CosmeticsPub Date : 2024-02-06DOI: 10.3390/cosmetics11010022
Inês Ferreira, Carla M. Lopes, Maria Helena Amaral
{"title":"Treatment Advances for Acne Vulgaris: The Scientific Role of Cannabinoids","authors":"Inês Ferreira, Carla M. Lopes, Maria Helena Amaral","doi":"10.3390/cosmetics11010022","DOIUrl":"https://doi.org/10.3390/cosmetics11010022","url":null,"abstract":"Acne vulgaris is a prevalent dermatological disorder that impacts the quality of life for millions of people around the world. The multifactorial nature of this disorder requires innovative and effective treatment strategies. Over time, there has been a growing interest regarding the use of natural topical therapies, with cannabinoids emerging as a promising group of compounds for investigation. In the context of acne treatment, cannabinoids are of particular interest due to their anti-acne properties, namely, lipostatic, anti-inflammatory, antiproliferative, and antimicrobial activities. Among these bioactive compounds, cannabidiol stands out as a notable derivative, exhibiting a promising spectrum of therapeutic actions. Pre-clinical and clinical studies have proven its ability to modulate sebum production, reduce inflammation, and inhibit bacterial proliferation—all of which are critical components in the pathogenesis of this dermatosis. This review provides a comprehensive overview of cannabinoids’ potential as a novel and holistic approach to acne vulgaris treatment and summarizes recent developments in this area.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139860124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-02-06DOI: 10.3390/cosmetics11010023
S. R. Mita, P. Husni, N. Putriana, Rani Maharani, Ryan Proxy Hendrawan, Dian Anggraeni Dewi
{"title":"A Recent Update on the Potential Use of Catechins in Cosmeceuticals","authors":"S. R. Mita, P. Husni, N. Putriana, Rani Maharani, Ryan Proxy Hendrawan, Dian Anggraeni Dewi","doi":"10.3390/cosmetics11010023","DOIUrl":"https://doi.org/10.3390/cosmetics11010023","url":null,"abstract":"Catechins are a type of flavonoid known for their beneficial functions as antioxidants and antibacterials. Recent research indicates the antioxidant potential of catechins on the skin. Catechin and epigallocatechin are reported to have significant potential in preventing ageing. Epigallocatechin gallate, gallocatechin gallate, and epigallocatechin can inhibit hyperpigmentation processes. Additionally, catechins exhibit potential in UV protection and inflammation inhibition in acne. Consequently, catechins are now being used in the cosmetics industry, with formulations containing catechins as the active ingredient developed to produce various products such as soap, sunscreen, creams, etc. Herein, this paper reviews the antioxidant potential of catechins for use in cosmetic formulations and the current status of clinical trials of catechins in cosmetics.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139801333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-02-06DOI: 10.3390/cosmetics11010023
S. R. Mita, P. Husni, N. Putriana, Rani Maharani, Ryan Proxy Hendrawan, Dian Anggraeni Dewi
{"title":"A Recent Update on the Potential Use of Catechins in Cosmeceuticals","authors":"S. R. Mita, P. Husni, N. Putriana, Rani Maharani, Ryan Proxy Hendrawan, Dian Anggraeni Dewi","doi":"10.3390/cosmetics11010023","DOIUrl":"https://doi.org/10.3390/cosmetics11010023","url":null,"abstract":"Catechins are a type of flavonoid known for their beneficial functions as antioxidants and antibacterials. Recent research indicates the antioxidant potential of catechins on the skin. Catechin and epigallocatechin are reported to have significant potential in preventing ageing. Epigallocatechin gallate, gallocatechin gallate, and epigallocatechin can inhibit hyperpigmentation processes. Additionally, catechins exhibit potential in UV protection and inflammation inhibition in acne. Consequently, catechins are now being used in the cosmetics industry, with formulations containing catechins as the active ingredient developed to produce various products such as soap, sunscreen, creams, etc. Herein, this paper reviews the antioxidant potential of catechins for use in cosmetic formulations and the current status of clinical trials of catechins in cosmetics.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139861396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-02-06DOI: 10.3390/cosmetics11010022
Inês Ferreira, Carla M. Lopes, Maria Helena Amaral
{"title":"Treatment Advances for Acne Vulgaris: The Scientific Role of Cannabinoids","authors":"Inês Ferreira, Carla M. Lopes, Maria Helena Amaral","doi":"10.3390/cosmetics11010022","DOIUrl":"https://doi.org/10.3390/cosmetics11010022","url":null,"abstract":"Acne vulgaris is a prevalent dermatological disorder that impacts the quality of life for millions of people around the world. The multifactorial nature of this disorder requires innovative and effective treatment strategies. Over time, there has been a growing interest regarding the use of natural topical therapies, with cannabinoids emerging as a promising group of compounds for investigation. In the context of acne treatment, cannabinoids are of particular interest due to their anti-acne properties, namely, lipostatic, anti-inflammatory, antiproliferative, and antimicrobial activities. Among these bioactive compounds, cannabidiol stands out as a notable derivative, exhibiting a promising spectrum of therapeutic actions. Pre-clinical and clinical studies have proven its ability to modulate sebum production, reduce inflammation, and inhibit bacterial proliferation—all of which are critical components in the pathogenesis of this dermatosis. This review provides a comprehensive overview of cannabinoids’ potential as a novel and holistic approach to acne vulgaris treatment and summarizes recent developments in this area.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139800272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-02-05DOI: 10.3390/cosmetics11010021
Angreni Ayuhastuti, Insan Syah, Sandra Megantara, A. Chaerunisaa
{"title":"Nanotechnology-Enhanced Cosmetic Application of Kojic Acid Dipalmitate, a Kojic Acid Derivate with Improved Properties","authors":"Angreni Ayuhastuti, Insan Syah, Sandra Megantara, A. Chaerunisaa","doi":"10.3390/cosmetics11010021","DOIUrl":"https://doi.org/10.3390/cosmetics11010021","url":null,"abstract":"Kojic acid (KA) has emerged as a prominent tyrosinase inhibitor with considerable potential in cosmetic applications; however, its susceptibility to instability during storage poses a challenge to its widespread use. This review explores the advancements in addressing this limitation through the development of various KA derivatives, focusing on the modification of the C-7 hydroxyl group. Strategies such as esterification, hydroxy-phenyl ether formation, glycosylation, and incorporation into amino acid or tripeptide derivatives have been employed to enhance stability and efficacy. Among these derivatives, Kojic Acid Dipalmitate (KDP), a palmitic ester derivative of KA, stands out for its notable improvements in stability, permeability, and low toxicity. Recent developments indicate a growing utilization of KDP in cosmetic formulations, with over 132 available products on the market, encompassing various formulations. Formulations based on nanotechnology, which incorporate KDP, have been provided, including nanosomes, nanocreams, multiple emulsions, liposomes, solid lipid nanoparticles (SLNs), ethosomes, and nanoemulsions. Additionally, three patents and seven advanced system deliveries of KDP further underscore its significance. Despite its increasing prevalence, the literature on KDP remains limited. This review aims to bridge this gap by providing insights into the synthesis process, physicochemical properties, pharmaceutical preparation, diverse applications of KDP in cosmetic products, and recent nanotechnology formulations of KDP. This review paper seeks to explore the recent developments in the use of KDP in cosmetics. The goal is to enhance stability, permeability, and reduce the toxicity of KA, with the intention of promoting future research in this promising sector.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139803472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-02-05DOI: 10.3390/cosmetics11010021
Angreni Ayuhastuti, Insan Syah, Sandra Megantara, A. Chaerunisaa
{"title":"Nanotechnology-Enhanced Cosmetic Application of Kojic Acid Dipalmitate, a Kojic Acid Derivate with Improved Properties","authors":"Angreni Ayuhastuti, Insan Syah, Sandra Megantara, A. Chaerunisaa","doi":"10.3390/cosmetics11010021","DOIUrl":"https://doi.org/10.3390/cosmetics11010021","url":null,"abstract":"Kojic acid (KA) has emerged as a prominent tyrosinase inhibitor with considerable potential in cosmetic applications; however, its susceptibility to instability during storage poses a challenge to its widespread use. This review explores the advancements in addressing this limitation through the development of various KA derivatives, focusing on the modification of the C-7 hydroxyl group. Strategies such as esterification, hydroxy-phenyl ether formation, glycosylation, and incorporation into amino acid or tripeptide derivatives have been employed to enhance stability and efficacy. Among these derivatives, Kojic Acid Dipalmitate (KDP), a palmitic ester derivative of KA, stands out for its notable improvements in stability, permeability, and low toxicity. Recent developments indicate a growing utilization of KDP in cosmetic formulations, with over 132 available products on the market, encompassing various formulations. Formulations based on nanotechnology, which incorporate KDP, have been provided, including nanosomes, nanocreams, multiple emulsions, liposomes, solid lipid nanoparticles (SLNs), ethosomes, and nanoemulsions. Additionally, three patents and seven advanced system deliveries of KDP further underscore its significance. Despite its increasing prevalence, the literature on KDP remains limited. This review aims to bridge this gap by providing insights into the synthesis process, physicochemical properties, pharmaceutical preparation, diverse applications of KDP in cosmetic products, and recent nanotechnology formulations of KDP. This review paper seeks to explore the recent developments in the use of KDP in cosmetics. The goal is to enhance stability, permeability, and reduce the toxicity of KA, with the intention of promoting future research in this promising sector.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139863395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-02-02DOI: 10.3390/cosmetics11010020
Pierfrancesco Morganti, G. Morganti, Hong-Duo Chen, M. Coltelli, A. Gagliardini
{"title":"Smart Tissue Carriers for Innovative Cosmeceuticals and Nutraceuticals","authors":"Pierfrancesco Morganti, G. Morganti, Hong-Duo Chen, M. Coltelli, A. Gagliardini","doi":"10.3390/cosmetics11010020","DOIUrl":"https://doi.org/10.3390/cosmetics11010020","url":null,"abstract":"The present review was conducted to investigate the possibilities in realizing novel nanostructured tissues containing functional molecules that can be commercialized as solid products (without using emulsifiers and preservatives) for cosmeceutical and nutraceutical applications. After considering the principal concepts regarding skin and mucous features and physiologies, the possibilities in using bio-based, biodegradable and biocompatible materials was explored by investigating the correlations between their structures and morphologies with respect to the characteristics of the skin extracellular matrix (ECM). Regarding the new smart type of biodegradable tissues, their possible composition was reviewed in relation to the skin aging process and to the current contest for novel, innovative cosmeceuticals and nutraceuticals that consider the “beauty from within” concept. The barriers to the development of these new tissues were mainly identified due the necessity in defining the claim regarding green products. Moreover, the market growth data regarding these novel products were highlighted to support the idea that the diffusion of smart tissue-based cosmeceuticals and nutraceuticals is an opportunity for new sustainable industrial chains in the development of bioeconomies.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139869290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-02-02DOI: 10.3390/cosmetics11010020
Pierfrancesco Morganti, G. Morganti, Hong-Duo Chen, M. Coltelli, A. Gagliardini
{"title":"Smart Tissue Carriers for Innovative Cosmeceuticals and Nutraceuticals","authors":"Pierfrancesco Morganti, G. Morganti, Hong-Duo Chen, M. Coltelli, A. Gagliardini","doi":"10.3390/cosmetics11010020","DOIUrl":"https://doi.org/10.3390/cosmetics11010020","url":null,"abstract":"The present review was conducted to investigate the possibilities in realizing novel nanostructured tissues containing functional molecules that can be commercialized as solid products (without using emulsifiers and preservatives) for cosmeceutical and nutraceutical applications. After considering the principal concepts regarding skin and mucous features and physiologies, the possibilities in using bio-based, biodegradable and biocompatible materials was explored by investigating the correlations between their structures and morphologies with respect to the characteristics of the skin extracellular matrix (ECM). Regarding the new smart type of biodegradable tissues, their possible composition was reviewed in relation to the skin aging process and to the current contest for novel, innovative cosmeceuticals and nutraceuticals that consider the “beauty from within” concept. The barriers to the development of these new tissues were mainly identified due the necessity in defining the claim regarding green products. Moreover, the market growth data regarding these novel products were highlighted to support the idea that the diffusion of smart tissue-based cosmeceuticals and nutraceuticals is an opportunity for new sustainable industrial chains in the development of bioeconomies.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139809803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Investigation of Collagen-Based Electrospun Nanofibers for Enhanced Delivery of Skincare Ingredients","authors":"Naveen Ashok Chand, Sanjukta Duarah, Blaine Ah Yuk-Winters, Dhevesh Fomra","doi":"10.3390/cosmetics11010018","DOIUrl":"https://doi.org/10.3390/cosmetics11010018","url":null,"abstract":"Nanofiber-based materials, due to their unique properties, are of remarkable interest across multiple fields of applications, including cosmetics. Collagen, a primary structural protein in human skin, is well-regarded for its critical role in maintaining skin health, elasticity, and enhancing skin regeneration. This study reports the characterization, safety, and efficacy evaluation of DermaLayr™, a novel collagen-based nanofiber platform, for skincare application. The collagen nanofibers were developed using a sonic electrospinning technique, and scanning electron microscopy (SEM) analyses indicated that the nanofibers were uniform with average fiber diameters ranging from 250 to 300 nm. The skin permeation studies on EpiDerm™ indicated that applying the test products resulted in around 5–25% higher collagen permeation into the epidermis, and 16–20% higher collagen permeation into the dermis when compared to the non-treated sample. Additionally, the safety of the developed nanofibers was assessed in vitro and in vivo and both the studies indicated their non-toxic and non-irritant properties. Moreover, clinical trials on human subjects further substantiated the clinical efficacy of DermaLayr™ by demonstrating significant improvement in several skin parameters such as hydration, elasticity, and overall skin health. In summary, the findings of this study emphasize the huge potential of DermaLayr™ nanofiber products for their safe application in cosmetics and skin therapeutics.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140475362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CosmeticsPub Date : 2024-01-31DOI: 10.3390/cosmetics11010019
D. Charnvanich, Kamonwan Singpanna, V. Panapisal
{"title":"Formulation and Optimization of Nanoemulsions Loaded with Gamma−Aminobutyric Acid (GABA) for Dermatological Application: Assessing Skin Permeation and Penetration Enhancement","authors":"D. Charnvanich, Kamonwan Singpanna, V. Panapisal","doi":"10.3390/cosmetics11010019","DOIUrl":"https://doi.org/10.3390/cosmetics11010019","url":null,"abstract":"Gamma−aminobutyric acid (GABA) presents several potential skin benefits, but its water−soluble nature poses challenges for effectively penetrating the skin to produce its effects. This research aimed to improve GABA’s skin penetration and availability by employing a nanoemulsion formulation, both with and without the aid of the penetration enhancer 1,8−cineole. Using a high−pressure homogenizer, an oil−in−water nanoemulsion was created, and its size and distribution were analyzed. The stability of these nanoemulsions was tested under various conditions, revealing their resilience over six months, even at elevated temperatures of 40 °C. In vitro tests on pig skin showed that GABA−loaded nanoemulsions, particularly those without the enhancer, demonstrated a nearly 2.89−fold increase in skin permeation compared to the solution form. Moreover, the addition of the enhancer amplified this effect, resulting in over a 3.37−fold increase in skin permeation compared to the solution. These results emphasize the potential of nanoemulsion formulations as effective tools for enhancing GABA’s skin permeation and availability, potentially expanding its use in dermatological applications. Further exploration and research are necessary to fully exploit GABA’s capabilities in supporting skin health and wellness.","PeriodicalId":10735,"journal":{"name":"Cosmetics","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140472789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}