youthful appearance has encouraged an accelerated development of innovative, minimally invasive aesthetic treatments for facial rejuvenation and regeneration. The close correlation between tissue repair, regeneration, and aging has paved the way for the application of regenerative medicine principles in cosmetic dermatology. The theoretical substrates of regenerative medicine applications in dermo-aesthetics are plentiful. However, regenerative dermatology is an emerging field and needs more data and in vivo trials to reach a consensus on the standardization of methods. In this review, we summarize the principles of regenerative medicine and techniques as they apply to cosmetic dermatology, suggesting unexplored fields and future directions.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140358741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-03-27DOI: 10.3390/cosmetics11020048
R. Achagar, Zouhair Ait-Touchente, Rafika El Ati, Khalid Boujdi, Abderrahmane Thoume, Achraf Abdou, Rachid Touzani
{"title":"A Comprehensive Review of Essential Oil–Nanotechnology Synergy for Advanced Dermocosmetic Delivery","authors":"R. Achagar, Zouhair Ait-Touchente, Rafika El Ati, Khalid Boujdi, Abderrahmane Thoume, Achraf Abdou, Rachid Touzani","doi":"10.3390/cosmetics11020048","DOIUrl":"https://doi.org/10.3390/cosmetics11020048","url":null,"abstract":"This review investigates the convergence of nanotechnology and essential oils in advanced dermocosmetic delivery. It outlines the pivotal role of inorganic and polymeric nanoparticles, such as titanium dioxide, zinc oxide, and gold nanocarriers, in cosmeceutical applications, facilitating slow release, deeper skin penetration, and increased retention of active compounds. Essential oils, renowned for therapeutic benefits, face translation challenges due to volatility and low water solubility. This review explores the potential use of plant nanovesicles as carriers, emphasizing safety, stability, and scalability, offering a sustainable and cost-effective industrial application. Nanomaterial integration in consumer products, particularly cosmetics, is prevalent, with nanocarriers enhancing the permeation of bioactive compounds into deeper skin layers. The review emphasizes recent nanotechnological advancements, covering nanoparticle penetration, experimental models, and therapeutic applications in dermatology, ranging from non-invasive vaccination to transdermal drug delivery. Additionally, the review delves into nanomaterials’ role in addressing skin aging, focusing on tissue regeneration. Nanomaterials loaded with cosmeceuticals, such as phytochemicals and vitamins, are explored as promising solutions to mitigate signs of aging, including wrinkles and dry skin, providing innovative approaches to skin rejuvenation. Overall, the review offers a comprehensive synthesis of essential oil–nanoparticle synergy, shedding light on the current landscape and future potential of advanced dermocosmetic delivery systems.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140373950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}