Clinical EEG and Neuroscience最新文献_第7页

Continuous Spikes and Waves During Sleep (CSWS), Severe Epileptic Encephalopathy, and Choreoathetosis due to Mutations in FRRS1L. FRRS1L基因突变引起的睡眠期间连续尖峰和波、严重癫痫性脑病和舞蹈病

IF 2 4区医学

Clinical EEG and Neuroscience Pub Date : 2023-09-01 DOI: 10.1177/15500594221112508

Ali Mir, Fawzia Amer, Mona Ali, Wajd Alotaibi, Manar Alotaibi, Abdullah Hedaithy, Fatimah Aldurayhim, Fatimah Hussain, Shahid Bashir, Yousef Housawi

{"title":"Continuous Spikes and Waves During Sleep (CSWS), Severe Epileptic Encephalopathy, and Choreoathetosis due to Mutations in FRRS1L.","authors":"Ali Mir, Fawzia Amer, Mona Ali, Wajd Alotaibi, Manar Alotaibi, Abdullah Hedaithy, Fatimah Aldurayhim, Fatimah Hussain, Shahid Bashir, Yousef Housawi","doi":"10.1177/15500594221112508","DOIUrl":"https://doi.org/10.1177/15500594221112508","url":null,"abstract":"Background. Biallelic pathogenic variants in the FRRS1L gene are now known to cause developmental and epileptic encephalopathy-37 (DEE37). It can also be associated with chorea and continuous spikes and waves during sleep (CSWS). CSWS is a rare age-related epileptic encephalopathy syndrome of childhood that is characterized by seizures, neurocognitive regression and electrical status epilepticus during sleep (ESES) on electroencephalogram (EEG) that evolves in four stages. Seizures start during the prodromal phase but the ESES on EEG appears only during acute stage and this is the stage when the diagnosis of CSWS can be made. Methods. We present two patients with FRRS1L mutation causing DEE37 with CSWS. We also review twenty-nine cases of DEE37 described in the literature before and discuss its association with CSWS in the total cohort of thirty-one cases. Results. Developmental regression was found in 80% of the patients, mean age of seizure onset was 18 months, ESES or slow spike and wave on the EEG were reported mostly in the older patients (median age of 11 years) and hypsarrhythmia was reported in younger patients (median age of 4 years). This could suggest that if the younger patients were followed longer their EEG would have evolved into ESES during the acute stage of this syndrome and a diagnosis of CSWS could be made. Conclusion. Recognizing ESES and the natural evolution of CSWS is important in diagnosis and proper management of these patients. More detailed report of EEG findings and the evolution of epilepsy and development are needed to further characterize this syndrome.","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10312667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Emotional Modulation of Response Inhibition in Adolescents During Acute Suicidal Crisis: Event-Related Potentials in an Emotional Go/NoGo Task. 青少年急性自杀危机反应抑制的情绪调节:情绪去/不去任务中的事件相关电位。

IF 2 4区医学

Clinical EEG and Neuroscience Pub Date : 2023-09-01 DOI: 10.1177/15500594211063311

Meggan Porteous, Paniz Tavakoli, Kenneth Campbell, Allyson Dale, Addo Boafo, Rebecca Robillard

{"title":"Emotional Modulation of Response Inhibition in Adolescents During Acute Suicidal Crisis: Event-Related Potentials in an Emotional Go/NoGo Task.","authors":"Meggan Porteous, Paniz Tavakoli, Kenneth Campbell, Allyson Dale, Addo Boafo, Rebecca Robillard","doi":"10.1177/15500594211063311","DOIUrl":"https://doi.org/10.1177/15500594211063311","url":null,"abstract":"Objectives. Suicide is the second leading cause of adolescent deaths and may be linked to difficulties with inhibitory and emotional processing. This study assessed the neural correlates of cognitive inhibition during emotional processing in adolescents hospitalized for a suicidal crisis. Methods. Event-related potentials were recorded during an emotional Go/NoGo task in 12 adolescents who attempted suicide and 12 age- and sex-matched healthy controls. Results. Compared to the control group, the suicidal group showed significantly reduced positivity at the time of the P3d (difference waveform reflecting NoGo minus Go trials) in response to happy and neutral, but not sad stimuli. For happy stimuli, this group difference was restricted to the right hemisphere. Further analyses indicated that the suicidal group had a reversed pattern of P3 amplitude in response to inhibition, with lower amplitudes in the NoGo compared to the Go conditions. Suicidal symptoms severity strongly correlated with lower amplitude of the P3d in response to neutral faces. Conclusions. These findings provide more insight into inhibition difficulties in adolescents with acute suicidal risk. Interactions between emotional and inhibition processing should be considered when treating acutely suicidal youths.","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9965291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Value of Concurrent Electrocardiography When Performing an Electroencephalograph. 进行脑电图时并发心电图的价值。

IF 2 4区医学

Clinical EEG and Neuroscience Pub Date : 2023-09-01 DOI: 10.1177/15500594221129434

Nimalan Harinesan, Dennis Cordato, Roy G Beran

{"title":"The Value of Concurrent Electrocardiography When Performing an Electroencephalograph.","authors":"Nimalan Harinesan, Dennis Cordato, Roy G Beran","doi":"10.1177/15500594221129434","DOIUrl":"https://doi.org/10.1177/15500594221129434","url":null,"abstract":"Introduction. The use of concurrent, single lead electrocardiograph (ECG) recording, when performing a routine electroencephalograph (EEG), has been standard practice for many years. Previous studies have reported on the usefulness of concurrent EEG in assessing syncope and the detection of newly identified cardiac dysrhythmia but have relied on specialist cardiologist interpretation of the ECG trace. This study expands the understanding of concurrent ECG and provides demographic information regarding the incidence, nature of ECG changes and diagnostic utility of ECG interpretation, during routine EEGs, as evaluated by neurologists. Methods. A single center, retrospective study of routine concurrent EEG and ECG recordings was performed. All routine EEGs, performed within a 12 month period were analysed. Demographic data, underlying comorbidities, reasons for referral and ECG changes were assessed. Results. ECG abnormalities were identified in 147 (13.5%) of concurrent ECG/EEG routine recordings. The presence of ECG abnormalities was significantly associated with the reason for referral, namely being assessed for the evaluation of seizure activity and with increasing patient age. Thirty-eight patients (3.5%) had newly identified ECG abnormalities, of which atrial fibrillation (AF) (12 patients) and sinus bradycardia (9 patients) were the most common. Five patients (0.5%) had a change in their management consequent to the identified ECG changes. Conclusions. These findings support the value of neurologists' interpretation and need for ongoing concurrent ECGs, during routine EEG recordings. The study raises concern about the requesting clinician's response to the identification of newly diagnosed cardiac dysrhythmias.","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10312686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal Cross Frequency Coupling of Brain Electroencephalographic Oscillations Related to Visual Oddball Task in Parkinson's Disease with Mild Cognitive Impairment. 帕金森病伴轻度认知障碍患者与视觉怪球任务相关的脑电图振荡异常交叉频率耦合

IF 2 4区医学

Clinical EEG and Neuroscience Pub Date : 2023-07-01 DOI: 10.1177/15500594221128713

Zübeyir Bayraktaroğlu, Tuba Aktürk, Görsev Yener, Tom A de Graaf, Lütfü Hanoğlu, Ebru Yıldırım, Duygu Hünerli Gündüz, İlayda Kıyı, Alexander T Sack, Claudio Babiloni, Bahar Güntekin

{"title":"Abnormal Cross Frequency Coupling of Brain Electroencephalographic Oscillations Related to Visual Oddball Task in Parkinson's Disease with Mild Cognitive Impairment.","authors":"Zübeyir Bayraktaroğlu, Tuba Aktürk, Görsev Yener, Tom A de Graaf, Lütfü Hanoğlu, Ebru Yıldırım, Duygu Hünerli Gündüz, İlayda Kıyı, Alexander T Sack, Claudio Babiloni, Bahar Güntekin","doi":"10.1177/15500594221128713","DOIUrl":"https://doi.org/10.1177/15500594221128713","url":null,"abstract":"Parkinson's disease (PD) is a movement disorder caused by degeneration in dopaminergic neurons. During the disease course, most of PD patients develop mild cognitive impairment (PDMCI) and dementia, especially affecting frontal executive functions. In this study, we tested the hypothesis that PDMCI patients may be characterized by abnormal neurophysiological oscillatory mechanisms coupling frontal and posterior cortical areas during cognitive information processing. To test this hypothesis, event-related EEG oscillations (EROs) during counting visual target (rare) stimuli in an oddball task were recorded in healthy controls (HC; N = 51), cognitively unimpaired PD patients (N = 48), and PDMCI patients (N = 53). Hilbert transform served to estimate instantaneous phase and amplitude of EROs from delta to gamma frequency bands, while modulation index computed ERO phase-amplitude coupling (PAC) at electrode pairs. As compared to the HC and PD groups, the PDMCI group was characterized by (1) more posterior topography of the delta-theta PAC and (2) reversed delta-low frequency alpha PAC direction, ie, posterior-to-anterior rather than anterior-to-posterior. These results suggest that during cognitive demands, PDMCI patients are characterized by abnormal neurophysiological oscillatory mechanisms mainly led by delta frequencies underpinning functional connectivity from frontal to parietal cortical areas.","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10053400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Aperiodic Neural Activity is a Better Predictor of Schizophrenia than Neural Oscillations. 非周期性神经活动比神经振荡更能预测精神分裂症。

IF 2 4区医学

Clinical EEG and Neuroscience Pub Date : 2023-07-01 DOI: 10.1177/15500594231165589

Erik J Peterson, Burke Q Rosen, Aysenil Belger, Bradley Voytek, Alana M Campbell

引用次数: 20

IF 1.6 4区医学

Clinical EEG and Neuroscience Pub Date : 2023-07-01 Epub Date: 2022-04-04 DOI: 10.1177/15500594221088258

Cindy L Ehlers, Derek Wills, Katherine J Karriker-Jaffe, Evelyn Phillips, Corrine Kim, David A Gilder

{"title":"Event-related Oscillations to Emotional Faces are Related to a History of Internalizing Disorders.","authors":"Cindy L Ehlers, Derek Wills, Katherine J Karriker-Jaffe, Evelyn Phillips, Corrine Kim, David A Gilder","doi":"10.1177/15500594221088258","DOIUrl":"10.1177/15500594221088258","url":null,"abstract":"Event-related oscillations (EROs) may represent sensitive biomarkers or endophenotypes for disorders that underlie risk behaviors such as suicidal thoughts and actions. In this study, young adults of American Indian (AI) (n = 821) and Mexican American (MA) (n = 721) ancestry (age 18-30 yrs) were clinically assessed for internalizing and externalizing disorders, and an internalizing scale was generated by extracting core diagnostic items from 6 lifetime DSM5-compatible diagnoses (social phobia, panic disorder, agoraphobia, obsessive compulsive disorder, post-traumatic stress disorder, major depressive episode) and symptoms of suicidality. EROs were generated to sad, happy and neutral faces, and energy and phase locking of delta ERO oscillations were assessed in frontal areas. An increase in delta ERO energy was found in the frontal lead (FZ) following presentation of the sad facial expressions in those with a history of 10 or more internalizing symptoms compared to those with no symptoms. Increases in delta ERO energy in FZ were also associated with a diagnosis of major depressive disorder (MDD), but not with anxiety disorders or antisocial personality disorder/conduct disorders (ASP). Major depression was also associated with increases in cross-cortical phase-locking (FZ-PZ). A decrease in the percentage of correctly identified neutral faces also was seen among those with 10 or more internalizing symptoms compared to those without internalizing symptoms, and in those with anxiety disorders, but not in those with ASP or MDD as compared to their controls. These findings suggest ERO measures may represent important potential biomarkers of depressive disorders as well as risk indicators for suicidal behaviors.","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10117579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Information Contained in EEG Allows Characterization of Cognitive Decline in Neurodegenerative Disorders. 脑电图中包含的信息允许表征神经退行性疾病的认知衰退。

IF 2 4区医学

Clinical EEG and Neuroscience Pub Date : 2023-07-01 DOI: 10.1177/15500594221120734

Sebastian M Keller, Cornelius Reyneke, Ute Gschwandtner, Peter Fuhr

{"title":"Information Contained in EEG Allows Characterization of Cognitive Decline in Neurodegenerative Disorders.","authors":"Sebastian M Keller, Cornelius Reyneke, Ute Gschwandtner, Peter Fuhr","doi":"10.1177/15500594221120734","DOIUrl":"https://doi.org/10.1177/15500594221120734","url":null,"abstract":"Over the last few decades, electroencephalography (EEG) has evolved from being a method that purely relies on visual inspection into a quantitative method. Quantitative EEG, or QEEG, enables the assessment of neurological disorders based on spectral features, dynamic characterizations of EEG resting-state activity, brain connectivity analyzes or quantification of EEG signal complexity. The information contained in EEG is multidimensional: Electrodes, positioned at different scalp locations, provide a spatial dimension to the analysis of EEG while time provides a dynamic dimension: This multidimensional property of EEG makes its quantification a challenging task. In this narrative review we present quantitative models focused on different aspects of EEG: While microstate models focus more on the quantification of the dynamic aspects of EEG, spectral methods, connectivity analysis and entropy based models are more concerned with its spatial aspects. Nevertheless, these diverse approaches have provided neurophysiology based biomarkers, especially for monitoring and predicting the course of various neurodegenerative disorders. However, their translation into clinical practice crucially depends on the ability to automate the analysis of EEG in a user-friendly manner, without compromising on the validity of the provided results. Once this has been accomplished, EEG would provide an inexpensive and widely available method for monitoring disease progression, identifying patients at risk of neurodegeneration-especially before the onset of clinical symptoms, and predicting future cognition. For stratification of patients to clinical trials, EEG would allow shortening the trial duration and lowering the number of necessary participants by identifying patients at risk of fast cognitive decline.","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9696224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Oscillatory Activities in Multiple Frequency Bands in Patients with Schizophrenia During Motion Perception. 精神分裂症患者运动知觉过程中多频带振荡活动。

IF 2 4区医学

Clinical EEG and Neuroscience Pub Date : 2023-07-01 DOI: 10.1177/15500594221141825

C Başar-Eroğlu, K M Küçük, L Rürup, C Schmiedt-Fehr, B Mathes

{"title":"Oscillatory Activities in Multiple Frequency Bands in Patients with Schizophrenia During Motion Perception.","authors":"C Başar-Eroğlu, K M Küçük, L Rürup, C Schmiedt-Fehr, B Mathes","doi":"10.1177/15500594221141825","DOIUrl":"https://doi.org/10.1177/15500594221141825","url":null,"abstract":"Patients with schizophrenia show impairment in binding stimulus features into coherent objects, which are reflected in disturbed oscillatory activities. This study aimed to identify disturbances in multiple oscillatory bands during perceptual organization of motion perception in patients with schizophrenia. EEG was recorded from healthy controls and patients with schizophrenia during continuous presentation of a motion stimulus which induces reversals between two exogenously generated perceptions. This stimulus was used to investigate differences in motion binding processes between healthy controls and patients with schizophrenia. EEG signals were transformed into frequency components by means of the Morlet wavelet transformation in order to analyse inter-trial coherences (ITC) in the delta (1-4 Hz), theta (4-7 Hz), alpha (8-12 Hz), and gamma (28-48 Hz) frequency bands during exogenous motion binding. Patients showed decreased delta-ITC in occipital and theta-ITC in central and parietal areas, while no significant differences were found for neither alpha nor gamma-ITCs. The present study provides one of the first insights on the oscillatory synchronizations related with the motion perception in schizophrenia. The ITC differences revealed alterations in the consistency of large-scale integration and transfer functions in patients with schizophrenia.","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9696240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental Activity as the Bridge between Neural Biomarkers and Symptoms of Psychiatric Illness. 心理活动是神经生物标志物与精神疾病症状之间的桥梁。

IF 2 4区医学

Clinical EEG and Neuroscience Pub Date : 2023-07-01 DOI: 10.1177/15500594221112417

Justin Riddle, Flavio Frohlich

{"title":"Mental Activity as the Bridge between Neural Biomarkers and Symptoms of Psychiatric Illness.","authors":"Justin Riddle, Flavio Frohlich","doi":"10.1177/15500594221112417","DOIUrl":"https://doi.org/10.1177/15500594221112417","url":null,"abstract":"The Research Domain Criteria (RDoC) initiative challenges researchers to build neurobehavioral models of psychiatric illness with the hope that such models identify better targets that will yield more effective treatment. However, a guide for building such models was not provided and symptom heterogeneity within Diagnostic Statistical Manual categories has hampered progress in identifying endophenotypes that underlie mental illness. We propose that the best chance to discover viable biomarkers and treatment targets for psychiatric illness is to investigate a triangle of relationships: severity of a specific psychiatric symptom that correlates to mental activity that correlates to a neural activity signature. We propose that this is the minimal model complexity required to advance the field of psychiatry. With an understanding of how neural activity relates to the experience of the patient, a genuine understanding for how treatment imparts its therapeutic effect is possible. After the discovery of this three-fold relationship, causal testing is required in which the neural activity pattern is directly enhanced or suppressed to provide causal, instead of just correlational, evidence for the biomarker. We suggest using non-invasive brain stimulation (NIBS) as these techniques provide tools to precisely manipulate spatial and temporal activity patterns. We detail how this approach enabled the discovery of two orthogonal electroencephalography (EEG) activity patterns associated with anhedonia and anxiosomatic symptoms in depression that can serve as future treatment targets. Altogether, we propose a systematic approach for building neurobehavioral models for dimensional psychiatry.","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10100601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phase Delay of the 40 Hz Auditory Steady-State Response Localizes to Left Auditory Cortex in Schizophrenia. 精神分裂症患者40 Hz听觉稳态反应的相位延迟定位于左听皮层。

IF 2 4区医学

Clinical EEG and Neuroscience Pub Date : 2023-07-01 DOI: 10.1177/15500594221130896

Brian J Roach, Yoji Hirano, Judith M Ford, Kevin M Spencer, Daniel H Mathalon

{"title":"Phase Delay of the 40 Hz Auditory Steady-State Response Localizes to Left Auditory Cortex in Schizophrenia.","authors":"Brian J Roach, Yoji Hirano, Judith M Ford, Kevin M Spencer, Daniel H Mathalon","doi":"10.1177/15500594221130896","DOIUrl":"https://doi.org/10.1177/15500594221130896","url":null,"abstract":"Background. The auditory steady state response (ASSR) is generated in bilateral auditory cortex and is the most used electroencephalographic (EEG) or magnetoencephalographic measure of gamma band abnormalities in schizophrenia. While the finding of reduced 40-Hz ASSR power and phase consistency in schizophrenia have been replicated many times, the 40-Hz ASSR phase locking angle (PLA), which assesses oscillation latency or phase delay, has rarely been examined. Furthermore, whether 40-Hz ASSR phase delay in schizophrenia is lateralized or common to left and right auditory cortical generators is unknown. Methods. Previously analyzed EEG data recorded from 24 schizophrenia patients and 24 healthy controls presented with 20-, 30-, and 40-Hz click trains to elicit ASSRs were re-analyzed to assess PLA in source space. Dipole moments in the right and left hemisphere were used to assess both frequency and hemisphere specificity of ASSR phase delay in schizophrenia. Results. Schizophrenia patients exhibited significantly reduced (ie, phase delayed) 40-Hz PLA in the left, but not the right, hemisphere, but their 20- and 30-Hz PLA values were normal. This left-lateralized 40-Hz phase delay was unrelated to symptoms or to previously reported left-lateralized PLF reductions in the schizophrenia patients. Conclusions. Consistent with sensor-based studies, the 40-Hz ASSR source-localized to left, but not right, auditory cortex was phase delayed in schizophrenia. Consistent with prior studies showing left temporal lobe volume deficits in schizophrenia, our findings suggest sluggish entrainment to 40-Hz auditory stimulation specific to left auditory cortex that are distinct from well-established deficits in gamma ASSR power and phase synchrony.","PeriodicalId":10682,"journal":{"name":"Clinical EEG and Neuroscience","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9796905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2