Clinical radiology最新文献

{"title":"Assessing clinical complexity in fluoroscopy-guided interventional procedures using the modified Delphi method: a pathway to define diagnostic reference levels (DRLs)","authors":"A. Pimenta ,&nbsp;P. Lopes ,&nbsp;F. Cavalheiro ,&nbsp;P. Sousa ,&nbsp;L. Azevedo ,&nbsp;I. Ramos ,&nbsp;J. Santos","doi":"10.1016/j.crad.2025.107052","DOIUrl":"10.1016/j.crad.2025.107052","url":null,"abstract":"<div><h3>AIM</h3><div>Diagnostic reference level (DRL) implementation for interventional radiology (IR) is challenging, considering exposure-value variation for the same procedure, due to different complexity levels. This study aims to define clinical criteria to assess the complexity level for three fluoroscopy-guided interventional procedures (FGIPs) in Portugal: percutaneous transhepatic biliary drainage (PTBD), transarterial chemoembolisation (TACE), and transjugular intrahepatic portosystemic shunt (TIPS).</div></div><div><h3>MATERIALS AND METHODS</h3><div>The modified Delphi method, a formal and standard group consensus process that systematically and quantitatively synthesises experts’ opinions, was used to obtain a consensus by experts, in the field of IR, regarding complexity criteria for FGIPs. Three rounds of interaction with the participation of the research team and experts were created to define the complexity criteria.</div></div><div><h3>RESULTS</h3><div>The complexity levels proposed in this paper were based on five articles available in the literature. Complexity criteria, subcriteria, and respective classification scores were approved for the three FGIPs.</div></div><div><h3>CONCLUSION</h3><div>The clinical criteria for PTBD and TACE were updated according to the clinical opinion of the expert panel participating in this study, and complexity levels were created for TIPS. FGIP categorisation according to the level of complexity is an additional tool to refine the analysis of dose values, facilitate clinical auditing, and make the optimisation process more effective. Identifying dose values, facilitate clinical auditing, and make the optimisation process more effective. Identifying the procedure level of complexity on the examination report will allow DRL definition, according to the appropriate procedure categorisation.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"90 ","pages":"Article 107052"},"PeriodicalIF":1.9,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary computed tomography angiography–derived fractional flow reserve (FFRCT) decreasing slope as a novel biomarker to identify culprit lesion precursors causing future acute coronary syndrome","authors":"X. Dai ,&nbsp;Y. Jiang ,&nbsp;K. Fang ,&nbsp;Y. Chen ,&nbsp;S. Yang ,&nbsp;Y. Zheng ,&nbsp;M. Ma ,&nbsp;S. Lin ,&nbsp;S. Yu","doi":"10.1016/j.crad.2025.107047","DOIUrl":"10.1016/j.crad.2025.107047","url":null,"abstract":"<div><h3>AIM</h3><div>Culprit lesion precursors are vulnerable and prone to rupture, leading to myocardial ischaemia. The aim of this study was to assess the value of coronary computed tomography angiography (CCTA)–derived fractional flow reserve (FFR_CT) decreasing slope through plaques to identify culprit lesion precursors.</div></div><div><h3>MATERIALS AND METHODS</h3><div>We studied 428 patients tracked for acute coronary syndrome (ACS) over 3 years. Fifty-three developed ACS and were matched to 53 controls. Using baseline computed tomography (CT) angiography (CCTA) scans, we measured culprit lesion precursors and non-culprit lesions, assessing their morphological parameters, FFR_CT slope, and lesion-specific FFR_CT.</div></div><div><h3>RESULTS</h3><div>Fifty-three culprit lesion precursors and 228 non-culprit lesions were compared. Culprit lesion precursors exhibited lower FFR_CT slope (-0.03 ± 0.03 vs -0.01 ± 0.01, <em>P</em>&lt;0.05) and lesion-specific FFR_CT (0.71 ± 0.11 vs 0.83 ± 0.10, <em>P</em>&lt;0.05) compared with non-culprit lesions. FFR_CT slopes of culprit lesion precursors varied according to the presence of plaque type, which was not obvious in non-culprit lesions. FFR_CT slope showed a better discriminatory value for future culprit lesions. In the multivariable analysis, FFR_CT slope and lesion-specific FFR_CT were associated with future culprit lesions. The risk of becoming a future culprit lesion within 3 years was significantly decreased with the increasing of FFR_CT slope (odds ratio [OR] = 0.27, 95% confidence interval [CI]: 0.17, 0.72, <em>P</em>&lt;0.01).</div></div><div><h3>CONCLUSION</h3><div>FFR_CT declines significantly in culprit lesion precursors, and FFR_CT slope is associated with future culprit lesions. FFR_CT slope has a better value for discriminating culprit lesion precursors. Lesions with low FFR_CT slopes have an increased risk of becoming future culprit, and care should be taken for those lesions.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"90 ","pages":"Article 107047"},"PeriodicalIF":1.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct traction device for wrist magnetic resonance (MR) imaging","authors":"M. Zhang,&nbsp;D.K.W. Yeung,&nbsp;S. Wu,&nbsp;S.W.Y. Yip,&nbsp;J.F. Griffith","doi":"10.1016/j.crad.2025.107050","DOIUrl":"10.1016/j.crad.2025.107050","url":null,"abstract":"<div><h3>AIM</h3><div>To evaluate the distraction effect, intrinsic structure visibility, and wearability of a novel direct wrist traction device for wrist magnetic resonance (MR) imaging.</div></div><div><h3>MATERIALS AND METHODS</h3><div>A total of 34 healthy subjects underwent wrist MR imaging initially without traction and then with traction using a direct traction device and were enrolled in this study. Joint space width, articular cartilage visibility, intrinsic ligaments and triangular fibrocartilage complex (TFCC) visibility, and lesion detection were assessed before and after traction. A 10-point visual analogue scale (VAS) questionnaire was used to assess pain during MRI. Paired sample t-test and marginal homogeneity test were used to compare joint space width, articular cartilage and intrinsic ligament visibility before and after traction, respectively.</div></div><div><h3>RESULTS</h3><div>Mean joint space width was 0.7 ± 0.34 mm wider after traction (adjusted <em>P</em> &lt; 0.001). Articular cartilage visibility improved at the radiolunate, scaphocapitate, and lunocapitate joints after traction (all adjusted <em>P</em> &lt; 0.001). Intrinsic ligaments and TFCC lesion detection tended to improve following traction with improved visibility. Twenty-one (62%) of 34 subjects had no wrist pain during traction while 13 (38%) had an average increase of 2.6 VAS points in wrist pain. No subjects had shoulder or neck pain.</div></div><div><h3>CONCLUSION</h3><div>This direct traction device effectively distracts the wrist joint, which may potentially improve articular cartilage visibility as well as the detection of intrinsic ligament and TFCC lesions.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"90 ","pages":"Article 107050"},"PeriodicalIF":1.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RCR meetings","authors":"","doi":"10.1016/S0009-9260(25)00249-1","DOIUrl":"10.1016/S0009-9260(25)00249-1","url":null,"abstract":"","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"88 ","pages":"Article 107044"},"PeriodicalIF":1.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of computed tomography (CT)-based radiomics and artificial intelligence (AI) models in hepatocellular carcinoma: a systematic review and meta-analysis","authors":"K. Sweta ,&nbsp;W. Dkhar ,&nbsp;R. Kadavigere ,&nbsp;A. Pradhan ,&nbsp;K. Nayak ,&nbsp;S. Sukumar ,&nbsp;N.A. Barnes","doi":"10.1016/j.crad.2025.107042","DOIUrl":"10.1016/j.crad.2025.107042","url":null,"abstract":"<div><h3>AIM</h3><div>Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related deaths worldwide. The clinical utility of artificial intelligence (AI) and radiomics models based on contrast-enhanced computed tomography (CECT) for HCC detection remains underexplored. This systematic review and meta-analysis evaluated the diagnostic performance of machine learning and radiomics-based models.</div></div><div><h3>MATERIALS AND METHODS</h3><div>A comprehensive literature search (2015-2025) across four major databases identified 29 eligible studies according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The risk of bias was assessed using the QUADAS-2 tool. Of these, 17 studies provided independent performance metrics and were included in the meta-analysis. Pooled estimates of sensitivity, specificity, accuracy, and the F1 score were calculated using a random effects model.</div></div><div><h3>RESULTS</h3><div>Models evaluated on independent test datasets, the pooled sensitivity and specificity were 0.562 and 0.570, respectively. A subgroup of radiomics-specific models (n=3) demonstrated comparatively higher sensitivity (0.660) and specificity (0.670), with minimal heterogeneity in sensitivity (I² = 0%, τ² ≈ 0), suggesting strong internal consistency. However, due to the limited number of studies, these results should be interpreted with caution. Combined models showed lower sensitivity (0.368) and specificity (0.297), with high heterogeneity (I² = 98.3%), likely due to the absence of independent test sets, which may have led to limited generalisability.</div></div><div><h3>CONCLUSION</h3><div>Radiomics-based models evaluated on independent datasets exhibit more consistent diagnostic accuracy for HCC detection using CECT. However, methodological variability underscores the need for standardised reporting, robust external validation, and incorporation of explainable AI techniques to enhance clinical adoption.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"89 ","pages":"Article 107042"},"PeriodicalIF":1.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel preoperative computed tomography (CT)-derived parameters to enhance self-expanding metallic stents (SEMS) outcomes in obstructive colorectal cancer","authors":"A. Akçay ,&nbsp;Z. Dönmez ,&nbsp;M.A. Gültekin ,&nbsp;A.A. Peker ,&nbsp;Ü.E. Karabulut ,&nbsp;D. Şahin ,&nbsp;S. Kiremitçi ,&nbsp;H. Şentürk ,&nbsp;R. Şerefoğlu ,&nbsp;H. Toprak","doi":"10.1016/j.crad.2025.107041","DOIUrl":"10.1016/j.crad.2025.107041","url":null,"abstract":"<div><h3>AIM</h3><div>This study aimed to evaluate whether preoperative computed tomography (CT)-based morphological parameters predict the clinical success of self-expanding metallic stents (SEMS) in malignant colorectal obstruction.</div></div><div><h3>MATERIALS AND METHODS</h3><div>Sixty-six patients with acute malignant colonic obstruction who underwent SEMS placement between 2016 and 2021 were retrospectively analysed. Tumour length, wall thickness, and lumen diameter were measured on preoperative CT, and ratios with SEMS dimensions were calculated. Clinical success was defined as decompression within 96 hours and no further stent-related intervention within three months.</div></div><div><h3>RESULTS</h3><div>A total of 47 patients (71.2%) achieved clinical success, while 19 patients (28.8%) did not. Unsuccessful cases demonstrated significantly greater tumour length (median: 58 mm vs 48 mm, <em>P</em>=.019) and higher tumour thickness-to-lumen diameter ratio (median: 6.66 mm vs 3.9 mm, <em>P</em>=.016). They also exhibited a narrower lumen diameter (median: 2.21 mm vs 2.85 mm, <em>P</em>=.03). Conversely, a higher SEMS length-to-tumour length ratio correlated with successful outcomes (median: 2 mm vs 1.46 mm, <em>P</em>=.009). Factors such as age, tumour wall thickness, colonic angulation, and SEMS diameter-to-lumen diameter ratio were not significantly associated with clinical success (all <em>P</em>&gt;.05).</div></div><div><h3>CONCLUSION</h3><div>Preoperative CT findings—particularly tumour length, lumen diameter, tumour thickness-to-lumen diameter ratio, and SEMS length-to-tumour length ratio—may serve as practical predictors for SEMS success in malignant colorectal obstruction. Incorporating these parameters into patient selection and stent-sizing decisions could improve both immediate and long-term outcomes. Further multicenter, prospective studies are required to validate these findings and optimise SEMS use in clinical practice.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"89 ","pages":"Article 107041"},"PeriodicalIF":1.9,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of relative enhancement metrics based on preconcurrent chemoradiotherapy magnetic resonance imaging (pre-CCRT MRI) volumetric segmentation in glioblastoma","authors":"T. Yuan ,&nbsp;F. Wang ,&nbsp;Y. Liu ,&nbsp;C. Li ,&nbsp;G. Gao ,&nbsp;G. Quan","doi":"10.1016/j.crad.2025.107040","DOIUrl":"10.1016/j.crad.2025.107040","url":null,"abstract":"<div><h3>AIM</h3><div>The purpose of this study was to identify the impact of relative contrast enhancement (rCE), based on volumetric segmentation from preconcurrent chemoradiotherapy magnetic resonance imaging (pre-CCRT MRI), in predicting tumour progression and unfavourable survival in glioblastoma (GBM) patients.</div></div><div><h3>MATERIALS AND METHODS</h3><div>Seventy-seven GBM patients underwent conventional MRI before and after radiochemotherapy. Residual cavity wall enhancement was segmented using Image J software, and rCE was calculated. Clinical and imaging variables were compared between shorter and longer overall survival (OS) groups. Multivariable logistic regression was performed to identify the significant predictors of survival outcomes. Diagnostic performance was evaluated using receiver operating characteristic curve (ROC) analysis. Survival outcomes based on rCE were compared using Kaplan-Meier analysis.</div></div><div><h3>RESULTS</h3><div>Older age, nodular and thick linear enhancement, larger orthogonal lesion size on fluid-attenuated inversion recovery (FLAIR) and contrast-enhanced T1-weighted imaging, and higher rCE (≥1.265) were significant predictors of tumour progression. Multivariate analysis showed that higher rCE was an independent predictor of shorter progression-free survival (HR = 4.829). Additionally, older age and higher rCE were independent predictors of shorter OS (HR = 1.048 and 3.792, respectively). A combined model incorporating rCE with clinical and conventional MR variables achieved an area under the ROC curve (AUC) of 0.845 and an accuracy of 79.6% in predicting shorter OS.</div></div><div><h3>CONCLUSION</h3><div>Pre-CCRT volumetric segmentation-based rCE may improve the prediction of GBM progression and survival, and holds potential as a practical imaging biomarker to guide personalised precision treatment.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"89 ","pages":"Article 107040"},"PeriodicalIF":1.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144920264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network meta-analysis of the efficacy and safety of ablation for hepatocellular carcinoma under different imaging guidance","authors":"L. Chen ,&nbsp;H. Xu ,&nbsp;Q. Li","doi":"10.1016/j.crad.2025.107039","DOIUrl":"10.1016/j.crad.2025.107039","url":null,"abstract":"<div><h3>AIM</h3><div>Hepatocellular carcinoma (HCC) remains a major global health challenge due to its high mortality rates. Imaging guidance is pivotal in ablation therapy, yet the optimal technique remains unclear, necessitating a comparative analysis. The aim of this network meta-analysis is to evaluate the safety and clinical efficacy of ablation for HCC under different imaging guidance techniques.</div></div><div><h3>MATERIALS AND METHODS</h3><div>Relevant studies published up to May 2024 were searched in PubMed, Embase, and Wanfang databases, and baseline information and endpoint data were extracted. The endpoints of this meta-analysis included treatment efficacy, safety, local recurrence, and survival rate.</div></div><div><h3>RESULTS</h3><div>The analysis included 11 randomised controlled trials with a total of 1206 patients undergoing ablation treatment for HCC guided by different imaging techniques. Network meta-analysis results for ablation efficacy showed that ablation guided by computed tomography (CT) (odds ratio [OR]=1.13; 95% confidence interval [CI]: 1.03, 1.24; <em>P</em>&lt;0.05) and magnetic resonance imaging (MRI) (OR=1.43; 95% CI: 1.07, 1.91; <em>P</em>&lt;0.05) was significantly more effective than by conventional ultrasound. Conventional meta-analysis results showed that the recurrence rate in the CT/MRI group was significantly lower than that in the conventional ultrasound group (relative risk [RR] = 0.45; 95% CI: 0.29, 0.67; <em>P</em>&lt;0.05). Safety analysis indicated that the risk of common adverse reactions in the CT/MRI group was significantly lower than in the conventional ultrasound group (RR=0.42; 95% CI: 0.22, 0.82; <em>P</em>&lt;0.05).</div></div><div><h3>CONCLUSION</h3><div>Ablation guided by CT or MRI is a safe and effective treatment for HCC. Further multicentre randomised clinical trials are needed to confirm these findings.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"89 ","pages":"Article 107039"},"PeriodicalIF":1.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of brain parenchyma in paediatric patients diagnosed with poorly controlled type 1 diabetes using volumetric magnetic resonance imaging (MRI)","authors":"D. Çeliker ,&nbsp;S. Taşar ,&nbsp;E.E. Altun ,&nbsp;F. Dursun ,&nbsp;H. Kırmızıbekmez","doi":"10.1016/j.crad.2025.107036","DOIUrl":"10.1016/j.crad.2025.107036","url":null,"abstract":"<div><h3>AIM</h3><div>To quantitatively assess brain volume changes in response to glycaemic excursions in paediatric patients with poorly controlled type 1 diabetes using software programs from magnetic resonance imaging (MRI).</div></div><div><h3>MATERIALS AND METHODS</h3><div>This study included 46 children (24 boys and 22 girls) aged 11–17 years with type 1 diabetes mellitus (T1 DM) diagnosed between February 1, 2014, and February 1, 2023, at our hospital. All patients had a diabetes diagnosis for at least 5 years and available brain MRI data. Brain imaging was performed using a 1.5 Tesla MRI machine (Siemens Magnetom Aera, Erlangen, Germany). Volumetric analysis of 3D T1 Magnetization Prepared Rapid Gradient Echo (MP-RAGE) images was conducted retrospectively using the vol2brain software.</div></div><div><h3>RESULTS</h3><div>Volumetric analysis using the vol2brain software revealed statistically significant atrophy in the nearly whole brain structures, especially in frontoparietal lobes and basal ganglia compared to the control group. Cerebral cortical thinning was observed globally, with more marked reduction in the insular and temporo-parieto-occipital regions. Among patients with basal ganglia involvement, the hippocampus and nucleus caudatus were the most affected structures. Of all groups, girls aged 15 and 17 were the most affected.</div></div><div><h3>CONCLUSION</h3><div>In diabetes, micro-level brain parenchymal changes that cannot be detected using conventional methods can be identified through software programs. These findings emphasise the importance of advanced imaging techniques in monitoring cerebral complications in diabetic patients.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"90 ","pages":"Article 107036"},"PeriodicalIF":1.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of the 18F-fluorodeoxyglucose (18F-FDG) and [18F] 9-fluoropropyl-(+)-dihydrotetrabenazine (18F-FP-DTBZ) positron emission tomography (PET) in patients with cognitive impairment in Parkinson's disease","authors":"S. Li ,&nbsp;W. Lu ,&nbsp;S. Yan ,&nbsp;T. Song ,&nbsp;C. Zhang ,&nbsp;C. Yang ,&nbsp;J. Lu","doi":"10.1016/j.crad.2025.107038","DOIUrl":"10.1016/j.crad.2025.107038","url":null,"abstract":"<div><h3>AIM</h3><div>Mild cognitive impairment (MCI) is common in Parkinson's disease (PD). This study compared cerebral metabolism and dopaminergic function in PD patients with MCI (PD-MCI) versus those with normal cognition (PD-NC) and healthy controls (HC).</div></div><div><h3>MATERIAL AND METHODS</h3><div>A total of 78 PD patients (40 PD-MCI, 38 PD-NC) and 28 HC underwent 18F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) (metabolism) and [¹⁸F] 9-fluoropropyl-(+)-dihydrotetrabenazine (¹⁸F-FP-DTBZ) PET (dopaminergic vesicular transporter). Group comparisons used t-tests. Correlations between PET measures and cognitive scores (MMSE, MoCA) were assessed.</div></div><div><h3>RESULTS</h3><div>PD-MCI patients showed significantly reduced FDG uptake in frontal and parietal regions compared to PD-NC (<em>P</em>=0.003, <em>P</em>=0.025). PD-MCI also exhibited lower ¹⁸F-FP-DTBZ binding, particularly in bilateral caudate (contralateral <em>P</em>=0.018; ipsilateral <em>P</em>=0.048). In PD patients, FDG uptake in frontal/parietal lobes and ¹⁸F-FP-DTBZ uptake in caudate and putamen positively correlated with MMSE and MoCA scores (all <em>P</em>&lt;0.05).</div></div><div><h3>CONCLUSION</h3><div>Striatal dopamine depletion and hypometabolism in frontal/parietal regions are associated with cognitive deficits in PD-MCI patients.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"89 ","pages":"Article 107038"},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}