Food Supplements for Skin Health: In Vitro Efficacy of a Combination of Rhodiola rosea, Tribulus terrestris, Moringa oleifera and Undaria pinnatifida on UV-Induced Damage

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cosmetics Pub Date : 2023-05-19 DOI:10.3390/cosmetics10030083

A. Paganelli, A. Pisciotta, Giulia Bertani, Rosanna Di Tinco, Nadia Tagliaferri, G. Orlandi, P. Azzoni, L. Bertoni

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引用次数: 0

Abstract

An increasing number of people seek treatment for aging-related conditions. Plant-derived nutraceuticals are currently of great interest in the setting of dermo-cosmetic studies for their preventive role in photoaging. We conducted an in vitro study on the possible preventive properties against photoaging of a commercially available product (Venerinase®). A mixture of Rhodiola rosea, Tribulus terrestris, Moringa oleifera, Undaria pinnatifida, folic acid and vitamin B12 (Venerinase®) was tested for its potential anti-aging effects on the skin in vitro. Conventional histology, immunofluorescence and real time PCR were employed in the research protocol. The tested product was proven to prevent UV-induced morphological changes both in keratinocytes and fibroblasts. Moreover, senescence-related and proinflammatory pathways commonly triggered by UV exposure were demonstrated to be inhibited by Venerinase® pretreatment. Our results support the potential clinical benefits of oral supplements for the treatment and/or prevention of cutaneous photodamage.

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食品补充剂对皮肤健康的影响:红景天、蒺藜、辣木和羽带草联合对紫外线损伤的体外疗效

越来越多的人寻求治疗与衰老有关的疾病。植物源性营养保健品由于其预防光老化的作用，目前在皮肤美容研究中引起了极大的兴趣。我们对市售产品(Venerinase®)可能的光老化预防特性进行了体外研究。我们在体外测试了红景天、蒺藜、辣木、山楂、叶酸和维生素B12 (Venerinase®)的混合物对皮肤的潜在抗衰老作用。研究方案采用常规组织学、免疫荧光和实时PCR。经测试的产品被证明可以防止紫外线诱导的角化细胞和成纤维细胞的形态变化。此外，通常由紫外线照射引发的衰老相关和促炎途径被Venerinase®预处理所抑制。我们的结果支持口服补充剂治疗和/或预防皮肤光损伤的潜在临床益处。

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来源期刊

Cosmetics Medicine-Surgery

CiteScore

5.20

自引率

12.10%

发文量

108

审稿时长

8 weeks